Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas
Piunti, Andrea, Hashizume, Rintaro, Morgan, Marc A, Bartom, Elizabeth T, Horbinski, Craig M, Marshall, Stacy A, Rendleman, Emily J, Ma, Quanhong, Takahashi, Yoh-hei, Woodfin, Ashley R, Misharin, Alexander V, Abshiru, Nebiyu A, Lulla, Rishi R, Saratsis, Amanda M, Kelleher, Neil L, James, C David, Shilatifard, Ali·2017·Nature Medicine
DOI 10.1038/nm.4296
Cited by (458)
Items 401–458 of 458
- Supplementary Data S1 from Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic PathwaysSriram Venneti, Abed Rahman Kawakibi, Sunjong Ji et al. · 2023
- Supplementary Data S2 from Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic PathwaysSriram Venneti, Abed Rahman Kawakibi, Sunjong Ji et al. · 2023
- Supplementary Data S2 from Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic PathwaysSriram Venneti, Abed Rahman Kawakibi, Sunjong Ji et al. · 2023
- Supplementary Data S1 from Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic PathwaysSriram Venneti, Abed Rahman Kawakibi, Sunjong Ji et al. · 2023
- Reviewer #1 (Public Review): BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomasPaul Huchedé, Swann Meyer, Clément Berthelot et al. · 2023
- Reviewer #2 (Public Review): BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomasPaul Huchedé, Swann Meyer, Clément Berthelot et al. · 2023
- BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomasPaul Huchedé, Swann Meyer, Clément Berthelot et al. · 2023 · eLife
- eLife Assessment: BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomasLynne-Marie M Postovit · 2023
- Dual Targeting of Histone Deacetylases and MYC as Potential Treatment Strategy for H3-K27M Pediatric GliomasDanielle Algranati, Roni Oren, Bareket Dassa, Liat Fellus-Alyagor, Alexander N. Plotnikov, Haim Michael Barr, Alon Harmelin, Nir London, Guy Ron, Noa Furth et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Additional file 1 of Reversal of cancer gene expression identifies repurposed drugs for diffuse intrinsic pontine gliomaGuisheng Zhao, Patrick A. Newbury, Yukitomo Ishi, Eugene Chekalin, Billy Zeng, Benjamin Scott Glicksberg, Anita Wen, Shreya Paithankar, Takahiro Sasaki, Amreena Suri et al. · 2022 · Figshare
- Additional file 3 of Reversal of cancer gene expression identifies repurposed drugs for diffuse intrinsic pontine gliomaGuisheng Zhao, Patrick A. Newbury, Yukitomo Ishi, Eugene Chekalin, Billy Zeng, Benjamin Scott Glicksberg, Anita Wen, Shreya Paithankar, Takahiro Sasaki, Amreena Suri et al. · 2022 · Figshare
- Additional file 8 of Reversal of cancer gene expression identifies repurposed drugs for diffuse intrinsic pontine gliomaGuisheng Zhao, Patrick A. Newbury, Yukitomo Ishi, Eugene Chekalin, Billy Zeng, Benjamin Scott Glicksberg, Anita Wen, Shreya Paithankar, Takahiro Sasaki, Amreena Suri et al. · 2022 · Figshare
- Additional file 7 of Reversal of cancer gene expression identifies repurposed drugs for diffuse intrinsic pontine gliomaGuisheng Zhao, Patrick A. Newbury, Yukitomo Ishi, Eugene Chekalin, Billy Zeng, Benjamin Scott Glicksberg, Anita Wen, Shreya Paithankar, Takahiro Sasaki, Amreena Suri et al. · 2022 · Figshare
- Additional file 2 of Reversal of cancer gene expression identifies repurposed drugs for diffuse intrinsic pontine gliomaGuisheng Zhao, Patrick A. Newbury, Yukitomo Ishi, Eugene Chekalin, Billy Zeng, Benjamin Scott Glicksberg, Anita Wen, Shreya Paithankar, Takahiro Sasaki, Amreena Suri et al. · 2022 · Figshare
- Additional file 2 of Defining super-enhancers by highly ranked histone H4 multi-acetylation levels identifies transcription factors associated with glioblastoma stem-like propertiesNando Dulal Das, Jen-Chien Chang, Chung-Chau Hon, S. Thomas Kelly, Shinsuke Ito, Marina Lizio, Bogumił Kaczkowski, Hisami Watanabe, Keisuke Katsushima, Atsushi Natsume et al. · 2023 · Figshare
- Additional file 6 of Reversal of cancer gene expression identifies repurposed drugs for diffuse intrinsic pontine gliomaGuisheng Zhao, Patrick A. Newbury, Yukitomo Ishi, Eugene Chekalin, Billy Zeng, Benjamin Scott Glicksberg, Anita Wen, Shreya Paithankar, Takahiro Sasaki, Amreena Suri et al. · 2022 · Figshare
