The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Interleukin-17–producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity
Open accessAbstract
Obesity is associated with the development of asthma, which is often difficult to control. To understand the immunological pathways that lead to obesity-associated asthma, we fed mice a high-fat diet for 12 weeks, which resulted in obesity and the development of airway hyperreactivity (AHR), a cardinal feature of asthma. This AHR was independent of adaptive immunity, as it occurred in obese Rag1−/− mice, which lack B and T cells, and was dependent on interleukin-17A (IL-17A) and the NLRP3 inflammasome, as it did not develop in obese Il17a−/− or Nlrp3−/− mice. AHR was also associated with the expansion of CCR6+ type 3 innate lymphoid cells (ILCs) producing IL-17A (ILC3 cells) in the lung, which could by themselves mediate AHR when adoptively transferred into Rag2−/−; Il2rg−/− mice treated with recombinant IL-1β. Macrophage-derived IL-1β production was induced by HFD and expanded the number of lung ILC3 cells. Blockade of IL-1β with an IL-1 receptor antagonist abolished obesity-induced AHR and reduced the number of ILC3 cells. As we found ILC3-like cells in the bronchoalveolar lavage fluid of individuals with asthma, we suggest that obesity-associated asthma is facilitated by inflammation mediated by NLRP3, IL-1β and ILC3 cells.
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Cites
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Cited by
Peters, U., Dixon, A. E., & Forno, E. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.02.004 · Cited by 934
Innate lymphoid cells: A new paradigm in immunology
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Immunosuppressive cells in cancer: mechanisms and potential therapeutic targets
Tie, Y., Tang, F., Wei, Y.-Q., & Wei, X.-W. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01282-8 · Cited by 591
Innate lymphoid cells in the initiation, regulation and resolution of inflammation
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The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces
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Metadata
- Authors
- Kim, H. Y., Lee, H. J., Chang, Y.-J., Pichavant, M., Shore, S. A., Fitzgerald, K. A., Iwakura, Y., Israel, E., Bolger, K., Faul, J., DeKruyff, R. H., & Umetsu, D. T.
- Venue
- Nature Medicine
- Published
- 2013-12-15
- Volume
- 20
- Issue
- 1
- Pages
- 54-61
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2158045379
- Cited by
- 635
- References
- 11
- FWCI
- 25.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Kim, H. Y., Lee, H. J., Chang, Y.-J., Pichavant, M., Shore, S. A., Fitzgerald, K. A., Iwakura, Y., Israel, E., Bolger, K., Faul, J., DeKruyff, R. H., & Umetsu, D. T. (2014). Interleukin-17–producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity. Nature Medicine. https://doi.org/10.1038/nm.3423
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