GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice

Kempf, Tibor, Zarbock, Alexander, Widera, Christian, Butz, Stefan, Stadtmann, Anika, Rossaint, Jan, Bolomini-Vittori, Matteo, Korf-Klingebiel, Mortimer +11 more·2011·Nature Medicine

DOI 10.1038/nm.2354

Cited by (525)

Items 201–300 of 525

Growth Differentiation Factor 15 May Predict Mortality of Peripheral and Coronary Artery Diseases and Correlate with Their Risk Factors
Lung‐An Hsu, Semon Wu, Jyh‐Ming Jimmy Juang, Fu‐Tien Chiang, Ming‐Sheng Teng, Jeng-Feng Lin, Hsuan‐Li Huang, Yu‐Lin Ko · 2017 · Mediators of Inflammation
Role of GDF15 in active lifestyle induced metabolic adaptations and acute exercise response in mice
Carla Igual Gil, Mario Ost, Juliane Kasch, Sara Schumann, Sarah Heider, Susanne Klaus · 2019 · Scientific Reports
Leucocyte recruitment in inflammation and novel endogenous negative regulators thereof
Triantafyllos Chavakis · 2012 · European Journal of Clinical Investigation
Functional roles of GDF15 in modulating microenvironment to promote carcinogenesis
Luc Rochette, Alexandre Méloux, Marianne Zeller, Yves Cottin, Catherine Vergely · 2020 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Elevated growth differentiation factor 15 levels predict outcome in patients undergoing transcatheter aortic valve implantation
Nora Krau, Nina‐Sophie Lünstedt, Sandra Freitag‐Wolf, Doreen Brehm, Rainer Petzina, Georg Lutter, Peter Bramlage, Astrid Dempfle, Norbert Frey, Derk Frank · 2015 · European Journal of Heart Failure
Practical approach to screening for scleroderma‐associated pulmonary arterial hypertension
Aryeh Fischer, Todd M. Bull, Virginia D. Steen · 2011 · Arthritis Care & Research
Increased plasma VEGF levels following ischemic preconditioning are associated with downregulation of miRNA-762 and miR-3072-5p
Koji Ueno, Makoto Samura, Tamami Nakamura, Yuya Tanaka, Yuriko Takeuchi, Daichi Kawamura, Masaya Takahashi, Tohru Hosoyama, Noriyasu Morikage, Kimikazu Hamano · 2016 · Scientific Reports
How neutrophils resist shear stress at blood vessel walls: molecular mechanisms, subcellular structures, and cell–cell interactions
Daniela Begandt, Sarah Thome, Markus Sperandio, Barbara Walzog · 2017 · Journal of Leukocyte Biology
Smad-dependent pathways in the infarcted and failing heart
Claudio D Humeres, Harikrishnan Venugopal, Nikolaos Georgios Frangogiannis · 2022 · Current Opinion in Pharmacology
The Maternal Maverick/GDF15-like TGF-β Ligand Panda Directs Dorsal-Ventral Axis Formation by Restricting Nodal Expression in the Sea Urchin Embryo
Emmanuel Haillot, Maria Dolores Molina, François Lapraz, Thierry Lepage · 2015 · PLoS Biology
Thrombospondins in the transition from myocardial infarction to heart failure
Jonathan A. Kirk, Oscar H. Cingolani · 2015 · Journal of Molecular and Cellular Cardiology
The Role of Cardiokines in Heart Diseases: Beneficial or Detrimental?
