Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation
Hilton, Matthew J, Tu, Xiaolin, Wu, Ximei, Bai, Shuting, Zhao, Haibo, Kobayashi, Tatsuya, Kronenberg, Henry M, Teitelbaum, Steven L +3 more·2008·Nature Medicine
DOI 10.1038/nm1716
Cited by (600)
Items 501–600 of 600
- Notch-dependent activation of periodontal cells osteogenic potentialDaria Semenova, Aleksandra S. Kostina, A. M. Mustaeva, Polina Klauzen, Mikhail A. Dobrynin, Боярская Надежда Владимировна, Yu. A. Dombrovskaya, Anna Malashicheva, Natella I. Enukashvily · 2020 · Translational Medicine
- A mutation in NOTCH2 gene first associated with Hajdu–Cheney syndrome in a Greek family: diversity in phenotype and response to treatmentZoe A. Efstathiadou, Charilaos Kostoulas, Stergios A. Pοlyzos, Fotini Adamidou, Ioannis A. Georgiou, Marina D. Kita · 2020 · Endocrine
- Inhibition of bone morphogenetic protein-induced osteoblast differentiationShoichiro Kokabu, Shizu Tsuchiya-Hirata, Hidefumi Fukushima, Goro Sugiyama, Jonathan Wayne Lowery, Takenobu Katagiri, Eijiro Jimi · 2015 · Journal of Oral Biosciences
- 6-Bromoindirubin-3′-oxime (BIO) induces proliferation of human mesenchymal stem cells (hMSCs)M Hoffman, Masahiko Takahata, D.S.M. Benoit · 2011 · IEEE Annual Northeast Bioengineering Conference (NEBEC)
- Deregulation of osteoblast differentiation in primary bone cancersPierre J. Marie, Olivia Fromigué, Dominique Modrowski · 2014 · Elsevier eBooks
- Notch effector Hes1 marks an early perichondrial population of skeletal progenitor cells at the onset of endochondral bone developmentYuki Matsushita, Mizuki Nagata, Joshua D. Welch, Sunny Y. Wong, Wanida Ono, Noriaki Ono · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Endochondral OssificationCourtney M. Karner, Matthew J. Hilton · 2018 · Wiley eBooks
- Multi-lineage transcriptional and cell communication signatures define evolving personalized mechanisms that initiate and perpetuate rheumatoid arthritisCong Liu, Z. Audrey Wang, Edward B. Prideaux, David L. Boyle, Katherine Nguyen, Vlad Tsaltskan, Amy Westermann, Andrea E. Ochoa, Kevin D. Deane, Marie L. Feser et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- A Spatiotemporal Model of CXCL10 as a Master Regulator of Immune Evasion and Metastasis in OsteosarcomaBenjamin Baffour Gyau, Tsz-Kwong Chris Man · 2025 · International Journal of Molecular Sciences
- Nutrient uptake and metabolism in osteoblastsCourtney M. Karner, Fanxin Long · 2023 · Current Opinion in Endocrine and Metabolic Research
- Osteoblastic erythropoietin is not required for bone mass accrualGiulia Lanzolla, Christophe Merceron, Mohd Parvez Khan, Elena Sabini, Amato J. Giaccia, Ernestina Schipani · 2024 · JBMR Plus
- RUNX transcription factors are essential in maintaining epididymal epithelial differentiationMervi Toriseva, Ida Björkgren, Arttu Junnila, Arfa Mehmood, Jesse Mattsson, Inka Raimoranta, Bongki Kim, Asta Laiho, Matthias Nees, Laura L. Elo et al. · 2024 · Cellular and Molecular Life Sciences
- Breast Cancer Metastases to Bone: Role of the MicroenvironmentE. Jenna, Валерьевна Светлана · 2011 · InTech eBooks
- Notch signaling and boneStefano Zanotti, ERNESTO M. CANALIS · 2011 · IBMS BoneKEy
