Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue

Yamada, Kazuhiko, Yazawa, Koji, Shimizu, Akira, Iwanaga, Takehiro, Hisashi, Yosuke, Nuhn, Matthew, O'Malley, Patricia, Nobori, Shuji, Vagefi, Parsia A, Patience, Clive, Fishman, Jay, Cooper, David K C, Hawley, Robert J, Greenstein, Julia, Schuurman, Henk-Jan, Awwad, Michel, Sykes, Megan, Sachs, David H·2005·Nature Medicine

DOI 10.1038/nm1172

Open this paper in CoChat — free account

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nm1172

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Results of Two Cases of Pig-to-Human Kidney Xenotransplantation
Montgomery, R. A., Stern, J. M., Lonze, B. E., Tatapudi, V. S., Mangiola, M., Wu, M., Weldon, E., Lawson, N., Deterville, C., Dieter, R. A., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmoa2120238 · Cited by 508
First clinical-grade porcine kidney xenotransplant using a human decedent model
Porrett, P. M., Orandi, B. J., Kumar, V., Houp, J., Anderson, D., Cozette Killian, A., Hauptfeld-Dolejsek, V., Martin, D. E., Macedon, S., Budd, N., et al. (2022) · American Journal of Transplantation · doi:10.1111/ajt.16930 · Cited by 417
The Galα1,3Galβ1,4GlcNAc-R (α-Gal) epitope: A carbohydrate of unique evolution and clinical relevance
Macher, B. A., & Galili, U. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2007.11.003 · Cited by 404
Human hepatocyte transplantation: current experience and future challenges
Dhawan, A., Puppi, J., Hughes, R. D., & Mitry, R. R. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.44 · Cited by 362
Immunogenicity in xenogeneic scaffold generation: Antigen removal vs. decellularization
Wong, M. L., & Griffiths, L. G. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.01.028 · Cited by 254
Anti‐Gal: an abundant human natural antibody of multiple pathogeneses and clinical benefits
Galili, U. (2013) · Immunology · doi:10.1111/imm.12110 · Cited by 225
Infection Barriers to Successful Xenotransplantation Focusing on Porcine Endogenous Retroviruses
Denner, J., & Tönjes, R. R. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.05011-11 · Cited by 208
Immunological and physiological observations in baboons with life‐supporting genetically engineered pig kidney grafts
Iwase, H., Hara, H., Ezzelarab, M., Li, T., Zhang, Z., Gao, B., Liu, H., Long, C., Wang, Y., Cassano, A., et al. (2017) · Xenotransplantation · doi:10.1111/xen.12293 · Cited by 204
Self-citation
Transplanting organs from pigs to humans
Sykes, M., & Sachs, D. H. (2019) · Science Immunology · doi:10.1126/sciimmunol.aau6298 · Cited by 191
Self-citation
Towards the creation of decellularized organ constructs using irreversible electroporation and active mechanical perfusion
Sano, M. B., Neal, R. E., Garcia, P. A., Gerber, D., Robertson, J., & Davalos, R. V. (2010) · BioMedical Engineering OnLine · doi:10.1186/1475-925x-9-83 · Cited by 117
Reduced Binding of Human Antibodies to Cells From GGTA1/CMAH KO Pigs
Burlak, C., Paris, L. L., Lutz, A. J., Sidner, R. A., Estrada, J., Li, P., Tector, M., & Tector, A. J. (2014) · American Journal of Transplantation · doi:10.1111/ajt.12744 · Cited by 87
Evaluation of the host immune response to decellularized lung scaffolds derived from α-Gal knockout pigs in a non-human primate model
Stahl, E. C., Bonvillain, R. W., Skillen, C. D., Burger, B. L., Hara, H., Lee, W., Trygg, C. B., Didier, P. J., Grasperge, B. F., Pashos, N. C., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.09.038 · Cited by 72
Anti-Neu5Gc and anti-non-Neu5Gc antibodies in healthy humans
Gao, B., Long, C., Lee, W., Zhang, Z., Gao, X., Landsittel, D., Ezzelarab, M., Ayares, D., Huang, Y., Cooper, D. K. C., et al. (2017) · PLOS ONE · doi:10.1371/journal.pone.0180768 · Cited by 58
Self-citation
Progress in Xenotransplantation: Immunologic Barriers, Advances in Gene Editing, and Successful Tolerance Induction Strategies in Pig-To-Primate Transplantation
Eisenson, D. L., Hisadome, Y., & Yamada, K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.899657 · Cited by 55
Self-citation
Cellular dynamics in pig-to-human kidney xenotransplantation
Pan, W., Zhang, W., Zheng, B., Camellato, B. R., Stern, J., Lin, Z., Khodadadi-Jamayran, A., Kim, J., Sommer, P., Khalil, K., et al. (2024) · Med · doi:10.1016/j.medj.2024.05.003 · Cited by 46
Modifying the sugar icing on the transplantation cake
Cooper, D. K. C. (2016) · Glycobiology · doi:10.1093/glycob/cww028 · Cited by 36
Self-citation
Models of immunogenicity in preclinical assessment of tissue engineered heart valves
Ground, M., Waqanivavalagi, S., Walker, R., Milsom, P., & Cornish, J. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.05.049 · Cited by 31
Quantification of α-Gal Antigen Removal in the Porcine Dermal Tissue by α-Galactosidase
Gao, H.-W., Li, S.-B., Sun, W. Q., Yun, Z.-M., Zhang, X., Song, J.-W., Zhang, S.-K., Leng, L., Ji, S.-P., Tan, Y.-X., et al. (2015) · Tissue Engineering Part C: Methods · doi:10.1089/ten.tec.2015.0129 · Cited by 23

Authors: Yamada, K., Yazawa, K., Shimizu, A., Iwanaga, T., Hisashi, Y., Nuhn, M., O'Malley, P., Nobori, S., Vagefi, P. A., Patience, C., Fishman, J., Cooper, D. K. C., Hawley, R. J., Greenstein, J., Schuurman, H.-J., Awwad, M., Sykes, M., & Sachs, D. H.
Venue: Nature Medicine
Publisher: Springer Science and Business Media LLC
Published: 2004-12-26
Volume: 11
Issue: 1
Pages: 32-34
ISSN: 1078-8956 (ISSN-L)
1546-170X
DOI: 10.1038/nm1172
OpenAlex: W2085878243
Cited by: 610
References: 0
FWCI: 44.83
Type: journal article
Language: en
Open access: closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review