Encapsulate this

Safety and Viability of Microencapsulated Human Islets Transplanted Into Diabetic Humans

Tuch, B., Keogh, G., Williams, L., Wu, W., Foster, J., Vaithilingam, V., & Philips, R. (2009) · Diabetes Care · doi:10.2337/dc09-0744 · Cited by 329 · see citing works

Transplantation of human islets without immunosuppression

Ludwig, B., Reichel, A., Steffen, A., Zimerman, B., Schally, A., Block, N., Colton, C., Ludwig, S., Kersting, S., Bonifacio, E., et al. (2013) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1317561110 · Cited by 265 · see citing works

Islet encapsulation: advances and obstacles

Weir, G. C. (2013) · Diabetologia · doi:10.1007/s00125-013-2921-1 · Cited by 80 · see citing works

Rapid Biocompatibility Analysis of Materials via In Vivo Fluorescence Imaging of Mouse Models

Bratlie, K. M., Dang, T. T., Lyle, S. R., Nahrendorf, M., Weissleder, R., Langer, R., & Anderson, D. G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010032 · Cited by 64 · see citing works

Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates

Veiseh, O., Doloff, J. C., Ma, M., Vegas, A. J., Tam, H. H., Bader, A. R., Li, J., Langan, E., Wyckoff, J., Loo, W. S., et al. (2015) · Nature Materials · doi:10.1038/nmat4290 · Cited by 897 · see citing works

Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

Vegas, A. J., Veiseh, O., Gürtler, M., Millman, J. R., Pagliuca, F. W., Bader, A. R., Doloff, J. C., Li, J., Chen, M., Olejnik, K., et al. (2016) · Nature Medicine · doi:10.1038/nm.4030 · Cited by 710 · see citing works

Managing diabetes with nanomedicine: challenges and opportunities

Omid Veiseh, A., Tang, B. C., Whitehead, K. A., Anderson, D. G., & Langer, R. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4477 · Cited by 618 · see citing works

Dealing with the Foreign‐Body Response to Implanted Biomaterials: Strategies and Applications of New Materials

Zhang, D., Chen, Q., Shi, C., Chen, M., Ma, K., Wan, J., & Liu, R. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202007226 · Cited by 304 · see citing works

Pharmapolymers in the 21st century: Synthetic polymers in drug delivery applications

Englert, C., Brendel, J. C., Majdanski, T. C., Yildirim, T., Schubert, S., Gottschaldt, M., Windhab, N., & Schubert, U. S. (2018) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2018.07.005 · Cited by 248 · see citing works

Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes

An, D., Chiu, A., Flanders, J. A., Song, W., Shou, D., Lu, Y.-C., Grunnet, L. G., Winkel, L., Ingvorsen, C., Christophersen, N. S., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1708806115 · Cited by 200 · see citing works

Device design and materials optimization of conformal coating for islets of Langerhans

Tomei, A. A., Manzoli, V., Fraker, C. A., Giraldo, J. A., Velluto, D., Najjar, M., Pileggi, A., Molano, R. D., Ricordi, C., Stabler, C. L., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402216111 · Cited by 192 · see citing works

Heart Repair Using Nanogel-Encapsulated Human Cardiac Stem Cells in Mice and Pigs with Myocardial Infarction

Tang, J., Cui, X., Caranasos, T. G., Hensley, M. T., Vandergriff, A. C., Hartanto, Y., Shen, D., Zhang, H., Zhang, J., & Cheng, K. (2017) · ACS Nano · doi:10.1021/acsnano.7b01008 · Cited by 153 · see citing works

A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes

Wang, X., Maxwell, K. G., Wang, K., Bowers, D. T., Flanders, J. A., Liu, W., Wang, L.-H., Liu, Q., Liu, C., Naji, A., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abb4601 · Cited by 119 · see citing works

Designing compartmentalized hydrogel microparticles for cell encapsulation and scalable 3D cell culture

Lu, Y., Song, W., An, D., Kim, B. J., Schwartz, R. E., Wu, M., & Ma, M. (2014) · Journal of Materials Chemistry B · doi:10.1039/c4tb01735h · Cited by 108 · see citing works

Developing robust, hydrogel-based, nanofiber-enabled encapsulation devices (NEEDs) for cell therapies.

