The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway

Haass, Christian, Lemere, Cynthia A., Capell, Anja, Citron, Martin, Seubert, Peter, Schenk, Dale, Lannfelt, Lars, Selkoe, Dennis J.·1995·Nature Medicine

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Items 301–400 of 598

  1. Impact of Age on the Cerebrovascular Proteomes of Wild-Type and Tg-SwDI Mice
    James L. Searcy, Thierry Le Bihan, Natalia Salvadores, James McCulloch, Karen J. Horsburgh · 2014 · PLoS ONE
  2. Post‐translational processing of beta‐secretase in Alzheimer's disease
    Christina Sidera, Richard B. Parsons, Brian Austen · 2005 · PROTEOMICS
  3. A mechanism for β‐amyloid overproduction in Alzheimer's disease: precursor‐independent generation of β‐amyloid via antisense RNA‐primed mRNA synthesis
    Vladimir Volloch · 1996 · FEBS Letters
  4. An APP ectodomain mutation outside of the Aβ domain promotes Aβ production in vitro and deposition in vivo
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  5. Role of BRI2 in Dementia
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  6. Fragile X mental retardation protein expression in Alzheimer’s disease
    Abigail J. Renoux, Nicholas M. Carducci, Arya A. Ahmady, Peter K. Todd · 2014 · Frontiers in Genetics
  7. Amyloid-β Precursor Protein Modulates the Sorting of Testican-1 and Contributes to Its Accumulation in Brain Tissue and Cerebrospinal Fluid from Patients with Alzheimer Disease
    Alvaro A. Barrera-Ocampo, Sönke Arlt, Jakob Matschke, Ursula Hartmann, Berta Puig, Isidró Ferrer, Petra Zürbig, Markus Glatzel, Diego Sepúlveda Falla, Holger Jahn · 2016 · Journal of Neuropathology & Experimental Neurology
  8. Selenoprotein S is required for clearance of C99 through endoplasmic reticulum-associated degradation
    Jun Ki Jang, Ki Jun Park, Jea Hwang Lee, Kwan Young Ko, Seongman Kang, Ick Young Kim · 2017 · Biochemical and Biophysical Research Communications
  9. Alzheimer’s Disease is Driven by Intraneuronally Retained Beta-Amyloid Produced in the AD-Specific, βAPP-Independent Pathway: Current Perspective and Experimental Models for Tomorrow
    Vladimir Volloch, Bjorn Reino Olsen, Sophia Rits‐Volloch · 2019 · Annals of Integrative Molecular Medicine
  10. Glycosaminoglycan‐induced activation of the β‐secretase (BACE1) of Alzheimer’s disease
    David William Klaver, Matthew C. J. Wilce, Robert Gasperini, Craig G. Freeman, John Paul Juliano, Christopher Richard Parish, Lisa C Foa, Marie‐Isabel Aguilar, David Henry Small · 2010 · Journal of Neurochemistry
  11. Regulation of Heparan Sulfate 6-O-Sulfation by β-Secretase Activity
    Naoko Nagai, Hiroko Habuchi, Shinobu Kitazume, Hidenao Toyoda, Yasuhiro Hashimoto, Koji Kimata · 2007 · Journal of Biological Chemistry
  12. Neurotoxic Traffic: Uncovering the Mechanics of Amyloid Production in Alzheimer's Disease
    Jason T. Huse, Robert W. Doms · 2001 · Traffic
  13. Protein kinase C and amyloid precursor protein processing in skin fibroblasts from sporadic and familial Alzheimer’s disease cases
    Monika Vestling, Ángel Cedazo-Mı́nguez, Abdu Adem, Birgitta Wiehager, Marco Racchi, Lars Lannfelt, Richard F. Cowburn · 1999 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  14. Aβ Assemblies Promote Amyloidogenic Processing of APP and Intracellular Accumulation of Aβ42 Through Go/Gβγ Signaling
    Magdalena Antonino, Paula Marmo, Carlos Leandro Freites, Gonzalo Quassollo, M. Florencia Sánchez, Alfredo Lorenzo, Elena Anahí Bignante · 2022 · Frontiers in Cell and Developmental Biology
