ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death
Open accessAbstract
Calreticulin surface exposure (ecto-CALR), ATP secretion, maturation of dendritic cells (DCs) and stimulation of T cells are prerequisites for anticancer therapy-induced immunogenic cell death (ICD). Recent evidence suggests that chemotherapy-induced autophagy may positively regulate ICD by favoring ATP secretion. We have recently shown that reactive oxygen species (ROS)-based endoplasmic reticulum (ER) stress triggered by hypericin-mediated photodynamic therapy (Hyp-PDT) induces bona fide ICD. However, whether Hyp-PDT-induced autophagy regulates ICD was not explored. Here we showed that, in contrast to expectations, reducing autophagy (by ATG5 knockdown) in cancer cells did not alter ATP secretion after Hyp-PDT. Autophagy-attenuated cancer cells displayed enhanced ecto-CALR induction following Hyp-PDT, which strongly correlated with their inability to clear oxidatively damaged proteins. Furthermore, autophagy-attenuation in Hyp-PDT-treated cancer cells increased their ability to induce DC maturation, IL6 production and proliferation of CD4(+) or CD8(+) T cells, which was accompanied by IFNG production. Thus, our study unravels a role for ROS-induced autophagy in weakening functional interaction between dying cancer cells and the immune system thereby helping in evasion from ICD prerequisites or determinants.
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Pre-mortem autophagy is required for optimal ATP release during ICD and for immunogenicity of cell death induced by several but not all ICD inducers.
“Accordingly, pre-mortem autophagy is required for optimal ATP release in the course of ICD, and hence for cell death induced by several (but not all) ICD inducers to be perceived as immunogenic [867, 900, 901].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [901]
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Cites
Photodynamic therapy of cancer: An update
Agostinis, P., Berg, K., Cengel, K. A., Foster, T. H., Girotti, A. W., Gollnick, S. O., Hahn, S. M., Hamblin, M. R., Juzeniene, A., Kessel, D., et al. (2011) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20114 · Cited by 5,145 · see citing works
Self-citationInterferon-γ: an overview of signals, mechanisms and functions
Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603252 · Cited by 4,120 · see citing works
Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996 · cited 1× · see citing works
“S4).(41) Consistent with our previous studies,(33) partial suppression of ATG5 expression reduced autophagy stimulation following Hyp-PDT in cancer cells as revealed by decreased LC3-conversion and formation of LC3 puncta (Fig.”
Self-citationImmunogenic cell death and DAMPs in cancer therapy
Krysko, D. V., Garg, A. D., Kaczmarek, A., Krysko, O., Agostinis, P., & Vandenabeele, P. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3380 · Cited by 3,223 · see citing works
Self-citationCalreticulin exposure dictates the immunogenicity of cancer cell death
Obeid, M., Tesniere, A., Ghiringhelli, F., Fimia, G. M., Apetoh, L., Perfettini, J.-L., Castedo, M., Mignot, G., Panaretakis, T., Casares, N., et al. (2007) · Nature Medicine · doi:10.1038/nm1523 · Cited by 3,216 · see citing works
Apetoh, L., Ghiringhelli, F., Tesniere, A., Obeid, M., Ortiz, C., Criollo, A., Mignot, G., Maiuri, M. C., Ullrich, E., Saulnier, P., et al. (2007) · Nature Medicine · doi:10.1038/nm1622 · Cited by 3,056 · see citing works
Martin, S. J., Reutelingsperger, C. P., McGahon, A. J., Rader, J. A., van Schie, R. C., LaFace, D. M., & Green, D. R. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.5.1545 · Cited by 2,824 · see citing works
Uyttenhove, C., Pilotte, L., Théate, I., Stroobant, V., Colau, D., Parmentier, N., Boon, T., & Van den Eynde, B. J. (2003) · Nature Medicine · doi:10.1038/nm934 · Cited by 2,305 · see citing works
