The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure
Open accessAbstract
The absence of a gold standard to determine when antibiotics induce a sterilizing cure has confounded the development of new approaches to treat pulmonary tuberculosis (PTB). We detected positron emission tomography and computerized tomography (PET–CT) imaging response patterns consistent with active disease, along with the presence of Mycobacterium tuberculosis (MTB) mRNA in sputum and bronchoalveolar lavage samples, in a substantial proportion of adult, HIV-negative patients with PTB after a standard 6-month treatment plus 1 year follow-up, including patients with a durable cure and others who later developed recurrent disease. The presence of MTB mRNA in the context of nonresolving and intensifying lesions on PET–CT images might indicate ongoing transcription, suggesting that even apparently curative treatment for PTB may not eradicate all of the MTB bacteria in most patients. This suggests an important complementary role for the immune response in maintaining a disease-free state. Sterilizing drugs or host-directed therapies, and better treatment response markers, are probably needed for the successful development of improved and shortened PTB-treatment strategies.
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Kinahan, P. E., & Fletcher, J. W. (2010) · Seminars in Ultrasound, CT and MRI · doi:10.1053/j.sult.2010.10.001 · Cited by 631
The Mycobacterium tuberculosis regulatory network and hypoxia
Galagan, J. E., Minch, K., Peterson, M., Lyubetskaya, A., Azizi, E., Sweet, L., Gomes, A., Rustad, T., Dolganov, G., Glotova, I., et al. (2013) · Nature · doi:10.1038/nature12337 · Cited by 431
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Cited by
Dorman, S. E., Schumacher, S. G., Alland, D., Nabeta, P., Armstrong, D. T., King, B., Hall, S. L., Chakravorty, S., Cirillo, D. M., Tukvadze, N., et al. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(17)30691-6 · Cited by 689
Self-citationDrain, P. K., Bajema, K. L., Dowdy, D., Dheda, K., Naidoo, K., Schumacher, S. G., Ma, S., Meermeier, E., Lewinsohn, D. M., & Sherman, D. R. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00021-18 · Cited by 565
Tuberculosis and lung damage: from epidemiology to pathophysiology
Ravimohan, S., Kornfeld, H., Weissman, D., & Bisson, G. P. (2018) · European Respiratory Review · doi:10.1183/16000617.0077-2017 · Cited by 531
Anti-tuberculosis treatment strategies and drug development: challenges and priorities
Dartois, V. A., & Rubin, E. J. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00731-y · Cited by 490
Cadena, A. M., Fortune, S. M., & Flynn, J. L. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.69 · Cited by 484
Metadata
- Authors
- the Catalysis TB–Biomarker Consortium, Malherbe, S. T., Shenai, S., Ronacher, K., Loxton, A. G., Dolganov, G., Kriel, M., Van, T., Chen, R. Y., Warwick, J., Via, L. E., Song, T., Lee, M., Schoolnik, G., Tromp, G., Alland, D., Barry, C. E., Winter, J., Walzl, G., Lucas, L., van der Spuy, G., Stanley, K., Thiart, L., Smith, B., Du Plessis, N., Beltran, C. G. G., Maasdorp, E., Ellmann, A., Choi, H., Joh, J., Dodd, L. E., Allwood, B., Koegelenberg, C., Vorster, M., & Griffith-Richards, S.
- Venue
- Nature Medicine
- Published
- 2016-09-05
- Volume
- 22
- Issue
- 10
- Pages
- 1094-1100
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2510407367
- Cited by
- 297
- References
- 2
- FWCI
- 29.12
- Type
- journal article
- Language
- en
- Open access
- green
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