Transplantation of bovine adrenocortical cells encapsulated in alginate
Open accessAbstract
Significance: Adrenal insufficiency is a life-threatening disorder that requires a complex and permanent hormone replacement strategy. All current replacement schemes suffer from numerous problems, as they fail to restore circadian variations in hormone secretion. Therefore, adrenal cell transplantation could be a preferable therapeutic alternative for patients suffering from primary adrenal dysfunction. This strategy is critically limited, however, by the lack of suitable donors of human organs and the requirement of chronic immunosuppression. Transplantation of immunoisolated xenogeneic adrenal cells could and would be a promising alternative for these patients. The most significant accomplishment of this study is the creation of long-term functional and immunoisolated artificial adrenals and their transplantation into animal models of adrenal insufficiency.
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Adrenal transplantation with novel technology using bovine adrenocortical cells has been successful in animal models of adrenal insufficiency.
“Adrenal transplantation with novel technology using bovine adrenocortical cells has been successful in animal models of adrenal insufficiency.149”
From Congenital adrenal hyperplasia (2017) · cites this paper as [149]
Xenogeneic adrenocortical cells from cows encapsulated in a microenvironment supporting cell viability and immune isolation showed encouraging results, including maintenance of steroidogenesis, when implanted into adrenalectomized rats.
“Xenogeneic adrenocortical cells from cows encapsulated in a microenvironment that supports cell viability and immune isolation were developed and showed encouraging results, including maintenance of steroidogenesis, when implanted into adrenalectomized rats158.”
From Management challenges and therapeutic advances in congenital adrenal hyperplasia (2022) · cites this paper as [158]
LHRH analog [D-Trp6]-LHRH and bombesin acutely stimulate adrenal glucocorticoid release.
“Finally, it has been reported that the LHRH analog [D-Trp6]-LHRH (Balyura et al., 2015) and bombesin (Malendowicz et al., 1995) acutely stimulate adrenal glucocorticoid release.”
From Modeling Congenital Adrenal Hyperplasia and Testing Interventions for Adrenal Insufficiency Using Donor-Specific Reprogrammed Cells (2018) · cites this paper as Balyura et al., 2015
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Cites
Congenital adrenal hyperplasia
El-Maouche, D., Arlt, W., & Merke, D. P. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31431-9 · Cited by 669 · see citing works
Congenital adrenal hyperplasia.
Merke, D. P., & Bornstein, S. R. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66736-0 · Cited by 628 · see citing works
Self-citationIntraadrenal interactions in the regulation of adrenocortical steroidogenesis.
Ehrhart-Bornstein, M., Hinson, J. P., Bornstein, S. R., Scherbaum, W. A., & Vinson, G. P. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.2.0326 · Cited by 600 · cited 2× · see citing works
“Discussion Primary cultures of BACs have been a widely used model to study different aspects of adrenal function in vitro and in vivo (16, 24).”
BackgroundSelf-citationIdentification of an angiogenic mitogen selective for endocrine gland endothelium
LeCouter, J. E., Kowalski, J., Foster, J., Hass, P., Zhang, Z., Dillard‐Telm, L., Frantz, G. D., Rangell, L. K., Deguzman, L., Keller, G.-A., et al. (2001) · Nature · doi:10.1038/35091000 · Cited by 554 · see citing works
Congenital Adrenal Hyperplasia
Levy, J. B., & Husmann, D. A. (1996) · The Journal of Urology · doi:10.1097/00005392-199608001-00060 · Cited by 416 · see citing works
Predisposing Factors for Adrenal Insufficiency
Bornstein, S. R. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804635 · Cited by 356 · see citing works
Self-citationAdrenomedullary dysplasia and hypofunction in patients with classic 21-hydroxylase deficiency.
