Physical activity and the endocannabinoid system: an overview

Tantimonaco, Mirko; Ceci, Roberta; Sabatini, Stefania; Catani, Maria Valeria; Rossi, Antonello; Gasperi, Valeria; Maccarrone, Mauro

doi:10.1007/s00018-014-1575-6

Cited by 112Cannabis and Cannabinoid ResearchPhysical Activity and HealthExercise and Physiological Responses

Physical activity and the endocannabinoid system: an overview

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Tantimonaco, Mirko, Ceci, Roberta, Sabatini, Stefania, Catani, Maria Valeria, Rossi, Antonello, Gasperi, Valeria, Maccarrone, Mauro·2014·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-014-1575-6PMC PMC11113821

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Abstract

Recognized as a "disease modifier", physical activity (PA) is increasingly viewed as a more holistic, cost-saving method for prevention, treatment and management of human disease conditions. The traditional view that PA engages the monoaminergic and endorphinergic systems has been challenged by the discovery of the endocannabinoid system (ECS), composed of endogenous lipids, their target receptors, and metabolic enzymes. Indeed, direct and indirect evidence suggests that the ECS might mediate some of the PA-triggered effects throughout the body. Moreover, it is now emerging that PA itself is able to modulate ECS in different ways. Against this background, in the present review we shall discuss evidence of the cross-talk between PA and the ECS, ranging from brain to peripheral districts and highlighting how ECS must be tightly regulated during PA, in order to maintain its beneficial effects on cognition, mood, and nociception, while avoiding impaired energy metabolism, oxidative stress, and inflammatory processes.

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Exercise-induced elevations of endocannabinoid levels have been proposed to account partially for anxiolytic, anti-nociceptive and neuroprotective properties of exercise.
“Exerciseinduced elevations of endocannabinoid levels have been proposed to account partially for anxiolytic (Tantimonaco et al., 2014;Fuss et al., 2015), anti-nociceptive (Galdino et al., 2014) and neuroprotective (Hill et al., 2010a) properties of exercise, which are all responses that instead are affected in a negative direction by sleep loss (e.g.Roy-Byrne et al., 1986;Schuh-Hofer et al., 2013;”
From Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans (2016) · cites this paper as Tantimonaco et al., 2014
The increase of circulating endocannabinoids following exercise has been proposed to partially account for anxiolytic, anti-nociceptive, and neuroprotective properties of physical exercise.
“The increase of circulating levels of endocannabinoids following exercise has been proposed to partially account for the anxiolytic (Tantimonaco et al., 2014), anti-nociceptive (Galdino et al., 2014) and neuroprotective (Hill et al., 2010a) properties of physical exercise.”
From Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans (2016) · cites this paper as Tantimonaco et al., 2014
Physical activity may operate through the endocannabinoid system by up-regulating circulating endocannabinoids such as anandamide, which can produce anxiolytic effects by regulating dopamine.
“For example, PA has been shown to up-regulate circulating endocannabinoids such as anandamide, which can produce anxiolytic effects by regulating other neurotransmitters, such as dopamine [84]⁠.”
From Moving to Beat Anxiety: Epidemiology and Therapeutic Issues with Physical Activity for Anxiety (2018) · cites this paper as [84]

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Changes in plasma endocannabinoid levels in viscerally obese men following a 1 year lifestyle modification programme and waist circumference reduction: associations with changes in metabolic risk factors
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CB1 Antagonism Exerts Specific Molecular Effects on Visceral and Subcutaneous Fat and Reverses Liver Steatosis in Diet-Induced Obese Mice
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Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-α nuclear receptorsPreprint
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Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress
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Long-Term Metformin Treatment Stimulates Cardiomyocyte Glucose Transport through an AMP-Activated Protein Kinase-Dependent Reduction in GLUT4 Endocytosis
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Moving to Beat Anxiety: Epidemiology and Therapeutic Issues with Physical Activity for Anxiety
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Italian Journal of Anatomy and Embryology - contenuto non piu disponibile
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The chemistry of endocannabinoids.
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Analysis of Endocannabinoid System in Rat Testis During the First Spermatogenetic Wave
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Authors: Tantimonaco, M., Ceci, R., Sabatini, S., Catani, M. V., Rossi, A., Gasperi, V., & Maccarrone, M.
Affiliations: Foro Italico University of Rome (IT)
University of Rome Tor Vergata (IT)
Università Campus Bio-Medico (IT)
Corresponding author: Gasperi, Valeria
Maccarrone, Mauro
ORCID: Ceci, Roberta
Sabatini, Stefania
Catani, Maria Valeria
Gasperi, Valeria
Maccarrone, Mauro
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2014-02-14
Volume: 71
Issue: 14
Pages: 2681-2698
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-014-1575-6
PMC: PMC11113821
OpenAlex: W2063762175
Cited by: 112
References: 201
Citations by year: 2026: 9 · 2025: 14 · 2024: 7 · 2023: 7 · 2022: 14 · 2021: 8 · 2020: 11 · 2019: 12 · 2018: 6 · 2017: 11 · 2016: 7 · 2015: 5 · 2014: 1
FWCI: 1.03
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Physiology › Physical Activity and Health
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords: physical activity, endocannabinoid system, endocannabinoid receptors, endocannabinoid metabolism, exercise-induced neuroplasticity, mood, cognition, nociception, energy metabolism, oxidative stress, inflammation
MeSH terms: Animals, Energy Intake, Central Nervous System, Energy Metabolism, Exercise Therapy, Humans, Models, Biological, Motor Activity, Mice, Endocannabinoids

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Physical activity and the endocannabinoid system: an overview

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