- Calcific Aortic Valve Disease: Pathobiology, Basic Mechanisms, and Clinical StrategiesPayal Vyas, Joshua D. Hutcheson, Elena Rabkin Aikawa · 2018 · Springer eBooks
- Correction to: A mutation in NOTCH2 gene first associated with Hajdu–Cheney syndrome in a Greek family: diversity in phenotype and response to treatmentZoe A. Efstathiadou, Charilaos Kostoulas, Stergios A. Pοlyzos, Fotini Adamidou, Ioannis A. Georgiou, Marina D. Kita · 2020 · Endocrine
- NOTCH1, 2, and 3 receptors enhance osteoblastogenesis of mesenchymal C3H10T1/2 cells and inhibit this process in preosteoblastic MC3T3-E1 cellsJose Luis Resuela‐Gonzalez, María-Julia González-Gómez, María-Milagros Rodríguez-Cano, Susana López‐López, Eva M. Monsalve, María-José M. Díaz-Guerra, Jorge Laborda, María‐Luisa Nueda, Victoriano Baladrón · 2025 · Differentiation
- Metformin Administration Protects Against Deltoid Tendon Damage Through Activation of Notch SignalingCan Liu, Runqi Wang, Yong Xu, Qingyi Liu, Yin Li, Xiangpeng Liu, Hui‐Kuo G. Shu, Kaige Gao, Xingye Zheng, Yingying Dong et al. · 2025 · iMeta
- Triptolide Attenuates Traumatic Heterotopic Ossification via Modulation of Inflammatory and Differentiation Pathways: Implications for Biochemical ToxicologyZuo‐Hua Li, Zonghuan Li, Zheng Wang, Xiang Wu Jiang, Aixi Yu · 2025 · Journal of Biochemical and Molecular Toxicology
- Role of Notch signaling in corticalizationGherardo Mazziotti, ERNESTO M. CANALIS · 2025 · Journal of Endocrinological Investigation
- A novel variant of NOTCH2 causes skeletal fragilityERNESTO M. CANALIS, Jungeun Yu, Emily Denker, Lauren Schilling, Alix C. Deymier, Bing Hao, Thomas Carpenter · 2025 · Bone
- An overview on osteogenic differentiation process: Minimum essential information for bone tissue engineeringAida Șelaru, Iuliana Samoilă, Sorina Dinescu, Marieta Costache · 2018 · Reviews in Biological and Biomedical Sciences
- Orthopaedic Manifestations of Alagille SyndromeMatthew J. Hall, Tracy M. Borsinger, Allen D. Nicholson, Cordelia W. Carter · 2019 · JBJS Case Connector
- Osteoporosis Genes Identified by Genome-wide Association StudiesFernando Rivadeneira, André Gerardus Uitterlinden · 2012 · Elsevier eBooks
- Hdac1 and Hdac2 positively regulate Notch1 gain‐of‐function pathogenic signaling in committed osteoblasts of male miceHaydee M. Torres, Leetoria Hinojosa, Ashley M. VanCleave, Tania G. Rodezno, Jennifer J. Westendorf, Jianning Tao · 2023 · Birth Defects Research
- The Jagged-1/Notch1 Signaling Pathway Promotes the Construction of Tissue-Engineered Heart ValvesKang Liu, Zhang-yan Wei, Xue-Hong Zhong, Xiaomei Liu, Hailong Chen, Yiyun Pan, Wen Zeng · 2023 · Tissue Engineering Part A
- The bidirectional effects of APPswe on the osteogenic differentiation of MSCs in bone homeostasis by regulating Notch signalingNan Wang, Xiaoyu Shen, Huakun Huang, Runhan Zhao, Habu Jiwa, Zongxin Li, Pei Li, Jixing Ye, Qiang Zhou · 2024 · Genes & Diseases
- In vitro analysis of bone phenotypes in Col1a1 and Jagged1 mutant mice using a standardized osteoblast cell culture systemFrank Thiele, Christian M. Cohrs, Gerhard K. H. Przemeck, Wolfgang Wurst, Helmut Fuchs, Martin Hrabě de Angelis · 2013 · Journal of Bone and Mineral Metabolism