Merke, D. P., Chrousos, G. P., Eisenhofer, G., Weise, M., Keil, M. F., Rogol, A. D., Van Wyk, J. J., & Bornstein, S. R. (2000) · New England Journal of Medicine · doi:10.1056/nejm200011093431903 · Cited by 266 · see citing works
Self-citationTransplantation of human islets without immunosuppression
Ludwig, B., Reichel, A., Steffen, A., Zimerman, B., Schally, A., Block, N., Colton, C., Ludwig, S., Kersting, S., Bonifacio, E., et al. (2013) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1317561110 · Cited by 265 · see citing works
Self-citationLudwig, B., Rotem, A., Schmid, J., Weir, G., Colton, C., Brendel, M., Neufeld, T., Block, N., Yavriyants, K., Steffen, A., et al. (2012) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1201868109 · Cited by 176 · see citing works
Self-citationEnhanced Oxygen Supply Improves Islet Viability in a New Bioartificial Pancreas
Barkai, U., Weir, G., Colton, C., Ludwig, B., Bornstein, S., Brendel, M., Neufeld, T., Bremer, C., Leon, A., Evron, Y., et al. (2013) · Cell Transplantation · doi:10.3727/096368912x657341 · Cited by 175 · see citing works
Self-citationMicroencapsulation using natural polysaccharides for drug delivery and cell implantation
Wang, W., Liu, X., Xie, Y., Zhang, H., Yu, W., Xiong, Y., Xie, W., & Ma, X. (2006) · Journal of Materials Chemistry · doi:10.1039/b603595g · Cited by 160 · see citing works
Park, J. Y., Hwang, T. K., Park, H. K., & Ahn, R. S. (2014) · Neuroendocrinology · doi:10.1159/000363367 · Cited by 158 · see citing works
Bonfig, W., Dalla Pozza, S. B., Schmidt, H., Pagel, P., Knorr, D., & Schwarz, H. P. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0942 · Cited by 136 · see citing works
Adrenal insufficiency: review of clinical outcomes with current glucocorticoid replacement therapy
Johannsson, G., Falorni, A., Skrtic, S., Lennernäs, H., Quinkler, M., Monson, J. P., & Stewart, P. M. (2015) · Clinical Endocrinology · doi:10.1111/cen.12603 · Cited by 122 · see citing works
The Efficacy of an Immunoisolating Membrane System for Islet Xenotransplantation in Minipigs
Neufeld, T., Ludwig, B., Barkai, U., Weir, G., Colton, C., Evron, Y., Balyura, M., Yavriyants, K., Zimermann, B., Azarov, D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070150 · Cited by 110 · see citing works
Self-citationA Novel Device for Islet Transplantation Providing Immune Protection and Oxygen Supply
Ludwig, B., Zimerman, B., Steffen, A., Yavriyants, K., Azarov, D., Reichel, A., Vardi, P., German, T., Shabtay, N., Rotem, A., et al. (2010) · Hormone and Metabolic Research · doi:10.1055/s-0030-1267916 · Cited by 105 · see citing works
Self-citationRegulation of the adrenocortical stem cell niche: implications for disease
Walczak, E. M., & Hammer, G. D. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.166 · Cited by 93 · see citing works
Haidan, A., Bornstein, S. R., Glasow, A., Uhlmann, K., Lübke, C., & Ehrhart‐Bornstein, M. (1998) · Endocrinology · doi:10.1210/endo.139.2.5740 · Cited by 90 · see citing works
Self-citationIsolation of Neural Crest Derived Chromaffin Progenitors from Adult Adrenal Medulla
Chung, K.-F., Sicard, F., Vukićević, V., Hermann, A., Storch, A., Huttner, W. Β., Bornstein, S. R., & Ehrhart‐Bornstein, M. (2009) · Stem Cells · doi:10.1002/stem.180 · Cited by 69 · see citing works
