Progranulin is a mediator of the wound response

He, Zhiheng, Ong, Colin H.P., Halper, Jaroslava, Bateman, Andrew·2003·Nature Medicine

DOI 10.1038/nm816

Cited by (490)

Items 201–300 of 490

Progranulin Improves Acute Lung Injury through Regulating the Differentiation of Regulatory T Cells and Interleukin-10 Immunomodulation to Promote Macrophage Polarization
Yanqing Chen, Chuanjiang Wang, Ke Xie, Ming Lei, Yu-sen Chai, Fang Xu, Shihui Lin · 2020 · Mediators of Inflammation
Targeting progranulin alleviated silica particles-induced pulmonary inflammation and fibrosis via decreasing Il-6 and Tgf-β1/Smad
Manyu Zhao, Mengzhu Wang, Xuxi Chen, Ying Gao, Qing Chen, Liqun Wang, Qixue Bao, Donglei Sun, Wen Du, Yunyi Xu et al. · 2023 · Journal of Hazardous Materials
Association between increased serum GP88 (progranulin) concentrations and prognosis in patients with malignant lymphomas
Yasuko Yamamoto, Naoe Goto, Masao Takemura, Wakana Yamasuge, Kuniaki Yabe, Tsuyoshi Takami, Tatsuhiko Miyazaki, Tamotsu Takeuchi, Makoto Shiraki, Masahito Shimizu et al. · 2017 · Clinica Chimica Acta
Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling
Fanhua Wei, Zhimin Jiang, Honglei Sun, Juan Pu, Yipeng Sun, Mingyang Wang, Qi Tong, Yuhai Bi, Xiaojing Ma, George F. Gao et al. · 2019 · PLoS Pathogens
Low plasma progranulin levels in children with autism
Laila Yousef AL-Ayadhi, Gehan Ahmed Mostafa · 2011 · Journal of Neuroinflammation
Development of a Potent Wound Healing Agent Based on the Liver Fluke Granulin Structural Fold
Paramjit S. Bansal, Michael J. Smout, David Wilson, Claudia Cobos Caceres, Mohadeseh Dastpeyman, Javier Sotillo, Julia Seifert, Paul J. Brindley, Alex C. Loukas, Norelle L. Daly · 2017 · Journal of Medicinal Chemistry
The perlecan-interacting growth factor progranulin regulates ubiquitination, sorting, and lysosomal degradation of sortilin
Ryuta Tanimoto, Chiara Palladino, Shi‐Qiong Xu, Simone Buraschi, Thomas Neill, Leonard G. Gomella, Stephen C. Peiper, Antonino Belfiore, Renato V. Iozzo, Andrea Morrione · 2017 · Matrix Biology
Progranulin Regulates Inflammation and Tumor
Chunxiao Liu, Jiayi Li, Wenjing Shi, Liujia Zhang, Shuang Liu, Yingcong Lian, Shujuan Liang, Hongyan Wang · 2019 · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Association of Progranulin and High Sensitivity CRP Concentrations in Gingival Crevicular Fluid and Serum in Chronic Periodontitis Subjects with and without Obesity
A.R. Pradeep, N Priyanka, M. V. R. Prasad, Nitish Kalra, Minal Kumari · 2012 · Disease Markers
Disease-modifying effects of metabolic perturbations in ALS/FTLD
Jawaid, Ali, Khan, Romesa, Polymenidou, Magdalini, Schulz, Paul E. · 2018 · Molecular Neurodegeneration
Core neuropathological abnormalities in progranulin-deficient mice are penetrant on multiple genetic backgrounds
Terri L. Petkau, A. Hill, Blair R. Leavitt · 2015 · Neuroscience
AZP2006, a new promising treatment for Alzheimer’s and related diseases
Callizot, N., Estrella, C., Burlet, S., Henriques, A., Brantis, C., Barrier, M., Campanari, M. L., Verwaerde, P. · 2021 · Scientific Reports
Expression, refolding and purification of Ov-GRN-1, a granulin-like growth factor from the carcinogenic liver fluke, that causes proliferation of mammalian host cells
Michael J. Smout, Jason P. Mulvenna, Malcolm K. Jones, Alex C. Loukas · 2011 · Protein Expression and Purification