- Mesenchymal Stromal Cells: Latest AdvancesSowmya Viswanathan, Armand Keating · 2011 · Humana Press eBooks
- Induction of cardiomyocyte calcification is dependent on FoxO1/NFATc3/Runx2 signalingJayeeta Samanta, Arunima Mondal, Shreya Das, Santanu Chakraborty, Arunima Sengupta · 2021 · In Vitro Cellular & Developmental Biology - Animal
- Tonifying Shen-Yin and-Yang Principles in Treating Osteoporosis:All Roads Lead to RomeWei Gou, Nanmei Liu, Chenglong Wang, Huiling Wang, Shi Shou Lu, Dongfeng Zhao, Xiu-Zhi Yu · 2016 · World Journal of Traditional Chinese Medicine
- Grapefruit juice exerts anti-osteoporotic activities in a prednisolone-induced osteoporosis rat femoral fracture model, possibly via the RANKL/OPG axisEslam M. Bastawy, Rasha R. Ahmed, Amer Ali Abd El‐Hafeez, Fatma Kamal Abd El-Hady, Toru Hosoi, Koichiro Ozawa, Monir A. El-Ganzuri · 2019 · Cytotechnology
- Updated results on the karyology of the WI-38, MRC-5 and MRC-9 cell strains.J P Jacobs · 1976 · PubMed
- Development of a three-dimensional haematopoietic stem cell-permissive bone marrow niche model using magnetic levitationNatasha S. Lewis · 2018 · Enlighten: Theses (The University of Glasgow)
- Notch Signaling in Skeletal DiseasesERNESTO M. CANALIS · 2020 · Elsevier eBooks
- Lineage Determination of Osteoblasts and ChondrocytesPrem Swaroop Yadav, Yingzi Yang · 2020 · Elsevier eBooks
- Alagille SyndromePaola Gaio, Elena Reffo, Claudia Mescoli, Mara Cananzi · 2021 · Springer eBooks
- Mechanisms of Bone Regeneration: An UpdateJaganmay Sarkar, Vijay Bhaskar Reddy Konala, Hiranmoy Das · 2025 · Springer eBooks
- Current Challenges and Future Perspectives in Bone Tissue EngineeringHeliasadat Haeriboroojeni, Navid Rabiee, Sepideh Ahmadi, Hanieh Nokhbatolfoghahaei · 2025 · Springer eBooks
- Development of the skeletonSylvain Provot, Ernestina Schipani, Joy Y. Wu, Henry M. Kronenberg · 2020 · Elsevier eBooks
- Notch signaling modulates Fgf23 expression through crosstalk with hypoxia and PTH pathways in osteogenic cellsYoshihiro Tamamura, Kenta Terai, Akira Yamaguchi · 2025 · Molecular and Cellular Endocrinology
- DAPT Mitigates Osteoarthritic Cartilage Degeneration and Enhances Articular Repair Through Targeted Modulation of the Gucy1a3 and Notch Signaling AxisXiaoyan Zheng, Rui Lin, Shan Huang, Qiqing Zeng, Xiang Gao, Yuyu Liu, Yanzhi Liu · 2026 · Drug Design Development and Therapy
- CDK12 mediates the inhibition effect of mechanical unloading on osteoblast proliferation by regulating RNAPII transcription activationLifang Hu, Wenjin Zhong, Linlin Wang, Shujing Liang, 贾云献, Zixiang Wu, Jingran Shen, Jiajun Sun, Airong Qian · 2026 · Bone and Joint Research
- Progeroid syndromes: models for stem cell aging?Ilaria Bellantuono, Guido Sanguinetti, W. Nicol Keith · 2011 · Biogerontology
- Regulatory Mechanisms of Notch Signaling in Osteoclast DifferentiationHidefumi Fukushima · 2010 · Journal of Oral Biosciences
- Skeletal Stem Cells/Bone Marrow Stromal CellsPamela Gehron Robey · 2017 · Elsevier eBooks
- Developmental Pathways and Aortic Valve CalcificationM. Victoria Gomez‐Stallons, Keira R. Hassel, Katherine E. Yutzey · 2020 · Contemporary cardiology
