The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.
GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice
Abstract
Inflammatory cell recruitment after myocardial infarction needs to be tightly controlled to permit infarct healing while avoiding fatal complications such as cardiac rupture. Growth differentiation factor-15 (GDF-15), a transforming growth factor-β (TGF-β)-related cytokine, is induced in the infarcted heart of mice and humans. We show that coronary artery ligation in Gdf15-deficient mice led to enhanced recruitment of polymorphonuclear leukocytes (PMNs) into the infarcted myocardium and an increased incidence of cardiac rupture. Conversely, infusion of recombinant GDF-15 repressed PMN recruitment after myocardial infarction. In vitro, GDF-15 inhibited PMN adhesion, arrest under flow and transendothelial migration. Mechanistically, GDF-15 counteracted chemokine-triggered conformational activation and clustering of β(2) integrins on PMNs by activating the small GTPase Cdc42 and inhibiting activation of the small GTPase Rap1. Intravital microscopy in vivo in Gdf15-deficient mice showed that Gdf-15 is required to prevent excessive chemokine-activated leukocyte arrest on the endothelium. Genetic ablation of β(2) integrins in myeloid cells rescued the mortality of Gdf15-deficient mice after myocardial infarction. To our knowledge, GDF-15 is the first cytokine identified as an inhibitor of PMN recruitment by direct interference with chemokine signaling and integrin activation. Loss of this anti-inflammatory mechanism leads to fatal cardiac rupture after myocardial infarction.
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“GDF-15 has also been shown to inhibit apoptosis and inflammation, and protects the heart from injury (36–38).”
From GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin (2020) · cites this paper as [37]
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Cites
Getting to the site of inflammation: the leukocyte adhesion cascade updated
Ley, K., Laudanna, C., Cybulsky, M. I., & Nourshargh, S. (2007) · Nature Reviews Immunology · doi:10.1038/nri2156 · Cited by 4,354
Self-citationOpal, S. M., & DePalo, V. A. (2000) · Chest · doi:10.1378/chest.117.4.1162 · Cited by 1,752
MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily
Bootcov, M. R., Bauskin, A. R., Valenzuela, S. M., Moore, A. G., Bansal, M., He, X. Y., Zhang, H. P., Donnellan, M., Mahler, S. M., Pryor, K., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11514 · Cited by 1,180
Heymans, S. R. B., Luttun, A., Nuyens, D., Theilmeier, G., Creemers, E. E., Moons, L., Dyspersin, G. D., Cleutjens, J. P. M., Shipley, M., Angellilo, A., et al. (1999) · Nature Medicine · doi:10.1038/13459 · Cited by 793
Kempf, T., Eden, M., Strelau, J., Naguib, M., Willenbockel, C., Tongers, J., Heineke, J., Kotlarz, D., Xu, J., Molkentin, J. D., et al. (2006) · Circulation Research · doi:10.1161/01.res.0000202805.73038.48 · Cited by 651
Self-citationThe Ins and Outs of Leukocyte Integrin Signaling
Abram, C. L., & Lowell, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132554 · Cited by 553
Shimaoka, M., Xiao, T. S., Liu, J.-H., Yang, Y., Dong, Y., Jun, C.-D., McCormack, A., Zhang, R., Joachimiak, A., Takagi, J., et al. (2003) · Cell · doi:10.1016/s0092-8674(02)01257-6 · Cited by 514
Periostin is essential for cardiac healingafter acute myocardial infarction
Shimazaki, M., Nakamura, K., Kii, I., Kashima, T. G., Amizuka, N., Li, M., Saito, M., Fukuda, K., Nishiyama, T., Kitajima, S., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071297 · Cited by 460
Shamri, R., Grabovsky, V., Gauguet, J.-M., Feigelson, S. W., Manevich, E., Kolanus, W., Robinson, M. K., Staunton, D. E., von Andrian, U. H., & Alon, R. (2005) · Nature Immunology · doi:10.1038/ni1194 · Cited by 409
Integrin activation and structural rearrangement
Takagi, J., & Springer, T. A. (2002) · Immunological Reviews · doi:10.1034/j.1600-065x.2002.18613.x · Cited by 384
Flagged first, then by citations
1 of the 53 references couldn’t be matched to a known paper.