Progranulin/EphA2 axis: A novel oncogenic mechanism in bladder cancer
Simone Buraschi, Thomas Neill, Shiqiong Xu, Chiara Palladino, Antonino Belfiore, Renato V. Iozzo, Andrea Morrione · 2020 · Matrix Biology
PGRN exacerbates the progression of non-small cell lung cancer via PI3K/AKT/Bcl-2 antiapoptotic signaling
Sicheng Chen, Mengjun Bie, Xiaowen Wang, Mengtian Fan, Bin Chen, Qiong Shi, Yingjiu Jiang · 2021 · Genes & Diseases
Serum progranulin irrelated with Breg cell levels, but elevated in RA patients, reflecting high disease activity
Jiaxi Chen, Shuang Li, Jianfeng Shi, Lili Zhang, Jun Li, Shiyong Chen, Chunlong Wu, Bo Shen · 2015 · Rheumatology International
Spatiotemporal expression pattern of progranulin in embryo implantation and placenta formation suggests a role in cell proliferation, remodeling, and angiogenesis
Joëlle A. Desmarais, Mingju Cao, Andrew Bateman, Bruce D. Murphy · 2008 · Reproduction
Utility of Progranulin and Serum Leukocyte Protease Inhibitor as Diagnostic and Prognostic Biomarkers in Ovarian Cancer
Aaron M. Carlson, Matthew John Maurer, Krista M. Goergen, Kimberly R. Kalli, Courtney L. Erskine, Marshall D. Behrens, Keith L. Knutson, Matthew Stephen Block · 2013 · Cancer Epidemiology Biomarkers & Prevention
Dedifferentiated Schwann cells secrete progranulin that enhances the survival and axon growth of motor neurons
Sujin Hyung, Sun‐Kyoung Im, Bo Yoon Lee, Jihye Shin, Jong‐Chul Park, Cheolju Lee, Jun‐Kyo Francis Suh, Eun‐Mi Hur · 2018 · Glia
Metabolism-Related Adipokines and Metabolic Diseases: Their Role in Osteoarthritis
Qian Zhang, Yi Xuan Zhao, Long Li, Qian Fan, Bin Huang, Hong Du, Chen Li, Wei Li · 2025 · Journal of Inflammation Research
Natriuretic Peptide Receptor A as a Novel Target for Prostate Cancer
Xiaoqin Wang, Payal Raulji, Shyam S. Mohapatra, Ronil A. Patel, Gary Hellermann, Xiaoyuan Kong, Pedro L. Vera, Katherine L. Meyer‐Siegler, Domenico Coppola, Subhra Mohapatra · 2011 · Molecular Cancer
Granulin and Granulin Repeats Interact with the Tat·P-TEFb Complex and Inhibit Tat Transactivation
Mainul Hoque, Bin Tian, Michael B. Mathews, Tsafi Pe’ery · 2005 · Journal of Biological Chemistry
Effects of Palm Oil Tocotrienol-Rich Fraction (TRF) and Carotenes in Ovalbumin (OVA)-Challenged Asthmatic Brown Norway Rats
Zaida Zainal, Afiqah Abdul Rahim, Huzwah Khaza’ai, Sui Kiat Chang · 2019 · International Journal of Molecular Sciences
The molecular basis for development of proinflammatory autoantibodies to progranulin
Lorenz Thurner, Natalie Fadle, Evi Regitz, Maria Kemele, Philipp Klemm, Marina Zaks, Elisabeth Stöger, Birgit Bette, Gabi Carbon, Vincent Zimmer et al. · 2015 · Journal of Autoimmunity
Genetic Modifiers in Neurodegeneration
Nimansha Jain, Alice S. Chen‐Plotkin · 2018 · Current Genetic Medicine Reports
Progranulin promotes osteogenic differentiation of human periodontal ligament stem cells via tumor necrosis factor receptors to inhibit TNF‐α sensitized NF‐kB and activate ERK/JNK signaling
Jing Chen, Miao Yu, Xiao Li, Qinfeng Sun, Chengzhe Yang, Pishan Yang · 2019 · Journal of Periodontal Research
Progranulin Overproduction Due to Fli‐1 Deficiency Contributes to the Resistance of Dermal Fibroblasts to Tumor Necrosis Factor in Systemic Sclerosis
