Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

Jeon, Ok Hee, Kim, Chaekyu, Laberge, Remi-Martin, Demaria, Marco, Rathod, Sona, Vasserot, Alain P, Chung, Jae Wook, Kim, Do Hun +6 more·2017·Nature Medicine
DOI 10.1038/nm.4324

Cited by (1,499)

Items 701–800 of 1,499

  1. The use of geroprotectors to prevent multimorbidity: Opportunities and challenges
    Samir Morsli, Ilaria Bellantuono · 2020 · Mechanisms of Ageing and Development
  2. Common risk factors and therapeutic targets in obstructive sleep apnea and osteoarthritis: An unexpectable link?
    Laetitia S. Gaspar, Cátia Sousa, Ana Rita Álvaro, Cláudia Cavadas, Alexandrina Ferreira Mendes · 2020 · Pharmacological Research
  3. Combining segmental bulk- and single-cell RNA-sequencing to define the chondrocyte gene expression signature in the murine knee joint
    Vikram Sunkara, Gitta Anne Heinz, Frederik Heinrich, Pawel Durek, Ali Mobasheri, Mir‐Farzin Mashreghi, Annemarie Lang · 2021 · Osteoarthritis and Cartilage
  4. Senescence and Aging: Does It Impact Cancer Immunotherapies?
    Damien Maggiorani, Christian M. Beausejour · 2021 · Cells
  5. Immunological Events, Emerging Pharmaceutical Treatments and Therapeutic Potential of Balneotherapy on Osteoarthritis
    Anna Scanu, Lucrezia Tognolo, Maria Chiara Maccarone, Stefano Masiero · 2021 · Frontiers in Pharmacology
  6. The tumor suppression theory of aging
    Alexander Martin Wolf · 2021 · Mechanisms of Ageing and Development
  7. Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect
    Rui Lu, Xiaojun Yu, Shuang Liang et al. · 2021 · Frontiers in Pharmacology
  8. Silencing circSERPINE2 restrains mesenchymal stem cell senescence via the YBX3/PCNA/p21 axis
    Fenglei Chen, Shan Wang, Chenying Zeng, Su’an Tang, Huimin Gu, Ziming Wang, Jinteng Li, Pei Feng, Yunhui Zhang, Peng Wang et al. · 2023 · Cellular and Molecular Life Sciences
  9. Quercetin induces senolysis of doxorubicin-induced senescent fibroblasts by reducing autophagy, preventing their pro-tumour effect on osteosarcoma cells
    Elisa Bientinesi, Sara Ristori, Matteo Lulli, Daniela Monti · 2024 · Mechanisms of Ageing and Development
  10. Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence
    Blanka Mrázková, Rastislav Dzijak, Terezie Hornofova, Lenka Kyjacová, Péter Baráth, Petr Džubák, Dušan Holub, Marián Hajdúch, Zuzana Nahácka, Ladislav Anděra et al. · 2018 · Aging
  11. The citrate transporters SLC13A5 and SLC25A1 elicit different metabolic responses and phenotypes in the mouse
    Gonzalo Fernandez-Fuente, Katherine A. Overmyer, Alexis J. Lawton, Ildikó Kasza, Samantha L. Shapiro, Patricia Gallego‐Muñoz, Joshua J. Coon, John M. Denu, Caroline M. Alexander, Luigi Puglielli · 2023 · Communications Biology
  12. Cellular senescence and frailty: a comprehensive insight into the causal links