  15. Effect of Apigenin on Neurodegenerative Diseases
    Kajal Gaur, Yasir Hasan Siddique · 2023 · CNS & Neurological Disorders - Drug Targets
  16. Amyloid beta peptides (Aβ) from Alzheimer's disease neuronal secretome induce endothelial activation in a human cerebral microvessel model
    Yu Jung Shin, Kira M. Evitts, Solhee Jin, Caitlin C. Howard, Margaret Sharp-Milgrom, Tiara A. Schwarze‐Taufiq, Chizuru Kinoshita, Jessica E. Young, Ying Yi Zheng · 2023 · Neurobiology of Disease
  17. Characterization of β-secretase inhibitory peptide purified from skate skin protein hydrolysate
    Jung Kwon Lee, Eunice C.Y. Li‐Chan, Hee‐Guk Byun · 2014 · European Food Research and Technology
  18. Alzheimer's disease genetic mutation evokes ultrastructural alterations: Correlation to an intracellular Aβ deposition and the level of GSK-3β-P(Y216) phosphorylated form
    Beata Pająk, Martyna Songin, Joanna Benigna Strosznajder, B Gajkowska · 2009 · NeuroToxicology
  19. Biochemical and kinetic characterization of BACE1: investigation into the putative species‐specificity for β‐ and β′‐cleavage sites by human and murine BACE1
    Hsiu‐Chiung Yang, Xiyun Chai, Marian K. Mosior, Wayne D. Kohn, Leonard N. Boggs, Jon A. Erickson, Don B. McClure, Wu‐Kuang Yeh, Lianshen Zhang, Patricia A. Gonzalez‐DeWhitt et al. · 2004 · Journal of Neurochemistry
  20. Novel α-secretase cleavage of Alzheimer's amyloid β precursor protein in the endoplasmic reticulum of COS7 cells
    Ryong‐Woon Shin, Takaomi C. Saido, Masahiro Maeda, Tetsuyuki Kitamoto · 2004 · Neuroscience Letters
  21. Progressive excitability changes in the medial entorhinal cortex in the 3xTg mouse model of Alzheimer’s disease pathology
    Chen, Lingxuan, Christenson Wick, Zoé, Vetere, Lauren M., Vaughan, Nick, Jurkowski, Albert, Galas, Angelina, Diego, Keziah S., Philipsberg, Paul A., Soler, Ivan, Feng, Yu et al. · 2023 · The Journal of Neuroscience
  22. Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models
    Rebekka Wittrahm, Mari Takalo, Teemu Kuulasmaa, Petra M. Mäkinen, Petri Mäkinen, Saša Končarević, Vadim Fartzdinov, Stefan Selzer, Tarja Kokkola, Leila Antikainen et al. · 2023 · Neurobiology of Disease
  23. EXPRESSION OF CONCERN: Novel proline endopeptidase inhibitors do not modify Aβ40/42 formation and degradation by human cells expressing wild‐type and Swedish mutated β‐amyloid precursor protein
    Agnès Petit-Paitel, Hélène Barelli, Philippe Morain, Frédéric Checler · 2000 · British Journal of Pharmacology
  24. Regulation of amyloid-β production by the prion protein
    Heledd Jarosz-Griffiths, Isobel J. Whitehouse, Nigel M. Hooper · 2012 · Prion
  25. Alzheimer's α‐secretase may be a calcium‐dependent protease
    Ming Chen · 1997 · FEBS Letters
  26. Intracellular site of γ‐secretase cleavage for Aβ42 generation in Neuro 2a cells harbouring a presenilin 1 mutation
    Shinji Sudoh, Gang Hua, Yuuki Kawamura, Kei Maruyama, Hiroto Komano, Katsuhiko Yanagisawa · 2000 · European Journal of Biochemistry
  27. Possible Mechanism for Resistance to Alzheimer's Disease (AD) in Mice Suggests a New Approach to Generate a Mouse Model for Sporadic AD and May Explain Familial Resistance to AD in Man
    Vladimir Volloch · 1997 · Experimental Neurology
  28. Differential effects of familial Alzheimer’s disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity
    Sandra Schilling, Ajay Pradhan, Amelie Heesch, Andrea Helbig, Kaj Blennow, Christian Koch, Lea Bertgen, Edward H. Koo, Gunnar Brinkmalm, Henrik Zetterberg et al. · 2023 · Acta Neuropathologica Communications
