The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
SOX2 promotes lineage plasticity and antiandrogen resistance in TP53 - and RB1 -deficient prostate cancer
Open accessAbstract
Evading cancer drugs by identity fraud: Prostate cancer growth is fueled by male hormones called androgens. Drugs targeting the androgen receptor (AR) are initially efficacious, but most tumors eventually become resistant (see the Perspective by Kelly and Balk). Mu et al. found that prostate cancer cells escaped the effects of androgen deprivation therapy through a change in lineage identity. Functional loss of the tumor suppressors TP53 and RB1 promoted a shift from AR-dependent luminal epithelial cells to AR-independent basal-like cells. In related work, Ku et al. found that prostate cancer metastasis, lineage switching, and drug resistance were driven by the combined loss of the same tumor suppressors and were accompanied by increased expression of the epigenetic regulator Ezh2. Ezh2 inhibitors reversed the lineage switch and restored sensitivity to androgen deprivation therapy in experimental models. Science , this issue p. 84 , p. 78 ; see also p. 29
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Metadata
- Authors
- Mu, P., Zhang, Z., Benelli, M., Karthaus, W. R., Hoover, E., Chen, C.-C., Wongvipat, J., Ku, S.-Y., Gao, D., Cao, Z., Shah, N., Adams, E. J., Abida, W., Watson, P. A., Prandi, D., Huang, C.-H., de Stanchina, E., Lowe, S. W., Ellis, L., Beltran, H., Rubin, M. A., Goodrich, D. W., Demichelis, F., & Sawyers, C. L.
- Venue
- Science
- Published
- 2017-01-06
- Volume
- 355
- Issue
- 6320
- Pages
- 84-88
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2567986926
- Cited by
- 1,050
- References
- 38
- FWCI
- 75.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Mu, P., Zhang, Z., Benelli, M., Karthaus, W. R., Hoover, E., Chen, C.-C., Wongvipat, J., Ku, S.-Y., Gao, D., Cao, Z., Shah, N., Adams, E. J., Abida, W., Watson, P. A., Prandi, D., Huang, C.-H., de Stanchina, E., Lowe, S. W., Ellis, L., . . . Sawyers, C. L. (2017). SOX2 promotes lineage plasticity and antiandrogen resistance in TP53 - and RB1 -deficient prostate cancer. Science. https://doi.org/10.1126/science.aah4307
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