    Serena Marcozzi, Giorgia Bigossi, Maria Elisa Giuliani, Robertina Giacconi, Francesco Piacenza, Maurizio Cardelli, Dario Brunetti, Agnese Segala, Alessandra Valerio, Enzo Nisoli et al. · 2023 · GeroScience
  13. Novel perspectives on leptin in osteoarthritis: Focus on aging
    Zimo Liu, Wenqing Xie, Hengzhen Li, Xu Liu, Yao Lu, Bangbao Lu, Zhenhan Deng, Yusheng Li · 2023 · Genes & Diseases
  14. Copper homeostasis and cuproptosis represent emerging targets for therapeutic intervention in inflammatory diseases
    Wenming Yang, Chuqiao Xiao, Jie Zheng, Jie Song, Xiangguang Li · 2025 · Pharmacological Research
  15. GRSF1 suppresses cell senescence
    Ji Heon Noh, Kyoung Mi Kim, Maria Laura Idda, Jennifer L. Martindale, Xiaoling Yang, Kotb Abdelmohsen, Myriam Gorospe · 2018 · Aging
  16. Nitidine Chloride Alleviates Inflammation and Cellular Senescence in Murine Osteoarthritis Through Scavenging ROS
    Changjian Lin, Lujie Ge, Luping Tang, Yuzhe He, Safwat Adel Abdo Moqbel, Kai Xu, Diana Ma, Xing Zhou, Jisheng Ran, Lidong Wu · 2022 · Frontiers in Pharmacology
  17. Endothelial senescence mediates hypoxia-induced vascular remodeling by modulating PDGFB expression
    Priscilla Kyi, Kathryn Hendee, Tendai Hunyenyiwa, Kienna Matus, Tadanori Mammoto, Akiko Mammoto · 2022 · Frontiers in Medicine
  18. Hippocampal Deletion of CB1 Receptor Impairs Social Memory and Leads to Age-Related Changes in the Hippocampus of Adult Mice
    Michela Palmisano, Alessandra Gargano, Bolanle Fatimat Olabiyi, Beat Lutz, András Bilkei‐Gorzó · 2022 · International Journal of Molecular Sciences
  19. Osteoarthritis today: Lost in translation?
    Sarah J. Kennedy, Jeyanesh R. S. Tambiah, Nancy E. Lane · 2022 · Best Practice & Research Clinical Rheumatology
  20. Ceria Nanoparticles Alleviated Osteoarthritis through Attenuating Senescence and Senescence-Associated Secretory Phenotype in Synoviocytes
    Xunshan Ren, Huangming Zhuang, Fuze Jiang, Yuelong Zhang, Panghu Zhou · 2023 · International Journal of Molecular Sciences
  21. H3K36 methyltransferase NSD1 protects against osteoarthritis through regulating chondrocyte differentiation and cartilage homeostasis
    Rui Shao, Jinlong Suo, Zhong Zhang et al. · 2023 · Cell Death and Differentiation
  22. The role of mitochondrial quality control mechanisms in chondrocyte senescence
    Tianlei Zhao, Dawei Niu, Yancheng Chen, Peiliang Fu · 2024 · Experimental Gerontology
  23. MiR-653-5p drives osteoarthritis pathogenesis by modulating chondrocyte senescence
    Yucheng Lin, Lu Zhang, Ming-liang Ji, Sinuo Shen, Yuzhi Chen, Shichao Wu, Xiao‐Tao Wu, Nancy Q. Liu, Jun Lu · 2024 · Arthritis Research & Therapy
  24. Regulation of cartilage damage caused by lack of Klotho with thioredoxin/peroxiredoxin (Trx/Prx) system and succedent NLRP3 activation in osteoarthritis mice.
