GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice

Kempf, Tibor, Zarbock, Alexander, Widera, Christian, Butz, Stefan, Stadtmann, Anika, Rossaint, Jan, Bolomini-Vittori, Matteo, Korf-Klingebiel, Mortimer +11 more·2011·Nature Medicine

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Items 101–200 of 525

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  3. Growth Differentiation Factor-15 Deficiency Augments Inflammatory Response and Exacerbates Septic Heart and Renal Injury Induced by Lipopolysaccharide
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  7. TGF-β contamination of purified recombinant GDF15
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  8. Targeting NPM1 Epigenetically Promotes Postinfarction Cardiac Repair by Reprogramming Reparative Macrophage Metabolism
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  9. Molecular imaging-guided repair after acute myocardial infarction by targeting the chemokine receptor CXCR4
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  10. A growth factor–expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15
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  11. Macrophages in cardiac homeostasis, injury responses and progenitor cell mobilisation
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  12. Hyaluronic Acid Oligosaccharides Improve Myocardial Function Reconstruction and Angiogenesis against Myocardial Infarction by Regulation of Macrophages
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  13. Critical appraisal of inflammatory markers in cardiovascular risk stratification
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  14. The Small Molecule Wnt Signaling Modulator ICG-001 Improves Contractile Function in Chronically Infarcted Rat Myocardium
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  15. Immunomodulatory interventions in myocardial infarction and heart failure: a systematic review of clinical trials and meta-analysis of IL-1 inhibition
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  17. Increased expression of the TGF-b superfamily cytokine MIC-1/GDF15 protects ApoE−/− mice from the development of atherosclerosis
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  18. Growth Differentiation Factor 15 in Adverse Cardiac Remodelling: From Biomarker to Causal Player
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  19. Myocyte signalling in leucocyte recruitment to the heart
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  20. GDF15 Regulates Malat-1 Circular RNA and Inactivates NFκB Signaling Leading to Immune Tolerogenic DCs for Preventing Alloimmune Rejection in Heart Transplantation
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  21. Cardiac Biomarkers and Risk of Incident Heart Failure in Chronic Kidney Disease: The CRIC (Chronic Renal Insufficiency Cohort) Study
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  24. Genetic deletion of growth differentiation factor 15 augments renal damage in both type 1 and type 2 models of diabetes
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  25. Growth differentiation factor-15, a novel systemic biomarker of oxidative stress, inflammation, and cellular aging: Potential role in cardiovascular diseases
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  28. Relations of circulating GDF-15, soluble ST2, and troponin-I concentrations with vascular function in the community: The Framingham Heart Study
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  30. Post-ischemic Myocardial Inflammatory Response: A Complex and Dynamic Process Susceptible to Immunomodulatory Therapies
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  31. The WAP Four-Disulfide Core Domain Protein HE4: A Novel Biomarker for Heart Failure
    Rudolf A. de Boer, Qi Cao, Douwe Postmus, Kevin Damman, Adriaan A. Voors, Tiny Jaarsma, Dirk Jan van Veldhuisen, W. Arnold Dijk, Hans L. Hillege, Herman H.W. Silljé · 2013 · JACC Heart Failure
  32. Targeting Amino Acid Metabolism for Molecular Imaging of Inflammation Early After Myocardial Infarction
    James T. Thackeray, Jens P. Bankstahl, Yong Wang, Kai Christoph Wollert, Frank Michael Bengel · 2016 · Theranostics
  33. Growth differentiation factor-15 is associated with cardiovascular outcomes in patients with coronary artery disease
    Li, Man, Duan, Lei, Cai, Yu-Lun, Li, Hui-Ying, Hao, Ben-Chuan, Chen, Jian-Qiao, Liu, Hong-Bin · 2020 · Cardiovascular Diabetology
  34. Neutrophils in the periodontium: Interactions with pathogens and roles in tissue homeostasis and inflammation
    Silvia M. Uriarte, George Hajishengallis · 2022 · Immunological Reviews
  35. NAG-1/GDF15 inhibits diabetic nephropathy via inhibiting AGE/RAGE-mediated inflammation signaling pathways in C57BL/6 mice and HK-2 cells
    Jiajun Chen, He Peng, Chaojie Chen, Ying Wang, Tingting Sang, Zheqi Cai, Qian Zhao, Shengjia Chen, Xiaojian Lin, Thomas E. Eling et al. · 2022 · Life Sciences