Yeshun Wu, Bin Zhu, Ailin Luo, Ling Yang, Chun Yang · 2018 · BioMed Research International
Cytokines in heart failure
Adina Elena Stanciu · 2019 · Advances in clinical chemistry
Mitochondrial stress and GDF15 in the pathophysiology of sepsis
Yasunori Fujita, Masafumi Ito, Ikuroh Ohsawa · 2020 · Archives of Biochemistry and Biophysics
Growth-differentiation factor 15 for long-term prognostication in patients with non-ST-elevation acute coronary syndrome: An Invasive versus Conservative Treatment in Unstable coronary Syndromes (ICTUS) substudy
Peter Damman, Tibor Kempf, Fons Windhausen, Jan P. van Straalen, Anja Guba‐Quint, Johan Fischer, Jan G.P. Tijssen, Kai Christoph Wollert, Robbert J. de Winter, Alexander Hirsch · 2014 · International Journal of Cardiology
GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin
Ouyang, Jing, Isnard, Stéphane, Lin, John, Fombuena, Brandon, Peng, Xiaorong, Chen, Yaokai, Routy, Jean-Pierre · 2020 · Frontiers in Endocrinology
The Clinical Value of GDF15 and Its Prospective Mechanism in Sepsis
Huan Li, Dongling Tang, Juanjuan Chen, Yuanhui Hu, Xin Cai, Pingan Zhang · 2021 · Frontiers in Immunology
Inhibition of Activin A Ameliorates Skeletal Muscle Injury and Rescues Contractile Properties by Inducing Efficient Remodeling in Female Mice
Benjamin C. Yaden, Yan X. Wang, Jonathan Matthew Wilson, Alexander E. Culver, Andrea Milner, Amita Datta‐Mannan, Pamela K. Shetler, Johnny E. Croy, Guoli Dai, Venkatesh Krishnan · 2014 · American Journal Of Pathology
Growth-Differentiation Factor-15 and Major Cardiac Events
Jeng-Feng Lin, Semon Wu, Shun‐Yi Hsu, Kuan-Hung Yeh, Hsin‐Hua Chou, Shih-Tsung Cheng, Tien-Yu Wu, Wen-Tze Hsu, Chun‐Chun Yang, Yu‐Lin Ko · 2014 · The American Journal of the Medical Sciences
GDF15: from biomarker to target in cancer cachexia
Max Hüllwegen, Maximilian Kleinert, Stephan von Haehling, Andreas Fischer · 2025 · Trends in cancer
Cardiac mTOR rescues the detrimental effects of diet-induced obesity in the heart after ischemia-reperfusion
Toshinori Aoyagi, Jason K. Higa, Hiroko Aoyagi, Naaiko Yorichika, Briana K. Shimada, Takashi Matsui · 2015 · American Journal of Physiology-Heart and Circulatory Physiology
Growth differentiation factor‐15 (GDF‐15) suppresses in vitro angiogenesis through a novel interaction with connective tissue growth factor (CCN2)
Ramon J. Whitson, Marshall Scott Lucia, James R. Lambert · 2013 · Journal of Cellular Biochemistry
Olmesartan prevents cardiac rupture in mice with myocardial infarction by modulating growth differentiation factor 15 and p53
Baihe Chen, Di Lu, Yujuan Fu, Jingwen Zhang, Xiaobo Huang, Shiping Cao, Dingli Xu, Jianping Bin, Masafumi Kitakaze, Qiaobing Huang et al. · 2014 · British Journal of Pharmacology
Interleukin 6, galectin 3, growth differentiation factor 15, and soluble ST2 for mortality prediction in critically ill patients
Benjamin Dieplinger, Margot Egger, Isabella Leitner, Fritz Firlinger, Werner Poelz, Kurt Lenz, Meinhard Haltmayer, Thomas Mueller · 2016 · Journal of Critical Care
Novel Mechanisms of Exercise-Induced Cardioprotective Factors in Myocardial Infarction
Yuan Guo, Jingyuan Chen, Haihua Qiu · 2020 · Frontiers in Physiology
Growth Differentiation Factor 15 Protects SH-SY5Y Cells From Rotenone-Induced Toxicity by Suppressing Mitochondrial Apoptosis