- Additional file 5 of Reversal of cancer gene expression identifies repurposed drugs for diffuse intrinsic pontine gliomaGuisheng Zhao, Patrick A. Newbury, Yukitomo Ishi, Eugene Chekalin, Billy Zeng, Benjamin Scott Glicksberg, Anita Wen, Shreya Paithankar, Takahiro Sasaki, Amreena Suri et al. · 2022 · Figshare
- Dual Targeting of Histone Deacetylases and MYC as Potential Treatment Strategy for H3-K27M Pediatric GliomasDanielle Algranati, Roni Oren, Bareket Dassa, Liat Fellus-Alyagor, Alexander N. Plotnikov, Haim Michael Barr, Alon Harmelin, Nir London, Guy Ron, Noa Furth et al. · 2024 · eLife
- Author Response: BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomasPaul Huchedé, Swann Meyer, Clément Berthelot et al. · 2023
- Chromatin remodeling with combined FACT and BET inhibition disrupts oncogenic transcription in Diffuse Midline GliomaHolly Holliday, Aaminah Khan, Anahid Ehteda, Hieu Trung Nguyen, Samuel E. Ross, Nisitha Jayatilleke, Anjana Gopalakrishnan, Eyden Wang, Yolanda Colino‐Sanguino, Daisy Kavanagh et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Reviewer #2 (Public Review): Dual Targeting of Histone Deacetylases and MYC as Potential Treatment Strategy for H3-K27M Pediatric GliomasDanielle Algranati, Roni Oren, Bareket Dassa et al. · 2024 · eLife
- Author response: Dual Targeting of Histone Deacetylases and MYC as Potential Treatment Strategy for H3-K27M Pediatric GliomasDanielle Algranati, Roni Oren, Bareket Dassa, Liat Fellus-Alyagor, Alexander N. Plotnikov, Haim Michael Barr, Alon Harmelin, Nir London, Guy Ron, Noa Furth et al. · 2024 · eLife
- eLife Assessment: Dual Targeting of Histone Deacetylases and MYC as Potential Treatment Strategy for H3-K27M Pediatric GliomasYamini Dalal · 2024 · eLife
- Dual Targeting of Histone Deacetylases and MYC as Potential Treatment Strategy for H3-K27M Pediatric GliomasDanielle Algranati, Roni Oren, Bareket Dassa, Liat Fellus-Alyagor, Alexander N. Plotnikov, Haim Michael Barr, Alon Harmelin, Nir London, Guy Ron, Noa Furth et al. · 2024 · eLife
- BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomasPaul Huchedé, Swann Meyer, Clément Berthelot et al. · 2024 · eLife
- eLife Assessment: BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomasLynne-Marie M Postovit · 2024
- Reviewer #1 (Public Review): BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomasPaul Huchedé, Swann Meyer, Clément Berthelot et al. · 2024
- Author response: BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomasPaul Huchedé, Swann Meyer, Clément Berthelot et al. · 2024
- A pontine-specific axonal niche supports de novo gliomagenesisZhigang Xie, Adrija Pathak, Vytas A. Bankaitis · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- The Impact of Epigenetic Methylation on Gliomagenesis: An Understanding and Therapeutic ApproachesKholoud K. Arafa, Zahra Hanafy, Mohamed Medhat, Reem K. Arafa · 2024 · Interdisciplinary cancer research
- Pediatric High Grade GliomaCraig Alexander Erker, Magimairajan Vanan, Vivek Mehta, David D. Eisenstat · 2024 · Springer eBooks
- The role of chemotherapy in patients with H3K27M-mutant diffuse midline gliomas: a SEER-based propensity scored matching studyJin Zhang, Shanshan Wang, Sichen Wang · 2024 · Research Square
- Pediatric-type diffuse high-grade gliomasMichelle Monje, Steve E. Braunstein, Mitchel Stuart Berger, Hannes S. Vogel · 2025 · Oxford University Press eBooks
- PALB2 deficiency may sensitize H3K27M-mutant pediatric HGG cells to BMN673/talazoparibXiaowen Guan, Xinke Xu, Xiaolan Mo, Houliang Deng · 2025 · Frontiers in Oncology
- Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processesKarin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon · 2025 · Molecular Oncology
- Priming Anti-Tumour Immunity in Paediatric High-Grade Brain Tumours Through Low-Dose Immunogenic Radiotherapy: A Preclinical Paradigm for Enhancing Survival and Preserving Neurodevelopment Literature AnalysisW. D. Chambers · 2025 · SSRN Electronic Journal
