The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway
Haass, Christian, Lemere, Cynthia A., Capell, Anja, Citron, Martin, Seubert, Peter, Schenk, Dale, Lannfelt, Lars, Selkoe, Dennis J.·1995·Nature Medicine
Cited by (598)
Items 501–598 of 598
- Isogenic cortical organoids enable precision targeting of APP variant-specific pathways in Alzheimer’s diseaseTobias Graß, Ilyas Mehmet Cosacak, Alban Ordureau, Feodor D. Price, Shrutika Kavali, A Caldarelli, Min N. Qiao, Badri Narayan Vardarajan, João A. Paulo, Michele Marass et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Presenilin und β-Amyloid: Schlüsselmoleküle der Alzheimerschen ErkrankungCh. Haass · 1998 · Springer eBooks
- Lésions sélectives de deux populations de neurones affectées dans la maladie d’Alzheimer : impact sur les performances cognitives et l’histopathologie des souris tg2576Nour Yassine · 2011 · OpenGrey (Institut de l'Information Scientifique et Technique)
- Targeting Early Stages of Alzheimer’s Disease in a Transgenic ModelAnna Lord · 2009 · KTH Publication Database DiVA (KTH Royal Institute of Technology)
- Chapter 1 Amyloid and Amyloid-Like Protein Aggregates in Neurodegenerative DiseaseTodd Eliot Golde · 2007 · Blue books of neurology
- Effects of A-beta immunotherapy and Omega-3 fatty acid administration in Alzheimer's transgenic miceMaren Jensen · 2006
- INDUCTION OF THE HEAT SHOCK RESPONSE TO PROTECT AGAINST POLYGLUTAMINE DISEASES AND THE ROLE OF PROTEIN SUMOYLATION IN LAMINOPATHIES AND ALZHEIMER'S DISEASEYu-Qian Zhang · 2008 · UKnowledge (University of Kentucky)
- Amyloid precursor protein with the Alzheimer´s disease 670/671 mutation : Animal and cellular modelsEwa Kloskowska · 2008 · Figshare
- CHAPTER 5.6 Identification and functional analysis of genes and genetic risk factors in Alzheimer's diseaseChris De Jonghe, Christine Van Broeckhoven · 1999 · Techniques in the behavioral and neural sciences
- Identification of a BACE dimer and characterization of its biochemical and enzymatic propertiesGil G. Westmeyer · 2006
- Role of the 39-kDa receptor-associated protein (RAP) in Alzheimer's diseaseHoang, T · 2012 · UTAS Research Repository
- Regulation of expression and cellular release of acetylcholinesteraseDavid A. Hicks · 2013 · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
- Characterization of proteins involved in the production of β-Amyloid peptides and tau hyperphosphorlation in Familial Alzheimer’s DiseaseBarrera Ocampo, Álvaro Andrés · 2012
- Genetics of early-onset Alzheimer diseasePeter St George‐Hyslop · 2001 · Birkhäuser Basel eBooks
- Pathogenic mechanisms of the Arctic Alzheimer mutation.Charlotte Sahlin · 2007 · Uppsala University Publications (Uppsala University)
- The Effect of Acute LPS-Induced Immune Activation and Brain Insulin Signaling Disruption in a Diabetic Model of Alzheimer's DiseaseAndrew S. Murtishaw · 2020 · Digital Scholarship - UNLV (University of Nevada Reno)
- The implications of genetic studies on the pathogenesis of Alzheimer's diseaseHidenao Sasaki · 1998 · Neuropathology
- Proteolysis of Mutant Gene Products are Key Mechanisms in Neurodegenerative DiseasesVIVIAN Y. H. HOOK · 2002 · Springer eBooks
- Characterisation of transgenic mouse models of Alzheimer's diseaseLindsay Graham · 2011 · OpenGrey (Institut de l'Information Scientifique et Technique)
- Modulation of BACE1 by a novel sorting nexin in Alzheimer's diseaseHirokazu Okada · ProQuest Demo Repository
- Molecular Processing Pathways of β-Amyloid Precursor Protein: Therapeutic ImplicationsChristian Haass · 1996 · Springer eBooks
- Synergistic effect of N-terminal pyroglutamyl amyloid ß protein in Alzheimer's disease and in normal agingYing-Chuan Wang, Ren‐Jing Huang, Shieh-Ding Wu, Chung Shan · 2009
- Signaltransduktion des humanen Neuropeptidrezeptors SorLA - γ-Secretase-abhängige Freisetzung der Intrazellulärdomäne desChristopher Böhm · 2005
- Dynamics of amyloid plaque formation in Alzheimer’s DiseaseJoanna F McCarter · 2014 · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München)