Peizheng Li, Hongbo Lv, Bohan Zhang, Ruonan Duan, Xiufang Zhang, Pengfei Lin, Chengyuan Song, Yiming Liu · 2022 · Frontiers in Aging Neuroscience
Role of GDF15 (growth and differentiation factor 15) in pulmonary oxygen toxicity
Kirti Kumar Tiwari, Bhagavatula Moorthy, Krithika Lingappan · 2015 · Toxicology in Vitro
Cardiokines as Modulators of Stress-Induced Cardiac Disorders
Anna Planavila, Joaquim Fernández‐Solà, Francesc Villarroya · 2017 · Advances in protein chemistry and structural biology
GDF-15 predicts cardiovascular events in acute chest pain patients
Stergios Tzikas, Lars Palapies, Constantinos Bakogiannis, Tanja Zeller, Christoph Sinning, Stephan Ernst Baldus, Christoph Bickel, Vassilios Pericles Vassilikos, Karl Johannes Lackner, Andreas Michael Zeiher et al. · 2017 · PLoS ONE
Current Use of Cardiac Biomarkers in Various Heart Conditions
Shahzad Maqsood Khan, Sahibzada Tasleem Rasool · 2020 · Endocrine Metabolic & Immune Disorders - Drug Targets
Growth/differentiation factor-15 and its role in peripheral nervous system lesion and regeneration
Xiaolong Wang, Julia Krebbers, Petar Charalambous, Venissa Machado, Andreas Schober, Frank Bosse, Hans-Werner Müller, Klaus Unsicker · 2015 · Cell and Tissue Research
Growth Differentiation Factor-15 (GDF-15) Is Associated With Mortality in Ischemic Stroke Patients Treated With Acute Revascularization Therapy
Céline Brenière, Alexandre Méloux, Martin Pédard, Christine Marie, Pierre Thouant, Catherine Vergely, Yannick Béjot · 2019 · Frontiers in Neurology
β1- and β2-integrins: central players in regulating vascular permeability and leukocyte recruitment during acute inflammation
Ziwei Ou, Elena V. Dolmatova, Bernard P Lassegue, Kathy K. Griendling · 2020 · American Journal of Physiology-Heart and Circulatory Physiology
Growth differentiation factor 15 is increased in stable MS
Andrea Amstad, Mali Coray, Corina Frick, Christian Barro, Johanna Oechtering, Michael Amann, Jörg Wischhusen, Ludwig Kappos, Yvonne Naegelin, Jens Kühle et al. · 2020 · Neurology Neuroimmunology & Neuroinflammation
11β-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI
Katie J. Mylonas, Neil A. Turner, Sumia A. Bageghni, Christopher J. Kenyon, Christopher I. White, Kieran McGregor, Robert A. Kimmitt, Richard J. Sulston, Valerie Kelly, Brian Robert Walker et al. · 2017 · Journal of Endocrinology
Bidirectional Relationship Between Cancer and Heart Failure: Insights on Circulating Biomarkers
Michela Chianca, Giorgia Panichella, Iacopo Fabiani, Alberto Giannoni, Serena L’Abbate, Alberto Aimo, Annamaria Del Franco, Giuseppe Vergaro, Chrysanthos Grigoratos, Vincenzo Castiglione et al. · 2022 · Frontiers in Cardiovascular Medicine
Cooperation between inhibitory immune checkpoints of senescent cells with immunosuppressive network to promote immunosenescence and the aging process
Antero Salminen · 2025 · Ageing Research Reviews
Reduced expression of GDF‐15 is associated with atrophic inflammatory lesions of the prostate
James R. Lambert, Ramon J. Whitson, Kenneth A. Iczkowski, Francisco G. La Rosa, Maxwell Lawrence Smith, R. Storey Wilson, Elizabeth Erin Smith, Kathleen C. Torkko, Hamid H. Gari, Marshall Scott Lucia · 2014 · The Prostate
Morphological Effects on Expression of Growth Differentiation Factor 15 (GDF15), a Marker of Metastasis