    Yanqing Gu, Kewei Ren, Chunzhi Jiang, Liming Wang, Qingqiang Yao · 2019 · Europe PMC (PubMed Central)
  25. The Dynamic Process and Its Dual Effects on Tumors of Therapy-Induced Senescence
    Chenxi Liao, Yin Xiao, Lingbo Liu · 2020 · Cancer Management and Research
  26. Celecoxib prevents tumor necrosis factor-α (TNF-α)-induced cellular senescence in human chondrocytes
    Qunli Wang, Qi Chen, Jie Sui, Yuanyuan Tu, Xiang Guo, Feng Li · 2021 · Bioengineered
  27. Osteoclast-derived exosomal miR-212-3p suppressed the anabolism and accelerated the catabolism of chondrocytes in osteoarthritis by targeting TGF-β1/Smad2 signaling
    Jingjin Dai, Zhaoyang Hu, Fanchun Zeng, Xiaoshan Gong, Hao Tang, Jiezhong Deng, Jian‐Mei Li, Shiwu Dong · 2023 · Archives of Biochemistry and Biophysics
  28. Advances in targeted therapies for age-related osteoarthritis: A comprehensive review of current research
    Yantao Zhang, Yan Zhou · 2024 · Biomedicine & Pharmacotherapy
  29. Enhancing the potential of aged human articular chondrocytes for high‐quality cartilage regeneration
    He Shen, Yuchen He, Ning Wang, Madalyn R. Fritch, Xinyu Li, Hang Lin, Rocky S. Tuan · 2021 · The FASEB Journal
  30. Autophagy and senescence, converging roles in pathophysiology as seen through mouse models
    Andrew R. J. Young, Liam D. Cassidy, Masashi Narita · 2021 · Advances in cancer research
  31. The role of senescence in the pathogenesis of atrial fibrillation: A target process for health improvement and drug development
    Guangran Guo, Steven Watterson, Shudong Zhang, Anthony J. Bjourson, Victoria McGilligan, Aaron J. Peace, Taranjit Singh · 2021 · Ageing Research Reviews
  32. Cellular senescence and its impact on the circadian clock
    Rezwana Ahmed, Hasan Mahmud Reza, Kazuyuki Shinohara, Yasukazu Nakahata · 2021 · The Journal of Biochemistry
  33. Meta-analysis Integrated With Multi-omics Data Analysis to Elucidate Pathogenic Mechanisms of Age-Related Knee Osteoarthritis in Mice
    Hirotaka Iijima, Gabrielle Gilmer, Kai Wang, Sruthi Sivakumar, Christopher H. Evans, Yusuke Matsui, Fabrisia Ambrosio · 2022 · The Journals of Gerontology Series A
  34. Toll-like receptor 3 activation promotes joint degeneration in osteoarthritis
    Josef Stolberg-Stolberg, Annika Boettcher, Meike Sambale, Sina Stuecker, J. Sherwood, Michael J. Raschke, Thomas Pap, Jessica Bertrand · 2022 · Cell Death and Disease
  35. Depressed Protein Synthesis and Anabolic Signaling Potentiate ACL Tear–Resultant Quadriceps Atrophy
    Alexander R. Keeble, Camille R. Brightwell, Christine M. Latham, Nicholas T. Thomas, Christopher Brooks Mobley, Kevin A. Murach, Darren L. Johnson, Brian W. Noehren, Christopher S. Fry · 2022 · The American Journal of Sports Medicine
  36. Senolytic Therapy: A Potential Approach for the Elimination of Oncogene-Induced Senescent HPV-Positive Cells
    Tareq Saleh, Ashraf I. Khasawneh, Nisreen M. Himsawi, Jumana A. Abu-Raideh, Vera Ejeilat, Ahmed M. Elshazly, David A. Gewirtz · 2022 · International Journal of Molecular Sciences
  37. CircZSWIM6 mediates dysregulation of ECM and energy homeostasis in ageing chondrocytes through RPS14 post‐translational modification
    Zhe Gong, Kefan Wang, Junxin Chen, Jinjin Zhu, Zhenhua Feng, Chenxin Song, Zheyuan Zhang, Haoming Wang, Shunwu Fan, Shuying Shen et al. · 2023 · Clinical and Translational Medicine
  38. Adenosine A2A receptor activation reduces chondrocyte senescence
