Shilatifard, Ali

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

Reyfman, P. A., Walter, J. M., Joshi, N., Anekalla, K. R., McQuattie-Pimentel, A. C., Chiu, S., Fernandez, R., Akbarpour, M., Chen, C.-I., Ren, Z., et al. (2019) · American Journal of Respiratory and Critical Care Medicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisSingle-cell and spatial transcriptomics

Cited by 1,203

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Misharin, A. V., Morales-Nebreda, L., Reyfman, P. A., Cuda, C. M., Walter, J. M., McQuattie-Pimentel, A. C., Chen, C.-I., Anekalla, K. R., Joshi, N., Williams, K. J. N., et al. (2017) · Journal of Experimental Medicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisTransplantation: Methods and Outcomes

Cited by 1,133

The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis

Shilatifard, A. (2012) · Annual Review of Biochemistry

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 1,091

New nomenclature for chromatin-modifying enzymes

Allis, C. D., Berger, S. L., Cote, J., Dent, S., Jenuwien, T., Kouzarides, T., Pillus, L., Reinberg, D., Shi, Y., Shiekhattar, R., et al. (2007) · Cell

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 957

Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8

Henry, K. W., Wyce, A., Lo, W.-S., Duggan, L. J., Emre, N. C. T., Kao, C.-F., Pillus, L., Shilatifard, A., Osley, M. A., & Berger, S. L. (2003) · Genes & Development

Genomics and Chromatin DynamicsUbiquitin and proteasome pathways

Cited by 714

Histone H4 lysine 16 acetylation regulates cellular lifespan

Dang, W., Steffen, K. K., Perry, R., Dorsey, J. A., Johnson, F. B., Shilatifard, A., Kaeberlein, M., Kennedy, B. K., & Berger, S. L. (2009) · Nature

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 667

Epigenetic balance of gene expression by Polycomb and COMPASS families

Piunti, A., & Shilatifard, A. (2016) · Science

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 524

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

Zhu, J., Sammons, M. A., Donahue, G., Dou, Z., Vedadi, M., Getlik, M., Barsyte-Lovejoy, D., Al-awar, R., Katona, B. W., Shilatifard, A., et al. (2015) · Nature

Cancer-related Molecular PathwaysChromatin Remodeling and Cancer

Cited by 493

Histone modification: cause or cog?

Henikoff, S., & Shilatifard, A. (2011) · Trends in Genetics

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 482

Born to run: control of transcription elongation by RNA polymerase II

Chen, F. X., Smith, E. R., & Shilatifard, A. (2018) · Nature Reviews Molecular Cell Biology

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 447

Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas

Piunti, A., Hashizume, R., Morgan, M. A., Bartom, E. T., Horbinski, C. M., Marshall, S. A., Rendleman, E. J., Ma, Q., Takahashi, Y.-H., Woodfin, A. R., et al. (2017) · Nature Medicine

Glioma Diagnosis and TreatmentChromatin Remodeling and Cancer

Cited by 445

The MLL3/MLL4 Branches of the COMPASS Family Function as Major Histone H3K4 Monomethylases at Enhancers

Hu, D., Gao, X., Morgan, M. A., Herz, H.-M., Smith, E. R., & Shilatifard, A. (2013) · Molecular and Cellular Biology

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 439

Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4

Herz, H.-M., Mohan, M., Garruss, A. S., Liang, K., Takahashi, Y.-H., Mickey, K., Voets, O., Verrijzer, C. P., & Shilatifard, A. (2012) · Genes & Development

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 388

Lung transplantation for patients with severe COVID-19

Bharat, A., Querrey, M., Markov, N. S., Kim, S., Kurihara, C., Garza-Castillon, R., Manerikar, A., Shilatifard, A., Tomic, R., Politanska, Y., et al. (2020) · Science Translational Medicine

Transplantation: Methods and OutcomesCOVID-19 Clinical Research Studies

Cited by 336

SET for life: biochemical activities and biological functions of SET domain-containing proteins

Herz, H.-M., Garruss, A., & Shilatifard, A. (2013) · Trends in Biochemical Sciences

Cancer-related gene regulationGenomics and Chromatin Dynamics

Cited by 314

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability

Rickels, R., Herz, H.-M., Sze, C. C., Cao, K., Morgan, M. A., Collings, C. K., Gause, M., Takahashi, Y.-H., Wang, L., Rendleman, E. J., et al. (2017) · Nature Genetics

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 217

Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling

Herz, H.-M., Morgan, M., Gao, X., Jackson, J., Rickels, R., Swanson, S. K., Florens, L., Washburn, M. P., Eissenberg, J. C., & Shilatifard, A. (2014) · Science

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 199

MLL3/MLL4/COMPASS Family on Epigenetic Regulation of Enhancer Function and Cancer

Sze, C. C., & Shilatifard, A. (2016) · Cold Spring Harbor Perspectives in Medicine

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 164

Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy

Liang, K., Smith, E. R., Aoi, Y., Stoltz, K. L., Katagi, H., Woodfin, A. R., Rendleman, E. J., Marshall, S. A., Murray, D. C., Wang, L., et al. (2018) · Cell

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 124

LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells

LeRoy, G., Oksuz, O., Descostes, N., Aoi, Y., Ganai, R. A., Kara, H. O., Yu, J.-R., Lee, C.-H., Stafford, J., Shilatifard, A., et al. (2019) · Science Advances

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 89

dELL is an essential RNA polymerase II elongation factor with a general role in development

Eissenberg, J. C., Ma, J., Gerber, M. A., Christensen, A., Kennison, J. A., & Shilatifard, A. (2002) · Proceedings of the National Academy of Sciences

Genomics and Chromatin DynamicsDevelopmental Biology and Gene Regulation

Cited by 79