Koh Meng Aw Yong, Yu Zeng, Donald Vindivich, Jude M. Phillip, Pei‐Hsun Wu, Denis Wirtz, Robert H. Getzenberg · 2013 · Journal of Cellular Physiology
Disturbed iron metabolism in erythropoietic protoporphyria and association of GDF15 and gender with disease severity
Jasmin Barman‐Aksözen, Domenico Girelli, Caterina Aurizi, Xiaoye Schneider‐Yin, Natascia Campostrini, Luca Barbieri, Elisabeth Irene Minder, Gianfranco Biolcati · 2017 · Journal of Inherited Metabolic Disease
Overexpression of integrin α11 induces cardiac fibrosis in mice
Andreas Romaine, Ida Wiig Sørensen, Cédric Zeltz, Ning Lü, Pugazendhi Murugan Erusappan, Arne Olav Melleby, L. Zhang, Bård Andre Bendiksen, Emma Louise Robinson, Jan Magnus Aronsen et al. · 2017 · Acta Physiologica
Activation and suppression of hematopoietic integrins in hemostasis and immunity
Martijn A. Nolte, Coert Margadant · 2019 · Blood
11C-Methionine PET Identifies Astroglia Involvement in Heart–Brain Inflammation Networking After Acute Myocardial Infarction
Pablo Bascuñana, Annika Hess, Tobias Borchert, Yong Wang, Kai Christoph Wollert, Frank Michael Bengel, James T. Thackeray · 2019 · Journal of Nuclear Medicine
Growth differentiation factor 15 (GDF-15) in kidney diseases
Charlotte Delrue, Reinhart Speeckaert, Joris Delanghe, Marijn M. Speeckaert · 2023 · Advances in clinical chemistry
Regulation of tissue infiltration by neutrophils
Pallavi Subramanian, Ioannis Mitroulis, George Hajishengallis, Triantafyllos Chavakis · 2015 · Current Opinion in Hematology
GDF15: a potential therapeutic target for type 1 diabetes
Soumyadeep Sarkar, John Melchior, Hayden R. Henry, Farooq Syed, Raghavendra G. Mirmira, Ernesto Satoshi Nakayasu, Thomas Metz · 2022 · Expert Opinion on Therapeutic Targets
Growth/differentiation factor 15 (GDF15) expression in the heart after myocardial infarction and cardioprotective effect of pre-ischemic rGDF15 administration
Geoffrey Dogon, Eve Rigal, Eliot Potel, Marie Josse, Luc Rochette, Yannick Béjot, Catherine Vergely · 2024 · Scientific Reports
Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation
Denise Tischner, Myriam Grimm, Harmandeep Kaur, Daniel Staudenraus, Jorge Carvalho, Mario Looso, Stefan Günther, Florian Wanke, Sonja Moos, Nelly Siller et al. · 2017 · JCI Insight
Validation of diagnostic criteria and histopathological characterization of cardiac rupture in the mouse model of nonreperfused myocardial infarction
Anis Hanna, Arti V. Shinde, Nikolaos Georgios Frangogiannis · 2020 · American Journal of Physiology-Heart and Circulatory Physiology
GDF15/MIC-1: a stress-induced immunosuppressive factor which promotes the aging process
Antero Salminen · 2024 · Biogerontology
Mutation in the CD45 Inhibitory Wedge Modulates Integrin Activation and Leukocyte Recruitment during Inflammation
Giulia Germena, Stephanie Volmering, Charlotte Sohlbach, Alexander Zarbock · 2014 · The Journal of Immunology
Growth Differentiation Factor-15–Induced Contractile Activity and Extracellular Matrix Production in Human Trabecular Meshwork Cells
Arumugam Ramachandran Muralidharan, Rupalatha Maddala, Nikolai P. Skiba, Ponugoti Vasantha Rao · 2016 · Investigative Ophthalmology & Visual Science
Less fibrosis in elderly subjects supplemented with selenium and coenzyme Q 10—A mechanism behind reduced cardiovascular mortality?
