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Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation
Open accessAbstract
Respiratory viral infections represent the most common cause of allergic asthma exacerbations. Amplification of the type-2 immune response is strongly implicated in asthma exacerbation, but how virus infection boosts type-2 responses is poorly understood. We report a significant correlation between the release of host double-stranded DNA (dsDNA) following rhinovirus infection and the exacerbation of type-2 allergic inflammation in humans. In a mouse model of allergic airway hypersensitivity, we show that rhinovirus infection triggers dsDNA release associated with the formation of neutrophil extracellular traps (NETs), known as NETosis. We further demonstrate that inhibiting NETosis by blocking neutrophil elastase or by degrading NETs with DNase protects mice from type-2 immunopathology. Furthermore, the injection of mouse genomic DNA alone is sufficient to recapitulate many features of rhinovirus-induced type-2 immune responses and asthma pathology. Thus, NETosis and its associated extracellular dsDNA contribute to the pathogenesis and may represent potential therapeutic targets of rhinovirus-induced asthma exacerbations.
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Cites
Neutrophil Extracellular Traps Kill Bacteria
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268
Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,306
Meijer, L., Nelson, D. J., Riazanski, V., Gabdoulkhakova, A. G., Hery-Arnaud, G., Le Berre, R., Loaëc, N., Oumata, N., Galons, H., Nowak, E., et al. (2016) · Journal of Innate Immunity · doi:10.1159/000444256 · Cited by 4,992
Extracellular DNA traps promote thrombosis
Fuchs, T. A., Brill, A., Duerschmied, D., Schatzberg, D., Monestier, M., Myers, D. D., Wrobleski, S. K., Wakefield, T. W., Hartwig, J. H., & Wagner, D. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005743107 · Cited by 2,492
Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps
Papayannopoulos, V., Metzler, K. D., Hakkim, A., & Zychlinsky, A. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201006052 · Cited by 2,103
Self-citationCommunity study of role of viral infections in exacerbations of asthma in 9–11 year old children
Johnston, S. L., Pattemore, P. K., Sanderson, G., Smith, S., Lampe, F., Josephs, L., Symington, P., Toole, S. O., Myint, S. H., Tyrrell, D. A. J., et al. (1995) · BMJ · doi:10.1136/bmj.310.6989.1225 · Cited by 1,991
Self-citationPlasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
Lande, R., Gregorio, J., Facchinetti, V., Chatterjee, B., Wang, Y.-H., Homey, B., Cao, W., Wang, Y.-H., Su, B., Nestle, F. O., et al. (2007) · Nature · doi:10.1038/nature06116 · Cited by 1,910
Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis
Hakkim, A., Fürnrohr, B. G., Amann, K., Laube, B., Abed, U. A., Brinkmann, V., Herrmann, M., Voll, R. E., & Zychlinsky, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909927107 · Cited by 1,469
Garcia-Romo, G. S., Caielli, S., Vega, B., Connolly, J., Allantaz, F., Xu, Z., Punaro, M., Baisch, J., Guiducci, C., Coffman, R. L., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001201 · Cited by 1,383
Lande, R., Ganguly, D., Facchinetti, V., Frasca, L., Conrad, C., Gregorio, J., Meller, S., Chamilos, G., Sebasigari, R., Riccieri, V., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001180 · Cited by 1,303
Diabetes primes neutrophils to undergo NETosis, which impairs wound healing