Yohei Ichimura, Yoshihide Asano, Kaname Akamata, Shinji Noda, Takashi Taniguchi, Takehiro Takahashi, Tetsuo Toyama, Yayoi Tada, Makoto Sugaya, Shinichi Sato et al. · 2015 · Arthritis & Rheumatology
Progranulin regulates zebrafish muscle growth and regeneration through maintaining the pool of myogenic progenitor cells
Yen-Hsing Li, Hsu-Yu Chen, Ya‐Wen Li, Sung–Yu Wu, Wangta-Liu, Gen-Hwa Lin, Shao‐Yang Hu, Zen-Kuei Chang, Hong‐Yi Gong, Chia-Hsuan Liao et al. · 2013 · Scientific Reports
Progranulin Stimulated by LPA Promotes the Migration of Aggressive Breast Cancer Cells
Muthulekha Swamydas, Do Nguyen, Lauren D. Allen, Jill M. Eddy, Didier Dréau · 2011 · Cell Communication & Adhesion
IRE1a constitutes a negative feedback loop with BMP2 and acts as a novel mediator in modulating osteogenic differentiation
F-J Guo, R. Jiang, Z Xiong, F Xia, MEI-CAI LI, Lin Chen, C.-J. Liu · 2014 · Cell Death and Disease
Biochemistry and Physiological Functions of ADAMTS7 Metalloprotease
Hayley A. Hanby · 2013 · Advances in Biochemistry
The Role of Progranulin (PGRN) in the Pathogenesis of Ischemic Stroke
Daryush Purrahman, Ali Shojaeian, Łukasz A. Poniatowski, Bartłomiej Piechowski‐Jóźwiak, Mohammad‐Reza Mahmoudian‐Sani · 2023 · Cellular and Molecular Neurobiology
Progranulin Peripheral Levels as a Screening Tool for the Identification of Subjects with Progranulin Mutations in a Portuguese Cohort
Maria Rosário Almeida, Inês Baldeiras, Maria Helena Ribeiro, Beatriz Santiago, Cristina Machado, João Massano, Joana Guimarães, Catarina Resende Oliveira, Isabel J. Santana · 2013 · Neurodegenerative Diseases
Identity and nature of neural stem cells in the adult human subventricular zone
Salma Baig, Javad Nadaf, Redouane Allache, Phuong Uyen Le, Michael Luo, Annisa Djedid, Andriniaina Andy Nkili-Meyong, Maryam Safisamghabadi, Alexandre Prat, Jack Perry Antel et al. · 2024 · iScience
A zebrafish model of granulin deficiency reveals essential roles in myeloid cell differentiation
Clyde Allen Campbell, Oksana V. Fursova, Xiaoyi Cheng, Elizabeth M. Snella, Abbigail McCune, Liangdao Li, Barbara Solchenberger, Bettina Schmid, Debashis Sahoo, Mark Morton et al. · 2021 · Blood Advances
A Brief Overview of Neutrophils in Neurological Diseases
Supriya Chakraborty, Zeynab Tabrizi, Nairuti Nikhil Bhatt, Sofia Andrea Franciosa, Oliver Bracko · 2023 · Biomolecules
Extracellular matrix protein 1, a direct targeting molecule of parathyroid hormone‐related peptide, negatively regulates chondrogenesis and endochondral ossification via associating with progranulin growth factor
Li Kong, Yun‐Peng Zhao, Qingyun Tian, Jianquan Feng, Tatsuya Kobayashi, J. Merregaert, C.-J. Liu · 2016 · The FASEB Journal
Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin
Simone Buraschi, Shi‐Qiong Xu, Manuela Stefanello, Igor Moskalev, Alaide Morcavallo, Marco Genua, Ryuta Tanimoto, Ruth Birbe, Stephen C. Peiper, Leonard G. Gomella et al. · 2016 · Oncotarget
Progranulin and granulin-like protein as novel VEGF-independent angiogenic factors derived from human mesothelioma cells
Ryoji Eguchi, Takashi Nakano, Ichiro Wakabayashi · 2016 · Oncogene
Secreted Progranulin Is a Homodimer and Is Not a Component of High Density Lipoproteins (HDL)
Andrew D. Nguyen, Thi A. Nguyen, Basar Cenik, Gang Yu, Joachim Herz, Tobias C. Walther, William Sean Davidson, Robert V. Farese · 2013 · Journal of Biological Chemistry