Self-citationLundström, E., Rencken, R. K., van Wyk, J. H., Coetzee, L. J. E., Bahlmann, J. C. M., Reif, S., Strasheim, E. A., Bigalke, M. C., Pontin, A. R., Goedhals, L., et al. (2009) · Clinical Drug Investigation · doi:10.2165/11319690-000000000-00000 · Cited by 56 · see citing works
Transplantation of primary bovine adrenocortical cells into scid mice
Thomas, M., & Hornsby, P. J. (1999) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(99)00070-2 · Cited by 53 · see citing works
Ziegler, C. G., Brown, J. W., Schally, A. V., Erler, A., Gebauer, L., Treszl, A., Young, L., Fishman, L. M., Engel, J. B., Willenberg, H. S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907843106 · Cited by 51 · see citing works
Self-citationBornstein, S. R., Ehrhart‐Bornstein, M., Güse‐Behling, H., & Scherbaum, W. (1992) · The Anatomical Record · doi:10.1002/ar.1092340212 · Cited by 49 · see citing works
Self-citationDolgin, E. (2014) · Nature Medicine · doi:10.1038/nm0114-9 · Cited by 47 · see citing works
Shteyer, E., Yaʼacov, A. B., Zolotaryova, L., Sinai, A., Lichtenstein, Y., Pappo, O., Kryukov, O., Elkayam, T., Cohen, S., & Ilan, Y. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.02.047 · Cited by 39 · see citing works
Acarregui, A., Herrán, E., Igartúa, M., Blanco, F. J., Pedraz, J. L., Orive, G., & Hernández, R. M. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.06.038 · Cited by 39 · see citing works
Kovács, M., & Schally, A. V. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211442598 · Cited by 37 · see citing works
Self-citationDifferentiation of Chromaffin Progenitor Cells to Dopaminergic Neurons
Vukićević, V., Schmid, J., Hermann, A., Lange, S., Qin, N., Gebauer, L., Chung, K.-F., Ravens, U., Eisenhofer, G., Storch, A., et al. (2012) · Cell Transplantation · doi:10.3727/096368912x638874 · Cited by 29 · see citing works
Self-citationAntitumoral effects of 9-cis retinoic acid in adrenocortical cancer
Szabó, D. R., Baghy, K., Szabó, P., Zsippai, A., Marczell, I., Nagy, Z., Varga, V., Éder, K., Tóth, S., Buzás, E. I., et al. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1408-z · Cited by 27 · see citing works
Horiguchi, I., Chowdhury, M. M., Sakai, Y., & Tabata, Y. (2014) · Biotechnology Progress · doi:10.1002/btpr.1891 · Cited by 22 · see citing works
Changes in gene expression during senescence of adrenocortical cells in culture
Hornsby, P. J., Cheng, C. Y., Lala, D. S., Maghsoudlou, S. S., Raju, S. G., & Yang, L. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90323-b · Cited by 21 · see citing works
Grodstein, E. I., Hardy, M. A., & Goldstein, M. J. (2009) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2009.02929.x · Cited by 19 · see citing works
Transplantation of Adrenocortical Cells
Hornsby, P. J. (2001) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/a:1011524701385 · Cited by 17 · see citing works
Optimizing Orthotopic Cell Transplantation in the Mouse Adrenal Gland
Cardoso, C. C., Bornstein, S. R., & Hornsby, P. J. (2010) · Cell Transplantation · doi:10.3727/096368910x509077 · Cited by 16 · see citing works
Self-citationUsing cell transplantation to investigate genes involved in aging
Hornsby, P. J., Chen, M., Hawks, C. L., Huang, Q., Sun, B., Wang, L., & Thomas, M. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00172-0 · Cited by 2 · see citing works
Flagged first, then by citations
1 of the 36 references couldn’t be matched to a known paper.