Wong, S. L., Demers, M., Martinod, K., Gallant, M., Wang, Y., Goldfine, A. B., Kahn, C. R., & Wagner, D. D. (2015) · Nature Medicine · doi:10.1038/nm.3887 · Cited by 1,264
Branzk, N., Lubojemska, A., Hardison, S. E., Wang, Q., Gutierrez, M. G., Brown, G. D., & Papayannopoulos, V. (2014) · Nature Immunology · doi:10.1038/ni.2987 · Cited by 1,037
Self-citationPlatelets induce neutrophil extracellular traps in transfusion-related acute lung injury
Caudrillier, A., Kessenbrock, K., Gilliss, B. M., Nguyen, J. X., Marques, M. B., Monestier, M., Toy, P., Werb, Z., & Looney, M. R. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61303 · Cited by 1,037
Yipp, B. G., & Kubes, P. (2013) · Blood · doi:10.1182/blood-2013-04-457671 · Cited by 989
Plantinga, M., Guilliams, M., Vanheerswynghels, M., Deswarte, K., Branco-Madeira, F., Toussaint, W., Vanhoutte, L., Neyt, K., Killeen, N., Malissen, B., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.10.016 · Cited by 895
de Heer, H. J., Hammad, H., Soullié, T., Hijdra, D., Vos, N., Willart, M. A. M., Hoogsteden, H. C., & Lambrecht, B. N. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040035 · Cited by 785
Role of viral respiratory infections in asthma and asthma exacerbations
Busse, W. W., Lemanske, R. F., & Gern, J. E. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61380-3 · Cited by 750
Yu, C., Cantor, A. B., Yang, H., Browne, C., Wells, R. A., Fujiwara, Y., & Orkin, S. H. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020656 · Cited by 600
IL-33–Dependent Type 2 Inflammation during Rhinovirus-induced Asthma Exacerbations In Vivo
Jackson, D. J., Makrinioti, H., Rana, B. M. J., Shamji, B. W. H., Trujillo-Torralbo, M.-B., Footitt, J., del-Rosario, J., Telcian, A. G., Nikonova, A., Zhu, J., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201406-1039oc · Cited by 573
Self-citationDNA released from dying host cells mediates aluminum adjuvant activity
Marichal, T., Ohata, K., Bedoret, D., Mesnil, C., Sabatel, C., Kobiyama, K., Lekeux, P., Coban, C., Akira, S., Ishii, K. J., et al. (2011) · Nature Medicine · doi:10.1038/nm.2403 · Cited by 535
Self-citationMurray, C. S. (2006) · Thorax · doi:10.1136/thx.2005.042523 · Cited by 497
Message, S. D., Laza-Stanca, V., Mallia, P., Parker, H. L., Zhu, J., Kebadze, T., Contoli, M., Sanderson, G., Kon, O. M., Papi, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804181105 · Cited by 487
Self-citationNET balancing: a problem in inflammatory lung diseases
Cheng, O. Z., & Palaniyar, N. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00001 · Cited by 449
Jenne, C. N., Wong, C. H. Y., Zemp, F. J., McDonald, B., Rahman, M. M., Forsyth, P. A., McFadden, G., & Kubes, P. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.01.005 · Cited by 443
Neutrophil extracellular traps promote differentiation and function of fibroblasts
Chrysanthopoulou, A., Mitroulis, I., Apostolidou, E., Arelaki, S., Mikroulis, D., Konstantinidis, T., Sivridis, E., Koffa, M., Giatromanolaki, A., Boumpas, D. T., et al. (2014) · The Journal of Pathology · doi:10.1002/path.4359 · Cited by 404
Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation
Bartlett, N. W., Walton, R. P., Edwards, M. R., Aniscenko, J., Caramori, G., Zhu, J., Glanville, N., Choy, K. J., Jourdan, P., Burnet, J., et al. (2008) · Nature Medicine · doi:10.1038/nm1713 · Cited by 375
Self-citationNeutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma
Wark, P. A. B., Johnston, S. L., Moric, I., Simpson, J. L., Hensley, M. J., & Gibson, P. G. (2002) · European Respiratory Journal · doi:10.1183/09031936.02.00226302 · Cited by 373
