The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Anemia: progress in molecular mechanisms and therapies
Open accessAbstract
Anemia is a major source of morbidity and mortality worldwide. Here we review recent insights into how red blood cells (RBCs) are produced, the pathogenic mechanisms underlying various forms of anemia, and novel therapies derived from these findings. It is likely that these new insights, mainly arising from basic scientific studies, will contribute immensely to both the understanding of frequently debilitating forms of anemia and the ability to treat affected patients. Major worldwide diseases that are likely to benefit from new advances include the hemoglobinopathies (β-thalassemia and sickle cell disease); rare genetic disorders of RBC production; and anemias associated with chronic kidney disease, inflammation, and cancer. Promising new approaches to treatment include drugs that target recently defined pathways in RBC production, iron metabolism, and fetal globin-family gene expression, as well as gene therapies that use improved viral vectors and newly developed genome editing technologies.
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Cites
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Identification of erythroferrone as an erythroid regulator of iron metabolism
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Cited by
Taher, A. T., Weatherall, D. J., & Cappellini, M. D. (2018) · The Lancet · doi:10.1016/s0140-6736(17)31822-6 · Cited by 807
Distinct routes of lineage development reshape the human blood hierarchy across ontogeny
Notta, F., Zandi, S., Takayama, N., Dobson, S., Gan, O. I., Wilson, G., Kaufmann, K. B., McLeod, J., Laurenti, E., Dunant, C. F., et al. (2016) · Science · doi:10.1126/science.aab2116 · Cited by 780
Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis
Khajuria, R. K., Munschauer, M., Ulirsch, J. C., Fiorini, C., Ludwig, L. S., McFarland, S. K., Abdulhay, N. J., Specht, H., Keshishian, H., Mani, D. R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.02.036 · Cited by 416
“Despite extensive studies, the mechanisms by which a defect in RPs could cause a selective absence of erythroid cells within the hematopoietic compartment, while allowing for normal differentiation of other lineages, has remained a mystery (Sankaran and Weiss, 2015).”
BackgroundSystematic Functional Dissection of Common Genetic Variation Affecting Red Blood Cell Traits
Ulirsch, J. C., Nandakumar, S. K., Wang, L., Giani, F. C., Zhang, X., Rogov, P., Melnikov, A., McDonel, P., Do, R., Mikkelsen, T. S., et al. (2016) · Cell · doi:10.1016/j.cell.2016.04.048 · Cited by 328
Self-citationOxidative stress, eryptosis and anemia: a pivotal mechanistic nexus in systemic diseases
Bissinger, R., Bhuyan, A. A. M., Qadri, S. M., & Lang, F. (2019) · The FEBS Journal · doi:10.1111/febs.14606 · Cited by 239
Metadata
- Authors
- Sankaran, V. G., & Weiss, M. J.
- Venue
- Nature Medicine
- Published
- 2015-03
- Volume
- 21
- Issue
- 3
- Pages
- 221-230
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2014865621
- Cited by
- 281
- References
- 31
- FWCI
- 16.96
- Type
- journal article
- Language
- en
- Open access
- green
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