    Benjamin Friedman, Ane Larranaga‐Vera, Cristina M. Castro, Carmen Corciulo, Piul S. Rabbani, Bruce Neil Cronstein · 2023 · The FASEB Journal
  39. A dynamical systems model for the measurement of cellular senescence
    Daniel Galvis, Darren A. Walsh, Lorna W. Harries, Eva Latorre, James Rankin · 2019 · Journal of The Royal Society Interface
  40. Andrographolide mitigates cartilage damage via miR‐27‐3p‐modulated matrix metalloproteinase13 repression
    Shaojian Chen, Zhihuan Luo, Xiaguang Chen · 2020 · The Journal of Gene Medicine
  41. Phenotypes in Osteoarthritis
    Murillo Dório, Leticia A. Deveza · 2022 · Clinics in Geriatric Medicine
  42. Engineered MSC‐sEVs as a Versatile Nanoplatform for Enhanced Osteoarthritis Treatment via Targeted Elimination of Senescent Chondrocytes and Maintenance of Cartilage Matrix Metabolic Homeostasis
    Kai Feng, Jiashuo Liu, Liangzhi Gong, Teng Ye, Zhengsheng Chen, Yang Wang, Qing Li, Xuetao Xie · 2025 · Advanced Science
  43. Cellular and molecular features of senescence in acute lung injury
    Covadonga Huidobro, Paula Martín-Vicente, Cecilia López‐Martínez, Inés López-Alonso, Laura Amado‐Rodríguez, Irene Crespo, Guillermo M. Albaiceta · 2020 · Mechanisms of Ageing and Development
  44. New Trends in Aging Drug Discovery
    Bellinda Benhamú, Mar Martín‐Fontecha, Henar Vázquez‐Villa, María Luz López-Rodríguez, Silvia Ortega‐Gutiérrez · 2022 · Biomedicines
  45. Nanoscale biophysical properties of small extracellular vesicles from senescent cells using atomic force microscopy, surface potential microscopy, and Raman spectroscopy
    Hyo Gyeong Lee, Seokbeom Roh, Hyun Jung Kim, Seokho Kim, Yoochan Hong, Gyudo Lee, Ok Hee Jeon · 2022 · Nanoscale Horizons
  46. Emerging therapeutic targets for osteoarthritis
    Ermina Hadzic, Frank Beier · 2023 · Expert Opinion on Therapeutic Targets
  47. Immunosenescence: A new direction in anti-aging research
    Hanzhou Li, Shan Lin, Yuming Wang, Yuexuan Shi, Xixing Fang, Jida Wang, Huantian Cui, Yuhong Bian, Xin Qi · 2024 · International Immunopharmacology
  48. Isolation of senescent cells by iodixanol (OptiPrep) density gradient‐based separation
    Kristina Locker Kovačovicova, Manlio Vinciguerra · 2019 · Cell Proliferation
  49. PHF23 negatively regulates the autophagy of chondrocytes in osteoarthritis
    Talatibaike Maimaitijuma, Jiahong Yu, Yali Ren et al. · 2020 · Life Sciences
  50. MicroRNA‑1 regulates the development of osteoarthritis in a Col2a1‑Cre‑ERT2/GFPfl/fl‑RFP‑miR‑1 mouse model of osteoarthritis through the downregulation of Indian hedgehog expression
    Xianda Che, Taoyu Chen, Wei Lei, Xiaodong Gu, Yangyang Gao, Shufen Liang, Penghua Li, Dongping Shi, Bin Liang, Chunfang Wang et al. · 2020 · International Journal of Molecular Medicine
  51. Promoting Articular Cartilage Regeneration through Microenvironmental Regulation
    Kai Liu, Bingjun Zhang, Xiaoling Zhang · 2024 · Journal of Immunology Research
  52. The context-dependent effect of cellular senescence: From embryogenesis and wound healing to aging
    Rupa Lavarti, Tatiana Alvarez‐Diaz, Kyarangelie Marti, Parmita Kar, Raghavan Pillai Raju · 2025 · Ageing Research Reviews
  53. The crosstalk between cellular reprogramming and senescence in aging and regeneration
    Aurélie Chiche, Cheng Chen, Han Li · 2020 · Experimental Gerontology
  54. Cellular senescence in vivo: From cells to tissues to pathologies
    Avadh Kumar, Daniele Bano, Dan Ehninger · 2020 · Mechanisms of Ageing and Development
  55. Naked mole‐rats are extremely resistant to post‐traumatic osteoarthritis