  36. Distinct single-cell immune ecosystems distinguish true and de novo HBV-related hepatocellular carcinoma recurrences
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  37. Anti-inflammatory mechanisms and therapeutic opportunities in myocardial infarct healing
    Tibor Kempf, Alexander Zarbock, Dietmar Vestweber, Kai Christoph Wollert · 2012 · Journal of Molecular Medicine
  38. Overview of growth differentiation factor 15 in metabolic syndrome
    Asrih, Mohamed, Wei, Shibo, Nguyen, Thanh T., Yi, Hyon‐Seung, Ryu, Dongryeol, Gariani, Karim · 2023 · Journal of Cellular and Molecular Medicine
  39. Growth Differentiation Factor-15 in Immunity and Aging
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  40. Targeting post-infarct inflammation by PET imaging: comparison of 68Ga-citrate and 68Ga-DOTATATE with 18F-FDG in a mouse model
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  43. Molecular Imaging of Myocardial Inflammation With Positron Emission Tomography Post-Ischemia
    James T. Thackeray, Frank Michael Bengel · 2018 · JACC. Cardiovascular imaging
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  45. Chemokines and the Signaling Modules Regulating Integrin Affinity
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  46. Growth/differentiation factor-15: prostate cancer suppressor or promoter?
    Petr Vaňhara, Aleš Hampl, Alois Kozubı́k, Karel Souček · 2012 · Prostate Cancer and Prostatic Diseases
  47. Increased expression and accumulation of GDF15 in IPF extracellular matrix contribute to fibrosis
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  48. GDF‐15 prevents platelet integrin activation and thrombus formation
    Jan Rossaint, Dietmar Vestweber, Alexander Zarbock · 2012 · Journal of Thrombosis and Haemostasis
  49. Targeting the Chemokines in Cardiac Repair
    Michele Cavalera, Nikolaos Georgios Frangogiannis · 2014 · Current Pharmaceutical Design
  50. Growth Differentiation Factor (GDF)-15 Blocks Norepinephrine-induced Myocardial Hypertrophy via a Novel Pathway Involving Inhibition of Epidermal Growth Factor Receptor Transactivation
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  51. Colchicine Ameliorates Dilated Cardiomyopathy Via SIRT2‐Mediated Suppression of NLRP3 Inflammasome Activation
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  52. Growth-Differentiation Factor 15 Predicts Worsening of Albuminuria in Patients With Type 2 Diabetes
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  53. CXCL5-mediated recruitment of neutrophils into the peritoneal cavity of Gdf15 -deficient mice protects against abdominal sepsis
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  54. Growth-Differentiation Factor 15 and Osteoprotegerin in Acute Myocardial Infarction Complicated by Cardiogenic Shock: A Biomarker Substudy of the IABP-SHOCK II-Trial
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  55. Novel insights into leukocyte extravasation
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  56. The Roles of Neutrophils Linking Periodontitis and Atherosclerotic Cardiovascular Diseases
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  57. Renoprotective and Immunomodulatory Effects of GDF15 following AKI Invoked by Ischemia-Reperfusion Injury
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  58. Leukocyte integrin activation and deactivation: novel mechanisms of balancing inflammation
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  59. Early Protective Role of Inflammation in Cardiac Remodeling and Heart Failure: Focus on TNFα and Resident Macrophages
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  60. Over-expression of growth differentiation factor 15 (GDF15) preventing cold ischemia reperfusion (I/R) injury in heart transplantation through Foxo3a signaling
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  61. Cardiomyocyte-specific deficiency of HSPB1 worsens cardiac dysfunction by activating NFκB-mediated leucocyte recruitment after myocardial infarction
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  62. Growth differentiation factor-15 is a predictor of important disease outcomes in patients with COPD
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  63. Clinically relevant strategies for lowering cardiomyocyte glucose uptake for 18F-FDG imaging of myocardial inflammation in mice
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  65. Dehydrated human amnion/chorion membrane regulates stem cell activity in vitro
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  67. Growth/differentiation factor-15 deficiency compromises dopaminergic neuron survival and microglial response in the 6-hydroxydopamine mouse model of Parkinson's disease
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  73. Emerging Roles of Growth Differentiation Factor 15 in Immunoregulation and Pathogenesis
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