Urban Alehagen, Jan Aaseth, Jan Alexander, Erland Svensson, Peter Johansson, Anders Olof Larsson · 2017 · BioFactors
Novel Cardiokine GDF3 Predicts Adverse Fibrotic Remodeling After Myocardial Infarction
Nihar D. Masurkar, Marion Bouvet, Damien Logeart, Charlène Jouve, Fatou Dramé, Olivier Claude, Maguelonne Roux, Clément Delacroix, Damien Bergerot, Jean-Jacques Mercadier et al. · 2022 · Circulation
Induction of the calcineurin variant CnAβ1 after myocardial infarction reduces post-infarction ventricular remodelling by promoting infarct vascularization
Marina M. López-Olañeta, María Villalba‐Orero, Jesús M. Gómez-Salinero, Luis Jesús Jiménez‐Borreguero, Ross A. Breckenridge, Paula Ortiz-Sánchez, Pablo García‐Pavía, Borja Ibáñez, Enrique Lara‐Pezzi · 2014 · Cardiovascular Research
Oligophrenin1 protects mice against myocardial ischemia and reperfusion injury by modulating inflammation and myocardial apoptosis
Christina Niermann, Simone Gorreßen, Meike Klier, Nina Sarah Gowert, Pierre Billuart, Malte Kelm, Marc W. Merx, Margitta Elvers · 2016 · Cellular Signalling
Prognostic Utility of Soluble TREM‐1 in Predicting Mortality and Cardiovascular Events in Patients With Acute Myocardial Infarction
Yun Kai Wang, Jia Ni Tang, Yun Li Shen, Bo Hu, Chun Yu Zhang, Minghui Li, Rui Zhen Chen, Jun Bo Ge, Xue Bo Liu · 2018 · Journal of the American Heart Association
Growth differentiation factor 15 may protect the myocardium from no-reflow by inhibiting the inflammatory-like response that predominantly involves neutrophil infiltration
MEI ZHANG, Kun-Ying Pan, Qianping Liu, Xin Zhou, TIEMIN JIANG, Yuming Li · 2015 · Molecular Medicine Reports
Novel molecular markers of cardiovascular disease risk in type 2 diabetes mellitus
Rosaria Vincenza Giglio, Anca Pantea Stoian, Martin Haluzı́k, Kalliopi Pafili, Angelo Maria Patti, Ali Abbas Rizvi, Marcello Ciaccio, Νικόλαος Παπάνας, Manfredi Rizzo · 2021 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Role and Mechanism of Growth Differentiation Factor 15 in Chronic Kidney Disease
Yifang Tang, Tao Liu, Shibo Sun, You-Bo Peng, Xiaoxiao Huang, Shuangquan Wang, Zhu Zhou · 2024 · Journal of Inflammation Research
Volatile anaesthetics reduce neutrophil inflammatory response by interfering with CXC receptor-2 signalling
Björn Müller‐Edenborn, R. Frick, Tobias Piegeler, Martin Schläpfer, Birgit Roth‐Z'graggen, Andreas Schlicker, Beatrice Beck‐Schimmer · 2014 · British Journal of Anaesthesia
GDF-15 prevents lipopolysaccharide-mediated acute lung injury via upregulating SIRT1
Hengya Song, Qian Chen, Songping Xie, Jie Huang, Ganjun Kang · 2020 · Biochemical and Biophysical Research Communications
GDF15 Suppresses Lymphoproliferation and Humoral Autoimmunity in a Murine Model of Systemic Lupus Erythematosus
Georg Lorenz, Andrea Ribeiro, Ekaterina von Rauchhaupt, Vivian Würf, Christoph Schmaderer, Clemens David Cohen, Twinkle Vohra, Hans‐Joachim Anders, Maja T. Lindenmeyer, Maciej Lech · 2022 · Journal of Innate Immunity
Development of Cancer in Patients With Heart Failure: How Systemic Inflammation Can Lay the Groundwork
Simonetta Ausoni, Giuseppe Azzarello · 2020 · Frontiers in Cardiovascular Medicine
