Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

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3. Cellular Senescence in Intervertebral Disc Aging and Degeneration: Molecular Mechanisms and Potential Therapeutic Opportunities
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4. Elimination of Radiation-Induced Senescence in the Brain Tumor Microenvironment Attenuates Glioblastoma Recurrence
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6. Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain
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7. Age-related inflammation triggers skeletal stem/progenitor cell dysfunction
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8. Cellular senescence: Molecular mechanisms and pathogenicity
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9. The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions
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11. The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date
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12. Senolytics and senostatics as adjuvant tumour therapy
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13. Strategies targeting cellular senescence
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14. Cartilage regeneration and ageing: Targeting cellular plasticity in osteoarthritis
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15. Senescence in osteoarthritis: from mechanism to potential treatment
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16. Cellular Senescence in Postmitotic Cells: Beyond Growth Arrest
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17. Senescent cells: a therapeutic target for cardiovascular disease
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18. Roles of extracellular vesicles in the aging microenvironment and age‐related diseases
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19. Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases
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20. Algorithmic assessment of cellular senescence in experimental and clinical specimens
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21. Reducing Senescent Cell Burden in Aging and Disease
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22. Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells
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23. Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7
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24. Senotherapeutics for healthy ageing
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25. Connecting aging biology and inflammation in the omics era
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26. Cellular senescence in cancer: from mechanisms to detection
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27. Sentinel <i>p16</i> ^INK4a+ cells in the basement membrane form a reparative niche in the lung
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28. Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis
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29. Clearance of therapy‐induced senescent tumor cells by the senolytic ABT‐263 via interference with BCL‐X_L–BAX interaction
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30. Survey of senescent cell markers with age in human tissues
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31. Senescence cell–associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers
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32. Adipokines: New Therapeutic Target for Osteoarthritis?
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33. P16INK4A—More Than a Senescence Marker
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34. Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition
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35. Astrocyte Senescence and Alzheimer’s Disease: A Review
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36. Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases
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37. The World Goes Bats: Living Longer and Tolerating Viruses
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38. Interleukin 17 and senescent cells regulate the foreign body response to synthetic material implants in mice and humans
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41. Senescence in Post-Mitotic Cells: A Driver of Aging?
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42. Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease
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43. Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy
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45. Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging
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46. Systemic clearance of p16 INK4a ‐positive senescent cells mitigates age‐associated intervertebral disc degeneration
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47. Cellular senescence in knee osteoarthritis: molecular mechanisms and therapeutic implications
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48. Senescent cell turnover slows with age providing an explanation for the Gompertz law
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49. Cell-Free Osteoarthritis Treatment with Sustained-Release of Chondrocyte-Targeting Exosomes from Umbilical Cord-Derived Mesenchymal Stem Cells to Rejuvenate Aging Chondrocytes
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50. Unveiling inflammatory and prehypertrophic cell populations as key contributors to knee cartilage degeneration in osteoarthritis using multi-omics data integration
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51. Expression of p16<scp>^INK</scp>^4a is a biomarker of chondrocyte aging but does not cause osteoarthritis
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52. Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence
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53. The curcumin analog EF24 is a novel senolytic agent
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56. Dynamic and diverse changes in the functional properties of vascular smooth muscle cells in pulmonary hypertension
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60. Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development
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63. The Senescence Markers p16INK4A, p14ARF/p19ARF, and p21 in Organ Development and Homeostasis
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64. Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development
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69. Environmental Exposures and Asthma Development: Autophagy, Mitophagy, and Cellular Senescence
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70. Cellular senescence in musculoskeletal homeostasis, diseases, and regeneration
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71. The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities
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72. Curcumin Inhibits the PERK-eIF2 α -CHOP Pathway through Promoting SIRT1 Expression in Oxidative Stress-induced Rat Chondrocytes and Ameliorates Osteoarthritis Progression in a Rat Model
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73. Sirtuins and Insulin Resistance
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74. Nrf2 dysfunction and impaired cellular resilience to oxidative stressors in the aged vasculature: from increased cellular senescence to the pathogenesis of age-related vascular diseases
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75. Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD‐L1)‐mediated immunosuppression
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76. Sirt6 attenuates chondrocyte senescence and osteoarthritis progression
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77. SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells
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80. Role of the inflammation-autophagy-senescence integrative network in osteoarthritis
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81. Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis
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82. Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts
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83. The chemistry of senescence
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84. Identifying effector molecules, cells, and cytokines of innate immunity in OA
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86. Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro
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87. Senescence and the tumor-immune landscape: Implications for cancer immunotherapy
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88. Lysosomal control of senescence and inflammation through cholesterol partitioning
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89. Identifying specific functional roles for senescence across cell types
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90. Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis
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91. Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis
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94. Sirtuins and FoxOs in osteoporosis and osteoarthritis
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95. Emerging therapies for cartilage regeneration in currently excluded ‘red knee’ populations
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96. Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities
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97. Exercise reduces circulating biomarkers of cellular senescence in humans
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98. Targeting senescent cells: approaches, opportunities, challenges
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99. Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases
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100. Recent advances in the discovery of senolytics
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