  29. Common defects of mitochondria and iron in neurodegeneration and diabetes (MIND): A paradigm worth exploring
    Matthew A. Stroh, Russell Howard Swerdlow, Hao Zhu · 2013 · Biochemical Pharmacology
  30. Loss of thioredoxin function in retinas of mice overexpressing amyloid β
    Folami Lamoke, Guido Ripandelli, Scott J. Webster, Anna Lisa Montemari, AnnaMaria Maraschi, Pamela Moore Martin, Dennis M. Marcus, Gregory I. Liou, Manuela Bartoli · 2012 · Free Radical Biology and Medicine
  31. Evidence of a Novel Mechanism for Partial γ-Secretase Inhibition Induced Paradoxical Increase in Secreted Amyloid β Protein
    E. Barnwell, V. Padmaraju, R. Baranello, Javier Pacheco-Quinto, C. Crosson, Z. Ablonczy, E. Eckman, C. Eckman, V. Ramakrishnan, N. Greig et al. · 2014 · PLoS ONE
  32. Dopamine induces apoptosis in APPswe-expressing Neuro2A cells following Pepstatin-sensitive proteolysis of APP in acid compartments
    Monica Cagnin, Matteo Ozzano, Natascia Bellio, Ilaria Fiorentino, Carlo Follo, Ciro Isidoro · 2012 · Brain Research
  33. The molecular significance of amyloid β-peptide for Alzheimer's disease
    Christian Haass · 1996 · European Archives of Psychiatry and Clinical Neuroscience
  34. Alzheimer’s disease basics: we all should know
    S.K. Das · 2025 · Neurological Research
  35. Multiomic prediction of therapeutic targets for human diseases associated with protein phase separation
    Christine Maria Lim, Alicia González Díaz, Mónika Fuxreiter, Frank W. Pun, Alex A. Zhavoronkov, Michele Vendruscolo · 2023 · Proceedings of the National Academy of Sciences
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    Helen M Collins, Susan Adele Greenfield · 2024 · International Journal of Molecular Sciences
  37. Potential Therapeutic Implications of Gelsolin in Alzheimer's Disease
    Lina Ji, Xi Zhao, Zichun Hua · 2015 · Journal of Alzheimer s Disease
  38. Molecular Pathology of Alzheimer's Disease
    Rudy J. Castellani, George L. Perry · 2013 · Colloquium Series on Neurobiology of Alzheimer s Disease
  39. 8-Tetrahydropyran-2-yl Chromans: Highly Selective Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors
    Allen A. Thomas, Kevin W. Hunt, Brad Newhouse, Ryan J. Watts, Xingrong Liu, Guy P. A. Vigers, Darin J. Smith, Susan P. Rhodes, Karin D. Brown, Jennifer N. Otten et al. · 2014 · Journal of Medicinal Chemistry
  40. Allosteric sodium binding cavity in GPR3: a novel player in modulation of Aβ production
    Stefano Capaldi, Eda Suku, Martina Antolini, Mattia Di Giacobbe, Alejandro Giorgetti, Mario Buffelli · 2018 · Scientific Reports
  41. AD “Statin”: Alzheimer’s Disorder is a “Fast” Disease Preventable by Therapeutic Intervention Initiated Even Late in Life and Reversible at the Early Stages
    Vladimir Volloch, Bjorn Reino Olsen, Sophia Rits‐Volloch · 2019 · Annals of Integrative Molecular Medicine
  42. Protein-Encoding RNA to RNA Information Transfer in Mammalian Cells: RNA-dependent mRNA Amplification. Identification of Chimeric RNA Intermediates and Putative RNA End Products
    Vladimir Volloch, Sophia Rits‐Volloch, Bjorn Reino Olsen · 2019 · Annals of Integrative Molecular Medicine
  43. The Impact of the hAPP695 SW Transgene and Associated Amyloid-β Accumulation on Murine Hippocampal Biochemical Pathways
    Mona Khorani, Gerd Bobe, Donald G. Matthews, Armando Alcázar Magaña, Maya A. Caruso, Nora E. Gray, Joseph F. Quinn, Jan Frederik Stevens, Amala Soumyanath, Claudia S. Maier · 2021 · Journal of Alzheimer s Disease