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Congenital adrenal hyperplasia
El-Maouche, D., Arlt, W., & Merke, D. P. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31431-9 · Cited by 669 · see citing works
Rushworth, R. L., Torpy, D. J., & Falhammar, H. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1807486 · Cited by 262 · see citing works
Hahner, S., Ross, R. J., Arlt, W., Bancos, I., Burger-Stritt, S., Torpy, D. J., Husebye, E. S., & Quinkler, M. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-021-00252-7 · Cited by 223 · see citing works
Management challenges and therapeutic advances in congenital adrenal hyperplasia
Mallappa, A., & Merke, D. P. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00655-w · Cited by 113 · see citing works
Alginate-Encapsulation for the Improved Hypothermic Preservation of Human Adipose-Derived Stem Cells
Swioklo, S., Constantinescu, A. A., & Connon, C. J. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0131 · Cited by 86 · see citing works
Primary adrenal insufficiency in children: Diagnosis and management
Kırkgöz, T., & Güran, T. (2018) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2018.05.010 · Cited by 80 · see citing works
Ruiz-Babot, G., Balyura, M., Hadjidemetriou, I., Ajodha, S. J., Taylor, D. R., Ghataore, L., Taylor, N. F., Schubert, U., Ziegler, C. G., Storr, H. L., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.003 · Cited by 65 · see citing works
Self-citationPhoto-cross-linkable hyaluronic acid bioinks for bone and cartilage tissue engineering applications
Ghorbani, F., Ghalandari, B., Khajehmohammadi, M., Bakhtiary, N., Tolabi, H., Sahranavard, M., Fathi‐karkan, S., Nazar, V., Niar, S. H. N., Armoon, A., et al. (2023) · International Materials Reviews · doi:10.1080/09506608.2023.2167559 · Cited by 63 · see citing works
Isolation and characterization of adrenocortical progenitors involved in the adaptation to stress
Steenblock, C., de Celis, M. F. R., Delgadillo-Silva, L. F., Pawolski, V., Brennand, A., Werdermann, M., Berger, I., Santambrogio, A., Peitzsch, M., Andoniadou, C. L., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1814072115 · Cited by 55 · see citing works
Self-citationYin, N., Han, Y., Xu, H., Gao, Y., Yi, T., Yao, J., Li, D., Cheng, D.-J., & Chen, Z. (2015) · Materials Science and Engineering C · doi:10.1016/j.msec.2015.11.009 · Cited by 52 · see citing works
Kim, J., Hope, C. M., Gantumur, N., Perkins, G. B., Stead, S. O., Yue, Z., Liu, X., Urigoitia-Asua, A., Kette, F. D., Penko, D., et al. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202000544 · Cited by 48 · see citing works
Adrenal crises in older patients
Rushworth, R. L., Torpy, D. J., & Falhammar, H. (2020) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(20)30122-4 · Cited by 47 · see citing works
The promising rise of bioprinting in revolutionalizing medical science: Advances and possibilities
Jamee, R., Araf, Y., Naser, I. B., & Promon, S. K. (2021) · Regenerative Therapy · doi:10.1016/j.reth.2021.05.006 · Cited by 46 · see citing works
Swioklo, S., Ding, P., Pacek, A. W., & Connon, C. J. (2016) · Process Biochemistry · doi:10.1016/j.procbio.2016.06.005 · Cited by 46 · see citing works
Quasi-Periodic Patterns of Neural Activity improve Classification of Alzheimer’s Disease in Mice
Belloy, M. E., Shah, D., Abbas, A., Kashyap, A., Roßner, S., der Linden, A. V., Keilholz, S. D., Keliris, G. A., & Verhoye, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-28237-9 · Cited by 45 · see citing works
Tonnus, W., Gembardt, F., Latk, M., Parmentier, S. P., Hugo, C., Bornstein, S. R., & Linkermann, A. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0193-5 · Cited by 42 · see citing works
Self-citationHia, I. L., Lam, W. H., Chai, S., Chan, E., & Pasbakhsh, P. (2018) · Materials Chemistry and Physics · doi:10.1016/j.matchemphys.2018.05.021 · Cited by 38 · see citing works
Lee, T. Y., Praveenkumar, R., Oh, Y., Lee, K., & Kim, S. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb00580b · Cited by 36 · see citing works
Stress-inducible-stem cells: a new view on endocrine, metabolic and mental disease?