Progranulin Controls Sepsis via C/EBPα-Regulated Il10 Transcription and Ubiquitin Ligase/Proteasome-Mediated Protein Degradation
Wenjun Yan, Aihao H. Ding, Ha-Jeong Kim, Hua Zheng, Fang Wei, Xiaojing Ma · 2016 · The Journal of Immunology
Progranulin aggravates pulmonary immunopathology during influenza virus infection
Qin Luo, Xingxing Yan, Hongmei Tu, Yibing Yin, Ju Cao · 2018 · Thorax
Defects of Nutrient Signaling and Autophagy in Neurodegeneration
Jon Ondaro, Haizea Hernández-Eguiazu, Maddi Garciandia-Arcelus, Raúl Loera‐Valencia, Laura Rodríguez-Gómez, Andrés Jiménez-Zúñiga, Julen Goikolea, Patricia Rodriguez‐Rodriguez, Javier Ruiz‐Martínez, Fermín Moreno et al. · 2022 · Frontiers in Cell and Developmental Biology
A network of RNA and protein interactions in Fronto Temporal Dementia
Francesca Fontana, Kavitha Siva, Michela A. Denti · 2015 · Frontiers in Molecular Neuroscience
Immortalized ovarian surface epithelial cells acquire tumorigenicity by Acrogranin gene overexpression
Masanori Miyanishi, Masaki Mandai, Noriomi Matsumura, Ken D Yamaguchi, Junzo Hamanishi, Toshihiro Higuchi, Kenji Takakura, Shingo Fujii · 2007 · Oncology Reports
Role of Progranulin as a Biomarker for Alzheimer's Disease
Kristel Sleegers, Nathalie Brouwers, Christine Van Broeckhoven · 2010 · Biomarkers in Medicine
Antibody against Granulin–Epithelin Precursor Sensitizes Hepatocellular Carcinoma to Chemotherapeutic Agents
Nicholas C.L. Wong, Phyllis F. Cheung, Chi Wai Yip, Kui Fat Chan, Irene Oi‐Lin Ng, Sheung Tat Fan, ST Cheung · 2014 · Molecular Cancer Therapeutics
Review: Molecular pathology of frontotemporal lobar degenerations
Barbara Borroni, Antonella Alberici, Emanuele Buratti · 2018 · Neuropathology and Applied Neurobiology
Progranulin Oncogenic Network in Solid Tumors
Elisa Ventura, Giacomo Ducci, Reyes Dominguez-Benot, Valentina Ruggiero, Antonino Belfiore, Elena Sacco, Marco Vanoni, Renato V. Iozzo, Antonio Giordano, Andrea Morrione · 2023 · Cancers
Progranulin promotes the retinal precursor cell proliferation and the photoreceptor differentiation in the mouse retina
Yoshiki Kuse, Kazuhiro Tsuruma, Sou Sugitani, Hiroshi Izawa, Yuta Ohno, Masamitsu Shimazawa, Hideaki Hara · 2016 · Scientific Reports
Co-induction of hepatic IGF-I and progranulin mRNA by growth hormone in tilapia, Oreochromis mossambiccus
Mark Hung‐Chih Chen, Yen-Hsing Li, Yvonne Chang, Shao‐Yang Hu, Hong‐Yi Gong, Gen-Hwa Lin, Thomas T. Chen, Jen‐Leih Wu · 2006 · General and Comparative Endocrinology
Therapeutic and diagnostic challenges for frontotemporal dementia
Simon Dâ€TMAlton, Jada M. Lewis · 2014 · Frontiers in Aging Neuroscience
The Role of PGRN in Alzheimer’s Disease
Hua Jing, Meng‐Shan Tan, Jin‐Tai Yu, Lan Tan · 2015 · Molecular Neurobiology
Involvement of Progranulin in Hypothalamic Glucose Sensing and Feeding Regulation
Hyun-Kyong Kim, Mi-Seon Shin, Byung‐Soo Youn, Cherl NamKoong, So Young Gil, Gil Myoung Kang, Ji Hee Yu, Min‐Seon Kim · 2011 · Endocrinology
Characterization of inclusion bodies with cytoprotective properties formed by seipinopathy-linked mutant seipin
Daisuke Ito, Takuya Yagi, Masahito Ikawa, Norihiro Suzuki · 2011 · Human Molecular Genetics
Progranulin and short‐term outcome in patients with acute ischaemic stroke