    Taketo Taguchi, Alexander Kotelsky, Masaki Takasugi · 2020 · Aging Cell
  56. Andrographolide suppresses osteoarthritis progression by regulating circ_Rapgef1/miR-383-3p/NLRP3 signaling axis
    Wei Yan, Hong Yu, Bo Liu, Zewei Jiang, Hailong Jin, Zhiheng Li, Lei Li, Debao Zou, Hongjiang Jiang · 2022 · Transplant Immunology
  57. Low-dose irradiation could mitigate osteoarthritis progression via anti-inflammatory action that modulates mitochondrial function
    Byoung Hyuck Kim, Hyun Cheol Bae, Sun Young Wang · 2022 · Radiotherapy and Oncology
  58. Identifying Novel Osteoarthritis-Associated Genes in Human Cartilage Using a Systematic Meta-Analysis and a Multi-Source Integrated Network
    Emily Shorter, Roberto A. Avelar, Margarita Zachariou, George M. Spyrou, Priyanka Raina, Aibek Smagul, Yalda A. Kharaz, Mandy Jayne Peffers, Katarzyna Goljanek‐Whysall, João Pedro de Magalhães et al. · 2022 · International Journal of Molecular Sciences
  59. Age-related mechanisms in the context of rheumatic disease
    Ghada Alsaleh, Felix Clemens Richter, Anna Katharina Simon · 2022 · Nature Reviews Rheumatology
  60. Selective Clearance of Senescent Chondrocytes in Osteoarthritis by Targeting Excitatory Amino Acid Transporter Protein 1 to Induce Ferroptosis
    Zi Wen, Guang Xia, Chi Liang, Xinxing Wang, Junjie Huang, Lína Zhang, Dongyong Shan, Wu Chang Song, Xu Cao · 2023 · Antioxidants and Redox Signaling
  61. LncRNA AC006064.4–201 serves as a novel molecular marker in alleviating cartilage senescence and protecting against osteoarthritis by destabilizing CDKN1B mRNA via interacting with PTBP1
    Panyang Shen, Jun Gao, Shaohan Huang, Chenan You, Haitao Wang, Pengyu Chen, Yao Teng, Tianyou Gao, Bohao Zhou, Shuying Shen et al. · 2023 · Biomarker Research
  62. Correlations between biomarkers of senescent cell accumulation at the systemic, tissue and cellular levels in elderly patients
    A. G. Sorokina, Yа. A. Orlova, Olga Grigorieva, Ekaterina Sergeevna Novoseletskaya, Nataliya Andreevna Basalova, Natalya Andreevna Alexandrushkina, Maksim A. Vigovskiy, K. I. Kirillova, Alexander Vladimirovich Balatsky, Larisa Mikhailovna Samokhodskaya et al. · 2023 · Experimental Gerontology
  63. Human Rotator Cuff Tears Reveal an Age‐Dependent Increase in Markers of Cellular Senescence and Selective Removal of Senescent Cells With Dasatinib + Quercetin Increases Genetic Expression of COL1A1 In Vitro
    Benjamin C. Hawthorne, Ian J. Wellington, Joshua T. Sabitsky, Kyle V. Murphy, Owen P. Karsmarski, Rohin O. Thomas, Matthew R. LeVasseur, Michael R. Mancini, Maxwell T. Trudeau, Sagar Gulati et al. · 2023 · Arthroscopy The Journal of Arthroscopic and Related Surgery
  64. Current therapies for osteoarthritis and prospects of CRISPR-based genome, epigenome, and RNA editing in osteoarthritis treatment
    Yuxi Chen, Xiao Ling Luo, Rui Kang, Kaixin Cui, Jianping Ou, Xiya Zhang, Puping Liang · 2023 · Journal of genetics and genomics/Journal of Genetics and Genomics
  65. Barasertib impedes chondrocyte senescence and alleviates osteoarthritis by mitigating the destabilization of heterochromatin induced by AURKB
    Xunshan Ren, Huangming Zhuang, Fuze Jiang, Yuelong Zhang, Panghu Zhou · 2023 · Biomedicine & Pharmacotherapy
  66. Application and prospect of the therapeutic strategy of inhibiting cellular senescence combined with pro‐regenerative biomaterials in regenerative medicine
    Qianyi Li, Zhenzhen Wang, Nuo Shi, Qi Yang, Wenfei Yao, Jie Yu, Yiming Lu · 2023 · Smart Medicine