Imaging Inflammation Past, Present, and Future: Focus on Cardioimmunology
James T. Thackeray, Kory J. Lavine, Yongjian Liu · 2023 · Journal of Nuclear Medicine
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Feng Wan, Emmanuel Letavernier, Claude Jourdan Le Saux, Amal Houssaini, Shariq Abid, Gábor Czibik, Daigo Sawaki, Élisabeth Marcos, Jean‐Luc Dubois‐Randé, Laurent Baud et al. · 2015 · American Journal of Physiology-Heart and Circulatory Physiology
Growth differentiation factor 15 can distinguish between hypertrophic cardiomyopathy and hypertensive hearts
Shinsuke Hanatani, Yasuhiro Izumiya, Seiji Takashio, Sunao Kojima, Megumi Yamamuro, Satoshi Araki, Taku Rokutanda, Kenichi Tsujita, Eiichiro Yamamoto, Tomoko Tanaka et al. · 2013 · Heart and Vessels
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Riba, Michela, Rausa, Marco, Sorosina, Melissa, Cittaro, Davide, Garcia Manteiga, Jose Manuel, Nai, Antonella, Pagani, Alessia, Martinelli-Boneschi, Filippo, Stupka, Elia, Camaschella, Clara et al. · 2013 · PLoS ONE
Pathophysiological pathways related to high plasma growth differentiation factor 15 concentrations in patients with heart failure
Daan C H Ceelen, Adriaan A. Voors, Jasper Tromp, Dirk Jan van Veldhuisen, Kenneth Dickstein, Rudolf A. de Boer, Chim Choy Lang, Stefan D. Anker, Leong L. Ng, Marco Metra et al. · 2022 · European Journal of Heart Failure
Cross-Talk between Shp1 and PIPKIγ Controls Leukocyte Recruitment
Anika Stadtmann, Helena Block, Stephanie Volmering, Clare L. Abram, Charlotte Sohlbach, Mark Boras, Clifford A. Lowell, Alexander Zarbock · 2015 · The Journal of Immunology
Mechanotransduction-Induced Reversible Phenotypic Switching in Prostate Cancer Cells
Koh Meng Aw Yong, Yubing Sun, Sofia Diana Merajver, Jianping Fu · 2017 · Biophysical Journal
Association between growth differentiation factor 15 and left ventricular hypertrophy in hypertensive patients and healthy adults
Huijuan Kou, Xin Jin, Dengfeng Gao, Rui Ma, Xin Dong, Jin jia Wei, Xin Wang · 2017 · Clinical and Experimental Hypertension
Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice
Foteini Moschovaki-Filippidou, Stefanie Steiger, Georg Lorenz, Christoph Schmaderer, Andrea Ribeiro, Ekaterina von Rauchhaupt, Clemens David Cohen, Hans‐Joachim Anders, Maja T. Lindenmeyer, Maciej Lech · 2020 · International Journal of Molecular Sciences
Growth Differentiation Factor-15 (GDF-15) Level and Relation to Clinical Manifestations in Egyptian Systemic Sclerosis patients: Preliminary Data
Sherif Mohammed Gamal, Fatema Talaat Elgengehy, Asmaa Kamal, Samah A. El Bakry, Elham Shabaan, Aliaa Elgendy, Iman Hamed Bassyouni · 2017 · Immunological Investigations
A systematic review of the neuroprotective role and biomarker potential of GDF15 in neurodegeneration
Finula I. Isik, Shannon Thomson, John F. Cueto, Jessica Spathos, Samuel N. Breit, Vicky Wang-Wei Tsai, David Alexander Brown, Caitlin A. Finney · 2024 · Frontiers in Immunology
Targeting CXCR2 signaling in inflammatory lung diseases: neutrophil-driven inflammation and emerging therapies