Shanhui Xie, Liping Lu, L. Liu, Guorong Bi, Liqiang Zheng · 2016 · European Journal of Neurology
Progranulin protects lung epithelial cells from cigarette smoking‐induced apoptosis
Kyoung Young Lee, So‐Young Park, Sunjoo Park, Gyong Hwa Hong, Keun‐Ai Moon, You‐Sun Kim, Yeon‐Mok Oh, Hyouk‐Soo Kwon, Tae‐Bum Kim, Hee‐Bom Moon et al. · 2017 · Respirology
New Genes, New Dilemmas: FTLD Genetics and Its Implications for Families
Jill S. Goldman, Jennifer L. Adamson, Anna Karydas, Bruce L. Miller, Mike Hutton · 2007 · American Journal of Alzheimer s Disease & Other Dementias®
Progranulin contributes to endogenous mechanisms of pain defense after nerve injury in mice
Hee‐Young Lim, Boris Albuquerque, Annett Häußler, Thekla Myrczek, Aihao H. Ding, Irmgard Tegeder · 2011 · Journal of Cellular and Molecular Medicine
Progranulin and frontotemporal lobar degeneration
Stuart M. Pickering-Brown · 2007 · Acta Neuropathologica
GRN Mutations Are Associated with Lewy Body Dementia
Paolo Reho, Shunsuke Koga, Zalak Shah, Ruth Chia, Rosa Rademakers, Clifton L. Dalgard, Bradley F. Boeve, Thomas G. Beach, Dennis W. Dickson, Owen A. Ross et al. · 2022 · Movement Disorders
Evidence of TRK-Fused Gene (TFG1) function in the ubiquitin–proteasome system
Takuya Yagi, Daisuke Ito, Norihiro Suzuki · 2014 · Neurobiology of Disease
Losing protein in the brain: The case of progranulin
Roberta Ghidoni, Anna Paterlini, Valentina Albertini, Giuliano Gb. Binetti, Luisa Benussi · 2012 · Brain Research
Chitinase-3-like Protein 1: A Progranulin Downstream Molecule and Potential Biomarker for Gaucher Disease
Jinlong Jian, Yuehong Chen, Rossella Liberti, Wenyu Fu, Wenhuo Hu, Rachel J. Saunders-Pullman, Gregory M. Pastores, Ying Chen, Ying Sun, Gregory Alex Grabowski et al. · 2018 · EBioMedicine
Extracellular proteomes of M‐CSF (CSF‐1) and GM‐CSF‐dependent macrophages
Mark J Bailey, Derek C. Lacey, Bernard de Kok, Paul D. Veith, Eric Charles Reynolds, John A. Hamilton · 2010 · Immunology and Cell Biology
Progranulin deficiency confers resistance to autoimmune encephalomyelitis in mice
Katja Schmitz, Annett Wilken‐Schmitz, Verica Vasić, Robert Brunkhorst, Mirko H. H. Schmidt, Irmgard Tegeder · 2019 · Cellular and Molecular Immunology
Progranulin from different gliocytes in the nucleus accumbens exerts distinct roles in FTD- and neuroinflammation-induced depression-like behaviors
Jing Wang, Simin Lai, Ting Zhou, Zhihao Xia, Weina Li, Wenqi Sha, Jingjie Liu, Yanjiong Chen · 2022 · Journal of Neuroinflammation
Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis
Atsushi Tanaka, Hiroshi Tsukamoto, Hiroki Mitoma, Chikako Kiyohara, Naoyasu Ueda, Masahiro Ayano, Shun-ichiro Ohta, Yasutaka Kimoto, Mitsuteru Akahoshi, Yojiro Arinobu et al. · 2015 · Arthritis Research & Therapy
Mechanisms of Progranulin Action and Regulation in Genitourinary Cancers
Ryuta Tanimoto, Kuojung G. Lu, Shi‐Qiong Xu, Simone Buraschi, Antonino Belfiore, Renato V. Iozzo, Andrea Morrione · 2016 · Frontiers in Endocrinology
Growth factor progranulin blocks tumor necrosis factor-α-mediated inhibition of osteoblast differentiation
Ning Wang, Jian Zhang, Jianhui Yang · 2016 · Genetics and Molecular Research
Type-II endometrial cancer: role of adipokines
Kusuma Kumari Garikapati, V. V. V. Ravi Kiran Ammu, Praveen Thaggikuppe Krishnamurthy, Pavan Kumar Chintamaneni, Sai Kiran S. S. Pindiprolu · 2019 · Archives of Gynecology and Obstetrics