  67. Semaglutide and Other GLP-1 Agonists: A Boon for the Arthroplasty Industry?
    Matthew L. Magruder, David Jacofsky, Bryan D. Springer, Giles R. Scuderi, Daniel Hameed, Michael A. Mont · 2024 · The Journal of Arthroplasty
  68. HIF-1α/m6A/NF-κB/CCL3 axis-mediated immunosurveillance participates in low level benzene-related erythrohematopoietic development toxicity
    Xiaowei Cong, Xiaoqin Li, Kai Xu, Lihong Yin, Geyu Liang, Rongli Sun, Yuepu Pu, Juan Zhang · 2024 · Environment International
  69. Phillyrin: A potential therapeutic agent for osteoarthritis via modulation of NF-κB and Nrf2 signaling pathways
    Jiawei Ma, Ze Wang, Yun Sun, Rukang Zheng, Hongye Tan, Hanwen Zhang, Zebin Jin, Yaosen Wu, Ze‐Ming Sun · 2024 · International Immunopharmacology
  70. Cellular senescence as a key contributor to secondary neurodegeneration in traumatic brain injury and stroke
    Zhihai Huang, Peisheng Xu, David Charles Hess, Quanguang Zhang · 2024 · Translational Neurodegeneration
  71. Oxidative Stress Response Is Mediated by Overexpression and Spatiotemporal Regulation of Caveolin-1
    Andreas Goutas, Ioanna V. Papathanasiou, Evanthia Mourmoura, Konstantinos Tsesmelis, Aspasia Tsezou, Varvara Trachana · 2020 · Antioxidants
  72. Crosstalk Between Mesenchymal Stromal Cells and Chondrocytes: The Hidden Therapeutic Potential for Cartilage Regeneration
    Teresa Z. Brose, Eva Johanna Kubosch, Hagen Schmal, Martin James Stoddart, Angela Rita Armiento · 2021 · Stem Cell Reviews and Reports
  73. Mechanical overloading leads to chondrocyte degeneration and senescence via Zmpste24-mediated nuclear membrane instability
    Keyu Kong, Minghao Jin, Chen Zhao, Hua Qiao, Xuzhuo Chen, Baixing Li, Kewei Rong, Pu Zhang, Shan Yu, Zhengquan Xu et al. · 2023 · iScience
  74. Decoding senescence of aging single cells at the nexus of biomaterials, microfluidics, and spatial omics
    Abhijeet Venkataraman, Ivan Kordic, Jiaxun Li, Nicholas Y. Zhang, Nivik Sanjay Bharadwaj, Zhou Fang, Sandip Das, Ahmet F. Coskun · 2024 · npj Aging
  75. Mitochondria-rich extracellular vesicles derived from the culture supernatant of human synovial Fluid‐derived mesenchymal stem cells Inhibited senescence of Stressed/inflammatory Licensed chondrocytes and Delayed Osteoarthritis progression
    Xingfu Li, Wei Lü, Linying Ni · 2025 · International Immunopharmacology
  76. Comparative transcriptomics and network pharmacology analysis to identify the potential mechanism of celastrol against osteoarthritis
    Siming Dai, Hui Wang, Meng Wang, Yue Zhang, Zhiyi Zhang, Zhiguo Lin · 2021 · Clinical Rheumatology
  77. Engineering osteoarthritic cartilage model through differentiating senescent human mesenchymal stem cells for testing disease-modifying drugs
    Ning Wang, Yuchen He, Silvia Liu, Meagan J. Makarcyzk, Guanghua Lei, Alexander Chang, Peter Geoffrey Alexander, Tingjun Hao, Anne-Marie Padget, Nuria de Pedro et al. · 2021 · Science China Life Sciences
