The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway

Haass, Christian, Lemere, Cynthia A., Capell, Anja, Citron, Martin, Seubert, Peter, Schenk, Dale, Lannfelt, Lars, Selkoe, Dennis J.·1995·Nature Medicine

Cited by (598)

Items 101–200 of 598

  1. The Role and Therapeutic Targeting of α-, β- and γ-Secretase in Alzheimer's Disease
    Ruth MacLeod, Ellin‐Kristina Hillert, Ryan T. Cameron, George S. Baillie · 2015 · Future Science OA
  2. Toward High‐Quality Epitaxial LiNbO 3 and LiTaO 3 Thin Films for Acoustic and Optical Applications
    Ausrine Bartasyte, Samuel H. Margueron, Thomas Baron, Stefania Oliveri, Pascal Boulet · 2017 · Advanced Materials Interfaces
  3. Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome
    Hamlett, Eric D., Goetzl, Edward J., Ledreux, Aurélie, Vasilevko, Vitaly, Boger, Heather A., LaRosa, Angela, Clark, David, Carroll, Steven L., Carmona‐Iragui, María, Fortea, Juan et al. · 2017 · Alzheimer's & Dementia
  4. Independent Inhibition of Alzheimer Disease β- and γ-Secretase Cleavage by Lowered Cholesterol Levels
    Marcus O.W. Grimm, Heike S. Grimm, Inge Tomic, Konrad T. Beyreuther, Tobias Hartmann, Christine Bergmann · 2008 · Journal of Biological Chemistry
  5. Alzheimer disease: Amyloidogenesis, the presenilins and animal models
    Morgan Newman, Ian Musgrave, Michael T. Lardelli · 2006 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  6. Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia
    Xia, Dan, Lianoglou, Steve, Sandmann, Thomas, Calvert, Meredith, Suh, Jung H., Thomsen, Elliot, Dugas, Jason, Pizzo, Michelle E., DeVos, Sarah L., Earr, Timothy K. et al. · 2022 · Molecular Neurodegeneration
  7. Alzheimer’s disease due to loss of function: A new synthesis of the available data
    Kasper P. Kepp · 2016 · Progress in Neurobiology
  8. Dishevelled Regulates the Metabolism of Amyloid Precursor Protein via Protein Kinase C/Mitogen-Activated Protein Kinase and c-Jun Terminal Kinase
    Amritpal K. Mudher, Susan C. Chapman, Jill C. Richardson, Ayodeji A. Asuni, Graham Gibb, Claire C. Pollard, Richard Killick, Tasfia Ahmed Iqbal, Frances Lucy Raymond, Ian M. Varndell et al. · 2001 · Journal of Neuroscience
  9. Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway
    Z. Goodger, L. Rajendran, Annette Trutzel, Bernhard M. Kohli, R. Nitsch, U. Konietzko · 2009 · Journal of Cell Science
  10. Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease
    Claudia Schwab, Masato Hosokawa, Patrick L. McGeer · 2004 · Experimental Neurology
  11. Beta-Secretase: Structure, Function, and Evolution
    Chitra Venugopal, Christina Demos, K. S. Jagannatha Rao, Miguel A. Pappolla, Kumar Sambamurti · 2008 · CNS & Neurological Disorders - Drug Targets
  12. Precise and efficient scarless genome editing in stem cells using CORRECT
    Dylan Kwart, Dominik Paquet, Shaun Teo, Marc Tessier‐Lavigne · 2017 · Nature Protocols