Ghiringhelli, F., Apetoh, L., Tesniere, A., Aymeric, L., Ma, Y., Ortiz, C., Vermaelen, K., Panaretakis, T., Mignot, G., Ullrich, E., et al. (2009) · Nature Medicine · doi:10.1038/nm.2028 · Cited by 1,898 · see citing works
Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death
Casares, N., Pequignot, M. O., Tesniere, A., Ghiringhelli, F., Roux, S., Chaput, N., Schmitt, E., Hamai, A., Hervas-Stubbs, S., Obeid, M., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050915 · Cited by 1,512 · see citing works
Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice
Michaud, M., Martins, I., Sukkurwala, A. Q., Adjemian, S., Ma, Y., Pellegatti, P., Shen, S., Kepp, O., Scoazec, M., Mignot, G., et al. (2011) · Science · doi:10.1126/science.1208347 · Cited by 1,377 · see citing works
Immunogenic and tolerogenic cell death
Green, D. R., Ferguson, T., Zitvogel, L., & Kroemer, G. (2009) · Nature Reviews Immunology · doi:10.1038/nri2545 · Cited by 1,176 · see citing works
Endoplasmic Reticulum Stress Triggers Autophagy
Yorimitsu, T., Nair, U., Yang, Z., & Klionsky, D. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607007200 · Cited by 941 · see citing works
PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress
Verfaillie, T., Rubio, N., Garg, A. D., Bultynck, G., Rizzuto, R., Decuypere, J.-P., Piette, J. G., Linehan, C., Gupta, S., Afshin Samali, A., et al. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.74 · Cited by 851 · see citing works
Self-citationMechanisms of pre‐apoptotic calreticulin exposure in immunogenic cell death
Panaretakis, T., Kepp, O., Brockmeier, U., Tesniere, A., Bjorklund, A., Chapman, D. C., Durchschlag, M., Joza, N., Pierron, G., van Endert, P., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.1 · Cited by 848 · see citing works
A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death
Garg, A. D., Krysko, D. V., Verfaillie, T., Kaczmarek, A., Ferreira, G. B., Marysael, T., Rubio, N., Firczuk, M., Mathieu, C., Roebroek, A. J. M., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2011.497 · Cited by 800 · see citing works
Self-citationRole of oxidative carbonylation in protein quality control and senescence
Nyström, T. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600599 · Cited by 791 · see citing works
Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release
Venereau, E., Casalgrandi, M., Schiraldi, M., Antoine, D. J., Cattaneo, A., De Marchis, F., Liu, J., Antonelli, A., Preti, A., Raeli, L., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120189 · Cited by 720 · see citing works
Kazama, H., Ricci, J.-E., Herndon, J. M., Hoppe, G., Green, D. R., & Ferguson, T. A. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.013 · Cited by 627 · see citing works
Bravo, R., Vicencio, J. M., Parra, V., Troncoso, R., Muñoz, J. P., Bui, M., Quiroga, C., Rodriguez, A. E., Verdejo, H., Ferreira, J., et al. (2011) · Journal of Cell Science · doi:10.1242/jcs.080762 · Cited by 607 · see citing works
The Two Faces of Interferon-γ in Cancer
Zaidi, M. R., & Merlino, G. T. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0482 · Cited by 594 · see citing works
Decoding Cell Death Signals in Inflammation and Immunity
Zitvogel, L., Kepp, O., & Kroemer, G. (2010) · Cell · doi:10.1016/j.cell.2010.02.015 · Cited by 558 · see citing works
Immunogenic cell death, DAMPs and anticancer therapeutics: An emerging amalgamation
Garg, A. D., Nowis, D., Gołąb, J., Vandenabeele, P., Krysko, D. V., & Agostinis, P. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.08.003 · Cited by 498 · see citing works
Self-citationMolecular characteristics of immunogenic cancer cell death
Tesnière, A., Panaretakis, T., Kepp, O., Apétoh, L., Ghiringhelli, F., Zitvogel, L., & Kroemer, G. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402269 · Cited by 492 · see citing works
ER stress-induced inflammation: does it aid or impede disease progression?