  78. Naturally-derived endoplasmic reticulum stress inhibitors for osteoarthritis?
    Siam-Yee Lee, Pooi‐Fong Wong, Juliana Jamal, Margaret M. Roebuck · 2022 · European Journal of Pharmacology
  79. Amelioration of experimental tendinopathy by lentiviral CD44 gene therapy targeting senescence-associated secretory phenotypes
    Shih‐Yao Chen, I‐Ming Jou, Po‐Yen Ko, Kai‐Lan Hsu, Wei‐Ren Su, Li‐Chieh Kuo, Pei‐Yuan Lee, Chao‐Liang Wu, Po‐Ting Wu · 2022 · Molecular Therapy — Methods & Clinical Development
  80. Does senescence play a role in age-related macular degeneration?
    Goldis Malek, Judith Campisi, Koji Kitazawa, Corey M. Webster, Aparna Lakkaraju, Dorota Skowronska‐Krawczyk · 2022 · Experimental Eye Research
  81. In Vitro Study of the Therapeutic Potential of Brown Crude Fucoidans in Osteoarthritis Treatment
    Carlos Vaamonde‐García, Emma Capelo-Mera, Noélia Flórez-Fernández, María Dolores Torres, Beatriz Rivas‐Murias, Rosa Meijide-Faílde, Francisco Javier Blanco, Herminia Domı́nguez · 2022 · International Journal of Molecular Sciences
  82. From Low-Grade Inflammation in Osteoarthritis to Neuropsychiatric Sequelae: A Narrative Review
    Vladimirs Naumovs, Valērija Groma, Jānis Mednieks · 2022 · International Journal of Molecular Sciences
  83. Dynamic chromatin accessibility tuning by the long noncoding RNA ELDR accelerates chondrocyte senescence and osteoarthritis
    Ming-liang Ji, Zhuang Li, Xin Yue Hu, Wei tuo Zhang, Hai xiang Zhang, Jun Lu · 2023 · The American Journal of Human Genetics
  84. The ageing immune system as a potential target of senolytics
    Peter Yandi Du, Ankesh Gandhi, Manraj Bawa, Justyna Gromala · 2023 · Oxford Open Immunology
  85. Accelerated aging in articular cartilage by ZMPSTE24 deficiency leads to osteoarthritis with impaired metabolic signaling and epigenetic regulation
    Jinlong Suo, Rui Shao, Ruici Yang, Jinghui Wang, Zhong Zhang, Duo Wang, Ningning Niu, Xianyou Zheng, Weiguo Zou · 2023 · Cell Death and Disease
  86. A p21-ATD mouse model for monitoring and eliminating senescent cells and its application in liver regeneration post injury
    Miaomiao Chen, Guoxiu Wu, Yanli Lu, Shiwen Sun, Yu Zhao, Xin Pan, Wenjian Chen, Jin Xu, Hua Qiu, Weizhi He et al. · 2024 · Molecular Therapy
  87. Prospects of Disease-Modifying Osteoarthritis Drugs
    Win Min Oo · 2024 · Rheumatic Disease Clinics of North America
  88. Cellular senescence: A novel therapeutic target for central nervous system diseases
    Shuang-Yin Lei, Yang Qu, Yu-Qian Yang, Jia‐Cheng Liu, Yi-Fei Zhang, Shengyu Zhou, Qianyan He, Hang Jin, Yi Yang, Zhen‐Ni Guo · 2024 · Biomedicine & Pharmacotherapy
  89. Unveiling the ageing-related genes in diagnosing osteoarthritis with metabolic syndrome by integrated bioinformatics analysis and machine learning