Bornstein, S. R., Steenblock, C., Chrousos, G. P., Schally, A. V., Beuschlein, F., Kline, G. A., Krone, N. P., Licinio, J., Wong, M., Ullmann, E., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0244-9 · Cited by 28 · see citing works
Self-citationNovel treatments for congenital adrenal hyperplasia
Schröder, M. A. M., & der Grinten, H. L. C. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09717-w · Cited by 29 · see citing works
The adrenal gland microenvironment in health, disease and during regeneration
Kanczkowski, W., Sue, M., & Bornstein, S. R. (2017) · HORMONES · doi:10.14310/horm.2002.1744 · Cited by 34 · see citing works
Self-citationBornstein, S. R., Shapiro, I., Malyukov, M., Züllig, R., Luca, E., Gelfgat, E., Beuschlein, F., Nölting, S., Berruti, A., Sigala, S., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05096-x · Cited by 24 · see citing works
Self-citationNew Horizons: Novel Adrenal Regenerative Therapies
Bornstein, S. R., Malyukov, M., Heller, C., Ziegler, C. G., Ruiz-Babot, G., Schedl, A., Ludwig, B., & Steenblock, C. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa438 · Cited by 23 · see citing works
Self-citationFuture Directions for Adrenal Insufficiency: Cellular Transplantation and Genetic Therapies
Graves, L. E., Torpy, D. J., Coates, P. T., Alexander, I. E., Bornstein, S. R., & Clarke, B. M. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac751 · Cited by 22 · see citing works
Self-citationTanaka, T., Aoyagi, C., Mukai, K., Nishimoto, K., Kodama, S., & Yanase, T. (2020) · Endocrinology · doi:10.1210/endocr/bqaa007 · Cited by 20 · see citing works
Scalable fabrication, compartmentalization and applications of living microtissues
Schot, M., Araújo‐Gomes, N., van Loo, B., Kamperman, T., & Leijten, J. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.04.005 · Cited by 20 · see citing works
Recent advances in endocrine organoids for therapeutic application
Jeon, S., Lee, Y.-S., Oh, S. R., Jeong, J., Lee, D., So, K., & Hwang, N. S.-Y. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114959 · Cited by 20 · see citing works
Fath‐Bayati, L., & Ai, J. (2019) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36795 · Cited by 18 · see citing works
Sarafoglou, K., & Auchus, R. J. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae759 · Cited by 16 · see citing works
Local field potentials in the parietal reach region reveal mechanisms of bimanual coordination
Mooshagian, E., Holmes, C. D., & Snyder, L. H. (2021) · Nature Communications · doi:10.1038/s41467-021-22701-3 · Cited by 16 · see citing works
Waheed, A., Mazumder, M. A. J., Al‐Ahmed, A., Roy, P., & Ullah, N. (2019) · Polymers and polymeric composites · doi:10.1007/978-3-319-95990-0_4 · Cited by 15 · see citing works
Natural‐Based Hydrogels: From Processing to Applications
Vieira, S., Morais, A. D. S., Silva‐Correia, J., Oliveira, J. M., & Reis, R. L. (2017) · Encyclopedia of Polymer Science and Technology · doi:10.1002/0471440264.pst652 · Cited by 15 · see citing works
Balyura, M., Gelfgat, E., Steenblock, C., Androutsellis‐Theotokis, A., Ruiz‐Babot, G., Guasti, L., Werdermann, M., Ludwig, B., Bornstein, T. D., Schally, A. V., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194643 · Cited by 14 · see citing works
Self-citation3D bioprinting for the endocrine glands
Gökyürek, M., Yılmaz, K. B., & Huri, P. Y. (2020) · Emergent Materials · doi:10.1007/s42247-020-00085-2 · Cited by 14 · see citing works
Frequency-dependent circuits anchored in the dorsal and ventral left anterior insula
Wang, Y., Zou, Q., Ao, Y., Liu, Y., Ouyang, Y., Wang, X., Biswal, B. B., Cui, Q., & Chen, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-73192-z · Cited by 13 · see citing works
Three Dimensional Cell Culturing for Modeling Adrenal and Pituitary Tumors