  44. FAD Mutations in Amyloid Precursor Protein Do Not Directly Perturb Intracellular Calcium Homeostasis
    Emily S. Stieren, Walter P. Werchan, Amina El Ayadi, Fuzhen Li, Darren F. Boehning · 2010 · PLoS ONE
  45. Concept of Disease in Geriatric Psychiatry
    Kousik Krishnan · 2006 · American Journal of Geriatric Psychiatry
  46. The Amyloid β Protein
    Noel D. Lazo, Samir Kumar Maji, Erica A. Fradinger, Gal Bitan, David B. Teplow · 2005 · Wiley eBooks
  47. Protein-Encoding RNA-to-RNA Information Transfer in Mammalian Cells: Principles of RNA-Dependent mRNA Amplification
    Vladimir Volloch · 2019 · Annals of Integrative Molecular Medicine
  48. MT5‐MMP controls APP and β‐CTF/C99 metabolism through proteolytic‐dependent and ‐independent mechanisms relevant for Alzheimer's disease
    Laura García‐González, Jean‐Michel Paumier, Laurence Louis, Dominika Piłat, Anne Bernard, Delphine Stephan, Nicolas Jullien, Frédéric Checler, Emmanuel Nivet, Michel Khrestchatisky et al. · 2021 · The FASEB Journal
  49. Comparison of Pharmacological Modulation of APP Metabolism in Primary Chicken Telencephalic Neurons and in a Human Neuroglioma Cell Line
    Stefan Czvitkovich, Stephan Duller, Else Mathiesen, Klaus Lorenzoni, Bruno Pietro Imbimbo, Birgit Hutter‐Paier, Manfred Windisch, Robert Wronski · 2010 · Journal of Molecular Neuroscience
  50. Intracellular and cell-surface distribution of amyloid precursor protein in cortical astrocytes
    Michael J. Young, Robert K. K. Lee, Sonal Jhaveri, Richard Jay Wurtman · 1999 · Brain Research Bulletin
  51. Secretases as targets for drug design in Alzheimer’s disease
    J. V. R. B. Hendriksen, Hans S.L.M. Nottet, Hessel A. Smits · 2002 · European Journal of Clinical Investigation
  52. Lexikon der Syndrome und Fehlbildungen
    Regine Witköwski, Otto Prokop, Eva Ullrich · 1999 · Springer eBooks
  53. Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence
    Jin‐Xiu Pan, Dong Sun, Daehoon Lee, Lei Xiong, Xiao Ren, Hao-Han Guo, Lingling Yao, Yuyi Lu, Caroline Jung, Wen‐Cheng Xiong · 2021 · Communications Biology
  54. Spatial–Temporal Mapping Reveals the Golgi as the Major Processing Site for the Pathogenic Swedish APP Mutation: Familial APP Mutant Shifts the Major APP Processing Site
    Jingqi Wang, Paul A. Gleeson, Lou Fourrière · 2024 · Traffic
  55. Towards a Unitary Hypothesis of Alzheimer’s Disease Pathogenesis
    E. Area-Gómez, E. Schon · 2024 · Journal of Alzheimer's Disease
  56. Assessing the Retinal Microvasculature in Individuals With Early and Late-Onset Alzheimer's Disease
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  57. Visualization of β-secretase cleavage in living cells using a genetically encoded surface-displayed FRET probe
    Jinling Lu, Zhihong Zhang, Jie Yang, Jun Chu, Pengcheng Li, Shaoqun Zeng, Qingming Luo · 2007 · Biochemical and Biophysical Research Communications
  58. γ‐Secretase‐dependent cleavage of amyloid precursor protein regulates osteoblast behavior
    Jane McLeod, Neil Curtis, Huw D. Lewis, Mark A. Good, Michael J. Fagan, Paul G. Genever · 2009 · The FASEB Journal
  59. Dysfunction of different cellular degradation pathways contributes to specific β‐amyloid42‐induced pathologies
    Xuan‐Ru Ji, Kuan‐Chung Cheng, Yu‐Ru Chen, Tzu‐Yu Lin, Chun Hei Antonio Cheung, Chia‐Lin Wu, Hsueh‐Cheng Chiang · 2017 · The FASEB Journal
  60. Proteolytic cleavage of Golgi glycosyltransferases by SPPL3 and other proteases and its implications for cellular glycosylation
    Matthias Voß · 2024 · Biochimica et Biophysica Acta (BBA) - General Subjects
