Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

kConFab, Lim, Elgene, Vaillant, François, Wu, Di, Forrest, Natasha C, Pal, Bhupinder, Hart, Adam H, Asselin-Labat, Marie-Liesse +13 more·2009·Nature Medicine
DOI 10.1038/nm.2000

Cited by (1,001)

Items 101–200 of 1,001

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  14. Epithelial-Mesenchymal Plasticity of Breast Cancer Stem Cells: Implications for Metastasis and Therapeutic Resistance
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    Silver, Daniel P., Livingston, David M. · 2012 · Cancer Discovery
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  74. Normal stem cells and cancer stem cells: similar and different
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    Marco Mazzone, Laura M. Selfors, John G. Albeck, Michael Overholtzer, Sanja Šale, Danielle L. Carroll, Darshan Pandya, Yiling Lu, Gordon Brent Mills, Jon Christopher Aster et al. · 2010 · Proceedings of the National Academy of Sciences
  76. The complex genetic landscape of familial breast cancer
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    Sproul, Duncan, Kitchen, Robert R, Nestor, Colm E, Dixon, J Michael, Sims, Andrew H, Harrison, David J, Ramsahoye, Bernard H, Meehan, Richard R · 2012 · Genome Biology
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  80. The Difficulty of Targeting Cancer Stem Cell Niches
    Mark A. LaBarge · 2010 · Clinical Cancer Research
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    Karolina Holm, Dorthe Aamand Grabau, Kristina Lövgren, Steina Aradottir, Sofia K. Gruvberger-Saal, Jillian Howlin, Lao H. Saal, Stephen P. Ethier, Pär‐Ola Bendahl, Olle Stål et al. · 2012 · Molecular Oncology
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    P-K Lo, Deepak Kanojia, X Liu, Udai Pratap Singh, F G Berger, Qian Wang, Hexin Chen · 2011 · Oncogene
  83. Profiles of Genomic Instability in High-Grade Serous Ovarian Cancer Predict Treatment Outcome
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  84. Lysyl oxidase‐like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal‐like breast carcinomas
    Gema Moreno‐Bueno, Fernando Salvador, Alberto Martín, Alfredo Floristán, Eva P. Cuevas, Vanesa Santos, Amalia Montes, Saleta Morales, María Ángeles Castilla, Alejandro Rojo‐Sebastián et al. · 2011 · EMBO Molecular Medicine
  85. Dietary polyphenol quercetin targets pancreatic cancer stem cells
    Herr · 2010 · International Journal of Oncology
  86. Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis
    Xiaowen Zhang, Huai-Chin Chiang, Yao Wang, Chi Zhang, Sabrina A. Smith, Xiayan Zhao, Sreejith J. Nair, Joel Edmund Michalek, Ismail Jatoi, Meeghan Ann Lautner et al. · 2017 · Nature Communications
  87. FOXA1 represses the molecular phenotype of basal breast cancer cells
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    Walid T. Khaled, Song Choon Lee, Julia Stingl, Xiongfeng Chen, H. Raza Ali, Oscar M. Rueda, Fazal Hadi, Juexuan Wang, Yong Yu, Suet‐Feung Chin et al. · 2015 · Nature Communications
  89. Evolutionary Pathways in BRCA1-Associated Breast Tumors
    Filipe Correia Martins, Subhajyoti De, Vanessa Almendro, Mithat Gönen, So Yeon Park, Joanne L. Blum, William G. Herlihy, Gabrielle Ethington, Stuart J. Schnitt, Nadine Tung et al. · 2012 · Cancer Discovery
  90. A human breast atlas integrating single-cell proteomics and transcriptomics
    G. Kenneth Gray, Carman Man-Chung Li, Jennifer M. Rosenbluth, Laura M. Selfors, Nomeda Girnius, Jia‐Ren Lin, Ron C.J. Schackmann, Walter L. Goh, Kaitlin Moore, Hana Shapiro et al. · 2022 · Developmental Cell
  91. Molecular stratification within triple-negative breast cancer subtypes
    Dong‐Yu Wang, Zhe Jiang, Yaacov Ben‐David, James Robert Woodgett, Eldad Zacksenhaus · 2019 · Scientific Reports
  92. Loss of primary cilia occurs early in breast cancer development
    Ina Menzl, Lauren Grasso LeBeau, Ritu Pandey, Nadia B. Hassounah, Frank W. Li, Ray B. Nagle, Karen L. Weihs, Kimberly M. McDermott · 2014 · Cilia
  93. A whole-genome sequence and transcriptome perspective on HER2-positive breast cancers
    Ferrari, Anthony, Vincent-Salomon, Anne, Pivot, Xavier, Sertier, Anne-Sophie, Thomas, Emilie, Tonon, Laurie, Boyault, Sandrine, Mulugeta, Eskeatnaf, Treilleux, Isabelle, MacGrogan, Gaëtan et al. · 2016 · Nature Communications
  94. Genomic Architecture Characterizes Tumor Progression Paths and Fate in Breast Cancer Patients
    Hege Giercksky Russnes, Hans Kristian Moen Vollan, Ole Christian Lingjærde, Alexander Krasnitz, Pär Lundin, Bjørn Naume, Thérese Sørlie, Elin Borgen, Inga Hansine Rye, Anita Langerød et al. · 2010 · Science Translational Medicine
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  98. Breast Cancer Stem Cells: Biomarkers, Identification and Isolation Methods, Regulating Mechanisms, Cellular Origin, and Beyond
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  99. RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation
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  100. MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state
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