The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
A role for interleukin-2 trans-presentation in dendritic cell–mediated T cell activation in humans, as revealed by daclizumab therapy
Open accessAbstract
Although previous studies have described CD25 expression and production of interleukin-2 (IL-2) by mature dendritic cells (mDCs), it remains unclear how these molecules participate in the activation of T cells. In search of the mechanisms by which daclizumab, a humanized monoclonal antibody against CD25, inhibits brain inflammation in multiple sclerosis, we observed that although the drug has limited effects on polyclonal T cell activation, it potently inhibits activation of antigen-specific T cells by mDCs. We show that mDCs (and antigen-experienced T cells) secrete IL-2 toward the mDC-T cell interface in an antigen-specific manner, and mDCs 'lend' their CD25 to primed T cells in trans to facilitate early high-affinity IL-2 signaling, which is crucial for subsequent T cell expansion and development of antigen-specific effectors. Our data reveal a previously unknown mechanism for the IL-2 receptor system in DC-mediated activation of T cells.
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Metadata
- Authors
- Wuest, S. C., Edwan, J. H., Martin, J. F., Han, S., Perry, J. S. A., Cartagena, C. M., Matsuura, E., Maric, D., Waldmann, T. A., & Bielekova, B.
- Venue
- Nature Medicine
- Published
- 2011-05
- Volume
- 17
- Issue
- 5
- Pages
- 604-609
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2164351607
- Cited by
- 284
- References
- 29
- FWCI
- 11.29
- Type
- journal article
- Language
- en
- Open access
- green
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