GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice

Kempf, Tibor, Zarbock, Alexander, Widera, Christian, Butz, Stefan, Stadtmann, Anika, Rossaint, Jan, Bolomini-Vittori, Matteo, Korf-Klingebiel, Mortimer +11 more·2011·Nature Medicine

DOI 10.1038/nm.2354

Cited by (525)

Items 301–400 of 525

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Phagocyte–myocyte interactions and consequences during hypoxic wound healing
Shuang Zhang, Shirley Dehn, Matthew DeBerge, Ki‐Jong Rhee, Barry Ian Hudson, Edward Benjamin Thorp · 2014 · Cellular Immunology
GDF-15 is associated with thrombus burden in patients with deep venous thrombosis
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Anna M. Imiela, Tomasz P Mikolajczyk, Piotr Pruszczyk · 2024 · Archivum Immunologiae et Therapiae Experimentalis
Small GTPase-dependent regulation of leukocyte–endothelial interactions in inflammation
Julia Y. Chu, Barry McCormick, Sonja Vermeren · 2018 · Biochemical Society Transactions
Soluble DC-HIL/Gpnmb Modulates T-Lymphocyte Extravasation to Inflamed Skin
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Muhammad Abubakar, Umema Irfan, Ahmad Abdelkhalek, Izzah Javed, Muhammad Imran Khokhar, Fraz Shakil, Saud Raza, Siffat Saima Salim, Muhammad Mahran Altaf, Rizwan Habib et al. · 2024 · Journal of Cardiovascular Translational Research
Association between growth differentiation factor-15 and chronic heart failure in coronary atherosclerosis patients
Zhenhua Zhu, Tao Sun · 2015 · Genetics and Molecular Research
Plasma GDF15 level is elevated in psychosis and inversely correlated with severity
Parvin Kumar, Vincent Millischer, J. Carlos Villaescusa, Ida A. K. Nilsson, Claes‐Göran Östenson, Martin Schalling, Urban Ösby, Catharina Lavebratt · 2017 · Scientific Reports
Growth Differentiation Factor-15 as a Predictor of Idiopathic Membranous Nephropathy Progression: A Retrospective Study
Young Rok Ham, Chang Hun Song, Hong Jin Bae, Jin Young Jeong, Min‐Kyung Yeo, Dae Eun Choi, Ki Ryang Na, Kang Wook Lee · 2018 · Disease Markers
Exerkines: Potential regulators of diabetic cardiomyopathy
Fengzhi Yu, Boyi Zong, Zhenjun Tian, Dandan Jia, Ru Wang · 2025 · Ageing Research Reviews
Regulating inflammation: ADAM8 – a new player in the game
Alexander Zarbock, Jan Rossaint · 2011 · European Journal of Immunology
Biomarkers of acute myocardial infarction: diagnostic and prognostic value. Part 2 (Literature review)
Aleksey Michailovich Chaulin, Dmitry Viktorovich Duplyakov · 2020 · Journal of clinical practice
GDF-15 Predicts In-Hospital Mortality of Critically Ill Patients with Acute Kidney Injury Requiring Continuous Renal Replacement Therapy: A Multicenter Prospective Study
Jeong‐Hoon Lim, Yena Jeon, Ji‐Sun Ahn, Sejoong Kim, Dong Ki Kim, Jung Pyo Lee, Dong‐Ryeol Ryu, Eun Young Seong, Shin Young Ahn, Seon Ha Baek et al. · 2021 · Journal of Clinical Medicine
Role of circulating molecules in age-related cardiovascular and metabolic disorders
Yung‐Ting Hsiao, Ippei Shimizu, Yohko Yoshida, Tohru Minamino · 2022 · Inflammation and Regeneration
Developmental endothelial locus-1 in cardiovascular and metabolic diseases: A promising biomarker and therapeutic target
Mengmeng Zhao, Zihui Zheng, Chenfei Li, Jun Wan, Menglong Wang · 2022 · Frontiers in Immunology