    Jian Huang, Lu Wang, Jiangfei Zhou, Tianming Dai, Weicong Zhu, Tianrui Wang, Hongde Wang, Yingze Zhang · 2025 · Artificial Cells Nanomedicine and Biotechnology
  90. WNT10A induces apoptosis of senescent synovial resident stem cells through Wnt/calcium pathway-mediated HDAC5 phosphorylation in OA joints
    Xu Cao, Xinxing Wang, Wenxiu Zhang, Guang Xia, Lina Zhang, Zi Wen, Jinshen He, Zili Wang, Junjie Huang, Wu Chang Song · 2021 · Bone
  91. Sonic Hedgehog Induces Mesenchymal Stromal Cell Senescence-Associated Secretory Phenotype and Chondrocyte Apoptosis in Human Osteoarthritic Cartilage
    Meng Feng, Wenguang Liu, Jing Ding, Yusheng Qiu, Qian Chen · 2021 · Frontiers in Cell and Developmental Biology
  92. Targeting cellular senescence to combat cancer and ageing
    Chen Wang, Xue Hao, Rugang Zhang · 2022 · Molecular Oncology
  93. Bench to bedside: Current advances in regenerative medicine
    Gabriella Clarke, Peter Harley, Ella-Louise Hubber, Teodora Manea, Luigi Manuelli, Emily Read, Fiona M. Watt · 2018 · Current Opinion in Cell Biology
  94. The potential role of senescence in limiting fibrosis caused by aging
    Xinghua Meng, Haoran Wang, Xiaopeng Song, Alancia Carol Clifton, Jianhua Xiao · 2019 · Journal of Cellular Physiology
  95. Exploring the emerging bidirectional association between inflamm‐aging and cellular senescence in organismal aging and disease
    Rohit Sharma · 2024 · Cell Biochemistry and Function
  96. ESC-sEVs alleviate non-early-stage osteoarthritis progression by rejuvenating senescent chondrocytes via FOXO1A-autophagy axis but not inducing apoptosis
    Kai Feng, Teng Ye, Xuetao Xie, Jiashuo Liu, Liangzhi Gong, Zhengsheng Chen, Juntao Zhang, Haiyan Li, Qing Li, Yang Wang · 2024 · Pharmacological Research
  97. Hypoxia, cuproptosis, and osteoarthritis: Unraveling the molecular crosstalk
    Zhanliang Jiang, Jin Li, Mingpeng Shi, Yunfei Li, Ning Sun, Kai Xi, Xiangyan Li, Daqing Zhao, Xiangyang Leng, Zhenwei Zhou et al. · 2025 · Redox Biology
  98. Recent Advances in Strategies for Imaging Detection and Intervention of Cellular Senescence
    Jili Li, Zhengyan Bi, Linlin Wang, Yinghao Xia, Yuqi Xie, Yanlan Liu · 2022 · ChemBioChem
  99. The variant senescence‐associated secretory phenotype induced by centrosome amplification constitutes a pathway that activates hypoxia‐inducible factor ‐1α
    Selwin K. Wu, Juliana K. Ariffin, Shu Chian Tay, Remigio Picone · 2023 · Aging Cell
  100. Increase of cell surface vimentin is associated with vimentin network disruption and subsequent stress-induced premature senescence in human chondrocytes
    Jana Riegger, Rolf Erwin Brenner · 2023 · eLife