  13. Gallic acid disruption of Aβ1–42 aggregation rescues cognitive decline of APP/PS1 double transgenic mouse
    Mei Yu, Xuwei Chen, Jihong Liu, Quan Ma, Zhan Zhuo, Hao Chen, Lin Zhou, Sen Yang, Lifeng Zheng, Chengqing Ning et al. · 2018 · Neurobiology of Disease
  14. A non‐amyloidogenic function of BACE‐2 in the secretory pathway
    Regina Fluhrer, Anja Capell, Gil G. Westmeyer, Michael Willem, Bianka Hartung, Margaret M. Condron, David B. Teplow, Christian Haass, Jochen Walter · 2002 · Journal of Neurochemistry
  15. The Carboxyl-Terminus of BACE Contains a Sorting Signal That Regulates BACE Trafficking but Not the Formation of Total Aβ
    Lucia Pastorino, Annat F. Ikin, Angus Clark Nairn, Amit K. Pursnani, Joseph D. Buxbaum · 2002 · Molecular and Cellular Neuroscience
  16. Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's β‐amyloid precursor protein
    Tommaso Russo, Raffaella Faraonio, Giuseppina Minopoli, Paola de Candia, Stefano De Renzis, Nicola Zambrano · 1998 · FEBS Letters
  17. Endothelial Mitochondrial Dysfunction in Cerebral Amyloid Angiopathy and Alzheimer’s Disease
    Rebecca Maria Parodi‐Rullán, Je Yeong Sone, Silvia Fossati · 2019 · Journal of Alzheimer s Disease
  18. Dimerization of β-Site β-Amyloid Precursor Protein-cleaving Enzyme
    Gil G. Westmeyer, Michael Willem, Stefan F. Lichtenthaler, Glenn J. Lurman, Gerd Multhaup, Irmgard Assfalg‐Machleidt, Karina Reiß, Paul Säftig, Christian Haass · 2004 · Journal of Biological Chemistry
  19. Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein
    Saoussen Ben Halima, Sabyashachi Mishra, Karuppiah Muruga Poopathi Raja, Michael Willem, Antonio Baici, Kai Simons, Oliver Brüstle, Philipp Koch, Christian Haass, Amedeo Caflisch et al. · 2016 · Cell Reports
  20. Copper Promotes the Trafficking of the Amyloid Precursor Protein
    Karla M. Acevedo, Ya Hui Hung, Andrew H. Dalziel, Qiao‐Xin Li, Katrina M. Laughton, Krutika Wikhe, Alan Rembach, Blaine Russell Roberts, Colin Louis Masters, Ashley Ian Bush et al. · 2010 · Journal of Biological Chemistry
  21. The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer’s Disease
    Sarah L. Cole, R. Vassar · 2007 · Current Genomics
  22. Transthyretin and the brain re-visited: Is neuronal synthesis of transthyretin protective in Alzheimer's disease?
    Xinyi Li, Joel N. Buxbaum · 2011 · Molecular Neurodegeneration
  23. Elevated vulnerability to oxidative stress‐induced cell death and activation of caspase‐3 by the Swedish amyloid precursor protein mutation
    Anne Eckert, Barbara Steiner, Celio A. Marques, Steffen Leutz, Helmut Romig, Christian Haass, Walter E. Müller · 2001 · Journal of Neuroscience Research
  24. Animal models of amyloid‐β‐related pathologies in Alzheimer’s disease
    Ola Philipson, Anna Lord, Astrid Gumucio, Paul W. O'Callaghan, Lars Lannfelt, Lars N. G. Nilsson · 2010 · FEBS Journal
  25. The Aβ Hypothesis: Leading Us to Rationally‐Designed Therapeutic Strategies for the Treatment or Prevention of Alzheimer Disease
