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Cited by 401

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

GOAT links dietary lipids with the endocrine control of energy balance

Open access
Kirchner, Henriette, Gutierrez, Jesus A, Solenberg, Patricia J, Pfluger, Paul T, Czyzyk, Traci A, Willency, Jill A, Schürmann, Annette, Joost, Hans-Georg, Jandacek, Ronald J, Hale, John E, Heiman, Mark L, Tschöp, Matthias H·2009·Nature Medicine
DOI 10.1038/nm.1997
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Abstract

Central nervous system nutrient sensing and afferent endocrine signaling have been established as parallel systems communicating metabolic status and energy availability in vertebrates. The only afferent endocrine signal known to require modification with a fatty acid side chain is the orexigenic hormone ghrelin. We find that the ghrelin O-acyl transferase (GOAT), which is essential for ghrelin acylation, is regulated by nutrient availability, depends on specific dietary lipids as acylation substrates and links ingested lipids to energy expenditure and body fat mass. These data implicate the ghrelin-GOAT system as a signaling pathway that alerts the central nervous system to the presence of dietary calories, rather than to their absence as is commonly accepted.

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Crossref · 10.1038/nm.1997

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Metadata

Authors
Kirchner, H., Gutierrez, J. A., Solenberg, P. J., Pfluger, P. T., Czyzyk, T. A., Willency, J. A., Schürmann, A., Joost, H.-G., Jandacek, R. J., Hale, J. E., Heiman, M. L., & Tschöp, M. H.
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
2009-06-05
Volume
15
Issue
7
Pages
741-745
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
DOI
10.1038/nm.1997
OpenAlex
W2039033342
Cited by
401
References
2
FWCI
20.08
Type
journal article
Language
en
Open access
green

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