Adenovirus-mediated siRNA targeting CXCR2 attenuates titanium particle-induced osteolysis by suppressing osteoclast formation
Chen Wang, Yang Liu, Yang Wang, Hao Li, Ranxi Zhang, Misi He, Liang Chen, Ningning Wu, Yong Liao, Zhong‐Liang Deng · 2016 · Medical Science Monitor
Long-term prognostic value of growth differentiation factor-15 in acute coronary syndromes
Óscar M. Peiró, Álvaro García‐Osuna, Jordi Ordóñez‐Llanos, Germán Cediel, Gil Bonet, Sergio Rojas, Verónica Quintern, Alfredo Bardajı́ · 2019 · Clinical Biochemistry
Molecular and Functional Significance of Growth Differentiation Factor-15: A Review on Cardiovascular-Kidney-Metabolic Biomarker
Krishna Tiwari, Aswini Saravanan, Abhishek Anil, Vikas Kumar Tiwari, Muhammad Aaqib Shamim, Surjit Singh, Pradeep Dwivedi, Surender Deora, Shoban Babu Varthya · 2025 · Current Cardiology Reviews
Age‐Associated Increase in Growth Differentiation Factor 15 Levels Correlates With Central Arterial Stiffness and Predicts All‐Cause Mortality in a Sardinian Population Cohort
Richard Oppong, Valeria Orrù, Michele Marongiu, Yong Qian, Carlo Sidore, Alessandro Delitala, Marco Orrù, Antonella Mulas, Maria Grazia Piras, Christopher H. Morrell et al. · 2025 · Journal of the American Heart Association
Proteome atlas for mechanistic discovery and risk prediction of diabetic retinopathy
Shaopeng Yang, Zhuoyao Xin, Ruilin Xiong, Ziyu Zhu, Huangdong Li, Yanping Chen, Zhenghao Zhong, Li Zhong Du, Zhuoting Zhu, Xianwen Shang et al. · 2025 · Nature Communications
Integrin α11β1 and syndecan-4 dual receptor ablation attenuate cardiac hypertrophy in the pressure overloaded heart
Andreas Romaine, Arne Olav Melleby, Jahedul Alam, Viola Hélène Lobert, Ning Lü, Francesca Lockwood, Almira Hasic, Ida Gjervold Lunde, Ivar Sjaastad, Harald Stenmark et al. · 2022 · American Journal of Physiology-Heart and Circulatory Physiology
Macrophage inhibitory cytokine‐1 promotes angiogenesis by eliciting the GFRAL‐mediated endothelial cell signaling
Jaeseob Lee, Young‐June Jin, Moon‐Sung Lee, Young‐Myeong Kim, Hansoo Lee · 2020 · Journal of Cellular Physiology
GDF‐15: Diagnostic, prognostic, and therapeutic significance in glioblastoma multiforme
Zahra Hasanpour Segherlou, Masoud Nouri‐Vaskeh, Sama Noroozi Guilandehi, Amir Baghbanzadeh, Ramin Zand, Behzad Baradaran, Mohammad Zarei · 2021 · Journal of Cellular Physiology
Circulating Growth Differentiation Factor 15 Is Associated with Diabetic Neuropathy
Shao‐Wen Weng, WenChieh Chen, Feng‐Chih Shen, Pei‐Wen Wang, Jung‐Fu Chen, Chia‐Wei Liou · 2022 · Journal of Clinical Medicine
Intramuscular delivery of neural crest stem cell spheroids enhances neuromuscular regeneration after denervation injury
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wRAPping Up Early Monocyte and Neutrophil Recruitment in Atherogenesis via AnnexinA1/FPR2 Signaling
Matthew J Butcher, Elena Galkina · 2015 · Circulation Research
Association of Exhaled Carbon Monoxide With Ideal Cardiovascular Health, Circulating Biomarkers, and Incidence of Heart Failure in the Framingham Offspring Study
Bradley Tun, Rachel Q. Ehrbar, Meghan I. Short, Susan C. Cheng, Ramachandran Srini Vasan, Vanessa Xanthakis · 2020 · Journal of the American Heart Association