Self-citationRegulating the adaptive immune response to respiratory virus infection
Braciale, T. J., Sun, J., & Kim, T. S. (2012) · Nature Reviews Immunology · doi:10.1038/nri3166 · Cited by 361
Green, R. M., Custovic, A., Sanderson, G., Hunter, J., Johnston, S. L., & Woodcock, A. (2002) · BMJ · doi:10.1136/bmj.324.7340.763 · Cited by 356
Self-citationThe role of viruses in acute exacerbations of asthma
Jackson, D. J., & Johnston, S. L. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.04.021 · Cited by 351
Self-citationBeale, J., Jayaraman, A., Jackson, D. J., Macintyre, J. D. R., Edwards, M. R., Walton, R. P., Zhu, J., Ching, Y. M., Shamji, B., Edwards, M., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009124 · Cited by 332
Self-citationGoritzka, M., Makris, S., Kausar, F., Durant, L. R., Pereira, C., Kumagai, Y., Culley, F. J., Mack, M., Akira, S., & Johansson, C. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20140825 · Cited by 279
Relationship of Upper and Lower Airway Cytokines to Outcome of Experimental Rhinovirus Infection
GERN, J. E., VRTIS, R., GRINDLE, K. A., SWENSON, C., & BUSSE, W. W. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.6.2003019 · Cited by 277
Neutrophil Extracellular Traps Go Viral
Schönrich, G., & Raftery, M. J. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00366 · Cited by 276
Innate immune recognition of, and regulation by, DNA
ISHII, K., & AKIRA, S. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.09.002 · Cited by 224
Grabcanovic-Musija, F., Obermayer, A., Stoiber, W., Krautgartner, W.-D., Steinbacher, P., Winterberg, N., Bathke, A. C., Klappacher, M., & Studnicka, M. (2015) · Respiratory Research · doi:10.1186/s12931-015-0221-7 · Cited by 209
Funchal, G. A., Jaeger, N., Czepielewski, R. S., Machado, M. S., Muraro, S. P., Stein, R. T., Bonorino, C. B. C., & Porto, B. N. (2015) · PLOS ONE · doi:10.1371/journal.pone.0124082 · Cited by 185
Chamilos, G., Gregorio, J., Meller, S., Lande, R., Kontoyiannis, D. P., Modlin, R. L., & Gilliet, M. (2012) · Blood · doi:10.1182/blood-2012-01-401364 · Cited by 182
Collison, A., Hatchwell, L., Verrills, N. M., Wark, P. A. B., de Siqueira, A. P., Tooze, M., Carpenter, H., Don, A. S., Morris, J. C., Zimmermann, N., et al. (2013) · Nature Medicine · doi:10.1038/nm.3049 · Cited by 149
Self-citationHouse dust mite–induced asthma causes oxidative damage and DNA double-strand breaks in the lungs
Chan, T. K., Loh, X. Y., Peh, H. Y., Tan, W. N. F., Tan, W. S. D., Li, N., Tay, I. J. J., Wong, W. S. F., & Engelward, B. P. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.02.017 · Cited by 146
McKee, A. S., Burchill, M. A., Munks, M. W., Jin, L., Kappler, J. W., Friedman, R. S., Jacobelli, J., & Marrack, P. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300392110 · Cited by 143
Modulation of neutrophil NETosis: interplay between infectious agents and underlying host physiology
Hahn, S., Giaglis, S., Chowdhury, C. S., Hösli, I., & Hasler, P. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0380-x · Cited by 118
Airway Inflammation and Illness Severity in Response to Experimental Rhinovirus Infection in Asthma
Zhu, J., Message, S. D., Qiu, Y., Mallia, P., Kebadze, T., Contoli, M., Ward, C. K., Barnathan, E. S., Mascelli, M. A., Kon, O. M., et al. (2014) · CHEST Journal · doi:10.1378/chest.13-1567 · Cited by 96
Self-citationSuzuki, T., Wang, W., Lin, J., Shirato, K., Mitsuhashi, H., & Inoue, H. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.4.8616573 · Cited by 84
Virus-Induced NETs – Critical Component of Host Defense or Pathogenic Mediator?
