Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
Jeon, Ok Hee, Kim, Chaekyu, Laberge, Remi-Martin, Demaria, Marco, Rathod, Sona, Vasserot, Alain P, Chung, Jae Wook, Kim, Do Hun +6 more·2017·Nature Medicine
DOI 10.1038/nm.4324
Cited by (1,499)
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- Senolytic therapeutics: An emerging treatment modality for osteoarthritisMd. Meraj Ansari, Mrinmoy Ghosh, Dong‐Sun Lee, Young‐Ok Son · 2024 · Ageing Research Reviews
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