- Notch1 is a marker for in situ resting osteocytes in a 3-dimensional gel culture modelYinghui Zhou, Jiayu Zhu, Yue Guo, Haoneng Tang, Fang Wang, Junaid Iqbal, Hui‐Xuan Wu, Nan Hu, Fen Xiao, Ting Wang et al. · 2023 · Connective Tissue Research
- Regulation of Breast Cancer Stem Cells by Mesenchymal Stem Cells in the Metastatic NicheFayaz Ahmad Malik, Hasan Körkaya, Shawn G. Clouthier, Max S. Wicha · 2015 · Wiley eBooks
- Origin and Differentiation of OsteoclastsArchana Sanjay, Julia F. Charles · 2019 · Elsevier eBooks
- Osteoblast DifferentiationFanxin Long · 2019 · Elsevier eBooks
- Role of Gli3 during intramembranous calvarial bone developmentLotta Veistinen · 2015 · Työväentutkimus Vuosikirja
- Notch signaling and bone fracture healingMichael I. Dishowitz · 2013 · ScholarlyCommons (University of Pennsylvania)
- Systematic proteomic analysis of oxygen mediated DNA damageSara Mcdonald · 2015 · Research Explorer (The University of Manchester)
- A notch in bone, hey, this is a phenotype…Florent Elefteriou · 2008 · IBMS BoneKEy
- Chondrocytes: Meeting report from the 30th Annual Meeting of the American Society for Bone and Mineral ResearchFanxin Long · 2008 · IBMS BoneKEy
- Chondrocytes and cartilage biology: Meeting report from the 33rd annual meeting of the American Society for Bone and Mineral ResearchTatsuya Kobayashi · 2011 · IBMS BoneKEy
- Achieving tissue specific levels of angiogenesis: Not(ch) a big deal!Claire Elizabeth Clarkin · 2015 · Europe PMC (PubMed Central)
- THE NOTCH TARGET HES4 PROMOTES OSTEOSARCOMA TUMOR GROWTH AND METASTASIS BY INHIBITING OSTEOGENIC DIFFERENTIATION, AND HAS POTENTIAL AS A PROGNOSTIC BIOMARKER FOR NEWLY DIAGNOSED PATIENTS WITH HIGH GRADE OSTEOSARCOMA.Madonna M. McManus · 2016 · Digital Commons-TMC (Texas Medical Center)
- Development of an osteoblast cell culture system for functional characterization and comparative analyses of mouse models with bone phenotypes and systemic investigation of an Osteogenesis imperfecta disease modelFrank Thiele · 2009 · Site cant be reached
- Diabetic Bone Marrow & Stem Cell DysfunctionMeghan A. Piccinin · 2015 · Scholarship@Western (Western University)
- Notch and Myeloid CellsChieko Ishifune, Koji Yasutomo · 2017 · Springer eBooks
- Unravelling the Mechanisms behind Periosteal Regeneration and its Application in Bone Tissue EngineeringJeremy Baldwin · 2017 · Queensland University of Technology
- Novel mechanisms of carboplatin resistance in epithelial ovarian cancer and their therapeutic potentialSamir H. Barghout · 2015 · ERA: Education and Research Archive (University of Alberta)
- Bone structural characteristics and response to bisphosphonate treatment in children with Hajdu--Cheney syndromeSophia D. Sakka, Gafni RachelI, Bart Lyman Clarke, Frank Rauch, Wolfgang Högler · 2015 · Bone Abstracts
- Le syndrome d’Hajdu-Cheney ou acro-ostéolyse autosomique dominanteQuitterie Rochoux, Nathalie Léon, Christian Marcelli · 2018 · Revue du Rhumatisme Monographies
- Clinical and basic research papers – April 2008Serge Ferrari, David Graham Little, Toshio Matsumoto, Ego Seeman · 2008 · IBMS BoneKEy
- Exploring the Regulatory Mechanism of the Notch Ligand Receptor Jagged1 Via the Aryl Hydrocarbon Receptor in Breast CancerSean A. Piwarski · 2018