Jenne, C. N., & Kubes, P. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004546 · Cited by 76
古賀, 光., Miyahara, N., Fuchimoto, Y., Ikeda, G., Waseda, K., Ono, K., Tanimoto, Y., Kataoka, M., Gelfand, E. W., Tanimoto, M., et al. (2013) · Respiratory Research · doi:10.1186/1465-9921-14-8 · Cited by 70
Mesnil, C., Sabatel, C. M., Marichal, T., Toussaint, M., Cataldo, D. D., Drion, P.-V., Lekeux, P. M., Bureau, F., & Desmet, C. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0053242 · Cited by 60
Self-citationMaffía, P. C., Zittermann, S. I., Scimone, M. L., Tateosian, N. L., Amiano, N. O., Guerrieri, D., Lutzky, V. P., Rosso, D. A., Romeo, H. E., García, V., et al. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.061043 · Cited by 58
Singanayagam, A., Glanville, N., Walton, R. P., Aniscenko, J., Pearson, R. M., Pinkerton, J., Horvat, J. C., Hansbro, P. M., Bartlett, N. W., & Johnston, S. L. (2015) · Clinical Science · doi:10.1042/cs20140654 · Cited by 49
Self-citationThe role of viral and atypical bacterial pathogens in asthma pathogenesis
Johnston, S. L. (1999) · Pediatric Pulmonology · Cited by 49
Self-citationNucleic acid sensing by T cells initiates Th2 cell differentiation
Imanishi, T., Ishihara, C., Badr, M. E. S. G., Hashimoto, A. S., Kimura, Y., Kawai, T., Takeuchi, O., Ishii, K. J., Taniguchi, S., Noda, T., et al. (2014) · Nature Communications · doi:10.1038/ncomms4566 · Cited by 49
ICOS+ Th cells produce distinct cytokines in different mucosal immune responses
Bonhagen, K., Liesenfeld, O., Stadecker, M. J., Hutloff, A., Erb, K. J., Coyle, A. J., Lipp, M., Kroczek, R. A., & Kamradt, T. (2003) · European Journal of Immunology · doi:10.1002/immu.200310013 · Cited by 49
Interferon response factor 3 is essential for house dust mite–induced airway allergy
Marichal, T., Bedoret, D., Mesnil, C., Pichavant, M., Goriely, S., Trottein, F., Cataldo, D. D., Goldman, M., Lekeux, P. M., Bureau, F., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.06.009 · Cited by 48
Self-citationToussaint, M., Fiévez, L., Drion, P. V., Cataldo, D. D., Bureau, F., Lekeux, P. M., & Desmet, C. J. (2012) · Mucosal Immunology · doi:10.1038/mi.2012.88 · Cited by 40
Self-citationTateosian, N. L., Reiteri, R. M., Amiano, N. O., Costa, M. J., Villalonga, X., Guerrieri, D., & Maffía, P. C. (2011) · Cellular Immunology · doi:10.1016/j.cellimm.2011.03.013 · Cited by 37
Skrzeczyńska-Moncznik, J., Włodarczyk, A., Banaś, M., Kwitniewski, M., Zabieglo, K., Kapińska-Mrowiecka, M., Dubin, A., & Cichy, J. (2013) · Europe PMC (PubMed Central) · Cited by 25
Doepker, L. E., White, J., Cambier, J. C., Kappler, J. W., & Marrack, P. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501565 · Cited by 17
Janss, T. J., Mesnil, C., Pirottin, D., Lemaître, P., Marichal, T., Bureau, F., & Desmet, C. J. (2016) · European Journal of Immunology · doi:10.1002/eji.201646513 · Cited by 13
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Metadata
- Authors
- Toussaint, M., Jackson, D. J., Swieboda, D., Guedán, A., Tsourouktsoglou, T.-D., Ching, Y. M., Radermecker, C., Makrinioti, H., Aniscenko, J., Bartlett, N. W., Edwards, M. R., Solari, R., Farnir, F., Papayannopoulos, V., Bureau, F., Marichal, T., & Johnston, S. L.
- Venue
- Nature Medicine
- Published
- 2017-05-01
- Volume
- 23
- Issue
- 6
- Pages
- 681-691
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2611509799
- Cited by
- 319
- References
- 58
- FWCI
- 22.15
- Type
- journal article
- Language
- en
- Open access
- green
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