The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation
Open accessAbstract
Respiratory viral infections represent the most common cause of allergic asthma exacerbations. Amplification of the type-2 immune response is strongly implicated in asthma exacerbation, but how virus infection boosts type-2 responses is poorly understood. We report a significant correlation between the release of host double-stranded DNA (dsDNA) following rhinovirus infection and the exacerbation of type-2 allergic inflammation in humans. In a mouse model of allergic airway hypersensitivity, we show that rhinovirus infection triggers dsDNA release associated with the formation of neutrophil extracellular traps (NETs), known as NETosis. We further demonstrate that inhibiting NETosis by blocking neutrophil elastase or by degrading NETs with DNase protects mice from type-2 immunopathology. Furthermore, the injection of mouse genomic DNA alone is sufficient to recapitulate many features of rhinovirus-induced type-2 immune responses and asthma pathology. Thus, NETosis and its associated extracellular dsDNA contribute to the pathogenesis and may represent potential therapeutic targets of rhinovirus-induced asthma exacerbations.
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Cites
Neutrophil Extracellular Traps Kill Bacteria
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Self-citationCommunity study of role of viral infections in exacerbations of asthma in 9–11 year old children
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Self-citationPlasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
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Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis
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Cited by
Neutrophil extracellular traps in immunity and disease
Papayannopoulos, V. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.105 · Cited by 3,397
Self-citationThe dual nature of type I and type II interferons
Lee, A. J., & Ashkar, A. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02061 · Cited by 690
NETosis: Molecular Mechanisms, Role in Physiology and Pathology
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Zhang, Y., Chandra, V., Riquelme Sanchez, E., Dutta, P., Quesada, P. R., Rakoski, A., Zoltan, M., Arora, N., Baydogan, S., Horne, W., et al. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20190354 · Cited by 448
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Metadata
- Authors
- Toussaint, M., Jackson, D. J., Swieboda, D., Guedán, A., Tsourouktsoglou, T.-D., Ching, Y. M., Radermecker, C., Makrinioti, H., Aniscenko, J., Bartlett, N. W., Edwards, M. R., Solari, R., Farnir, F., Papayannopoulos, V., Bureau, F., Marichal, T., & Johnston, S. L.
- Venue
- Nature Medicine
- Published
- 2017-05-01
- Volume
- 23
- Issue
- 6
- Pages
- 681-691
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2611509799
- Cited by
- 319
- References
- 58
- FWCI
- 22.15
- Type
- journal article
- Language
- en
- Open access
- green
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