- Determining the Transmembrane Topology of the PresenilinsGopal Thinakaran, Andrew Doan · 2003 · Humana Press eBooks
- MALATTIA DI ALZHEIMER E DEGENERAZIONE LOBARE FRONTOTEMPORALE: RICERCA DI MUTAZIONI AUTOSOMICHE DOMINANTI E ANALISI GENETICA E FUNZIONALE DI GENI CANDIDATIMaría Serpente · 2013 · Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)
- Using TUDCA to treat Alzheimer's disease after pathology onset in APP/PS1 micePedro Dionísio · 2014 · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
- An Investigation into the Role of Iron, Copper, and Gender in a Transgenic Mouse Model of Alzheimer's Disease.Caitlin M. Groeber · 2013
- Der Einfluss des Geschlechts auf die Neuronenanzahl in einem APP/PS1- doppeltransgenen Mausmodell der Alzheimer-KrankheitAbteilung für Neurobiologie · 2006
- Pathological Consequences of Aβ From Extracellular to IntraneuronalMichael R. D’Andrea · 2016 · Elsevier eBooks
- Development of Neoepitope Antibodies Against the β-Secretase Cleavage Site in the Amyloid Precursor ProteinCarol W. Gray, Eric H. Karran · 2003 · Humana Press eBooks
- Using TUDCA to treat Alzheimer's disease after pathology onset in APP/PS1 miceFaculdade De Farmácia · 2014
- Activity-inducible kinase Plk2 regulates APP amyloidogenic processing and Abeta mediated synaptic depressionYeunKum Lee · 2012 · Georgetown University-Graduate School of Arts & Sciences
- Analyse des neuen Proteins TMEM59 und seiner Funktion in dem Transport und der Prozessierung des Amyloid-Vorläufer-ProteinsDissertation der Fakultät, Ludwig-Maximilian-Universität München · 2008
- Therapeutic Targeting of Aβ42Todd Eliot Golde, Christian B. Lessard, Yong Ran · 2016 · Elsevier eBooks
- Pathological Changes in the Elderly Human BrainDavid M. A. Mann · 1997 · Springer eBooks
- Biochemical Characterization of Amyloid Precursor ProteinWeiming Xia · 2004 · CRC Press eBooks
- A characterization of deficits associated with loss of NCB5OR in the mouse brainMatthew A. Stroh · 2016 · KU ScholarWorks (The University of Kansas)
- Dissecting the role of Proteolysis and Cytoskeleton remodeling in protein aggregation related diseasesCatarina Santos Silva · 2015 · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
- de dans la maladie d'AlzheimerJean Sévalle · 2009
- EFFECTS OF THE NOVEL IDO INHIBITOR DWG-1036 ON THE BEHAVIOUR AND NEUROCHEMISTRY OF THE TRIPLE TRANSGENIC MOUSE MODEL OF ALZHEIMER’S DISEASEEmre Fertan · 2017 · DalSpace (Dalhousie University)
- Lessons From Using Genome Editing to Create a Faithful Model of a Novel Congenital AnemiaXiaoli Mi · 2018 · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
- Analyse structurale et fonctionnelle de la préséniline-1 humaine : implications dans la maladie d'AlzheimerSébastien S. Hébert · 2003 · Corpus Université Laval (Université Laval)
- The interplay between mitochondria-endoplasmic reticulum contacts and Alzheimer’s diseaseSantos Leal, Nuno João · 2019 · Figshare
- Genomics of Alzheimer’s diseaseRoger N. Rosenberg, Doris Lambracht‐Washington, Gang Yu, Weiming Xia · 2020 · Elsevier eBooks
- Molecular basis of amyloid-β chaperone activity of lipocalin-type prostaglandin D synthase (L-PGDS)Bhuvaneswari Kannaian · 2019
- Targeting Alzheimer’s disease and related dementias with CRISPR and human pluripotent stem cell technologiesAndrew A. Sproul · 2021 · Elsevier eBooks
- Lexikalischer TeilRegine Witköwski, Otto Prokop, Eva Ullrich, Gundula Thiel · 2003 · Springer eBooks
- Etiological ConsiderationsDavid M. A. Mann · 1997 · Springer eBooks
- SpinosinJessica Pandohee, Mohamad Fawzi Mahomoodally · 2020 · Elsevier eBooks
- Animal Models of Amyloid/PS-1 PathologyAkihiko Takashima · 2011 · Royal Society of Chemistry eBooks
- Maladie d’Alzheimer, peptides β-amyloïdes et système ubiquitine-protéasomePhilippe Yves Rémy Simon, Johanna Bus, Renaud David · 2023 · médecine/sciences
- Sterol Biomarker Discovery In Neurodegenerative DiseasesManuela Pacciarini · 2023
- Tau Transgenic Mouse Models in Therapeutic DevelopmentHanno M. Roder · 2009 · Springer eBooks
- Human genetics: Establishment of cause-and-effect relationshipsTakaomi C. Saido · 2024 · Elsevier eBooks
