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Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients

Porter, Peggy L., Malone, Kathleen E., Heagerty, Patrick J., Alexander, Gail M., Gatti, Laura A., Firpo, Eduardo J., Daling, Janet R., Roberts, James M.·1997·Nature Medicine

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Research works printed but not linked: 20

  1. Clurman, B. & Roberts, J. cellcycle and cancer. J. Natl. Cancer Inst. 87, 1499–1501 (1995). · DOI
  2. Pietenpol, J. et al. Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias. Cancer Res. 55, 1206–1210 (1995).
  3. Ponce-Castaneda, M. et al. p27Kip1: Chromosomal mapping to 12p12–l2p13 and absence of mutations in human tumors. Cancer Res. 55, 1211–1214 (1995).
  4. Konstantin, S. et al. p27/Kip1 mutation found in breast cancer. Cancer Res. 56, 2400–2404 (1996).
  5. Leach, F. et al. Amplification of cyclin genes in colorectal carcinomas. Cancer Res. 53, 1986–1989 (1993).
  6. Keyomarsi, K. et al. Cyclin E, a potential prognostic marker for breast cancer. Cancer Res. 54, 380–385 (1994).
  7. Said, T. & Medina, D. Cell cyclins and cyclin-dependent kinase activities in mouse mammary tumor development. Carcinogenesls 16, 823–830 (1995). · DOI
  8. Fero, M.L. et al. A syndrome of multi-organ hyperplasia with features of gigantism, tumorigenesis and female sterility in p27Kip1–deficient mice. Cell 85, 733–744 (1996). · DOI · Paper page
  9. Clurman, B., Sheaff, R., Thress, K., Groudine, M. & Roberts, J. Turnover of cyclin E by the ubiquitin-proteosome pathway is regulated by CDK2 binding and cyclin phosphorylation. Genes Dev. 10, 1979–1990 (1996). · DOI · Paper page
  10. Pagano, M. et al. Role of the ubiquitin-proteosome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 269, 682–685 (1995). · DOI · Paper page
  11. Dulic, V., Lees, E. & Reed, S. Association of human cyclin E with a periodic G1–S phase protein kinase. Science 257, 1958–1961 (1992). · DOI · Paper page
  12. Koff, A. et al. Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family. Cell 66, 1217–1228 (1991). · DOI · Paper page
  13. Nourse, J. et al. lnterleukin-2-mediated elimination of p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372, 570–573 (1994). · DOI · Paper page
  14. Coats, S., Flannagan, W., Nourse, J. & Roberts, J. Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle. Science 272, 877–880 (1996). · DOI · Paper page
  15. McGuire, W. & Clark, G. Prognostic factors and treatment decisions in axillarynode negative breast cancer. N. Engl. J. Med. 326, 1756–1761 (1992). · DOI · Paper page
  16. Dutta, A., Chandra, R., Leiter, L. & Lester, S. Cyclins as markers of tumor proliferation: Immunocytochemical studies in breast cancer. Proc. Natl. Acad. Sci. USA 92, 5386–5390 (1995). · DOI · Paper page
  17. Ohtsubo, M., Theodoras, A., Schumacher, J., Roberts, J. & Pagano, M. Human cyclin E, a nuclear protein essential for the Gl-to-S phase transition. Mol. Cell. Biol. 15, 2612–2624 (1995). · DOI · Paper page
  18. Ohtsubo, M. & Roberts, J. Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science 259, 1908–1912 (1993). · DOI · Paper page
  19. Gerdes, J., Becker, M. & Key, G. Immunohistological detection of tumour growth fraction (Ki-67 antigen) in formalin-fixed and routinely processed tissues J. Pathol. 168, 85–86 (1992). · DOI · Paper page
  20. Lin, D. & Ying, Z. Cox regression with incomplete covariate measurements. J. Am. Statist. Assoc. 88, 1341–1349 (1993). · DOI · Paper page

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Metadata

Authors
Porter, P. L., Malone, K. E., Heagerty, P. J., Alexander, G. M., Gatti, L. A., Firpo, E. J., Daling, J. R., & Roberts, J. M.
Venue
Nature Medicine
Published
1997-02
Volume
3
Issue
2
Pages
222-225
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
OpenAlex
W1971254046
Cited by
901
References
0
FWCI
38.81
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)

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CoChat. (2026). Citation check: Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. https://app.cochat.ai/papers/10.1038/nm0297-222
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Porter, P. L., Malone, K. E., Heagerty, P. J., Alexander, G. M., Gatti, L. A., Firpo, E. J., Daling, J. R., & Roberts, J. M. (1997). Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. Nature Medicine. https://doi.org/10.1038/nm0297-222

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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