    Todd E. Golde · 2005 · Brain Pathology
  26. Transgenic mouse models of Alzheimer's disease: How useful have they been for therapeutic development?
    Karen Duff · 2004 · Briefings in Functional Genomics and Proteomics
  27. The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer’s Disease and Beyond
    Bastian Dislich, Stefan F. Lichtenthaler · 2012 · Frontiers in Physiology
  28. An Update of Animal Models of Alzheimer Disease with a Reevaluation of Plaque Depositions
    Jung Eun Lee, Pyung‐Lim Han · 2013 · Experimental Neurobiology
  29. GSK3: A potential target and pending issues for treatment of Alzheimer's disease
    Jiahui Zhao, Mengying Wei, Minsong Guo, Mengyao Wang, Hongxia Niu, Tengfei Xu, Yuan Zhou · 2024 · CNS Neuroscience & Therapeutics
  30. Beta-secretase as a target for Alzheimer’s disease drug discovery: an overview of in vitro methods for characterization of inhibitors
    Francesca Mancini, Angela De Simone, Vincenza Andrisano · 2011 · Analytical and Bioanalytical Chemistry
  31. Elevating the Levels of Calcium Ions Exacerbate Alzheimer’s Disease via Inducing the Production and Aggregation of β-Amyloid Protein and Phosphorylated Tau
    Pei-Pei Guan, Long‐Long Cao, Pu Wang · 2021 · International Journal of Molecular Sciences
  32. Synaptogenic effect of APP -Swedish mutation in familial Alzheimer’s disease
    Bo Zhou, Jacqueline G. Lu, Alberto Siddu, Marius Wernig, Thomas Christian Südhof · 2022 · Science Translational Medicine
  33. Genetics of Alzheimer’s Disease
    Perry G. Ridge, Mark Ebbert, John S. K. Kauwe · 2013 · BioMed Research International
  34. β-Amyloid Precursor Protein
    Edmund Tischer, Barbara Cordell · 1996 · Journal of Biological Chemistry
  35. Amyloidogenic Processing of Human Amyloid Precursor Protein in Hippocampal Neurons Devoid of Cathepsin D
    Paul Säftig, Christoph Peters, Kurt VON FIGURA, Katleen Craessaerts, Fred VAN LEUVEN, Bart De Strooper · 1996 · Journal of Biological Chemistry
  36. Infectious origin of Alzheimer’s disease: Amyloid beta as a component of brain antimicrobial immunity
    Vojtechova, Iveta, Machacek, Tomas, Kristofikova, Zdenka, Stuchlik, Ales, Petrasek, Tomas · 2022 · PLOS Pathogens
  37. Alzheimer’s disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production
    Mitko I. Dimitrov, Jean‐René Alattia, Thomas Lemmin, Rajwinder Lehal, Andrzej Fligier, Jemila Houacine, Ishrut Hussain, Freddy Radtke, Matteo Dal Peraro, Dirk Beher et al. · 2013 · Nature Communications
  38. Withanolide A and Asiatic Acid Modulate Multiple Targets Associated with Amyloid-β Precursor Protein Processing and Amyloid-β Protein Clearance
    Sachin P. Patil, Sarah Maki, Santosh A. Khedkar, Alan C. Rigby, Christina Chan · 2010 · Journal of Natural Products
  39. Role of amyloid beta in lipid homeostasis
    Grösgen, Sven, Grimm, Marcus O.W., Frieß, Petra, Hartmann, Tobias · 2010 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  40. Clathrin-dependent APP endocytosis and Aβ secretion are highly sensitive to the level of plasma membrane cholesterol
    Jack‐Christophe Cossec, Anne Simon, Catherine Marquer, Randal X. Moldrich, Christophe Leterrier, Jean Rossier, Charles J. Duyckaerts, Zsolt Lenkei, Marie‐Claude Potier · 2010 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  41. Endocytic disturbances distinguish among subtypes of alzheimer's disease and related disorders
    Cataldo, Anne, Rebeck, G. William, Ghetti, Bernadino, Hulette, Christine, Lippa, Carol, Van Broeckhoven, Christine, Van Duijn, Cornelia, Cras, Patrick, Bogdanovic, Nenad, Bird, Thomas et al. · 2001 · Annals of Neurology
  42. Dynamics of Aβ Turnover and Deposition in Different β-Amyloid Precursor Protein Transgenic Mouse Models Following γ-Secretase Inhibition
    Abramowski, Dorothee, Wiederhold, Karl-Heinz, Furrer, Ulrich, Jaton, Anne-Lise, Neuenschwander, Anton, Runser, Marie-Josephine, Danner, Simone, Reichwald, Julia, Ammaturo, Domenico, Staab, Dieter et al. · 2008 · The Journal of Pharmacology and Experimental Therapeutics
