The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1
Open accessAbstract
Primary astrocytomas of grade 3 or 4 according to the classification system of the World Health Organization (high-grade astrocytomas or HGAs) are preponderant among adults and are almost invariably fatal despite the use of multimodal therapy. Here we show that the juvenile brain has an endogenous defense mechanism against HGAs. Neural precursor cells (NPCs) migrate to HGAs, reduce glioma expansion and prolong survival time by releasing endovanilloids that activate the vanilloid receptor (transient receptor potential vanilloid subfamily member-1 or TRPV1) on HGA cells. TRPV1 is highly expressed in tumor and weakly expressed in tumor-free brain. TRPV1 stimulation triggers tumor cell death through the branch of the endoplasmic reticulum stress pathway that is controlled by activating transcription factor-3 (ATF3). The antitumorigenic response of NPCs is lost with aging. NPC-mediated tumor suppression can be mimicked in the adult brain by systemic administration of the synthetic vanilloid arvanil, suggesting that TRPV1 agonists have potential as new HGA therapeutics.
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Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast
de Godoy, L. M. F., Olsen, J. V., Cox, J., Nielsen, M. L., Hubner, N. C., Fröhlich, F., Walther, T. C., & Mann, M. (2008) · Nature · doi:10.1038/nature07341 · Cited by 873
Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years
Knoth, R., Singec, I., Ditter, M., Pantazis, G., Capetian, P., Meyer, R. P., Horvat, V., Volk, B., & Kempermann, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008809 · Cited by 650
Melck, D., Bisogno, T., De Petrocellis, L., Chuang, H.-H., Julius, D., Bifulco, M., & Di Marzo, V. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1105 · Cited by 188
Unal Cevik, I., & Dalkara, T. (2003) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401250 · Cited by 114
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Self-citationAdvances in TRP channel drug discovery: from target validation to clinical studies
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Gargiulo, G., Cesaroni, M., Serresi, M., de Vries, N., Hulsman, D., Bruggeman, S. W., Lancini, C., & van Lohuizen, M. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.03.030 · Cited by 176
Physical activity and the endocannabinoid system: an overview
Tantimonaco, M., Ceci, R., Sabatini, S., Catani, M. V., Rossi, A., Gasperi, V., & Maccarrone, M. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1575-6 · Cited by 112
Metadata
- Authors
- Stock, K., Kumar, J., Synowitz, M., Petrosino, S., Imperatore, R., Smith, E. S. J., Wend, P., Purfürst, B., Nuber, U. A., Gurok, U., Matyash, V., Wälzlein, J.-H., Chirasani, S. R., Dittmar, G., Cravatt, B. F., Momma, S., Lewin, G. R., Ligresti, A., De Petrocellis, L., Cristino, L., Di Marzo, V., Kettenmann, H., & Glass, R.
- Venue
- Nature Medicine
- Published
- 2012-07-22
- Volume
- 18
- Issue
- 8
- Pages
- 1232-1238
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1999407700
- Cited by
- 196
- References
- 5
- FWCI
- 6.25
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