Frontotemporal Lobar Degeneration with Ubiquitin-Positive Inclusions: A Molecular Genetic Update
Julie van der Zee, Ilse Gijselinck, Daniel Nicolae Pirici, Samir Kumar‐Singh, Marc Cruts, Christine Van Broeckhoven · 2007 · Neurodegenerative Diseases
Progranulin deficiency in the brain: the interplay between neuronal and non-neuronal cells
Katarzyna Gawęda-Walerych, Vanessa Aragona, Simona Lodato, Emilia Jadwiga Sitek, Ewa Narożańska, Emanuele Buratti · 2025 · Translational Neurodegeneration
Evidence of the Innate Antiviral and Neuroprotective Properties of Progranulin
Hyeon-Sook Suh, Yungtai Lo, Namjong Choi, Scott Lee Letendre, Sunhee C. Lee · 2014 · PLoS ONE
Tumor co-expression of progranulin and sortilin as a prognostic biomarker in breast cancer
Karoline Berger, Sara Rhost, Svanheiður Rafnsdóttir, Éamon Hughes, Ylva Magnusson, Maria Ekholm, Olle Stål, Lisa Rydén, Göran Landberg · 2021 · BMC Cancer
Potential skin involvement in ALS: revisiting Charcot’s observation – a review of skin abnormalities in ALS
Bastien Paré, François Gros‐Louis · 2017 · Reviews in the Neurosciences
Serum progranulin levels in relation to insulin resistance in childhood obesity
Eman Mokbel Alissa, Rima H. Sutaih, Hayat Z. Kamfar, Abdulmoein Eid Al-Agha, Zuhair M. Marzouki · 2017 · Journal of Pediatric Endocrinology and Metabolism
Frontotemporal dementia non-sense mutation of progranulin rescued by aminoglycosides
Lisha Kuang, Kei Hashimoto, Eric Jinsheng Huang, Matthew S. Gentry, Haining Zhu · 2019 · Human Molecular Genetics
Lysosomal Dysfunction and Other Pathomechanisms in FTLD: Evidence from Progranulin Genetics and Biology
Xiaolai Zhou, Thomas L. Kukar, Rosa Rademakers · 2021 · Advances in experimental medicine and biology
Association between GRN rs5848 Polymorphism and Parkinson′s Disease in Taiwanese Population
Kuo Hsuan Chang, Chiung‐Mei Chen, Yi‐Chun Chen, Ya-Chin Hsiao, Chin‐Chang Huang, Hung Chou Kuo, Hsuan-Chu Hsu, Guey Jen Lee-Chen, Yih‐Ru Wu · 2013 · PLoS ONE
XBP 1S, a BMP 2‐inducible transcription factor, accelerates endochondral bone growth by activating GEP growth factor
Fengjin Guo, Zhangyuan Xiong, Xiaofeng Han, C.-J. Liu, Yanna Liu, Rong Jiang, Peng Zhang · 2014 · Journal of Cellular and Molecular Medicine
Structural Variants of a Liver Fluke Derived Granulin Peptide Potently Stimulate Wound Healing
Mohadeseh Dastpeyman, Paramjit S. Bansal, David T. R. Wilson, Javier Sotillo, Paul J. Brindley, Alex C. Loukas, Michael J. Smout, Norelle L. Daly · 2018 · Journal of Medicinal Chemistry
Correction: Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling
Fanhua Wei, Zhimin Jiang, Honglei Sun, Juan Pu, Yipeng Sun, Mingyang Wang, Qi Tong, Yuhai Bi, Xiaojing Ma, George F. Gao et al. · 2020 · PLoS Pathogens
PGRN deficiency exacerbates, whereas a brain penetrant PGRN derivative protects, GBA1 mutation-associated pathologies and diseases
Xiangli Zhao, Yi Lin, Benjamin Liou, Wenyu Fu, Jinlong Jian, Venette Fannin, Wujuan Zhang, Kenneth D.R. Setchell, Gregory Alex Grabowski, Ying Sun et al. · 2022 · Proceedings of the National Academy of Sciences
Modulation of extracellular matrix by nutritional hepatotrophic factors in thioacetamide-induced liver cirrhosis in the rat
