The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
MRSA epidemic linked to a quickly spreading colonization and virulence determinant
Open accessAbstract
The molecular processes underlying epidemic waves of methicillin-resistant Staphylococcus aureus (MRSA) infection are poorly understood. Although a major role has been attributed to the acquisition of virulence determinants by horizontal gene transfer, there are insufficient epidemiological and functional data supporting that concept. We here report the spread of clones containing a previously extremely rare mobile genetic element–encoded gene, sasX. We demonstrate that sasX has a key role in MRSA colonization and pathogenesis, substantially enhancing nasal colonization, lung disease and abscess formation and promoting mechanisms of immune evasion. Moreover, we observed the recent spread of sasX from sequence type 239 (ST239) to invasive clones belonging to other sequence types. Our study identifies sasX as a quickly spreading crucial determinant of MRSA pathogenic success and a promising target for therapeutic interference. Our results provide proof of principle that horizontal gene transfer of key virulence determinants drives MRSA epidemic waves.
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Klevens, R. M. (2007) · JAMA · doi:10.1001/jama.298.15.1763 · Cited by 3,726
Waves of resistance: Staphylococcus aureus in the antibiotic era
Chambers, H. F., & DeLeo, F. R. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2200 · Cited by 2,718
The role of nasal carriage in Staphylococcus aureus infections
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Methicillin-Resistant S. aureus Infections among Patients in the Emergency Department
Moran, G. J., Krishnadasan, A., Gorwitz, R. J., Fosheim, G. E., McDougal, L. K., Carey, R. B., & Talan, D. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055356 · Cited by 2,285
Nasal Carriage as a Source of Staphylococcus aureus Bacteremia
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Antimicrobial resistance: the example of Staphylococcus aureus
Lowy, F. D. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18535 · Cited by 1,445
Immune evasion by staphylococci
Foster, T. J. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1289 · Cited by 1,222
Evolution of MRSA During Hospital Transmission and Intercontinental Spread
Harris, S. R., Feil, E. J., Holden, M. T. G., Quail, M. A., Nickerson, E. K., Chantratita, N., Gardete, S., Tavares, A., Day, N., Lindsay, J. A., et al. (2010) · Science · doi:10.1126/science.1182395 · Cited by 1,091
Wang, R., Braughton, K. R., Kretschmer, D., Bach, T.-H. L., Queck, S. Y., Li, M., Kennedy, A. D., Dorward, D. W., Klebanoff, S. J., Peschel, A., et al. (2007) · Nature Medicine · doi:10.1038/nm1656 · Cited by 1,046
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Cited by
Tong, S. Y. C., Davis, J. S., Eichenberger, E., Holland, T. L., & Fowler, V. G. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00134-14 · Cited by 5,192
Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus
Foster, T. J., Geoghegan, J. A., Ganesh, V. K., & Höök, M. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3161 · Cited by 1,533
Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance
Dickey, S. W., Cheung, G. Y. C., & Otto, M. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.23 · Cited by 799
Self-citationRegulation of Staphylococcus aureus Virulence
Jenul, C., & Horswill, A. R. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0031-2018 · Cited by 549
Molecular Basis of In Vivo Biofilm Formation by Bacterial Pathogens
Joo, H.-S., & Otto, M. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.10.022 · Cited by 434
Self-citationClinical Impact of Staphylococcus aureus Skin and Soft Tissue Infections
Linz, M. S., Mattappallil, A., Finkel, D., & Parker, D. (2023) · Antibiotics · doi:10.3390/antibiotics12030557 · Cited by 293
Protein-based biofilm matrices in Staphylococci
Speziale, P., Pietrocola, G., Foster, T. J., & Geoghegan, J. A. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00171 · Cited by 269
Metadata
- Authors
- Li, M., Du, X., Villaruz, A. E., Diep, B. A., Wang, D., Song, Y., Tian, Y., Hu, J., Yu, F., Lu, Y., & Otto, M.
- Venue
- Nature Medicine
- Published
- 2012-04-22
- Volume
- 18
- Issue
- 5
- Pages
- 816-819
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2094618802
- Cited by
- 278
- References
- 33
- FWCI
- 19.83
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