  43. Inhibition of Amyloid β-Protein Production in Neural Cells by the Serine Protease Inhibitor AEBSF
    Martin Citron, Thekla S. Diehl, Anja Capell, Christian Haass, David B. Teplow, Dennis J. Selkoe · 1996 · Neuron
  44. The Protective Effects of Osteocyte‐Derived Extracellular Vesicles Against Alzheimer's Disease Diminished with Aging
    Yaling Jiang, Zhen‐Xing Wang, Xixi Liu, Meidan Wan, Yiwei Liu, Bin Jiao, Xinxin Liao, Zhong‐Wei Luo, Yiyi Wang, Chun‐Gu Hong et al. · 2022 · Advanced Science
  45. Binding of β-Amyloid (1–42) Peptide to Negatively Charged Phospholipid Membranes in the Liquid-Ordered State: Modeling and Experimental Studies
    Hasna Ahyayauch, Michal Raab, Jon V. Busto, Nagore Andraka, José-Luis R. Arrondo, Massimo Masserini, Igor Tvaroška, Félix M. Goñi · 2012 · Biophysical Journal
  46. Function, regulation and therapeutic properties of β-secretase (BACE1)
    Michael Willem, Sven Lammich, Christian Haass · 2009 · Seminars in Cell and Developmental Biology
  47. GGA1 Is Expressed in the Human Brain and Affects the Generation of Amyloid β-Peptide
    Tina Wahle, Dietmar Rudolf Thal, Magdalena Sastre, Andrea Rentmeister, Nenad Bogdanović, Michael Famulok, Michael Thomas Heneka, Jochen Walter · 2006 · Journal of Neuroscience
  48. An overview of the genes and biomarkers in Alzheimer’s disease
    Hari Krishnan Krishnamurthy, Vasanth Jayaraman, Karthik Krishna, Tianhao Wang, Kang Bei, Chithra Changalath, John J. Rajasekaran · 2024 · Ageing Research Reviews
  49. Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells
    Holger Cynis, Stephan Schilling, Mandy Bodnár, Torsten Hoffmann, Ulrich F. Heiser, Takaomi C. Saido, Hans‐Ulrich Demuth · 2006 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  50. Separation of presenilin function in amyloid β-peptide generation and endoproteolysis of Notch
    Luka Kulic, Jochen Walter, Gerd Multhaup, David B. Teplow, Ralf Baumeister, Helmut Romig, Anja Capell, Harald Steiner, Christian Haass · 2000 · Proceedings of the National Academy of Sciences
  51. A Novel Sorting Nexin Modulates Endocytic Trafficking and α-Secretase Cleavage of the Amyloid Precursor Protein
    Susanne Schöbel, Stephanie Neumann, Maren Hertweck, Bastian Dislich, Peer‐Hendrik Kuhn, Elisabeth Kremmer, Brian Seed, Ralf Baumeister, Christian Haass, Stefan F. Lichtenthaler · 2008 · Journal of Biological Chemistry
  52. The neuroprotective effects of Cerebrolysin? in a transgenic model of Alzheimer?s disease are associated with improved behavioral performance
    Edward M. Rockenstein, Anthony Adame, Michael Mante, Herbert Moessler, Manfred Windisch, Eliezer Masliah · 2003 · Journal of Neural Transmission
  53. β-Amyloid Prions and the Pathobiology of Alzheimer’s Disease
    Joel C. Watts, Stanley B. Prusiner · 2017 · Cold Spring Harbor Perspectives in Medicine
  54. Ectodomain Phosphorylation of β-Amyloid Precursor Protein at Two Distinct Cellular Locations
    Jochen Walter, Anja Capell, Albert Y. Hung, Hanno Langen, Martina Schnölzer, Gopal Thinakaran, Sangram S. Sisodia, Dennis J. Selkoe, Christian Haass · 1997 · Journal of Biological Chemistry
  55. Understanding BACE1: essential protease for amyloid-β production in Alzheimer’s disease
    J. Stockley, C. O'Neill · 2008 · Cellular and Molecular Life Sciences
  56. SIRT3 activator Honokiol attenuates β-Amyloid by modulating amyloidogenic pathway
    Sindhu Ramesh, Manoj Govindarajulu, Tyler O. Lynd, Gwyneth Helen Briggs, Danielle Adamek, Ellery Jones, Jake Heiner, Mohammed Majrashi, Timothy Moore, Rajesh Amin et al. · 2018 · PLoS ONE
  57. Identification of a β-Secretase Activity, Which Truncates Amyloid β-Peptide after Its Presenilin-dependent Generation
    Regina Fluhrer, Gerd Multhaup, Andrea Schlicksupp, Masayasu Okochi, Masatoshi Takeda, Sven Lammich, Michael Willem, Gil G. Westmeyer, Wolfram Bode, Jochen Walter et al. · 2003 · Journal of Biological Chemistry
  58. Processing of Amyloid Precursor Protein in Human Primary Neuron and Astrocyte Cultures
