Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity

Inflammation and metabolic disorders

Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

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Mitochondrial dysfunction and type 2 diabetes

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Mitochondria as sensors and regulators of calcium signalling

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Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

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Endoplasmic reticulum-mitochondria contacts: Function of the junction

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Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms

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Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

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Upregulated function of mitochondria‐associated ER membranes in Alzheimer disease

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The role of mitochondria in the pathogenesis of type 2 diabetes

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Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance

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Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss

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Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals

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Mitochondria-associated endoplasmic reticulum membrane (MAM) integrity is required for insulin signaling and is implicated in hepatic insulin resistance

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Foxo1 integrates insulin signaling with mitochondrial function in the liver

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Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance

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Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence

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Inflammation, metaflammation and immunometabolic disorders

Hotamisligil, G. S. (2017) · Nature · doi:10.1038/nature21363 · Cited by 2,570

The machineries, regulation and cellular functions of mitochondrial calcium

Giorgi, C., Marchi, S., & Pinton, P. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0052-8 · Cited by 941

Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives

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Metabolic Control of Longevity

López-Otín, C., Galluzzi, L., Freije, J. M. P., Madeo, F., & Kroemer, G. (2016) · Cell · doi:10.1016/j.cell.2016.07.031 · Cited by 753

Biochemical and cellular properties of insulin receptor signalling

Haeusler, R. A., McGraw, T. E., & Accili, D. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.89 · Cited by 739