The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Restorative effects of human neural stem cell grafts on the primate spinal cord
Open accessAbstract
We grafted human spinal cord–derived neural progenitor cells (NPCs) into sites of cervical spinal cord injury in rhesus monkeys (Macaca mulatta). Under three-drug immunosuppression, grafts survived at least 9 months postinjury and expressed both neuronal and glial markers. Monkey axons regenerated into grafts and formed synapses. Hundreds of thousands of human axons extended out from grafts through monkey white matter and synapsed in distal gray matter. Grafts gradually matured over 9 months and improved forelimb function beginning several months after grafting. These findings in a 'preclinical trial' support translation of NPC graft therapy to humans with the objective of reconstituting both a neuronal and glial milieu in the site of spinal cord injury.
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Cites
Statistical Analysis with Missing Data
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Molecular logic of neocortical projection neuron specification, development and diversity
Greig, L. C., Woodworth, M. B., Galazo, M. J., Padmanabhan, H., & Macklis, J. D. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3586 · Cited by 863
Windrem, M. S., Nunes, M. C., Rashbaum, W. K., Schwartz, T. H., Goodman, R. A., McKhann, G., Roy, N. S., & Goldman, S. A. (2004) · Nature Medicine · doi:10.1038/nm974 · Cited by 451
Cited by
Spinal cord repair: advances in biology and technology
Courtine, G., & Sofroniew, M. V. (2019) · Nature Medicine · doi:10.1038/s41591-019-0475-6 · Cited by 508
Ice Inhibition for Cryopreservation: Materials, Strategies, and Challenges
Chang, T., & Zhao, G. (2021) · Advanced Science · doi:10.1002/advs.202002425 · Cited by 419
A First-in-Human, Phase I Study of Neural Stem Cell Transplantation for Chronic Spinal Cord Injury
Curtis, E., Martin, J. R., Gabel, B., Sidhu, N., Rzesiewicz, T. K., Mandeville, R., Van Gorp, S., Leerink, M., Tadokoro, T., Marsala, S., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.05.014 · Cited by 377
Regulation of axonal regeneration after mammalian spinal cord injury
Zheng, B., & Tuszynski, M. H. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00562-y · Cited by 328
Self-citationStrategies and prospects of effective neural circuits reconstruction after spinal cord injury
Yang, B., Zhang, F., Cheng, F., Ying, L., Wang, C., Shi, K., Wang, J., Xia, K., Gong, Z., Huang, X., et al. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-2620-z · Cited by 128
Metadata
- Authors
- Rosenzweig, E. S., Brock, J. H., Lu, P., Kumamaru, H., Salegio, E. A., Kadoya, K., Weber, J. L., Liang, J. J., Moseanko, R., Hawbecker, S., Huie, J. R., Havton, L. A., Nout-Lomas, Y. S., Ferguson, A. R., Beattie, M. S., Bresnahan, J. C., & Tuszynski, M. H.
- Venue
- Nature Medicine
- Published
- 2018-02-26
- Volume
- 24
- Issue
- 4
- Pages
- 484-490
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2790049490
- Cited by
- 342
- References
- 5
- FWCI
- 27.16
- Type
- journal article
- Language
- en
- Open access
- green
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