- Genomics of Alzheimer’s diseaseRoger N. Rosenberg, Doris Lambracht‐Washington, Gang Yu, Weiming Xia · 2024 · Elsevier eBooks
- The role of ROS in cardiovascular and neurological disordersShyamal K. Goswami · 2025 · Elsevier eBooks
- Etude de la dynamique de tau dans le compartiment synaptique dans un contexte physiologique et pathologique exemple de la maladie d'AlzheimerMarie‐Lise Frandemiche · 2013 · theses.fr (ABES)
- The role of Hsp20 in Alzheimer's diseaseRyan T. Cameron · 2014 · Enlighten: Theses (The University of Glasgow)
- The Processing of Amyloid Precursor Protein in the Central Nervous System of Humans and Rhesus MacaquesJustyna A. Dobrowolska Zakaria · 2013 · Open Scholarship Institutional Repository (Washington University in St. Louis)
- Characterisation of visuospatial memory in the Tg2576 model of Alzheimer's diseaseGemma Hale · 2007 · ORCA Online Research @Cardiff (Cardiff University)
- Untersuchungen zur intrazellulären Lokalisation der γ-SekretaseStéphanie Schmitt · 2011 · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München)
- Additional file 17 of Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microgliaDan Xia, Lianoglou, Steve, Thomas Sandmann, Meredith Calvert, Jung H. Suh, Elliot R. Thomsen, Jason C. Dugas, Michelle E. Pizzo, Sarah L. DeVos, Timothy Earr et al. · 2022 · Figshare
- Additional file 10 of Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microgliaDan Xia, Lianoglou, Steve, Thomas Sandmann, Meredith Calvert, Jung H. Suh, Elliot R. Thomsen, Jason C. Dugas, Michelle E. Pizzo, Sarah L. DeVos, Timothy Earr et al. · 2022 · Figshare
- Additional file 9 of Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microgliaDan Xia, Lianoglou, Steve, Thomas Sandmann, Meredith Calvert, Jung H. Suh, Elliot R. Thomsen, Jason C. Dugas, Michelle E. Pizzo, Sarah L. DeVos, Timothy Earr et al. · 2022 · Figshare
- Mouse models of Alzheimer’s disease pathologySunwoo Kim, Nora E. Gray · 2025 · Elsevier eBooks
- Glial Dysfunction in Alzheimer's Disease: Contributions to Disease Progression, Pathomechanism and Therapeutic Opportunities.Ina Dreschnack, Paul A. Dreschnack · 2025 · Medical Research Archives
- Decoding Alzheimer's disease through down syndrome: insights from a genetically defined populationJason K Russell, Zinayida Schlachetzki, Michael S. Rafii · 2026 · Current Opinion in Neurology
- Probing APP Cleavage and Amyloid-β Assembly via Synthetic MUC-Type O -Glycosylated APP GlycopeptidesNancy Vela, Gustavo De Nadai Mundim, Deepika Regmi, Ivet Boneva, Ramya Ayyalasomayajula, Maria E. Vezzi, Valentina Sopo Borraez, Alexis Crowder, Alejandra Coronel-Zegarra, Hasham Shafi et al. · 2026 · ACS Chemical Neuroscience
- Implication du complexe récepteur 5-HT4/APP/ADAM10 dans la voie non-amyloïdogénique de la maladie d’AlzheimerMaud Cochet · 2011 · theses.fr (ABES)
- Synaptic modifications in hippocampal CA3 pyramidal cells in an Alzheimer's mouse modelPei Zhang · 2017 · theses.fr (ABES)
- Métalloprotéases matricielles et maladie d'Alzheimer : étude des rôles de MT1- et MT5-MMP dans l'amyloïdogenèse et la neuro-inflammationJean‐Michel Paumier · 2018 · theses.fr (ABES)
- Altérations des synapses et des corps cellulaires neuronaux chez les souris APPxPS1-KI et dans la Maladie d'AlzheimerAlexandre Androuin · 2018 · theses.fr (ABES)
- Les APP-CTFs au cœur du processus pathologique de la maladie d’Alzheimer : contribution du système lysosomal-autophagique et de la sécrétion exosomaleAnaïs Bécot · 2019 · theses.fr (ABES)
- MT5-MMP promotes neuroinflammation, pathogenic processing of amyloid precursor protein and synaptic dysfunction at early stages in an Alzheimer's disease modelDominika Piłat · 2021 · theses.fr (ABES)
- Comparaison des effets de la viniférine et du resvératrol dans des modèles expérimentaux de la maladie d'AlzheimerAline Freyssin · 2020 · theses.fr (ABES)
- Impact of α-synuclein fibrillar strains and ß-amyloid assemblies on cultured mouse cortical neurons endo-lysosomal logisticsQiao-Ling Chou · 2021 · theses.fr (ABES)