Krokker, L., Szabó, B., Németh, K., Tóháti, R., Sarkadi, B., Mészáros, K. V., Patócs, A., & Butz, H. (2021) · Pathology & Oncology Research · doi:10.3389/pore.2021.640676 · Cited by 13 · see citing works
The temporal dedifferentiation of global brain signal fluctuations during human brain ageing
Ao, Y., Kou, J., Yang, C., Wang, Y., Huang, L., Jing, X., Cui, Q., Cai, X., & Chen, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-07578-6 · Cited by 13 · see citing works
Liu, Y., Shi, F., Bo, L., Zhi, W., Weng, J., & Qu, S. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.05.119 · Cited by 11 · see citing works
Towards novel treatments for adrenal diseases: Cell- and gene therapy-based approaches
Mariniello, K., & Guasti, L. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111160 · Cited by 10 · see citing works
Adrenocortical stem cells in health and disease
Chu, Y., Setayesh, J., Dumontet, T., Krumeich, L. N., Werner, J., Moretti, I. F., Sousa, K. D., Kennedy, C., LaPensee, C. R., Lerário, A. M., et al. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01091-2 · Cited by 10 · see citing works
Transplantation of porcine adrenal spheroids for the treatment of adrenal insufficiency
Malyukov, M., Gelfgat, E., Ruiz‐Babot, G., Schmid, J., Lehmann, S., Spinas, G. A., Beuschlein, F., Hantel, C., Reisch, N., Nawroth, P. P., et al. (2023) · Xenotransplantation · doi:10.1111/xen.12819 · Cited by 8 · see citing works
Self-citationCell preservation methods and its application to studying rare disease
Dewhurst, R. M., Molinari, E., & Sayer, J. A. (2021) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2021.101694 · Cited by 8 · see citing works
2.11 Polymers of Biological Origin ☆
Silva, S. S., Fernandes, E. M., Pina, S., Silva‐Correia, J., Vieira, S., Oliveira, J. M., & Reis, R. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803581-8.10134-1 · Cited by 73 · see citing works
Human adrenocortical organoids for tissue regeneration and disease modeling
Li, Q., Li, X., Zhang, Y., Shen, Y., Lu, Z., Chen, W., Liu, Y., Wu, S., Gong, X., Li, X., et al. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102679 · Cited by 7 · see citing works
Development of Advanced Cell-Based Therapy by Regulating Cell–Cell Interactions
Kusamori, K. (2021) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b21-00276 · Cited by 7 · see citing works
3D printed hydrogel scaffold promotes the formation of hormone-active engineered parathyroid tissue
Gökyürek, M., Güler, S., Gökyer, Ş., Yazıhan, N., Akıncı, M., Gülçelik, M. A., Yılmaz, K. B., & Yilgor, P. (2023) · Biomedical Materials · doi:10.1088/1748-605x/acc99d · Cited by 7 · see citing works
Models of Congenital Adrenal Hyperplasia for Gene Therapies Testing
Glazova, O., Bastrich, A., Deviatkin, A. A., Onyanov, N., Kaziakhmedova, S., Shevkova, L., Sakr, N., Petrova, D., Vorontsova, M. V., & Volchkov, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065365 · Cited by 7 · see citing works
Severe hypertension caused by 17α-hydroxylase deficiency: A case report
Zhao, Y., Wang, C., Guo, Z.-H., Yi, C., & Zhang, W. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e14062 · Cited by 7 · see citing works
Current Perspective and Advancements of Alginate-Based Transplantation Technologies
Rodriguez, S., Tuli, R., Wheeler, A., Nguyen, A., Luong, J. C., Mohammadi, R., Alexander, M., & Lakey, J. R. T. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.87120 · Cited by 7 · see citing works
Агапова, О. И., Efimov, А. Е., Мойсенович, М. М., Bogush, V. G., & Agapov, I. I. (2015) · Russian Journal of Transplantology and Artificial Organs · doi:10.15825/1995-1191-2015-2-37-44 · Cited by 6 · see citing works
Clinical features, investigation, and management of Addison's disease
Dong, J., Hahner, S., Bancos, I., & Tomlinson, J. (2026) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(25)00393-6 · Cited by 5 · see citing works
Engineering human renal epithelial cells for transplantation in regenerative medicine.