Md Sadique Hussain, Ahsas Goyal, Kavita Goyal, Renuka Jyothi S., Jayshree Nellore, Moyad Jamal Shahwan, A. Rekha, Haider Ali, Muralikrishnan Dhanasekaran, Ronan J. MacLoughlin et al. · 2025 · Naunyn-Schmiedeberg s Archives of Pharmacology
Relationship between plasma growth differentiation factor-15 levels and diabetic retinopathy in individuals with type 2 diabetes
Jin Ook Chung, Seon‐Young Park, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung · 2020 · Scientific Reports
Mechanisms and Therapeutic Modulation of Neutrophil-Mediated Inflammation
George Hajishengallis, Triantafyllos Chavakis · 2022 · Journal of Dental Research
Circular RNA hsa-circ-0007766 modulates the progression of Gastric Carcinoma via miR-1233-3p/GDF15 axis
Weiguo Xu, Bin Zhou, Jun Wu, Pan Jiang, Huanqiu Chen, Feng Yan · 2020 · International Journal of Medical Sciences
Engineered Exosomes with Growth Differentiation Factor-15 Overexpression Enhance Cardiac Repair After Myocardial Injury
Ailin Zou, Tingting Xiao, Boyu Chi, Yu Wang, Lipeng Mao, Dabei Cai, Qingqing Gu, Q. Chen, Qingjie Wang, Yuan Ji et al. · 2024 · International Journal of Nanomedicine
Novel tracers to assess myocardial inflammation with radionuclide imaging
Yousif A. Lucinian, Patrick Martineau, Gad Abikhzer, François Harel, Matthieu Pelletier‐Galarneau · 2024 · Journal of Nuclear Cardiology
The role of Interleukin Receptor Associated Kinase (IRAK)-M in regulation of myofibroblast phenotype in vitro, and in an experimental model of non-reperfused myocardial infarction
Amit Saxena, Arti V. Shinde, Zaffar K. Haque, Yi-Jin Wu, Wei Chen, Ya Su, Nikolaos Georgios Frangogiannis · 2015 · Journal of Molecular and Cellular Cardiology
Protein Tyrosine Phosphatase Receptor Type γ Is a JAK Phosphatase and Negatively Regulates Leukocyte Integrin Activation
Michela Mirenda, Lara Toffali, Alessio Montresor, Giovanni Scardoni, Claudio Sorio, Carlo Laudanna · 2015 · The Journal of Immunology
The TGFβ superfamily in cardiac dysfunction
Jian Wu, Olan Jackson‐Weaver, Jian Xu · 2018 · Acta Biochimica et Biophysica Sinica
The Relationship Between Circulating Growth Differentiation Factor 15 Levels and Diabetic Retinopathy in Patients With Type 2 Diabetes
Yixin Niu, Weiwei Zhang, Jie Shi, Yueming Liu, Hongmei Zhang, Ning Lin, Xiaoyong Li, Li Qin, ZHEN KUN YANG, Qing Su · 2021 · Frontiers in Endocrinology
Decreasing GDF15 Promotes Inflammatory Signals and Neutrophil Infiltration in Psoriasis Models
Jieyu Zhang, Lei He, Zhaowei Wang, Shuai Shao, Pei Qiao, Jine Zhang, Kuo Zhang, Caixia Li, Yingqi Zhang, Gang Wang et al. · 2022 · Journal of Investigative Dermatology
Extracellular vesicle mediated targeting delivery of growth differentiation factor-15 improves myocardial repair by reprogramming macrophages post myocardial injury
Tingting Xiao, Jun Stephen Wei, Dabei Cai, Yu Wang, Zhiwei Cui, Qianwen Chen, Qingqing Gu, Ailin Zou, Lipeng Mao, Boyu Chi et al. · 2024 · Biomedicine & Pharmacotherapy
A Tale from TGF-β Superfamily for Thymus Ontogeny and Function
Arnon Dias Jurberg, Larissa Vasconcelos‐Fontes, Vinı́cius Cotta-de-Almeida · 2015 · Frontiers in Immunology
Impact of Smoking Status on Growth Differentiation Factor 15 and Mortality in Patients With Suspected or Known Coronary Artery Disease: The ANOX Study