- Multiplexed measurements of protein-protein interactions and protein abundance across cellular conditions using Prod&PQ-seqTianyao Xu, Jingyao Wang, Yoonju Shin, Yuwei Cao, Lingzhi Zhang, Eduardo Modolo, Tamar Dishon, Jeremy Fisher, Matthew Norton, Christopher J. Fry et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Direct Readout of Multivalent Chromatin Reader-Nucleosome Interactions by Nucleosome Mass SpectrometryAlexander S. Lee, Nickolas P. Fisher, M. Marunde, Pei Su, Laiba F. Khan, Ryan J. Ezell, Zachary B. Gillespie, Bria Graham, Hailey F. Taylor, Ugochi C. Onuoha et al. · 2026 · ACS Central Science
- A new hope: Clinical advances in targeted therapies for pediatric diffuse midline gliomaJoshua Zhu, Maria Tsoli, Jean Borges Bertoldo, Sabine Mueller, David Simon Ziegler · 2025 · Neuro-Oncology Advances
- Outcomes of H3K27M-altered diffuse midline glioma adult Chinese patients and real-world experience with German-sourced ONC201 targeted therapy: A multi-center study in Hong KongPeter YM Woo, Clara KW Lee, Lai‐Fung Li et al. · 2026 · Neuro-Oncology Advances
- Acetylation modification in malignant progression and therapeutic resistance of gliomasJiayi Zhang, Mengying Wang, Hong Wang, Xuemei Jiang, Hanyan Zou · 2026 · Frontiers in Cell and Developmental Biology
- Développement et caractérisation de modèles vitro et vivo de cancers pédiatriques infiltrant du tronc cérébral (DIPG)Alexandre Plessier · 2018 · theses.fr (ABES)
- The tale of the histone H3.3 tail An essential role for the histone variant H3.3S31 residue during gastrulation in XenopusDavid Sitbon · 2018 · theses.fr (ABES)
- Role of histone variant H3.3 mutations in the development of pediatric high-grade gliomaAlexia Vidal · 2019 · theses.fr (ABES)
- Modélisation in vitro & in vivo de la résistance à la radiothérapie dans les gliomes infiltrants du tronc cérébral (DIPG)Coralie Werbrouck · 2020 · theses.fr (ABES)
- Exon-Skipping Antisense Oligonucleotides for H3.3K27M-Altered Diffuse Midline Glioma TherapyLucia Yang, Qian Zhang, John Erby Wilkinson, Adrian R. Krainer · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Dérégulations épigénétiques et maintien de l'intégrité du génome dans les gliomes pédiatriques mutés H3-K27M (DMG)Chloé Subecz · 2023 · theses.fr (ABES)
- Nouvelles stratégies thérapeutiques dans le traitement du gliome infiltrant du tronc cérébralGuillaume Herrault · 2024 · theses.fr (ABES)
- Histone mark remodeling in cancer: an enhancer-centered perspectiveJiyoon Park, 전진하, Sujeong Gim, Chan Chung · 2026 · Genes & Genomics
- Evidence for coordinate CTCF and histone H3.3 activities in K27M diffuse midline gliomasRachel Herndon Klein, Jennifer Q. Yee, Paul S. Knoepfler · 2026 · Acta Neuropathologica Communications
- H3K27M-altered diffuse midline glioma: Experience and outcomes from a low-middle income country setting in the contemporary eraMeenakshi Jeeva, Mamta Gurav, Abhishek Chatterjee et al. · 2026 · Neuro-Oncology Advances
- Elongin B orchestrates chromatin and transcriptional programs in H3K27M-mutant diffuse midline gliomaAlan L. Jiao, Rebecca L. Murdaugh, Adam Fiseha Kebede, Claudia A. Mimoso, Barry M. Zee, Rosemary U. Richard, Kwanha Yu, Caitlin L. Bagnetto, Karen Adelman, Mariella G. Filbin et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Selective histone deacetylase inhibition as a therapeutically relevant strategy in H3K27M-gliomaAndrew Groves, Orville O. Kirkland, Costanza Lo Cascio, Xiuqi Wang, Caleb Heaslip, Joana Graca Marques, Chen Song, Rebecca Poetschke, Tingjian Wang, Diana H. Chin et al. · 2026 · Neuro-Oncology
- Overview of transcriptomics and epigenomics approaches in the diagnosis, prognosis, and therapeutics of primary brain cancersLuna Guerra-Núñez, David Hughes-Herrera, Juan Manuel Molina-López, Luis Miguel Valor · 2026 · Epigenomics
- Mapping epigenetic alterations across brain tumor hallmarksCeleste Antonacci, Luana Abballe, Angela Di Giannatale, Evelina Miele · 2026 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Exon-skipping antisense oligonucleotides for H3.3K27M-altered diffuse midline glioma therapyLucia Yang, Qian Zhang, John Erby Wilkinson, Shivani Deshpande, Adrian R. Krainer · 2026 · Molecular Therapy — Nucleic Acids
- Histone tail mutants: versatile tools for decoding chromatin, development, and diseaseMasaki Yagi, Xiangle Ren, Konrad Hochedlinger · 2026 · Trends in Genetics
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