Manzoli, V., Colter, D., Dhanaraj, S., Fornoni, A., Ricordi, C., Pileggi, A., & Tomei, A. (2017) · Medical Engineering and Physics · doi:10.1016/j.medengphy.2017.03.009 · Cited by 5 · see citing works
Kwon, Y., Choi, K.-B., Lim, H., Lee, S., & Lee, J. (2018) · Japanese Journal of Applied Physics · doi:10.7567/jjap.57.06he03 · Cited by 5 · see citing works
Glucocorticoid replacement therapies: past, present and future
Liew, S.-Y., Akker, S. A., Guasti, L., & Pittaway, J. F. H. (2019) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2019.08.011 · Cited by 6 · see citing works
Steenblock, C., Fliedner, S. M. J., Spinas, G. A., Ofir, R., Kugelmeier, P., Ludwig, B., & Bechmann, N. (2023) · doi:10.37349/eemd.2023.00005 · Cited by 4 · see citing works
Self-citationClarke, B. M., Kireta, S., Johnston, J. K., Christou, C., Greenwood, J., Hurtado, P. R., Manavis, J., Coates, P. T., & Torpy, D. J. (2024) · Endocrinology · doi:10.1210/endocr/bqae086 · Cited by 4 · see citing works
The Application of Alginate Scaffold in Neural Tissue Engineering
Borhani‐Haghighi, M., Razavi, S., & Khosravizadeh, Z. (2017) · The Neuroscience Journal of Shefaye Khatam · doi:10.18869/acadpub.shefa.5.4.76 · Cited by 4 · see citing works
Balyura, M., Gelfgat, E., Ullmann, E., Ludwig, B., Barnea, E. R., & Bornstein, S. R. (2017) · Hormone and Metabolic Research · doi:10.1055/s-0043-120064 · Cited by 4 · see citing works
Self-citationFunctional Restoration of Pituitary after Pituitary Allotransplantation into Hypophysectomized Rats
Choi, J. H., Lee, J. E., Kim, H.-L., Ko, S., Kim, S. H., & Yang, S.-H. (2021) · Cells · doi:10.3390/cells10020267 · Cited by 3 · see citing works
Isolation and characterization of adrenocortical progenitors involved in the adaptation to stress
Steenblock, C., de Celis, M. F. R., Delgadillo Silva, L. F., Pawolski, V., Brennand, A., Werdermann, M., Berger, I., Santambrogio, A., Peitzsch, M., Andoniadou, C. L., et al. (2019) · Yearbook of pediatric endocrinology · doi:10.1530/ey.16.8.2 · Cited by 3 · see citing works
Self-citationIn Vivo Engraftment and Functional Efficacy of a 3D-Bioprinted Human Parathyroid Equivalent
Güler, S., Gökyer, Ş., Öztürk, S. C., Çelik, E., Yanık, H., Bahçecioğlu, İ. B., Gülçelik, M. A., Huri, P. Y., & YILMAZ, K. B. (2026) · Medicina · doi:10.3390/medicina62030442 · Cited by 2 · see citing works
Approach to the Child and Adolescent With Adrenal Insufficiency
Patti, G., Zucconi, A., Matarese, S., Tedesco, C., Panciroli, M., Napoli, F., Iorgi, N. D., & Maghnie, M. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae564 · Cited by 3 · see citing works
Застосування стовбурових клітин в ендокринології: проблеми і перспективи
Tronko, M. D., Ковзун, О. І., & Pushkarev, V. M. (2021) · Endokrynologia · doi:10.31793/1680-1466.2021.26-4.376 · Cited by 2 · see citing works
Gene and cell therapy of adrenal pathology: achievements and prospects
Glazova, O., Vorontsova, M. V., Sakr, N., Shevkova, L., Onyanov, N., Kaziakhmedova, S., & Volchkov, P. (2021) · Problems of Endocrinology · doi:10.14341/probl12818 · Cited by 1 · see citing works
Ruiz‐Babot, G., Balyura, M., Hadjidemetriou, I., Ajodha, S. J., Taylor, D. R., Ghataore, L., Taylor, N., Schubert, U., Ziegler, C. G., Storr, H. L., et al. (2018) · Yearbook of pediatric endocrinology · doi:10.1530/ey.15.8.14 · Cited by 1 · see citing works