Correlation between serum GDF-15 level and pulmonary vascular morphological changes and prognosis in patients with pulmonary arterial hypertension
Yasenjiang Maimaiti, Hui Cheng, Zitong Guo, Xiaolin Yu, Tuohuti Adilijiang, Guoqing Li · 2023 · Frontiers in Cardiovascular Medicine
Imperatorin ameliorates pulmonary fibrosis via GDF15 expression
Cheng‐Fang Tsai, Yen-Chang Chen, Yazhen Li, Chen-Teng Wu, Pei-Chun Chang, Wei‐Lan Yeh · 2023 · Frontiers in Pharmacology
Identification of a distinct cluster of GDF15high macrophages induced by in vitro differentiation exhibiting anti-inflammatory activities
Chaochao Dai, Hongyu Zhang, Zhijian Zheng, Chun Guang Li, Mingyuan Ma, Haiqing Gao, Qunye Zhang, Fan Jiang, Xiaopei Cui · 2024 · Frontiers in Immunology
Prognostic Value of Circulating Fibrosis Biomarkers in Dilated Cardiomyopathy (DCM): Insights into Clinical Outcomes
Elham Kayvanpour, Farbod Sedaghat‐Hamedani, Daniel Tian Li, Tobias Miersch, Tanja Weis, Imo E. Hoefer, Norbert Frey, Benjamin Meder · 2024 · Biomolecules
Pretreatment with growth differentiation factor 15 augments cardioprotection by mesenchymal stem cells in myocardial infarction by improving their survival
Xinran Huang, Xiaoting Liang, Qian Han, Ying Shen, Jiaqi Chen, Ziqi Li, Jie Qiu, Xiaoyan Gao, Yimei Hong, Lin Fang et al. · 2024 · Stem Cell Research & Therapy
Biomechanical stress in myocardial infarctions: can endothelin-1 and growth differentiation factor 15 serve as immunohistochemical markers?
M. Falk, Ragnar Huhn, Friederike Behmenburg, St. Ritz-Timme, Felix Mayer · 2017 · International Journal of Legal Medicine
Elevated circulating growth differentiation factor 15 is related to decreased heart rate variability in chronic kidney disease patients
Lulu Wang, Jing Luo, Wenjin Liu, Xiaoqin Huang, Jie Xu, Yang Zhou, Lei Jiang, Junwei Yang · 2021 · Renal Failure
GDF15 upregulation in Parkinson's disease: Compensatory mechanisms and causal insights
Sultan Mohammed Alshahrani, Hayder Mutter Al-Kuraishy, Ali K. Albuhadily, Ali Ismail Al-Gareeb, Ahmed M Abdelaziz, Athanasios T. Alexiou, Marios Papadakis, Mubarak Alruwaili, Gaber El‐Saber Batiha · 2025 · Cytokine
GDF15 attenuates myocardial infarction-induced injury by preserving mitochondrial function and suppressing oxidative stress
Xiaogang Yuan, Cheng Wang, Haiyan Zhu · 2025 · European journal of medical research
Peritumoral colonic epithelial cell-derived GDF15 sustains colorectal cancer via regulation of glycolysis and histone lactylation
Bingjie Guan, Mantang Zhou, Weixing Dai, Jing Zhang, Bowen Xie, Yushuai Mi, Xin Zhang, Ping Wei, Youdong Liu, Shanbao Li et al. · 2025 · Nature Aging
GDF-15 at Admission Predicts Cardiovascular Death, Heart Failure, and Bleeding Outcomes in Patients with CAD
Jiali Wang, Tao Zhang, Feng Xu, Wei Dong Gao, Ming Chen, Huadong Zhu, Jun Xu, Xinxin Yin, Jiaojiao Pang, Song Zhang et al. · 2023 · ESC Heart Failure
Interplay between Senescence and Macrophages in Diabetic Cardiomyopathy: A Review of the Potential Role of GDF-15 and Klotho
Ghada M. Almohaimeed, Asma S. Alonazi, Anfal F. Bin Dayel, Tahani K. Alshammari, Hanan K. Alghibiwi, Maha A. Alamin, Ahmad R. Almotairi, Nouf Mohamed Al-Rasheed · 2024 · Biomedicines
Novel Dual and Triple Agonists Targeting GLP-1, GIP, Glucagon, and GDF15 for Type 2 Diabetes and Obesity Management