    Andrea Claire LeBlanc, Maria Papadopoulos, Caroline Bélair, William N. Chu, Milena Crosato, Jaqueline Powell, Cynthia Gates Goodyer · 1997 · Journal of Neurochemistry
  59. Identification and biology of β‐secretase
    Patty C. Kandalepas, Robert J. Vassar · 2011 · Journal of Neurochemistry
  60. Aβ-oligomers: A potential therapeutic target for Alzheimer's disease
    Sudeshna Ghosh, Rafat Ali, Sandeep Kumar Verma · 2023 · International Journal of Biological Macromolecules
  61. Novel Role of RanBP9 in BACE1 Processing of Amyloid Precursor Protein and Amyloid β Peptide Generation
    Madepalli Krishnappa Lakshmana, Il‐Sang Yoon, Eunice Chen, Elizabetta Bianchi, Edward H. Koo, David E. Kang · 2009 · Journal of Biological Chemistry
  62. Axonal generation of amyloid-β from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes
    Raja Bhattacharyya, Sophia E. Black, Madhura S. Lotlikar, Rebecca H. Fenn, Mehdi Jorfi, Dora M. Kovacs, Rudolph E. Tanzi · 2021 · Cell Reports
  63. Exosomal biomarkers in Down syndrome and Alzheimer's disease
    Eric Daniel Hamlett, Aurélie Ledreux, Huntington Potter, Heidi J. Chial, David Patterson, Joaquin Maximiliano Espinosa, Brianne Magouirk Bettcher, Ann‐Charlotte Granholm · 2017 · Free Radical Biology and Medicine
  64. Lipid rafts play an important role in Aβ biogenesis by regulating the β-secretase pathway
    Han Win Tun, Laura A. Marlow, Inga Pinnix, Rachel Kinsey, Kumar Sambamurti · 2002 · Journal of Molecular Neuroscience
  65. Low‐density lipoprotein receptor‐related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway
    Il‐Sang Yoon, Eunice Chen, Tracy Busse, Emanuela Repetto, Madepalli Krishnappa Lakshmana, Edward H. Koo, David E. Kang · 2007 · The FASEB Journal
  66. FBL2 Regulates Amyloid Precursor Protein (APP) Metabolism by Promoting Ubiquitination-Dependent APP Degradation and Inhibition of APP Endocytosis
    Tomomichi Watanabe, Yukiko Hikichi, Antje Willuweit, Yasushi Shintani, Takashi Horiguchi · 2012 · Journal of Neuroscience
  67. Alzheimer's Disease-Linked Mutations in Presenilin-1 Result in a Drastic Loss of Activity in Purified γ-Secretase Complexes
    Cacquevel, Matthias, Aeschbach, Lorène, Houacine, Jemila, Fraering, Patrick C. · 2012 · PLoS ONE
  68. A lipid boundary separates APP and secretases and limits amyloid β-peptide generation
    Christoph Kaether, Christian Haass · 2004 · The Journal of Cell Biology
  69. Intracellular A-Beta Amyloid, A Sign for Worse Things to Come?
    Valentina Echeverrı́a, A. Claudio Cuello · 2002 · Molecular Neurobiology
  70. Rapid and Direct Transport of Cell Surface APP to the Lysosome defines a novel selective pathway
    Angela Lorenzen, Jonathan Samosh, Kenneth Van Dewark, Pieter H. Anborgh, Claudia Seah, Ana C. Magalhães, Sean P. Cregan, Stephen S. G. Ferguson, Stephen Pasternak · 2010 · Molecular Brain
  71. Increased amyloidogenic secretion in cerebellar granule cells undergoing apoptosis
    Cinzia Galli, Alessandra Piccini, Maria Teresa Ciotti, Loriana Castellani, Pietro Calissano, D Zaccheo, Massimo Tabaton · 1998 · Proceedings of the National Academy of Sciences
  72. α‐secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Aβ generation
    Sebastian Jäger, Stefanie Leuchtenberger, Anne Marie Martin, Eva Czirr, Johanna Wesselowski, Marco Dieckmann, Elaine Waldron, Carsten Korth, Edward H. Koo, Michael Thomas Heneka et al. · 2009 · Journal of Neurochemistry
  73. Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer’s disease
    Robert J. Andrew, Celia G. Fernandez, Molly Stanley, Hong Jiang, Phuong Anh H. Nguyen, Richard C. Rice, Virginie Buggia-Prévot, Pierre De Rossi, Kulandaivelu S. Vetrivel, Raza Lamb et al. · 2017 · Proceedings of the National Academy of Sciences
  74. β‐secretase as a target for the treatment of Alzheimer's disease
    Martin Citron · 2002 · Journal of Neuroscience Research
  75. Protein Kinase C Activation Increases Release of Secreted Amyloid Precursor Protein without Decreasing Aβ Production in Human Primary Neuron Cultures.