- Notch Signaling in Cartilage Development and DiseaseYinshi Ren, Yihan Liao, Matthew J. Hilton · 2020 · Elsevier eBooks
- Use of Antisense Oligonucleotides to Target Notch2 in Mouse ChondrocytesGabrielle Viviana Lanza · 2021 · OpenCommons - UConn (University of Connecticut)
- Stem cells and regenerative medicine for musculoskeletal tissueEmma R. Payne, Jenny Ji, Ding Xiao, Jie Shen · 2022 · Elsevier eBooks
- Bone Development and RemodelingChrista Maes, Henry M. Kronenberg · 2010 · Elsevier eBooks
- Materiobiological Effects Regulate the Bone MicroenvironmentShuangshuang Chen · 2022 · Wiley eBooks
- Systems biology approach for the establishment of veterinary bone tissue engineering: the proteomics of cBM-MSCs and cDPSCs osteogenic modelsSirirat Nantavisai · 2018
- Functional Role of Human-Derived Stem Cells in Bone Tissue RegenerationDuaa Azmi Abuarqoub, Abdalla Awidi, Walhan Alshaer, Mohammad Suleiman Mubarak · 2024 · Elsevier eBooks
- Effect of Zika virus on the osteogenic capacity of mesenchymal stem cells via the Notch signaling pathwayShanglin Li, Jie Gao, Shanshan Shi, Jiayi Mei, Sha Wu, Junmei Zhou, Lifang Jiang, Huijun Yan, Lihua Huang, Zhenyou Jiang · 2024 · Research Square
- Multi-lineage transcriptional and cell communication signatures define pathways in individuals at-risk for developing rheumatoid arthritis that initiate and perpetuate diseaseWei Wang, Cong Liu, Gary S. Firestein, Peter J. Skene, Kevin D. Deane, Vernon Michael Holers, Jane Hoyt Buckner · 2025 · Research Square
- Jagged ligand expression by alpha-SMA progenitors is required for normal fracture healingFatma Betul Kabadas, Emma Wessels, Madison Buckles, Christina Capobianco, Luke Schroeder, A.J. Ford, Kyle Cragg, Jacob Noorily, Tanisha Deshmukh, Matthew Hart et al. · 2026 · Bone
- Huo Xue Tong Luo capsule epigenetically activates β-catenin, promotes Prx1-lineage cells proliferation and endochondral bone formation during fracture healingPeng Yang, Ding Wang, Qiangqiang Zhao, Liangliang Xu, Shuo Huang, Yamei Liu · 2025 · Journal of Orthopaedic Surgery and Research
- Transcriptomic profiling confirms microRNA-140 is more functional in joint development than in diseaseYao Hao, Hua Lin, Jamie Soul, Lynne M. Overman, Steven Lisgo, Jonathan M Coxhead, Katarzyna Anna Piróg, Ian M. Clark, Matt J. Barter, Louise N. Reynard et al. · 2025 · Osteoarthritis and Cartilage
- MicroRNA‐127‐3p Inhibits In Vitro Osteogenesis and Dampens Trauma‐Induced Heterotopic Ossification In VivoVictor Gustavo Balera Brito, Austin Bell‐Hensley, Hongjun Zheng, Jin Liu, Arya Narayan, Sandra Helena Penha Oliveira, Hua Pan, Audrey McAlinden · 2025 · Journal of Orthopaedic Research®
- Spatiotemporal Regulation and Lineage Specification in Embryonic Endochondral OssificationSixun Wu, Keita Kondo, Yuki Matsushita · 2026 · International Journal of Molecular Sciences
- Endothelial lncRNA-HOXA responses to combined chemical hypoxia and shear stressAnderson Moreira Gomes, Gerson Santos de Almeida, Thais Silva Pinto, Suélen Aparecida Teixeira, William Fernando Zambuzzi · 2026 · Experimental Cell Research
- Biology of bone and cartilageBrendan F. Boyce, Michael J. Zuscik, Lianping Xing · 2026 · Elsevier eBooks
