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Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
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Research works printed but not linked: 20
- Clurman, B. & Roberts, J. cellcycle and cancer. J. Natl. Cancer Inst. 87, 1499–1501 (1995). · DOI
- Pietenpol, J. et al. Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias. Cancer Res. 55, 1206–1210 (1995).
- Ponce-Castaneda, M. et al. p27Kip1: Chromosomal mapping to 12p12–l2p13 and absence of mutations in human tumors. Cancer Res. 55, 1211–1214 (1995).
- Konstantin, S. et al. p27/Kip1 mutation found in breast cancer. Cancer Res. 56, 2400–2404 (1996).
- Leach, F. et al. Amplification of cyclin genes in colorectal carcinomas. Cancer Res. 53, 1986–1989 (1993).
- Keyomarsi, K. et al. Cyclin E, a potential prognostic marker for breast cancer. Cancer Res. 54, 380–385 (1994).
- Said, T. & Medina, D. Cell cyclins and cyclin-dependent kinase activities in mouse mammary tumor development. Carcinogenesls 16, 823–830 (1995). · DOI
- Fero, M.L. et al. A syndrome of multi-organ hyperplasia with features of gigantism, tumorigenesis and female sterility in p27Kip1–deficient mice. Cell 85, 733–744 (1996). · DOI · Paper page
- Clurman, B., Sheaff, R., Thress, K., Groudine, M. & Roberts, J. Turnover of cyclin E by the ubiquitin-proteosome pathway is regulated by CDK2 binding and cyclin phosphorylation. Genes Dev. 10, 1979–1990 (1996). · DOI · Paper page
- Pagano, M. et al. Role of the ubiquitin-proteosome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 269, 682–685 (1995). · DOI · Paper page
- Dulic, V., Lees, E. & Reed, S. Association of human cyclin E with a periodic G1–S phase protein kinase. Science 257, 1958–1961 (1992). · DOI · Paper page
- Koff, A. et al. Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family. Cell 66, 1217–1228 (1991). · DOI · Paper page
- Nourse, J. et al. lnterleukin-2-mediated elimination of p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372, 570–573 (1994). · DOI · Paper page
- Coats, S., Flannagan, W., Nourse, J. & Roberts, J. Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle. Science 272, 877–880 (1996). · DOI · Paper page
- McGuire, W. & Clark, G. Prognostic factors and treatment decisions in axillarynode negative breast cancer. N. Engl. J. Med. 326, 1756–1761 (1992). · DOI · Paper page
- Dutta, A., Chandra, R., Leiter, L. & Lester, S. Cyclins as markers of tumor proliferation: Immunocytochemical studies in breast cancer. Proc. Natl. Acad. Sci. USA 92, 5386–5390 (1995). · DOI · Paper page
- Ohtsubo, M., Theodoras, A., Schumacher, J., Roberts, J. & Pagano, M. Human cyclin E, a nuclear protein essential for the Gl-to-S phase transition. Mol. Cell. Biol. 15, 2612–2624 (1995). · DOI · Paper page
- Ohtsubo, M. & Roberts, J. Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science 259, 1908–1912 (1993). · DOI · Paper page
- Gerdes, J., Becker, M. & Key, G. Immunohistological detection of tumour growth fraction (Ki-67 antigen) in formalin-fixed and routinely processed tissues J. Pathol. 168, 85–86 (1992). · DOI · Paper page
- Lin, D. & Ying, Z. Cox regression with incomplete covariate measurements. J. Am. Statist. Assoc. 88, 1341–1349 (1993). · DOI · Paper page
Cited by
CDK inhibitors: positive and negative regulators of G1-phase progression
Sherr, C. J., & Roberts, J. M. (1999) · Genes & Development · doi:10.1101/gad.13.12.1501 · Cited by 6,115
Self-citationThe RB and p53 pathways in cancer
Sherr, C. J., & McCormick, F. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00102-2 · Cited by 1,690
Cyclin-Dependent Kinase Pathways As Targets for Cancer Treatment
Shapiro, G. I. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.03.7689 · Cited by 1,036
The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy
Chu, I. M., Hengst, L., & Slingerland, J. M. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2347 · Cited by 990
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
Hartwell, L. H., Szankasi, P., Roberts, C. J., Murray, A. W., & Friend, S. H. (1997) · Science · doi:10.1126/science.278.5340.1064 · Cited by 773
Metadata
- Authors
- Porter, P. L., Malone, K. E., Heagerty, P. J., Alexander, G. M., Gatti, L. A., Firpo, E. J., Daling, J. R., & Roberts, J. M.
- Venue
- Nature Medicine
- Published
- 1997-02
- Volume
- 3
- Issue
- 2
- Pages
- 222-225
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1971254046
- Cited by
- 901
- References
- 0
- FWCI
- 38.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
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- This page
- CoChat. (2026). Citation check: Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. https://app.cochat.ai/papers/10.1038/nm0297-222
- The paper
- Porter, P. L., Malone, K. E., Heagerty, P. J., Alexander, G. M., Gatti, L. A., Firpo, E. J., Daling, J. R., & Roberts, J. M. (1997). Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. Nature Medicine. https://doi.org/10.1038/nm0297-222
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.