Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

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    M. Yoshimoto, Koki Sadamori, Kazuya Tokumura, Yuki Tanaka, Kazuya Fukasawa, E. Hinoi · 2023 · Frontiers in Endocrinology
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    Jessica Bertschmann, Subhash Thalappilly, Karl T. Riabowol · 2018 · Mechanisms of Ageing and Development
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    Wenyu Xiao, Weibing Sun, Hui Lian · 2020 · Evidence-based Complementary and Alternative Medicine
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    Yanfeng Ding, Zhimin Li, Wenwen Hu et al. · 2021 · Biomaterials Science
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    Tianrui Wang, Junjie Wang, Zewen Sun, Lu Zhang, Chenghao Yu, Haibo Zhao, Mingyue Yan, Shenjie Sun, Zhenhao Ye, Yingze Zhang et al. · 2022 · Frontiers in Cell and Developmental Biology
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44. Senescent cells in the development of cardiometabolic disease
    Andrea C. Postmus, Ines Sturmlechner, Johan W. Jonker, Jan M. van Deursen, Bart van de Sluis, Janine K. Kruit · 2019 · Current Opinion in Lipidology
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    Sagar Gaikwad, Nicha Puangmalai, Alice Bittar, Mauro Montalbano, Stephanie Garcia, S. McAllen, Nemil Bhatt, Urmi Sengupta, R. Kayed · 2020 · Social Science Research Network
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    Nozomi Hori, Shimpei Kawamoto, Ken Uemura, Yumiko Okumura, Kentaro Tanaka, Jeong Hoon Park, Naoko Ohtani, Daisuke Motooka, Eiji Hara · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
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    Zhuochang Cai, Haoyuan Wang, Jiacheng Hu, Cheng Qu, Shuai Chen, Xudong Liu, Cunyi Fan · 2025 · The American Journal of Sports Medicine
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    Ali Guermazi, F. Eckstein, Garry Evan Gold et al. · 2026 · Nature Reviews Rheumatology
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    Xiaonan Liu, Qiao-Yue Guo, Lei Wang, Yi-Ru Gu, Senxiong Meng, Yuan Gu, Bin Yu · 2023 · Frontiers in Cell and Developmental Biology
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    Feng Xu, Juanjuan Zhang, Iingzhi Wu, Youfu Xu, Taochun Yu, Jiliang Kang, Feiyan Wu · 2025 · BMC Oral Health
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