An, D., Ji, Y.-W., Chiu, A., Lu, Y.-C., Song, W., Zhai, L., Qi, L., Luo, D., & Ma, M.-L. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2014.10.032 · Cited by 80 · see citing works

Engraftment of human induced pluripotent stem cell-derived hepatocytes in immunocompetent mice via 3D co-aggregation and encapsulation

Song, W., Lu, Y., Frankel, A. S., An, D., Schwartz, R. E., & Ma, M. (2015) · Scientific Reports · doi:10.1038/srep16884 · Cited by 91 · see citing works

An actuatable soft reservoir modulates host foreign body response

Dolan, E. B., Varela, C. E., Mendez, K. L., Whyte, W., Levey, R. E., Robinson, S. T., Maye, E., O’Dwyer, J., Beatty, R., Rothman, A. S., et al. (2019) · Science Robotics · doi:10.1126/scirobotics.aax7043 · Cited by 87 · see citing works

Transplantation of bovine adrenocortical cells encapsulated in alginate

Balyura, M., Gelfgat, E., Ehrhart-Bornstein, M., Ludwig, B., Gendler, Z., Barkai, U., Zimerman, B., Rotem, A., Block, N. L., Schally, A. V., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1500242112 · Cited by 77 · see citing works

Single cells in nanoshells for the functionalization of living cells

Geng, W., Wang, L., Jiang, N., Cao, J., Xiao, Y., Hao, W., Yetisen, A. K., Yang, X., & Su, B. (2018) · Nanoscale · doi:10.1039/c7nr08556g · Cited by 72 · see citing works

A smart insulin patch

Omid Veiseh, A., & Langer, R. (2015) · Nature · doi:10.1038/524039a · Cited by 72 · see citing works

The bioartificial pancreas (BAP): Biological, chemical and engineering challenges

Iacovacci, V., Ricotti, L., Menciassi, A., & Dario, P. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.08.107 · Cited by 59 · see citing works

A Safe, Fibrosis‐Mitigating, and Scalable Encapsulation Device Supports Long‐Term Function of Insulin‐Producing Cells

Liu, W. H., Flanders, J. A., Wang, L., Liu, Q., Bowers, D. T., Wang, K., Chiu, A., Wang, X., Ernst, A. U., Shariati, K., et al. (2021) · Small · doi:10.1002/smll.202104899 · Cited by 53 · see citing works

Tuning the Properties of Hydrogel Microspheres by Adding Chemical Cross-linking Functionality to Sodium Alginate

Mahou, R., Borcard, F., Crivelli, V., Montanari, E., Passemard, S., Noverraz, F., Gerber‐Lemaire, S., Bühler, L. H., & Wandrey, C. (2015) · Chemistry of Materials · doi:10.1021/acs.chemmater.5b01098 · Cited by 50 · see citing works

Millimeter-thick xenoislet-laden fibers as retrievable transplants mitigate foreign body reactions for long-term glycemic control in diabetic mice

Watanabe, T., Okitsu, T., Ozawa, F., Nagata, S., Matsunari, H., Nagashima, H., Nagaya, M., Teramae, H., & Takeuchi, S. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120162 · Cited by 36 · see citing works

Alginate Microcapsules for Drug Delivery

Gonzalez‐Pujana, A., Orive, G., Pedraz, J. L., Santos‐Vizcaíno, E., & Hernández, R. M. (2017) · Springer series in biomaterials science and engineering · doi:10.1007/978-981-10-6910-9_3 · Cited by 34 · see citing works

Theranostic Advances of Bionanomaterials against Gestational Diabetes Mellitus: A Preliminary Review

Barani, M., Sargazi, S., Mohammadzadeh, V., Rahdar, A., Pandey, S., Jha, N. K., Gupta, P. K., & Thakur, V. K. (2021) · Journal of Functional Biomaterials · doi:10.3390/jfb12040054 · Cited by 33 · see citing works