    Andrea Claire LeBlanc, Maria Koutroumanis, Cynthia Gates Goodyer · 1998 · Journal of Neuroscience
  76. Inhibition of BACE1 for therapeutic use in Alzheimer's disease.
    Xiaoyang Luo, Riqiang Yan · 2010 · Europe PMC (PubMed Central)
  77. Reactive astrocytes as treatment targets in Alzheimer's disease—Systematic review of studies using the <scp>APPswePS1dE9</scp> mouse model
    Smit, Tamar, Deshayes, Natasja A. C., Borchelt, David R., Kamphuis, Willem, Middeldorp, Jinte, Hol, Elly M. · 2021 · Glia
  78. Protein Aggregation Landscape in Neurodegenerative Diseases: Clinical Relevance and Future Applications
    Niccolò Candelise, Silvia Scaricamazza, Illari Salvatori, Alberto Ferri, Cristiana Valle, Valeria Manganelli, Tina Garofalo, Maurizio Sorice, Roberta Misasi · 2021 · International Journal of Molecular Sciences
  79. Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes
    Lauren K. Fong, Max M. Yang, Rodrigo dos Santos Chaves, Sol M. Reyna, Vanessa F. Langness, Grace Woodruff, Elizabeth A. Roberts, Jessica E. Young, Lawrence S.B. Goldstein · 2018 · Journal of Biological Chemistry
  80. Emerging Alzheimer’s disease therapies: inhibition of β-secretase
    Martin Citron · 2002 · Neurobiology of Aging
  81. The Protease Inhibitor, MG132, Blocks Maturation of the Amyloid Precursor Protein Swedish Mutant Preventing Cleavage by β-Secretase
    Michelle Leigh Steinhilb, Raymond Scott Turner, James R. Gaut · 2001 · Journal of Biological Chemistry
  82. Prion Protein Interacts with BACE1 Protein and Differentially Regulates Its Activity toward Wild Type and Swedish Mutant Amyloid Precursor Protein
    Heledd Jarosz-Griffiths, Isobel J. Whitehouse, Herbert N. Baybutt, Debbie Brown, Katherine A. B. Kellett, Carolyn D. Jackson, Anthony J. Turner, Pedro Piccardo, Jean C. Manson, Nigel M. Hooper · 2011 · Journal of Biological Chemistry
  83. Insights into the Phosphoregulation of β‐Secretase Sorting Signal by the VHS Domain of GGA1
    T. Shiba, Satoshi Kametaka, Masato Kawasaki, Masahiro Shibata, Satoshi Waguri, Yasuo Uchiyama, Soichi Wakatsuki A · 2004 · Traffic
  84. Cdk5–Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models
    Chun Shi, Keith Viccaro, Hyoung‐gon Lee, Kavita Shah · 2016 · Journal of Cell Science
  85. Apical Sorting of β-Secretase Limits Amyloid β-Peptide Production
    Anja Capell, Liane Meyn, Regina Fluhrer, David B. Teplow, Jochen Walter, Christian Haass · 2002 · Journal of Biological Chemistry
  86. Competition of Aβ amyloid peptide and apolipoprotein E for receptor-mediated endocytosis
    Karl Winkler, Hubert Scharnagl, U Tisljar, Heinz Hoschützky, I. Friedrich, Michael M. Hoffmann, Manfred Hüttinger, Heinrich Wieland, Winfried März · 1999 · Journal of Lipid Research
  87. The consequences of mitochondrial amyloid β-peptide in Alzheimer's disease
    Kirsty E. A. Muirhead, Eva Borger, Laura Aitken, Stuart J. Conway, Frank J. Gunn‐Moore · 2010 · Biochemical Journal
  88. M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer’s disease genes and improving memory
