Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

Hilton, Matthew J, Tu, Xiaolin, Wu, Ximei, Bai, Shuting, Zhao, Haibo, Kobayashi, Tatsuya, Kronenberg, Henry M, Teitelbaum, Steven L, Ross, F Patrick, Kopan, Raphael, Long, Fanxin·2008·Nature Medicine
DOI 10.1038/nm1716

Cited by (600)

Items 201–300 of 600

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  3. SIRT1/FOXO3a axis plays an important role in the prevention of mandibular bone loss induced by 1,25(OH)2D deficiency
    Haiyun Chen, Xiaoqing Hu, Renlei Yang, Guoping Wu, Qian Tan, David Goltzman, Dengshun Miao · 2020 · International Journal of Biological Sciences
  4. Inhibition of Notch1 signaling by Runx2 during osteoblast differentiation
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  5. Canonical Notch activation in osteocytes causes osteopetrosis
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  6. Characterization of Notch Signaling During Osteogenic Differentiation in Human Osteosarcoma Cell Line MG63
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  7. Bone Density in Children With Chronic Liver Disease Correlates With Growth and Cholestasis
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  8. Icariin promotes osteogenic differentiation by suppressing Notch signaling
    Yuexin Xu, Lingyun Li, Yuting Tang, Jia‐Shu Yang, Yucui Jin, Changyan Ma · 2019 · European Journal of Pharmacology
  9. Cellular Proliferation, Self-Assembly, and Modulation of Signaling Pathways in Silk Fibroin Gelatin-Based 3D Bioprinted Constructs
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  10. Downregulation of Notch Modulators, Tetraspanin 5 and 10, Inhibits Osteoclastogenesis in Vitro
    Jian Ping Zhou, Toshifumi Fujiwara, Shiqiao Ye, Xiaolin Li, Haibo Zhao · 2014 · Calcified Tissue International
  11. Wnt10b activates the wnt, notch, and NFκB pathways in u2os osteosarcoma cells
    Ulrike I. Mödder, Merry Jo Oursler, Sundeep Khosla, David G. Monroe · 2011 · Journal of Cellular Biochemistry
  12. NOTCH Signaling Is Activated through Mechanical Strain in Human Bone Marrow-Derived Mesenchymal Stromal Cells
    Fani Ziouti, Regina Ebert, Maximilian Rummler, Melanie Krug, Sigrid Maria Müller-Deubert, Martin Lüdemann, Franz Josef Jakob, Bettina M. Willie, Franziska Jundt · 2019 · Stem Cells International
  13. NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis
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  14. Deregulation of Bone Forming Cells in Bone Diseases and Anabolic Effects of Strontium-Containing Agents and Biomaterials
    Shuang Tan, Bin-Bin Zhang, Xiaomei Zhu, Ping Ao, Huajie Guo, Weihong Yi, Guangqian Zhou · 2014 · BioMed Research International
  15. Interleukin 6 Mediates Select Effects of Notch in Chondrocytes
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  16. Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells
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  17. MicroRNAs and Bone Regeneration
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  18. Scaffolds Fabricated from Natural Polymers/Composites by Electrospinning for Bone Tissue Regeneration
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  19. Modulation of Notch1 signaling regulates bone fracture healing
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  20. Understanding the Role of Notch in Osteosarcoma
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  21. Bone circuitry and interorgan skeletal crosstalk
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  23. Signaling pathways regulating the specification and differentiation of the osteoblast lineage
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  24. miR-34a promotes bone regeneration in irradiated bone defects by enhancing osteoblastic differentiation of mesenchymal stromal cells in rats
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  25. Culture and differentiation of osteoblasts on coral scaffold from human bone marrow mesenchymal stem cells
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  26. Intermittent activation of notch signaling promotes bone formation.
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  27. The Application of microRNAs in Biomaterial Scaffold‐Based Therapies for Bone Tissue Engineering
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  28. Notch signaling during chondrogenesis of human bone marrow stem cells
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  29. RUNX3 Maintains the Mesenchymal Phenotype after Termination of the Notch Signal
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  30. Dose-dependent mechanism of Notch action in promoting osteogenic differentiation of mesenchymal stem cells
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  31. Signaling pathways in chronic myeloid leukemia and leukemic stem cell maintenance: Key role of stromal microenvironment
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  32. Targeting Notch1 signaling pathway positively affects the sensitivity of osteosarcoma to cisplatin by regulating the expression and/or activity of Caspase family
