The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
A First-in-Human, Phase I Study of Neural Stem Cell Transplantation for Chronic Spinal Cord Injury
Open accessAbstract
We tested the feasibility and safety of human-spinal-cord-derived neural stem cell (NSI-566) transplantation for the treatment of chronic spinal cord injury (SCI). In this clinical trial, four subjects with T2-T12 SCI received treatment consisting of removal of spinal instrumentation, laminectomy, and durotomy, followed by six midline bilateral stereotactic injections of NSI-566 cells. All subjects tolerated the procedure well and there have been no serious adverse events to date (18-27 months post-grafting). In two subjects, one to two levels of neurological improvement were detected using ISNCSCI motor and sensory scores. Our results support the safety of NSI-566 transplantation into the SCI site and early signs of potential efficacy in three of the subjects warrant further exploration of NSI-566 cells in dose escalation studies. Despite these encouraging secondary data, we emphasize that this safety trial lacks statistical power or a control group needed to evaluate functional changes resulting from cell grafting.
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Embryonic Stem Cell-Derived Glial Precursors: A Source of Myelinating Transplants
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Long-Distance Growth and Connectivity of Neural Stem Cells after Severe Spinal Cord Injury
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Autologous olfactory ensheathing cell transplantation in human spinal cord injury
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Cited by
Spinal cord injury: molecular mechanisms and therapeutic interventions
Hu, X., Xu, W., Ren, Y., Wang, Z., He, X., Huang, R., Ma, B., Zhao, J., Zhu, R., & Cheng, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01477-6 · Cited by 770
Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials
Zipser, C. M., Cragg, J. J., Guest, J. D., Fehlings, M. G., Jutzeler, C. R., Anderson, A. J., & Curt, A. (2022) · The Lancet Neurology · doi:10.1016/s1474-4422(21)00464-6 · Cited by 269
Ayoub, R., Ruddy, R. M., Cox, E., Oyefiade, A., Derkach, D., Laughlin, S., Ades-aron, B., Shirzadi, Z., Fieremans, E., MacIntosh, B. J., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0985-2 · Cited by 117
Metadata
- Authors
- Curtis, E., Martin, J. R., Gabel, B., Sidhu, N., Rzesiewicz, T. K., Mandeville, R., Van Gorp, S., Leerink, M., Tadokoro, T., Marsala, S., Jamieson, C., Marsala, M., & Ciacci, J. D.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 22
- Issue
- 6
- Pages
- 941-950.e6
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2807053207
- Cited by
- 377
- References
- 31
- FWCI
- 20.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Curtis, E., Martin, J. R., Gabel, B., Sidhu, N., Rzesiewicz, T. K., Mandeville, R., Van Gorp, S., Leerink, M., Tadokoro, T., Marsala, S., Jamieson, C., Marsala, M., & Ciacci, J. D. (2018). A First-in-Human, Phase I Study of Neural Stem Cell Transplantation for Chronic Spinal Cord Injury. Cell Stem Cell. https://doi.org/10.1016/j.stem.2018.05.014
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