  61. Amino-Terminal β-Amyloid Antibody Blocks β-Amyloid-Mediated Inhibition of the High-Affinity Choline Transporter CHT
    Leah K. Cuddy, Claudia Seah, Stephen Pasternak, Rebecca Jane Rylett · 2017 · Frontiers in Molecular Neuroscience
  62. Development of an Efficient Enzyme Production and Structure-Based Discovery Platform for BACE1 Inhibitors
    Yu‐Chen Yen, Annalissa M. Kammeyer, Katherine C. Jensen, Jagannadharao Tirlangi, Arun Kumar Ghosh, Andrew D. Mesecar · 2019 · Biochemistry
  63. APP in the Neuromuscular Junction for the Development of Sarcopenia and Alzheimer’s Disease
    Minyi Wu, Wen-Jun Zou, Daehoon Lee, Lin Mei, Wen‐Cheng Xiong · 2023 · International Journal of Molecular Sciences
  64. Control of Amyloid-β-Peptide Generation by Subcellular Trafficking of the β-Amyloid Precursor Protein and β-Secretase
    Jochen Walter · 2006 · Neurodegenerative Diseases
  65. Expression and characterization of human β-secretase candidates metalloendopeptidase MP78 and cathepsin D in βAPP-overexpressing cells
    Annick Thompson, Fiona Grueninger‐Leitch, Gerda Huber, Pari Malherbe · 1997 · Molecular Brain Research
  66. The type of Aβ-related neuronal degeneration differs between amyloid precursor protein (APP23) and amyloid β-peptide (APP48) transgenic mice
    Ajeet Rijal Upadhaya, Frederik Scheibe, Irina Kosterin, Dorothée Abramowski, Janina Gerth, Sathish Kumar, Stefan Liebau, Haruyasu Yamaguchi, Jochen Walter, Matthias Staufenbiel et al. · 2013 · Acta Neuropathologica Communications
  67. Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-β or Pathologic Phenotype
    Isobel J. Whitehouse, Deborah Brown, Herbert N. Baybutt, Abigail B. Diack, Katherine A. B. Kellett, Pedro Piccardo, Jean C. Manson, Nigel M. Hooper · 2016 · PLoS ONE
  68. BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats
    Martin Weber, Tiffany Z. Wu, William J. Meilandt, Sara L. Domínguez, Hilda O. Solanoy, Janice A. Maloney, Hai Ngu, Miriam Baca, Chung Kung, Lisa M. Lima et al. · 2017 · Scientific Reports
  69. Novel amyloid precursor protein mutation, Val669Leu (“Seoul APP”), in a Korean patient with early-onset Alzheimer's disease
    Eva Bagyinszky, Min Ju Kang, Vo Van Giau, KyuHwan Shim, Jung‐Min Pyun, Jeewon Suh, Seong Soo A. An, SangYun Kim · 2019 · Neurobiology of Aging
  70. Precursor-Independent Overproduction of Beta-Amyloid in AD: Mitochondrial Dysfunction as Possible Initiator of Asymmetric RNA-Dependent βAPP mRNA Amplification. An Engine that Drives Alzheimer’s Disease
    Vladimir Volloch, Bjorn Reino Olsen, Sophia Rits‐Volloch · 2019 · Annals of Integrative Molecular Medicine
  71. Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-β precursor protein
    Julien Chapuis, Valérie Vingtdeux, Fabien Campagne, Peter Davies, Philippe Marambaud · 2011 · Human Molecular Genetics
  72. Impairment of Tricarboxylic Acid Cycle (TCA) Cycle in Alzheimer's Disease: Mechanisms, Implications, and Potential Therapies
    Gudimetla Susmitha Mohan, Rahul Kumar · 2025 · Aging and Disease
  73. Aging, microglia and cytoskeletal regulation are key factors in the pathological evolution of the APP23 mouse model for Alzheimer's disease
    Leen Janssen, Marissa Lisa Dubbelaar, Inge R. Holtman, Jelkje J. de Boer-Bergsma, Bart J. L. Eggen, H. W. G. M. Boddeke, Peter Paul De Deyn, Debby Van Dam · 2016 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  74. Multimodal analyses of a non-human primate model harboring mutant amyloid precursor protein transgenes driven by the human EF1α promoter.