Garg, A. D., Kaczmarek, A., Krysko, O., Vandenabeele, P., Krysko, D., & Agostinis, P. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.06.010 · Cited by 429 · see citing works
Self-citationCardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death
Menger, L., Vacchelli, E., Adjemian, S., Martins, I., Ma, Y., Shen, S., Yamazaki, T., Sukkurwala, A. Q., Michaud, M., Mignot, G., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003807 · Cited by 423 · see citing works
Targeting ER stress induced apoptosis and inflammation in cancer.
Verfaillie, T., Garg, A., & Agostinis, P. (2013) · Cancer Letters · doi:10.1016/j.canlet.2010.07.016 · Cited by 409 · see citing works
Self-citationSuppression of autophagy by FIP200 deletion inhibits mammary tumorigenesisPreprint
Wei, H., Wei, S., Gan, B., Xu, P., Zou, W., & Guan, J. (2011) · Genes & Development · doi:10.1101/gad.2051011 · Cited by 402 · see citing works
The ins and outs of calreticulin: from the ER lumen to the extracellular space
Johnson, S. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)01926-2 · Cited by 337 · see citing works
Constitutive Activation of Chaperone-mediated Autophagy in Cells with Impaired Macroautophagy
Kaushik, S., Massey, A. C., Mizushima, N., & Cuervo, A. M. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-11-1155 · Cited by 331 · see citing works
Metabolism in T cell activation and differentiation
Pearce, E. L. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.01.018 · Cited by 314 · see citing works
Photodynamic therapy: illuminating the road from cell death towards anti-tumour immunity
Garg, A. D., Nowis, D., Golab, J., & Agostinis, P. (2010) · Apoptosis · doi:10.1007/s10495-010-0479-7 · Cited by 297 · see citing works
Self-citationGarg, A. D., Krysko, D. V., Vandenabeele, P., & Agostinis, P. (2011) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-011-1184-2 · Cited by 293 · see citing works
Self-citationChemotherapy induces ATP release from tumor cells
Martins, I., Tesnière, A., Kepp, O., Michaud, M., Schlemmer, F., Senovilla, L., Séror, C., Métivier, D., Perfettini, J., Zitvogel, L., et al. (2009) · Cell Cycle · doi:10.4161/cc.8.22.10026 · Cited by 278 · see citing works
Autophagy regulates selective HMGB1 release in tumor cells that are destined to die
Thorburn, J., Horita, H., Redzic, J., Hansen, K., Frankel, A. E., & Thorburn, A. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2008.143 · Cited by 268 · see citing works
Autophagy: shaping the tumor microenvironment and therapeutic response
Maes, H., Rubio, N., Garg, A. D., & Agostinis, P. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.04.005 · Cited by 266 · see citing works
Self-citationNoman, M. Z., Janji, B., Kaminska, B., Van Moer, K., Pierson, S., Przanowski, P., Buart, S., Berchem, G., Romero, P., Mami-Chouaib, F., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1094 · Cited by 256 · see citing works
Kühn, H., & Borchert, A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00855-9 · Cited by 253 · see citing works
Inducers of immunogenic cancer cell death
Dudek, A. M., Garg, A. D., Krysko, D. V., Ruysscher, D. D., & Agostinis, P. (2013) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2013.01.005 · Cited by 249 · see citing works
Self-citationBuytaert, E., Callewaert, G., Hendrickx, N., Scorrano, L., Hartmann, D., Missiaen, L., Vandenheede, J. R., Heirman, I., Grooten, J., & Agostinis, P. (2006) · The FASEB Journal · doi:10.1096/fj.05-4305fje · Cited by 245 · see citing works
Self-citationDanger signalling during cancer cell death: origins, plasticity and regulation
Garg, A. D., Martin, S., Gołąb, J., & Agostinis, P. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.48 · Cited by 225 · see citing works
Self-citationCD98 at the crossroads of adaptive immunity and cancer