Hiromichi Wada, Masahiro Suzuki, Morihiro Matsuda, Yoichi Ajiro, Tsuyoshi Shinozaki, Satoru Sakagami, Kazuya Yonezawa, Masatoshi Shimizu, Junichi Funada, Takashi Takenaka et al. · 2020 · Journal of the American Heart Association
Diabetes mellitus associated neurovascular lesions in the retina and brain: A review
Stephen H. Sinclair, Elan S. Miller, Kiran Shankar Talekar, Stanley S. Schwartz · 2022 · Frontiers in Ophthalmology
Growth differentiation factor 15 alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy
Jordan S. F. Chan, Seyed Amirhossein Tabatabaei Dakhili, Maria Areli Lorenzana Carrillo, Keshav Gopal, Serena M. Pulente, Amanda A. Greenwell, Kunyan Yang, Christina T. Saed, Magnus J. Stenlund, Sally R Ferrari et al. · 2024 · Cell Reports
Decision shaping neutrophil‐platelet interplay in inflammation: From physiology to intervention
Oliver Soehnlein · 2017 · European Journal of Clinical Investigation
Weight Loss Induced by Bariatric Surgery Restricts Hepatic GDF15 Expression
Timon Erik Adolph, Felix Grabherr, Lisa Mayr, Christoph Grander, Barbara Enrich, Alexander Rupert Moschen, Herbert Tilg · 2018 · Journal of Obesity
Growth and differentiation factor 15 is a biomarker for low back pain-associated disability
Nader Tarabeih, Adel Shalata, Svetlana Trofimov, Alexander Kalinkovich, Gregory Livshits · 2019 · Cytokine
Conserved function of zebrafish (Danio rerio) Gdf15 as a sepsis tolerance mediator
Patricia Pereiro, Marta Librán-Pérez, Antonio J. Figueras, Beatriz Novoa · 2020 · Developmental & Comparative Immunology
Growth Differentiation Factor 15 in Severe Aortic Valve Stenosis: Relationship with Left Ventricular Remodeling and Frailty
Iacopo Fabiani, Tatiana Santoni, Marco Angelillis, Serena Petricciuolo, Andrea Colli, Giovanni Pellegrini, Deborah Mazzei, Nicola Riccardo Pugliese, Anna Sonia Petronio, Raffaele De Caterina · 2020 · Journal of Clinical Medicine
Biomarkers for the prediction of venous thromboembolism in the community
Marja Kaarina Puurunen, Danielle M. Enserro, Vanessa Xanthakis, Martin G. Larson, Emelia J. Benjamin, Geoffrey H. Tofler, Kai Christoph Wollert, Christopher J. O’Donnell, Ramachandran Srini Vasan · 2016 · Thrombosis Research
A GDF-15–GFRAL axis controls autoimmune T cell responses during neuroinflammation
Jana K. Sonner, Audrey Kahn, Lars Binkle-Ladisch, Jan Broder Engler, Beatrice Haack, Christina Zeiler, Lisa Unger, Simone Bauer, Felix Fischbach, Giovanni Almanzar et al. · 2026 · Nature Immunology
LPS induces rapid increase in GDF15 levels in mice, rats, and humans but is not required for anorexia in mice
Anita R. Patel, Henriette Frikke‐Schmidt, Olivier Bézy, Paul V. Sabatini, Nikolaj Fibiger Rittig, Niels Jessen, Martin Grosvenor Myers, Randy J. Seeley · 2021 · American Journal of Physiology-Gastrointestinal and Liver Physiology
Change in Growth Differentiation Factor 15, but Not C-Reactive Protein, Independently Predicts Major Cardiac Events in Patients with Non-ST Elevation Acute Coronary Syndrome
Alberto Domínguez‐Rodríguez, Pedro Abreu-González, Idaira Famara Hernández-Baldomero, Pablo Avanzas y, Francisco Bosa‐Ojeda · 2014 · Mediators of Inflammation