β-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment

The metabolic syndrome

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Protein Sensors for Membrane Sterols

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A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis

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Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase

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Triggering and amplifying pathways of regulation of insulin secretion by glucose.

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PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

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Fatty acid-induced β cell apoptosis: A link between obesity and diabetes

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Multiple Rare Alleles Contribute to Low Plasma Levels of HDL Cholesterol

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Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications

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Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*

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ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation

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The Importance of β-Cell Failure in the Development and Progression of Type 2 Diabetes

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Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts

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High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1

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Intestinal ABCA1 directly contributes to HDL biogenesis in vivo

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Molecular Cloning of the Human ATP-Binding Cassette Transporter 1 (hABC1): Evidence for Sterol-Dependent Regulation in Macrophages

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ABCA1: the gatekeeper for eliminating excess tissue cholesterol

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Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I

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SNARE proteins are highly enriched in lipid rafts in PC12 cells: Implications for the spatial control of exocytosis

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Increased islet apoptosis in Pdx1+/– mice

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ABCA1 mRNA and Protein Distribution Patterns Predict Multiple Different Roles and Levels of Regulation

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Troglitazone Lowers Islet Fat and Restores Beta Cell Function of Zucker Diabetic Fatty Rats

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Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans

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Troglitazone prevents mitochondrial alterations, β cell destruction, and diabetes in obese prediabetic rats

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Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance.

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Insulin-secreting β-Cell Dysfunction Induced by Human Lipoproteins

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Dietary Monounsaturated Fatty Acids Promote Aortic Atherosclerosis in LDL Receptor–Null, Human ApoB100–Overexpressing Transgenic Mice

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Disruption of Pancreatic β-Cell Lipid Rafts Modifies Kv2.1 Channel Gating and Insulin Exocytosis

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LXRβ Is Required for Adipocyte Growth, Glucose Homeostasis, and β Cell Function

Gerin, I., Dolinsky, V. W., Shackman, J. G., Kennedy, R. T., Chiang, S.-H., Burant, C. F., Steffensen, K. R., Gustafsson, J.-Å., & MacDougald, O. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412564200 · Cited by 165

Variations on a Gene: Rare and Common Variants in ABCA1 and Their Impact on HDL Cholesterol Levels and Atherosclerosis

Brunham, L. R., Singaraja, R. R., & Hayden, M. R. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.26.061505.111214 · Cited by 148

Low Density Lipoprotein Can Cause Death of Islet β-Cells by Its Cellular Uptake and Oxidative Modification

Cnop, M., Hannaert, J. C., Grupping, A. Y., & PIPELEERS, D. G. (2002) · Endocrinology · doi:10.1210/en.2002-220273 · Cited by 138

PPAR Agonists Protect Mesangial Cells from Interleukin 1β-Induced Intracellular Lipid Accumulation by Activating the ABCA1 Cholesterol Efflux Pathway

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Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population

Daimon, M., Sato, H., Oizumi, T., Toriyama, S., Saito, T., Karasawa, S., Jimbu, Y., Wada, K., Kameda, W., Susa, S., et al. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.10.180 · Cited by 74

Hypercholesterolemia abolishes voltage-dependent K+ channel contribution to adenosine-mediated relaxation in porcine coronary arterioles

Heaps, C. L., Tharp, D. L., & Bowles, D. K. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00157.2004 · Cited by 74

Low Density Lipoprotein Binding and Uptake by Human and Rat Islet Cells

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Endocytosis of Low-Density Lipoprotein by Human Pancreatic β Cells and Uptake in Lipid-Storing Vesicles, Which Increase with Age

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The X-Linked Inhibitor of Apoptosis Protein Enhances Survival of Murine Islet Allografts

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Effect of Cholesterol Depletion on Exocytosis of Alveolar Type II Cells

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Cholesterol content regulates acrosomal exocytosis by enhancing Rab3A plasma membrane association

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Association of the ABCA1 gene polymorphisms with type 2 DM in a Japanese population

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Glucolipotoxicity: fuel excess and β-cell dysfunction

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Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy

Lu, X., Xie, Q., Pan, X., Zhang, R., Zhang, X., Peng, G., Zhang, Y., Shen, S., & Tong, N. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01951-9 · Cited by 665

Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics

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Obesity, adiposity, and dyslipidemia: a consensus statement from the National Lipid Association

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High-Density Lipoprotein Modulates Glucose Metabolism in Patients With Type 2 Diabetes Mellitus

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