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  33. Hajdu-Cheney Syndrome, a Disease Associated with NOTCH2 Mutations
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  34. Impaired mesenchymal stem cell differentiation and osteoclastogenesis in mice deficient for Igf2-P2 transcripts
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  36. Runx2 is required for hypertrophic chondrocyte mediated degradation of cartilage matrix during endochondral ossification
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  37. HES1, a target of Notch signaling, is elevated in canine osteosarcoma, but reduced in the most aggressive tumors
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  38. The notch‐responsive transcription factor Hes‐1 attenuates osteocalcin promoter activity in osteoblastic cells
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  39. Adipose-Derived Stem Cells: A Review of Signaling Networks Governing Cell Fate and Regenerative Potential in the Context of Craniofacial and Long Bone Skeletal Repair
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  40. Osteoblast-specific Notch2 inactivation causes increased trabecular bone mass at specific sites of the appendicular skeleton
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  41. The regulatory roles of Notch in osteocyte differentiation via the crosstalk with canonical Wnt pathways during the transition of osteoblasts to osteocytes
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  42. Induction of osteogenesis by bone-targeted Notch activation
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  43. The role of notch signaling in bone development and disease
    Maria P. Yavropoulou, John G. Yovos · 2014 · HORMONES
  44. Myogenic lineage differentiated mesenchymal stem cells enhance recovery from dextran sulfate sodium-induced colitis in the rat
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  45. Reciprocal Regulation of Notch and Nuclear Factor of Activated T-cells (NFAT) c1 Transactivation in Osteoblasts
    Stefano Zanotti, Anna Smerdel‐Ramoya, ERNESTO M. CANALIS · 2010 · Journal of Biological Chemistry
  46. The lateral meningocele syndrome mutation causes marked osteopenia in mice
    ERNESTO M. CANALIS, Jungeun Yu, Lauren Schilling, Siu‐Pok Yee, Stefano Zanotti · 2018 · Journal of Biological Chemistry
  47. Membrane Transport Proteins in Osteoclasts: The Ins and Outs
    A. Ribet, Pei Ying Ng, Nathan John Pavlos · 2021 · Frontiers in Cell and Developmental Biology
  48. Notch1 and Notch2 expression in osteoblast precursors regulates femoral microarchitecture
    Stefano Zanotti, ERNESTO M. CANALIS · 2014 · Bone
  49. Strategies to Enhance Implantation and Survival of Stem Cells After Their Injection in Ischemic Neural Tissue
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  50. Surface Markers for Chondrogenic Determination: A Highlight of Synovium-Derived Stem Cells
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  51. Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance
    Zhaoyang Liu, Yinshi Ren, Anthony J. Mirando, C. Wang, Michael J. Zuscik, Regis J. O’Keefe, Matthew J. Hilton · 2015 · Osteoarthritis and Cartilage
  52. Hypoxia reduces the osteogenic differentiation of peripheral blood mesenchymal stem cells by upregulating Notch-1 expression
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  53. Hyperglycemia inhibits osteoblastogenesis of rat bone marrow stromal cells via activation of the Notch2 signaling pathway
    Kuo‐Chin Huang, Po‐Yao Chuang, Tien‐Yu Yang, Tsan-Wen Huang, Shun‐Fu Chang · 2019 · International Journal of Medical Sciences
  54. Recent Advances in Silk Fibroin-Based Composites for Bone Repair Applications: A Review
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  55. Constitutive Activation of IKK2/NF-κB Impairs Osteogenesis and Skeletal Development
    Gaurav Swarnkar, Kaihua Zhang, Gabriel Mbalaviele, Fanxin Long, Yousef Abu‐Amer · 2014 · PLoS ONE
  56. HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development
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  57. Deubiquitinase MYSM1 Is Essential for Normal Bone Formation and Mesenchymal Stem Cell Differentiation
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  58. Bone Regeneration
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  60. Emulating the early phases of human tooth development in vitro
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  61. Notch Suppresses Nuclear Factor of Activated T Cells (Nfat) Transactivation and Nfatc1 Expression in Chondrocytes
    Stefano Zanotti, ERNESTO M. CANALIS · 2012 · Endocrinology
  62. Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development
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  64. Mesenchymal stem cells and dental implant osseointegration during aging: from mechanisms to therapy
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  74. Nuclear Factor of Activated T-cells (NFAT)c2 Inhibits Notch Receptor Signaling in Osteoblasts
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