Ricardo Romão Guerra, Mauricio De Rosa Trotta, Osório Miguel Parra, José Luís Avanzo, Andrew Bateman, Thiago Pinheiro Arrais Aloia, M.L. Dagli, Francisco Javier Hernandez‐Blazquez · 2009 · Brazilian Journal of Medical and Biological Research
Progranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer’s disease model mice
Masato Hosokawa, Yoshinori Tanaka, Tetsuaki Arai, Hiromi Kondo, Haruhiko Akiyama, Masato Hasegawa · 2017 · EXPERIMENTAL ANIMALS
PGRN exerts inflammatory effects via SIRT1-NF-κB in adipose insulin resistance
Huixia Li, Zhuanmin Zhang, Dongxu Feng, Lin Xu, Fang Li, Jiali Liu, Xinxin Jin, Zhuang Qian, Xiaomin Kang, Hongzhi Sun · 2020 · Journal of Molecular Endocrinology
Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells
Anfei Huang, Prashant V. Shinde, Jun Huang, Tina Senff, Haifeng C. Xu, Cassandra Margotta, Dieter Häussinger, Thomas E. Willnow, Jinping Zhang, Aleksandra A. Pandyra et al. · 2019 · JCI Insight
Effects of progranulin on the pathological conditions in experimental myocardial infarction model
Takahiro Sasaki, Masamitsu Shimazawa, Hiromitsu Kanamori, Yoshihisa Yamada, Anri Nishinaka, Yoshiki Kuse, Genjiro Suzuki, Tomomi Masuda, Shinsuke Nakamura, Masato Hosokawa et al. · 2020 · Scientific Reports
GEP associates with wild-type p53 in hepatocellular carcinoma
ST Cheung, San Wong, Yuk Ting Lee, Sheung Tat Fan · 2006 · Oncology Reports
Abnormal angiogenesis of placenta in progranulin‑deficient mice
Bai-Ruo Xu, Xingyou Chen, Yubin Ding, Chang Chen, Tai‐Hang Liu, Hua Zhang · 2020 · Molecular Medicine Reports
Smart coating by thermo-sensitive Pluronic F-127 for enhanced corneal healing via delivery of biological macromolecule progranulin
Dan Yan, Weijie Ouyang, Jinyou Lin, Zuguo Liu · 2023 · International Journal of Biological Macromolecules
Progranulin Inhibits Human T Lymphocyte Proliferation by Inducing the Formation of Regulatory T Lymphocytes
Kyu Hwan Kwack, Hyeon‐Woo Lee · 2017 · Mediators of Inflammation
Serum cytokines in periodontal diseases
Paras Ahmad, Jørgen Slots, Walter L. Siqueira · 2025 · Periodontology 2000
Do adipokines link obesity to its related metabolic and cardiovascular diseases?
Matthias Blüher · 2010 · Clinical Lipidology
Fully reduced granulin-B is intrinsically disordered and displays concentration-dependent dynamics
Gaurav Ghag, Lauren M. Wolf, Randi G. Reed, Nicholas P. van der Munnik, Claudius Mundoma, Melissa A. Moss, Vijayaraghavan Rangachari · 2016 · Protein Engineering Design and Selection
Progranulin modulates cartilage-specific gene expression via sirtuin 1–mediated deacetylation of the transcription factors SOX9 and P65
Dongxu Feng, Xiaomin Kang, Ruiqi Wang, He Chen, Kun Zhang, Weilou Feng, Huixia Li, Yangjun Zhu, Shufang Wu · 2020 · Journal of Biological Chemistry
Defective Lysosomal Lipid Catabolism as a Common Pathogenic Mechanism for Dementia
J. Y. Lee, Oana C. Marian, A. Don · 2021 · Neuromolecular medicine
Expression Pattern of Progranulin in the Human Placenta and Its Effect on Cell Proliferation in the Choriocarcinoma Cell Line BeWo
Johannes Stubert, Dagmar-Ulrike Richter, Bernd Gerber, Volker Briese · 2010 · Journal of Reproduction and Development
Growth factors and chemotactic factors from parasitic helminths: Molecular evidence for roles in host–parasite interactions versus parasite development
Tori C. Freitas, Edward J. Pearce · 2010 · International Journal for Parasitology