    Sho Yoshimatsu, Fumiko Seki, Junko Okahara, Hirotaka Watanabe, Hiroki Sasaguri, Yawara Haga, Junichi Hata, Tsukasa Sanosaka, Takashi Inoue, Takayuki Mineshige et al. · 2022 · Neuroscience Research
  75. Salivary Aβ Secretion and Altered Oral Microbiome in Mouse Models of AD
    Angela Marie Floden, Mona Sohrabi, Suba Nookala, Jay Cao, Colin Kelly Combs · 2021 · Current Alzheimer Research
  76. Differential regulation of the high‐affinity choline transporter by wild‐type and Swedish mutant amyloid precursor protein
    Leah K. Cuddy, Claudia Seah, Stephen Pasternak, Rebecca Jane Rylett · 2015 · Journal of Neurochemistry
  77. Brain regions and genes affecting myoclonus in animals
    Robert Lalonde, C. Strazielle · 2012 · Neuroscience Research
  78. pHluorin-BACE1-mCherry Acts as a Reporter for the Intracellular Distribution of Active BACE1 In Vitro and In Vivo
    Lu Zhao, Yang Zhao, Fu‐Lei Tang, Lei Xiong, Ce Su, Lin Mei, Xiaojuan Zhu, Wen‐Cheng Xiong · 2019 · Cells
  79. Mixed signals in Alzheimer's disease
    Rachael L. Neve · 1996 · Trends in Neurosciences
  80. Function of Flotillins in Receptor Tyrosine Kinase Signaling and Endocytosis: Role of Tyrosine Phosphorylation and Oligomerization
    Nina Kurrle, Bincy Anu John, Melanie Meister, Ritva Tikkane · 2012 · InTech eBooks
  81. Presumed LRP1-targeting transport peptide delivers β-secretase inhibitor to neurons in vitro with limited efficiency
    Jong Ah Kim, Tommaso Casalini, Davide Brambilla, Jean‐Christophe Leroux · 2016 · Scientific Reports
  82. Altered Expression of Urea Cycle Enzymes in Amyloid-β Protein Precursor Overexpressing PC12 Cells and in Sporadic Alzheimer’s Disease Brain
    Henryk M. Jęśko, Walter J. Lukiw, Anna Wilkaniec, Magdalena Cieślik, Magdalena Gąssowska-Dobrowolska, Emilia Murawska, Wojciech Hilgier, Agata Adamczyk · 2018 · Journal of Alzheimer s Disease
  83. Alpha- and Gamma-Tocopherol Modulates the Amyloidogenic Pathway of Amyloid Precursor Protein in an in vitro Model of Alzheimer’s Disease: A Transcriptional Study
    Aslina Pahrudin Arrozi, Siti Nur Syazwani Shukri, Nuraqila Mohd Murshid, Ahmad Baihaqi Ahmad Shahzalli, Wan Zurinah Wan Ngah, Hanafi Ahmad Damanhuri, Suzana Makpol · 2022 · Frontiers in Cellular Neuroscience
  84. Subcellular localization of the Alzheimer's disease amyloid precursor protein and derived polypeptides expressed in a recombinant yeast system
    Janetta Gladys Culvenor, Anna Henry, Tobias Hartmann, Genevieve M. Evin, Denise Galatis, Anna M. Friedhuber, Rajiv Jayasena, John R. Underwood, Konrad T. Beyreuther, Colin Louis Masters et al. · 1998 · Amyloid
  85. Amyloid Structural Changes Studied by Infrared Microspectroscopy in Bigenic Cellular Models of Alzheimer’s Disease
    Agnes Paulus, Anders Engdahl, Yiyi Yang, Antonio Boza‐Serrano, Sara Bachiller, Laura Torres-Garcia, Alexander Svanbergsson, Megg G. Garcia, Gunnar K. Gouras, Jiayi Li et al. · 2021 · International Journal of Molecular Sciences
  86. Investigating the Synergistic Potential of Low-Dose HDAC3 Inhibition and Radiotherapy in Alzheimer’s Disease Models