Self-citationNatural-Based Hydrogels: From Processing to Applications: NATURAL-BASED HYDROGELS
Vieira, S., Morais, A. D. S., Silva‐Correia, J., Oliveira, J. M., & Reis, R. L. (2017) · Cited by 1 · see citing works
New Horizons: Novel adrenal regenerative therapies
Bornstein, S. R., Malyukov, M., Heller, C., Ziegler, C. G., Ruiz‐Babot, G., Schedl, A., Ludwig, B., & Steenblock, C. (2021) · Yearbook of pediatric endocrinology · doi:10.1530/ey.18.8.11 · Cited by 1 · see citing works
Self-citationWaheed, A., Mazumder, M. A. J., Al‐Ahmed, A., Roy, P., & Ullah, N. (2018) · Polymers and polymeric composites · doi:10.1007/978-3-319-92066-5_4-1
Cerebral Oxygenation Dynamics in Awake Behaving Mice
Zhang, Q., Roche, M., Gheres, K. W., Chaigneau, E. M., Haselden, W. D., Kedarasetti, R. T., Charpak, S., & Drew, P. J. (2022) · Optics in the Life Sciences · doi:10.1364/translational.2022.jm3a.67
Duin, S., Lode, A., Ludwig, B., & Gelinsky, M. (2022) · Royal Society of Chemistry eBooks · doi:10.1039/9781839165498-00233
Self-citation(2024) · Hormone and Metabolic Research · doi:10.1055/a-2452-0604
de la Perrière, A. B., & Martinerie, L. (2026) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/j.banm.2026.01.004
Engineering next-generation in vitro platforms for endocrine disruptor testing via bioprinting
Sana, M., Mota, C., & Moroni, L. (2026) · Precision medicine and engineering. · doi:10.1016/j.preme.2026.100071
Stem cell strategies for cell replacement therapy in endocrine diseases
Mi, C., Xie, C., Tang, J., Gao, Y., Zhang, J., Yang, Y., Tan, G., Zheng, C., & Liu, H. (2026) · Cell Transplantation · doi:10.1177/09636897261486242
- Authors
- Balyura, M., Gelfgat, E., Ehrhart-Bornstein, M., Ludwig, B., Gendler, Z., Barkai, U., Zimerman, B., Rotem, A., Block, N. L., Schally, A. V., & Bornstein, S. R.
- Affiliations
- University Hospital Carl Gustav Carus (DE)
- University Hospital Carl Gustav Carus, Department of Medicine III and
- Beta-O2 Technologies (Israel) (IL)
- University of Miami (US)
- King's College London (GB)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-02-09
- Volume
- 112
- Issue
- 8
- Pages
- 2527-2532
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4345555
- OpenAlex
- W2110990511
- Cited by
- 77
- References
- 36
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 5 · 2023: 8 · 2022: 7 · 2021: 11 · 2020: 6 · 2019: 6 · 2018: 11 · 2017: 10 · 2016: 4 · 2015: 2
- FWCI
- 7.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Site cant be reached (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (KFO 252, SFB-TRR 127)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- adrenal insufficiency, alginate encapsulation, hypothalamic-pituitary-adrenal axis, ACTH stimulation test, GnRH agonist, cortisol secretion, immunocompetent rats, 3D cell culture, cell survival
- MeSH terms
- Adrenal Cortex, Alginates, Animals, Cattle, Cell Survival, Cells, Cultured, Female, Glucocorticoids, Hexuronic Acids, Rats, Nude, Time Factors, Tretinoin, Reproducibility of Results, Rats, Wistar, Triptorelin Pamoate, Cells, Immobilized, Hormone Replacement Therapy, Glucuronic Acid, Bioartificial Organs
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