- Computational fragment-based design of chemically modified oligonucleotides for selective protein inhibition : BACE1 as a case studyRoy González‐Alemán · 2023
- Contribution à l'étude des facteurs de risque pour la maladie d'Alzheimer : analyse de candidats identifiés par étude d'association pangénomique ou GWASCharlotte Bauer · 2023 · theses.fr (ABES)
- Histoire évolutive du plus ancien gène d’enveloppe rétrovirale endogène HEMO encore codant chez l’homme, exprimé dans le placenta et les tumeurs : acquisition récente d’une interaction avec une protéase transmembranaire chez les primatesAnthony Béguin · 2024 · theses.fr (ABES)
- Etude des mécanismes physiοpathοlοgiques de la maladie d'Alzheimer : appοrt de l'étude des variants du gène SΟRL1Romain Castelot · 2024 · theses.fr (ABES)
- Intracellular protein GBF1 displays significant associations with amyloid pathology in Alzheimer's diseaseSean J. Miller, Dmitry Prokopenko, Ping Bai, Prasenjit Mondal, Abigael Scott, Wei Zhang, Ashley Gomm, Siyi Zhang, Daniel D. Child, Nolan Shen et al. · 2026 · Alzheimer s & Dementia
- Beta-Secretase InhibitorsJustyna A. Dobrowolska Zakaria, Robert J. Vassar · 2026 · Topics in medicinal chemistry
- Advances and Limitations of Rodent Models in Alzheimer’s Disease Pathogenesis and TherapeuticsAbhinav Singh, Lena Duerner · 2026 · Science Discovery Medicine
- Animal Models of Genetically-Determined Neurodegenerative Diseases and Their DevelopmentAyumu Konno, Yasunori Matsuzaki, Hirokazu Hirai · 2026 · Contemporary clinical neuroscience
- Neuronal overexpression of Nrf2 reduces dystrophic neurites in 5XFAD Alzheimer’s disease model miceKatherine R. Sadleir, Karen P Gomez, Sidhanth Chandra, Makenna L. Ley, Ammaarah W. Khatri, Joanna Guo, Yunlu Xue, Constance L. Cepko, Robert J. Vassar · 2026 · Alzheimer s Research & Therapy
- De novo formation of familial Alzheimer’s disease-relevant Aβ strains occurs exclusively in the human brainAlison Mao, Alejandro Ruiz‐Riquelme, Marim M. Barghash, Nicholas R. G. Silver, Heather H. C. Lau, Erica Stuart, Silvia Zampar, Dag Sehlin, Stina Syvänen, Michael S. Pollanen et al. · 2026 · Acta Neuropathologica Communications
- Mechanisms of Aβ1-42-mediated oxidative stress-induced neuronal apoptosis in neonatal hypoxic-ischemic brain injuryLi-Xuan Hou, Li-Hua Li · 2026 · Pediatrics & Neonatology
- PrPC limits APP delivery to the plasma membrane and alters its processing to facilitate Aβ releaseNikita A. Mehta, Sungro Jo, Stanislau Smirnou, Gopal Thinakaran, James A. Mastrianni · 2026 · Neurobiology of Disease
- Swedish APP follows distinct neuronal trafficking itineraries that underlie its increased β-cleavageCameron R. Plowinske, Sarah Tedesco, Alec T. Nabb, Geraldine B. Quinones, Marvin Bentley · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Structural biology of protein misfolding and aggregation: from disease to therapeutic innovationsNeha Kausar Ansari, Aabgeena Naeem · 2026 · Elsevier eBooks
- BindingDB Entry 50036937: Secretase targets for Alzheimer's disease: identification and therapeutic potential.BindingDB · 2012 · UC San Diego
- BindingDB Entry 50043934: Discovery of 7-tetrahydropyran-2-yl chromans:ß-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloidß-protein (Aß) in the central nervous system.BindingDB · 2014 · UC San Diego
- BindingDB Entry 50044864: 8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors.BindingDB · 2016 · UC San Diego
- BindingDB Entry 50044847: Lead optimization and modulation of hERG activity in a series of aminooxazoline xantheneß-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.BindingDB · 2016 · UC San Diego
- BindingDB Entry 50042875: Spirocyclicß-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloidß in a higher species.BindingDB · 2013 · UC San Diego
- Ectodomain Mutations Alter the Proteolysis of the Amyloid-β Precursor Protein (APP)Michael Mitsumori · 2015
- Identification of the physiologically relevant α-secretase of the Alzheimer’s disease-related amyloid precursor protein and its relationship with β-secretaseHuanhuan Wang · 2012 · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München)