Cantor, J. M., & Ginsberg, M. H. (2012) · Journal of Cell Science · doi:10.1242/jcs.096040 · Cited by 183 · see citing works
DAMPs and PDT-mediated photo-oxidative stress: exploring the unknown
Garg, A. D., Krysko, D. V., Vandenabeele, P., & Agostinis, P. (2011) · Photochemical & Photobiological Sciences · doi:10.1039/c0pp00294a · Cited by 155 · see citing works
Self-citationFerradini, L., Mackensen, A., Genevée, C., Bosq, J., Duvillard, P., Avril, M.-F., & Hercend, T. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116278 · Cited by 142 · see citing works
Autophagy pathways activated in response to PDT contribute to cell resistance against ROS damage
Dewaele, M., Martinet, W., Rubio, N., Verfaillie, T., de Witte, P. A. M., Piette, J. G., & Agostinis, P. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01118.x · Cited by 136 · see citing works
Self-citationHypericin‐induced photosensitization of HeLa cells leads to apoptosis or necrosis
Vantieghem, A., Assefa, Z., Vandenabeele, P., Declercq, W., Courtois, S. J., Vandenheede, J. R., Merlevede, W. J., de Witte, P. A. M., & Agostinis, P. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01416-1 · Cited by 135 · see citing works
Self-citationEnlightening the impact of immunogenic cell death in photodynamic cancer therapy
Galluzzi, L., Kepp, O., & Kroemer, G. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.2 · Cited by 133 · see citing works
Tufi, R., Panaretakis, T., Bianchi, K., Criollo, A., Fazi, B., Sano, F. D., Tesnière, A., Kepp, O., Paterlini-Bréchot, P., Zitvogel, L., et al. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402275 · Cited by 118 · see citing works
KDEL proteins are found on the surface of NG108-15 cells
Xiao, G., Chung, T.-F., Pyun, H. Y., Fine, R. E., & Johnson, R. J. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00188-6 · Cited by 113 · see citing works
ER calcium depletion impacts chaperone secretion, innate immunity and phagocytic uptake of cells
Peters, L., & Raghavan, M. (2011) · Journal of Immunology · doi:10.4049/jimmunol.1100690 · Cited by 112 · see citing works
The emergence of phox-ER stress induced immunogenic apoptosis
Garg, A. D., Krysko, D. V., Vandenabeele, P., & Agostinis, P. (2012) · OncoImmunology · doi:10.4161/onci.19750 · Cited by 106 · see citing works
Self-citationMolecular effectors and modulators of hypericin-mediated cell death in bladder cancer cells
Buytaert, E., Matroule, J., Durinck, S., Close, P., Kocanova, S., Vandenheede, J. R., de Witte, P. A. M., Piette, J. G., & Agostinis, P. (2007) · Oncogene · doi:10.1038/sj.onc.1210825 · Cited by 100 · see citing works
Self-citationA Mechanism of Release of Calreticulin from Cells During Apoptosis
Tarr, J. M., Young, P. J., Morse, R., Shaw, D. J., Haigh, R. C., Petrov, P. G., Johnson, S., Winyard, P. G., & Eggleton, P. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.06.064 · Cited by 100 · see citing works
Rubio, N., Coupienne, I., Valentin, E. D., Heirman, I., Grooten, J., Piette, J. G., & Agostinis, P. (2012) · Autophagy · doi:10.4161/auto.20763 · Cited by 70 · see citing works
Self-citationGarg, A. D., Bose, M., Ahmed, M. I., Bonass, W. A., & Wood, S. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034475 · Cited by 60 · see citing works
Self-citationFerreira, G., van Etten, E., Lage, K., Hansen, D. A., Moreau, Y., Workman, C., Waer, M., Verstuyf, A., Waelkens, E., Overbergh, L., et al. (2009) · Proteomics · doi:10.1002/pmic.200800848 · Cited by 57 · see citing works
Self-citationLy, L. V., Sluijter, M., Versluis, M., Luyten, G. P. M., van der Burg, S. H., Melief, C. J. M., Jager, M. J., & van Hall, T. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2288 · Cited by 50 · see citing works
A fluorimetric semi-microplate format assay of protein carbonyls in blood plasma
Mohanty, J. G., Bhamidipaty‐Pelosi, S., Evans, M. K., & Rifkind, J. M. (2010) · Analytical Biochemistry · doi:10.1016/j.ab.2010.01.032 · Cited by 37 · see citing works