Research works printed but not linked: 6
- Hsiao, E.C. et al. Characterization of growth-differentiation factor 15, a transforming growth factor β superfamily member induced following liver injury. Mol. Cell. Biol. 20, 3742–3751 (2000). · DOI · Paper page
- Kempf, T. et al. The transforming growth factor-β superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury. Circ. Res. 98, 351–360 (2006). · DOI · Paper page
- Matsumura, S. et al. Targeted deletion or pharmacological inhibition of MMP-2 prevents cardiac rupture after myocardial infarction in mice. J. Clin. Invest. 115, 599–609 (2005). · DOI
- Bolomini-Vittori, M. et al. Regulation of conformer-specific activation of the integrin LFA-1 by a chemokine-triggered Rho signaling module. Nat. Immunol. 10, 185–194 (2009). · DOI
- Dransfield, I. & Hogg, N. Regulated expression of Mg2+ binding epitope on leukocyte integrin α subunits. EMBO J. 8, 3759–3765 (1989). · DOI
- Lum, A.F., Green, C.E., Lee, G.R., Staunton, D.E. & Simon, S.I. Dynamic regulation of LFA-1 activation and neutrophil arrest on intercellular adhesion molecule 1 (ICAM-1) in shear flow. J. Biol. Chem. 277, 20660–20670 (2002). · DOI
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Koenen, R. R., & Weber, C. (2012) · Pan Stanford Publishing eBooks · doi:10.1201/b13723-2
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Hou, J., Deng, Q., Qiu, X., Liu, S., Li, Y., Huang, C., Wang, X., Zhang, Q., Deng, X., Zhong, Z., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25329835
Li, Y., Mei, T., Sun, T., Xiao, X., & Peng, R. (2024) · Figshare · doi:10.6084/m9.figshare.26560895
Hou, J., Deng, Q., Qiu, X., Liu, S., Li, Y., Huang, C., Wang, X., Zhang, Q., Deng, X., Zhong, Z., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25329754
Hou, J., Deng, Q., Qiu, X., Liu, S., Li, Y., Huang, C., Wang, X., Zhang, Q., Deng, X., Zhong, Z., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26687714
Hou, J., Deng, Q., Qiu, X., Liu, S., Li, Y., Huang, C., Wang, X., Zhang, Q., Deng, X., Zhong, Z., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26687708
Li, L. K., Huang, W.-C., Hsueh, Y.-Y., Yamauchi, K., Olivares, N., Davila, R., Fang, J., Ding, X., Zhao, W., Soto, J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19778350
Hou, J., Deng, Q., Qiu, X., Liu, S., Li, Y., Huang, C., Wang, X., Zhang, Q., Deng, X., Zhong, Z., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26687702
Hou, J., Deng, Q., Qiu, X., Liu, S., Li, Y., Huang, C., Wang, X., Zhang, Q., Deng, X., Zhong, Z., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26687699
Metadata
- Authors
- Kempf, T., Zarbock, A., Widera, C., Butz, S., Stadtmann, A., Rossaint, J., Bolomini-Vittori, M., Korf-Klingebiel, M., Napp, L. C., Hansen, B., Kanwischer, A., Bavendiek, U., Beutel, G., Hapke, M., Sauer, M. G., Laudanna, C., Hogg, N., Vestweber, D., & Wollert, K. C.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- University of Münster (DE)
- University of Verona (IT)
- Cancer Research UK (GB)
- Corresponding author
- Vestweber, Dietmar
- Wollert, Kai C
- ORCID
- Venue
- Nature Medicine
- Published
- 2011-04-24
- Volume
- 17
- Issue
- 5
- Pages
- 581-588
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2010044292
- Cited by
- 518
- References
- 53
- Citations by year
- 2026: 21 · 2025: 30 · 2024: 50 · 2023: 32 · 2022: 38 · 2021: 32 · 2020: 52 · 2019: 27 · 2018: 29 · 2017: 31 · 2016: 33 · 2015: 42 · 2014: 32 · 2013: 29 · 2012: 29
- FWCI
- 23.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › GDF15 and Related Biomarkers
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Keywords
- GDF15, myocardial infarction, leukocyte recruitment, beta2 integrins, leukocyte transmigration, polymorphonuclear leukocytes, cardiac rupture, Cdc42, Rap1, chemokine signaling, anti-inflammatory cytokines, leukocyte adhesion, transendothelial migration, myeloid cells
- MeSH terms
- Animals, Cell Adhesion, Cell Movement, Male, Mice, Inbred C57BL, Myocardial Infarction, Neutrophils, Signal Transduction, Integrins, Mice, Knockout, CD18 Antigens, cdc42 GTP-Binding Protein, rap1 GTP-Binding Proteins, Myeloid Cells, Mice, Growth Differentiation Factor 15, Mice, 129 Strain
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