- Bone marrow stromal cells/skeletal stem cellsPamela Gehron Robey · 2026 · Elsevier eBooks
- Mesenchymal potentials of the trunk neural crest cellsJuliana De Mattos Coelho Aguiar · 2012 · theses.fr (ABES)
- Etude du rôle du facteur de transcription Krox20 dans le développement et la maturation des valves cardiaques chez la sourisGaëlle Odelin · 2015
- Attenuation of oxidative phosporylation and induction of hypoxic celle response : [alpha]-tocopherolacetate and miR-210 effects on mesenchymal stromal cellsDarija Loncaric · 2019 · theses.fr (ABES)
- Caractérisation phénotypique et fonctionnelle des cellules stromales mésenchymateuses natives de la moelle osseuse humaine adulteLoïc Fiévet · 2020 · theses.fr (ABES)
- Chondrodysplasia with multiple dislocations : understanding the molecular and physiopathological bases by analyzing animal and cellular modelsAlessandra Guasto · 2021
- Unraveling the role of the lysosomal protein Prosaposin in neural stem cell quiescenceMiriam Labusch · 2022 · theses.fr (ABES)
- Role of osteoblast-lineage cells in the systemic control of breast cancer growth and metastasisLea Hanna Doumit Sakr · 2023 · theses.fr (ABES)
- G protein-coupled receptor signaling in osteogenic bone mesenchymal stem/stromal cellsTrevor J. Wolfe, Samantha R. Weaver · 2026 · Frontiers in Cell and Developmental Biology
- Pediatric leukemia: origins, pathogenesis, the role of microenvironment and immunological modulationWeronika Małkowska, Anna Małkowska, Łukasz Kiraga · 2026 · Frontiers in Immunology
- Analyzing immune serum characteristics through electrochemical biosensors: Analytical quantification of a PF4-centred angiogenesis–immune serum signature for steroid-induced osteonecrosis of the femoral headChuan Wang, Chaode Cen, Zhou Fang, Zhimin Shen, Xiaoxia Wang, Meiming Qian, Jiajia Wan, Xiaonan Liu, Guangdi Li · 2026 · Microchemical Journal
- Role of Notch signaling pathway in joint homeostasis and osteoarthritisXiaohan Wei, Bowen Guan, Xinyi He, Songsong Zhu, Ruiye Bi · 2026 · Frontiers in Bioengineering and Biotechnology
- Reprogramming bone homeostasis: The recoupling-oriented framework of bidirectional regulation strategies for osteoporosisJiayao Niu, Zheng Li, Yunpeng Zou, Zhipeng Wang, Jianning Kang, Ying Zhang, Shuya Wang, Ronghan Liu, Xiaoguang Han · 2026 · iScience
- Direct 3D isolation in gelatin methacryloyl microbeads versus conventional 2D isolation and culture: a trade-off between mesenchymal stromal cell purity and niche-associated transcriptional profilesNali Hussein, Cornelius Miller, Yvonne Roger, Letizia Venturini, Michael Stadler, Marco Haertlé, Antonina V. Lavrentieva, Nadin Haase, Sophia Rudorf, Andrea Hoffmann et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- ADAM-10 Is Involved in Osteoblast Mineralization and Rheumatoid Arthritis-Associated Bone DestructionHaruka Nakamura, Hiroyuki Kojima, Kohei Maeda, Kosuke Sakurai, Toshihiro Tanioka, 石井翔, Kuninobu Wakabayashi, Masahiro Hosonuma, Yuki Azetsu, Masayuki Iyoda et al. · 2026 · International Journal of Molecular Sciences
- Defining the mechanisms in lineage specification of progenitor cells in the regenerating adult liverLuke Boulter · 2011 · ERA