Current Advances in Immunomodulatory Biomaterials for Cell Therapy and Tissue Engineering

Kim, B., Pradhan, L., Hernández, A., Yenurkar, D., Nethi, S. K., & Mukherjee, S. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202300002 · Cited by 28 · see citing works

Alginate beads as a carrier for omeprazole/SBA-15 inclusion compound: A step towards the development of personalized paediatric dosage forms

Gaudio, P. D., Cicco, F. D., Sansone, F., Aquino, R. P., Adami, R., Ricci, M., & Giovagnoli, S. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.07.064 · Cited by 27 · see citing works

Magnetoencapsulated human islets xenotransplanted into swine: a comparison of different transplantation sites

Arifin, D. R., Valdeig, S., Anders, R. A., Bulte, J. W. M., & Weiss, C. R. (2016) · Xenotransplantation · doi:10.1111/xen.12235 · Cited by 26 · see citing works

Cell Immobilization: Fundamentals, Technologies, and Applications

Ge, X., Yang, L., & Xu, J. (2016) · Industrial Biotechnology · doi:10.1002/9783527807833.ch7 · Cited by 21 · see citing works

Droplet spreading on liquid–fluid interface

Rahman, M. R., Mullagura, H. N., Bharath, K. S., & Waghmare, P. R. (2018) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2018.05.042 · Cited by 19 · see citing works

In vitro oxygen imaging of acellular and cell-loaded beta cell replacement devices

Kotecha, M., Wang, L.-H., Hameed, S., Viswakarma, N., Ma, M.-L., Stabler, C., Hoesli, C., & Epel, B. (2023) · Scientific Reports · doi:10.1038/s41598-023-42099-w · Cited by 15 · see citing works

Interim report on the effective intraperitoneal therapy of insulin-dependent diabetes mellitus in pet dogs using “Neo-Islets,” aggregates of adipose stem and pancreatic islet cells (INAD 012-776)

Gooch, A. M., Zhang, P., Hu, Z., Son, N. K. L., Avila, N., Fischer, J. R., Roberts, G. D., Sellon, R. K., & Westenfelder, C. S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218688 · Cited by 15 · see citing works

Encapsulate this: the do's and don'ts

Orive, G., Emerich, D. F., & de Vos, P. (2014) · Nature Medicine · doi:10.1038/nm.3486 · Cited by 13 · see citing works

Xenotransplantation of Cells, Tissues, Organs and the German Research Foundation Transregio Collaborative Research Centre 127

Reichart, B., Guethoff, S., Brenner, P., Pöttinger, T., Wolf, E., Ludwig, B., Kind, A., Mayr, T., & Abicht, J. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-18603-0_9 · Cited by 7 · see citing works

Hybrid extracellular matrix microspheres for development of complex multicellular architectures

Affolter-Zbaraszczuk, C., Özçelik, H., Meyer, F., Gallet, O., Lavalle, P., Ball, V., Ghimbeu, C., Schaaf, P., & Knopf-Marques, H. (2017) · RSC Advances · doi:10.1039/c6ra27680f · Cited by 4 · see citing works

Engineering human renal epithelial cells for transplantation in regenerative medicine.

Manzoli, V., Colter, D., Dhanaraj, S., Fornoni, A., Ricordi, C., Pileggi, A., & Tomei, A. (2017) · Medical Engineering and Physics · doi:10.1016/j.medengphy.2017.03.009 · Cited by 5 · see citing works

TiO2 Nanoflowers on Conducting Substrates Ameliorate Effective Transdifferentiation of Human Hepatic Progenitor Cells for Long‐Term Hyperglycemia Reversal in Diabetic Mice

Vishwakarma, S. K., Jaiswal, J., Park, K., Lakkireddy, C., Raju, N., Bardia, A., Habeeb, M. A., Paspala, S. A. B., Khan, A. A., & Dhayal, M. (2020) · Advanced Therapeutics · doi:10.1002/adtp.201900205 · Cited by 5 · see citing works

[Injury characteristics and therapeutic strategy of patients injured in "8·8" Jiuzhaigou earthquake].