    Claude‐Henry Volmar, Hasib Salah-Uddin, Karolina J. Janczura, Paul Halley, Guerline Lambert, Andrew P. K. Wodrich, Sivan Manoah, Nidhi H. Patel, Gregory C. Sartor, Neil Mehta et al. · 2017 · Proceedings of the National Academy of Sciences
  89. Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression
    Filip Liebsch, Luka Kulic, Charlotte Elisabeth Teunissen, Adeola Shobo, Irem Ulku, Vivienne Engelschalt, Mark A. Hancock, Wiesje M. van der Flier, Peter Kunach, Pedro Rosa‐Neto et al. · 2019 · Nature Communications
  90. Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways
    Christopher Böhm, F. Chen, Jean Sévalle, Seema Qamar, Roger B. Dodd, Y. Li, Gerold Schmitt‐Ulms, Paul E. Fraser, Peter St George‐Hyslop · 2015 · Molecular and Cellular Neuroscience
  91. The amyloid precursor protein protects PC12 cells against endoplasmic reticulum stress‐induced apoptosis
    Donat Kögel, Robert Schomburg, Tina Schürmann, Claus Reimertz, Hans‐Georg König, Monika Poppe, Anne Eckert, Walter E. Müller, Jochen H.M. Prehn · 2003 · Journal of Neurochemistry
  92. Transgenic animals relevant to Alzheimer’s disease
    Guy R. Seabrook, Thomas W. Rosahl · 1999 · Neuropharmacology
  93. The Amyloid-β Rise and γ-Secretase Inhibitor Potency Depend on the Level of Substrate Expression
    Catherine R. Burton, Jere E. Meredith, Donna M. Barten, Margi E. Goldstein, Carol Krause, Cathy J. Kieras, Lisa M. Sisk, Lawrence G. Iben, Craig T. Polson, Mark W. Thompson et al. · 2008 · Journal of Biological Chemistry
  94. The pharmacology of amyloid precursor protein processing
    Marco Racchi · 2003 · Experimental Gerontology
  95. The Arctic Alzheimer mutation favors intracellular amyloid‐β production by making amyloid precursor protein less available to α‐secretase
    Charlotte Sahlin, Anna Lord, Kristina Magnusson, Hillevi Englund, Cláudia Guimas Almeida, Paul Greengard, Fred Nyberg, Gunnar K. Gouras, Lars Lannfelt, Lars N. G. Nilsson · 2007 · Journal of Neurochemistry
  96. Genetics of Alzheimer’s disease: From pathogenesis to clinical usage
    Wen Shao, Dantao Peng, Xiaomin Wang · 2017 · Journal of Clinical Neuroscience
  97. Spirocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: From Hit to Lowering of Cerebrospinal Fluid (CSF) Amyloid β in a Higher Species
    Kevin W. Hunt, Adam W. Cook, Ryan J. Watts, Christopher T. Clark, Guy P. A. Vigers, Darin J. Smith, Andrew T. Metcalf, Indrani W. K. Gunawardana, Michael Burkard, April Cox et al. · 2013 · Journal of Medicinal Chemistry
  98. Anesthesia and the Old Brain
    Junxia X. Tang, Maryellen Fazen Eckenhoff, Roderic G. Eckenhoff · 2010 · Anesthesia & Analgesia
  99. Cholinergic agonists stimulate secretion of soluble full-length amyloid precursor protein in neuroendocrine cells.
    Spiros Efthimiopoulos, Dido Vassilacopoulou, James A. Ripellino, Nikolaos Tezapsidis, Nikolaos K. Robakis · 1996 · Proceedings of the National Academy of Sciences
  100. Retention of the Alzheimer's Amyloid Precursor Fragment C99 in the Endoplasmic Reticulum Prevents Formation of Amyloid β-Peptide
    William A. Maltese, Susan E. Wilson, Yizheng Tan, Susanna Suomensaari, Sukanto Sinha, Robin Barbour, Lisa McConlogue · 2001 · Journal of Biological Chemistry