    Natalie R. Ricciardi, Farzaneh Modarresi, Ines Lohse, Nadja S. Andrade, Ian A. Newman, Jonathan Mark Brown, Caroline Borja, Brian Marples, Claes Wahlestedt, Claude‐Henry Volmar · 2023 · Molecular Neurobiology
  87. E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion
    Stefano Benvegnù, Tina Wahle, Carlos G. Dotti · 2017 · Oncotarget
  88. Composition of white matter bovine brain coated vesicles: evidence that several components influence β-amyloid peptide to form oligomers and aggregates in vitro
    Martin J. Berg, Robert Durrie, Victor S. Sapirstein, Neville Marks · 1997 · Brain Research
  89. Visualization and Quantification of APP Intracellular Domain-Mediated Nuclear Signaling by Bimolecular Fluorescence Complementation
    Florian Riese, Sonja Grinschgl, Manuel T. Gersbacher, Natalie Russi, Christoph Höck, Roger M. Nitsch, Uwe Konietzko · 2013 · PLoS ONE
  90. Late age increase in soluble amyloid-beta levels in the APP23 mouse model despite steady-state levels of amyloid-beta-producing proteins
    Leen Janssen, Cleo Keppens, Peter Paul De Deyn, Debby Van Dam · 2015 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  91. Alzheimer’s Disease Prevention and Treatment: Case for Optimism
    Vladimir Volloch, Bjorn Reino Olsen, Sophia Rits‐Volloch · 2019 · Annals of Integrative Molecular Medicine
  92. Molecular pathology of Alzheimer's disease
    Tsuneo Yamazaki, Yasuo Ihara · 1997 · Neuropathology
  93. Human β-secretase and Alzheimer’s disease
    Martin Citron · 2001 · Expert Opinion on Therapeutic Targets
  94. Inducers and modulators of protein aggregation in Alzheimer's disease - Critical tools for understanding the foundations of aggregate structures
    Kerry T. Sun, Sue‐Ann Mok · 2025 · Neurotherapeutics
  95. Vascular models of Alzheimer's disease: An overview of recent in vitro models of the blood-brain barrier
    Lily E Takeuchi, Lorraine V. Kalia, Craig A. Simmons · 2025 · Neurobiology of Disease
  96. Mettl3 regulates the pathogenesis of Alzheimer’s disease via fine-tuning Lingo2
    Xingsen Zhao, Chengyi Ma, Qihang Sun, Xiaoli Huang, Wenzheng Qu, Yusheng Chen, Ziqin Liu, Ai‐Min Bao, Binggui Sun, Ying Yang et al. · 2025 · Molecular Psychiatry
  97. Discovery of an APP-selective BACE1 inhibitor for Alzheimer's disease
    Jesus J. Campagna, B. Jagodzinska, Dongwook Wi, Chun-Ni Zhu, Jessica T. Lee, W. Cohn, Michael Jun, C. Elias, Samar Padder, O. Descamps et al. · 2023 · bioRxiv
  98. Nutraceutical and Probiotic Approaches to Examine Molecular Interactions of the Amyloid Precursor Protein APP in Drosophila Models of Alzheimer’s Disease
    David Jalali, Justine Anne Guevarra, Luz Martinez, Lily Hung, Fernando Vonhoff · 2021 · International Journal of Molecular Sciences
  99. An Overview of β-Amyloid Cleaving Enzyme 1 (BACE1) in Alzheimer's Disease Therapy: Elucidating its Exosite-Binding Antibody and Allosteric Inhibitor
    Samuel Chima Ugbaja, Monsurat M. Lawal, Hezekiel Mathambo Kumalo · 2021 · Current Medicinal Chemistry
  100. Anti‐amyloid precursor protein immunoglobulins inhibit amyloid‐β production by steric hindrance
    Rhian S. Thomas, J. Eryl Liddell, Emma J. Kidd · 2010 · FEBS Journal