The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs
Open accessAbstract
HIV causes a chronic infection characterized by depletion of CD4+ T lymphocytes and the development of opportunistic infections. Despite drugs that inhibit viral spread, HIV infection has been difficult to cure because of uncharacterized reservoirs of infected cells that are resistant to highly active antiretroviral therapy (HAART) and the immune response. Here we used CD34+ cells from infected people as well as in vitro studies of wild-type HIV to show infection and killing of CD34+ multipotent hematopoietic progenitor cells (HPCs). In some HPCs, we detected latent infection that stably persisted in cell culture until viral gene expression was activated by differentiation factors. A unique reporter HIV that directly detects latently infected cells in vitro confirmed the presence of distinct populations of active and latently infected HPCs. These findings have major implications for understanding HIV bone marrow pathology and the mechanisms by which HIV causes persistent infection.
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Cites
Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene Delivery
Zufferey, R., Dull, T., Mandel, R. J., Bukovsky, A., Quiroz, D., Naldini, L., & Trono, D. (1998) · Journal of Virology · doi:10.1128/jvi.72.12.9873-9880.1998 · Cited by 1,815
GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells
Caux, C., Dezutter-Dambuyant, C., Schmitt, D., & Banchereau, J. (1992) · Nature · doi:10.1038/360258a0 · Cited by 1,554
Schwartz, O., Maréchal, V., Gall, S. L., Lemonnier, F., & Heard, J.-M. (1996) · Nature Medicine · doi:10.1038/nm0396-338 · Cited by 1,060
HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
Collins, K. L., Chen, B. K., Kalams, S. A., Walker, B. D., & Baltimore, D. (1998) · Nature · doi:10.1038/34929 · Cited by 1,021
Self-citationQuiescent T Lymphocytes as an Inducible Virus Reservoir in HIV-1 Infection
Bukrinsky, M. I., Stanwick, T. L., Dempsey, M. P., & Stevenson, M. (1991) · Science · doi:10.1126/science.1925601 · Cited by 590
Clouse, K. A., Powell, D., Washington, I., Poli, G., Strebel, K., Farrar, W., Barstad, P., Kovacs, J., Fauci, A. S., & Folks, T. M. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.2.431 · Cited by 542
Bailey, J. R., Sedaghat, A. R., Kieffer, T., Brennan, T., Lee, P. K., Wind-Rotolo, M., Haggerty, C. M., Kamireddi, A. R., Liu, Y., Lee, J., et al. (2006) · Journal of Virology · doi:10.1128/jvi.00591-06 · Cited by 417
Collman, R., Balliet, J. W., Gregory, S. A., Friedman, H., Kolson, D. L., Nathanson, N., & Srinivasan, A. (1992) · Journal of Virology · doi:10.1128/jvi.66.12.7517-7521.1992 · Cited by 358
Zhang, C. C., Kaba, M., Iizuka, S., Huynh, H., & Lodish, H. F. (2008) · Blood · doi:10.1182/blood-2007-11-122119 · Cited by 246
Chen, B. K., Gandhi, R. T., & Baltimore, D. (1996) · Journal of Virology · doi:10.1128/jvi.70.9.6044-6053.1996 · Cited by 220
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The International AIDS Society Scientific Working Group on HIV Cure (2012) · Nature Reviews Immunology · doi:10.1038/nri3262 · Cited by 554
Siliciano, R. F., & Greene, W. C. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007096 · Cited by 513
Redefining the Viral Reservoirs that Prevent HIV-1 Eradication
Eisele, E., & Siliciano, R. F. (2012) · Immunity · doi:10.1016/j.immuni.2012.08.010 · Cited by 474
Yang, X., Su, B., Zhang, X., Liu, Y., Wu, H., & Zhang, T. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.4mr1019-189r · Cited by 341
The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies
Cohn, L. B., Chomont, N., & Deeks, S. G. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.03.014 · Cited by 284
Breaking down the barrier: The effects of HIV-1 on the blood–brain barrier
Strazza, M., Pirrone, V., Wigdahl, B., & Nonnemacher, M. R. (2011) · Brain Research · doi:10.1016/j.brainres.2011.05.015 · Cited by 218
Targeting CCR5 as a Component of an HIV-1 Therapeutic Strategy
Mohamed, H., Gurrola, T., Berman, R., Collins, M., Sariyer, I. K., Nonnemacher, M. R., & Wigdahl, B. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.816515 · Cited by 81
Vpr Overcomes Macrophage-Specific Restriction of HIV-1 Env Expression and Virion Production
Mashiba, M., Collins, D. R., Terry, V. H., & Collins, K. L. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.10.014 · Cited by 71
Self-citationMannose receptor is an HIV restriction factor counteracted by Vpr in macrophages
Lubow, J., Virgilio, M. C., Merlino, M., Collins, D. R., Mashiba, M., Peterson, B. G., Lukic, Z., Painter, M. M., Gomez-Rivera, F., Terry, V., et al. (2020) · eLife · doi:10.7554/elife.51035 · Cited by 35
Self-citationVpr Promotes Macrophage-Dependent HIV-1 Infection of CD4+ T Lymphocytes
Collins, D. R., Lubow, J., Lukic, Z., Mashiba, M., & Collins, K. L. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1005054 · Cited by 34
Self-citationHIV-1 Vpr combats the PU.1-driven antiviral response in primary human macrophages
Virgilio, M. C., Ramnani, B., Chen, T., Disbennett, W. M., Lubow, J., Welch, J. D., & Collins, K. L. (2024) · Nature Communications · doi:10.1038/s41467-024-49635-w · Cited by 14
“6-Δ GPEN-mCherry-pSFFV-EGFP single-round infection plasmid was previously described 78 and further modi fi ed by replacing gag and pol with mCherry.”
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Metadata
- Authors
- Carter, C. C., Onafuwa-Nuga, A., McNamara, L. A., Riddell, J., Bixby, D., Savona, M. R., & Collins, K. L.
- Venue
- Nature Medicine
- Published
- 2010-03-07
- Volume
- 16
- Issue
- 4
- Pages
- 446-451
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2112858422
- Cited by
- 317
- References
- 20
- FWCI
- 13.47
- Type
- journal article
- Language
- en
- Open access
- green
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