Shi, B., Liu, G., Li, L., Tang, S., Wang, J., Xie, M., Dai, X., He, J., Zhang, Y., Tang, Y., et al. (2018) · Europe PMC (PubMed Central) · doi:10.7507/1002-1892.201710077 · Cited by 5 · see citing works

Islet immunoisolation by macroencapsulation

Ludwig, B. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814833-4.00060-5 · Cited by 4 · see citing works

Correction of Hyperglycemia in Diabetic Rats With the Use of Microencapsulated Young Market Pig Islets

Jiang, X.-F., Qian, T., Chen, D., Lu, H., Xue, P., Yang, X.-W., Zhang, L.-H., Hu, Y., & Zhang, D.-W. (2018) · Transplantation Proceedings · doi:10.1016/j.transproceed.2018.09.017 · Cited by 3 · see citing works

Medications development for substance-use disorders: contextual influences (dis)incentivizing pharmaceutical-industry positioning

Janero, D. R. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.951631 · Cited by 2 · see citing works

Skin deep: from dermal fibroblasts to pancreatic beta cells

Manzar, G. S., Kim, E., Rotti, P. G., & Zavazava, N. (2014) · Immunologic Research · doi:10.1007/s12026-014-8546-8 · Cited by 2 · see citing works

Regenerative Medicine: Clinical Islet Transplantation

Thomas, H., Graham, K., Loudovaris, T., & Kay, T. (2016) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-45307-1_11

Microscale Cell Encapsulation Materials and Fabrication Techniques for Type 1 Diabetes

Zhang, Y., & Ma, M. (2015) · Springer eBooks · doi:10.1007/978-3-319-20726-1_11

Capturing Islet Stem Cells for a Bio-Artificial Pancreas

Pothuloori, A., & Chaidarun, S. (2015) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2015.42

Cytotherapy Clinical Trials in Genetic Disorders of the Blood and Options for Reimbursement

Carmona, G., & Smith, D. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-812034-7.00014-5

Engineering Mammalian Cells to Control Glucose Homeostasis

Shao, J., Qiu, X., & Xie, M. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1441-9_3

Xenogene Zelltherapeutika

Godehardt, A. W., Schilling-Leiß, D., Sanzenbacher, R., & Tönjes, R. R. (2015) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-015-2246-y

Reply to Encapsulate this: the do's and don'ts

(2014) · Nature Medicine · doi:10.1038/nm.3491

Use of Immunomodulatory Biomaterials in Diabetes Therapy

Kim, B., & Mukherjee, S. (2024) · Synthesis lectures on biomedical engineering · doi:10.1007/978-3-031-50844-8_3

Encapsulated islet transplantation

Liu, S. S., Shim, S., Kudo, Y., Stabler, C. L., O’Cearbhaill, E. D., Karp, J. M., & Yang, K. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00238-6 · Cited by 41 · see citing works

Islet Encapsulation

Lakey, J. R. T., Robles, L. Y., Lamb, M. W., Alexander, M., Botvinick, E. L., & Foster, C. E. (2013) · Springer eBooks · doi:10.1007/978-94-007-6884-0_29-2

The Holy Grail of Tissue Engineering? Islet Cell Microencapsulation in Type 1 Diabetes Mellitus

Woods, B. (2015) · Trinity Student Medical Journal

Engineering a Clinically Translatable Bioartificial Pancreas to Treat Type I Diabetes

Orive, G., Emerich, D. F., Khademhosseini, A., Matsumoto, S., Hernández, R. M., Pedraz, J. L., Desai, T. A., Calafiore, R., & de Vos, P. (2018) · Trends in biotechnology · doi:10.1016/j.tibtech.2018.01.007 · Cited by 78 · see citing works

Engineering Strategies to Improve Islet Transplantation for Type 1 Diabetes Therapy

White, A. M., Shamul, J., Xu, J.-S., Stewart, S., Bromberg, J. S., & He, X.-M. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b01406 · Cited by 28 · see citing works