Jiudan Zhang, Shriya Sanan, Marta Csanalosi, Chao Zheng, Andreas F. H. Pfeiffer · 2025 · Endocrinology
Risk of Cardiovascular Disease in Women With a History of Hyperemesis Gravidarum, With and Without Preeclampsia
Bianca Cécile, Brian James Potter, Antoine Lewin, Jessica Healy‐Profitós, Émilie Brousseau, Nathalie Auger · 2023 · Journal of the American Heart Association
Loss of growth differentiation factor 15 exacerbates lung injury in neonatal mice
Faeq Al‐Mudares, Manuel Eliezer Cantu Gutierrez, Abiud Cantu, Weiwu Jiang, Lihua Wang, Xiaoyu Dong, Bhagavatula Moorthy, Enikö Sajti, Krithika Lingappan · 2023 · American Journal of Physiology-Lung Cellular and Molecular Physiology
PET Assessment of Immune Cell Activity and Therapeutic Monitoring Following Myocardial Infarction
James T. Thackeray · 2018 · Current Cardiology Reports
Deficiency of Duffy Antigen Receptor for Chemokines Ameliorated Cochlear Damage From Noise Exposure
Bouchra Edderkaoui, Liana Sargsyan, Alisa P. Hetrick, Hongzhe Li · 2018 · Frontiers in Molecular Neuroscience
Growth differentiation factor-15 is a prognostic marker in patients with intermediate coronary artery disease.
Wei Wang, Xiantao Song, Yundai Chen, Fei Yuan, Feng Xu, Min Zhang, Kai Tan, Xing-Sheng Yang, Xianpeng Yu, Kongyong Cui et al. · 2020 · PubMed Central
The association of growth differentiation factor 15 (GDF-15) level with extent of left atrial fibrosis in patients with nonvalvular atrial fibrillation
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Pinni Yang, Shuyao Wang, Chongke Zhong, Jieyun Yin, Jingyuan Yang, Aili Wang, Tan Xu, Yonghong Zhang · 2024 · Journal of the American Heart Association
Growth differentiation factor-15 predicts all-cause death and major adverse cardiovascular events in patients with coronary heart disease: a prospective cohort study
Lyu Lyu, Cui Xv, Juan Xu, Zhenzhen Liu, HE Yan-ru, Wenjing Zhu, Lin Lin, Qiang Yang, Yun Wei, Jinda Wang et al. · 2024 · Journal of Thrombosis and Thrombolysis
Progress in heart failure treatment in Germany
Mark Luedde, Martina E. Spehlmann, Norbert Frey · 2018 · Clinical Research in Cardiology
Altered circulating GDF-15 level predicts sex hormone imbalance in males with major depressive disorder
Ying Li, Ting Mei, Ting Sun, Xuan Xiao, Rui Peng · 2023 · BMC Psychiatry
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Gdf-15 deficiency does not alter vulnerability of nigrostriatal dopaminergic system in MPTP-intoxicated mice
Venissa Machado, Ralf Gilsbach, Richa Das, Andreas Schober, Lioudmila Bogatyreva, Dieter Hauschke, Kerstin G. KRIEGLSTEIN, Klaus Unsicker, Björn Spittau · 2016 · Cell and Tissue Research
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Yu Jiang, Guoxiang Zhou, Yongzheng Guo, Yang Long · 2024 · Cardiovascular Innovations and Applications
GDF15: An emerging disease target and biomarker of metabolic diseases
Chenyun Yang, Huiling Chen, Xiaojing Huang, Ligang Zhou, Xinlu Yuan · 2025 · Journal of Endocrinological Investigation
Chronic Peripheral Ghrelin Injection Exerts Antifibrotic Effects by Increasing Growth Differentiation Factor 15 in Rat Hearts With Myocardial Fibrosis Induced by Isoproterenol
Qiang Ren, P LIN, Qing Wang, Bo Zhang, L FENG · 2020 · Physiological Research
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