Pyo, J.-O., Nah, J., Kim, H., Lee, H., Heo, J., Lee, H., & Jung, Y. (2008) · Autophagy · doi:10.4161/auto.5525 · Cited by 35 · see citing works
In vivo veritas, in vitro artificia
Matarese, G., Cava, A. L., & Horváth, T. L. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.05.003 · Cited by 19 · see citing works
Sub-Cellular Distribution of Calreticulin
Papp, S., & Opas, M. (2003) · Molecular biology intelligence unit · doi:10.1007/978-1-4419-9258-1_5 · Cited by 7 · see citing works
Garg, A. D., Verfaillie, T., Rubio, N., Ferreira, G., Mathieu, C., & Agostinis, P. (2010) · Cited by 4 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- Kühn H, Borchert A. Regulation of enzymatic lipid peroxidation: the interplay of peroxidizing and peroxide reducing enzymes. Free Radic Biol Med 2002; 33:154-72; PMID:12106812
- Kharbanda S, Garg AD. F1000 Recommendation of [Venereau E et al., J Exp Med 2012, 209:1519-28]. Faculty of 1000 2012; f1000. com/717953753#eval793459358
Cited by
Sorted by citations
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works
Self-citationGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894 · see citing works
Self-citationImmunogenic cell death in cancer and infectious disease
Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L., & Kroemer, G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.107 · Cited by 3,119 · see citing works
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,622 · see citing works
Self-citationROS and the DNA damage response in cancer
Srinivas, U. S., Tan, B. W. Q., Vellayappan, B. A., & Jeyasekharan, A. D. (2019) · Redox Biology · doi:10.1016/j.redox.2018.101084 · Cited by 2,144 · see citing works
“Induction of autophagy via increased levels of ROS results in biochemical hallmarks of ICD evasion [130].”
BackgroundImmunogenic cell stress and death
Kroemer, G., Galassi, C., Zitvogel, L., & Galluzzi, L. (2022) · Nature Immunology · doi:10.1038/s41590-022-01132-2 · Cited by 1,353 · see citing works
Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors
Galluzzi, L., Humeau, J., Buqué, A., Zitvogel, L., & Kroemer, G. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0413-z · Cited by 1,349 · see citing works
Consensus guidelines for the definition, detection and interpretation of immunogenic cell death
Galluzzi, L., Vitale, I., Warren, S., Adjemian, S., Agostinis, P., Buqué, A., Chan, T. A.-T., Coukos, G., Demaria, S., Deutsch, É., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000337 · Cited by 1,151 · see citing works
Self-citationLi, W., Yang, J., Luo, L., Jiang, M., Qin, B., Yin, H., Zhu, C., Yuan, X., Zhang, J., Luo, Z., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11269-8 · Cited by 1,129 · see citing works
Consensus guidelines for the detection of immunogenic cell death
Kepp, O., Senovilla, L., Vitale, I., Vacchelli, E., Adjemian, S., Agostinis, P., Apetoh, L., Aranda, F., Barnaba, V., Bloy, N., et al. (2014) · OncoImmunology · doi:10.4161/21624011.2014.955691 · Cited by 832 · see citing works
Self-citationInduction of reactive oxygen species: an emerging approach for cancer therapy
Zou, Z., Chang, H., Li, H., & Wang, S. (2017) · APOPTOSIS · doi:10.1007/s10495-017-1424-9 · Cited by 586 · see citing works
Targeting immunogenic cancer cell death by photodynamic therapy: past, present and future
Alzeibak, R., Mishchenko, T. A., Shilyagina, N. Y., Владимировна, Б. И., Vedunova, M. V., & Krysko, D. V. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001926 · Cited by 579 · see citing works
Self-citationOhta, S. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.04.006 · Cited by 526 · see citing works
Photodynamic therapy (PDT) of cancer: from local to systemic treatment
Dabrowski, J. M., & Arnaut, L. G. (2015) · Photochemical & Photobiological Sciences · doi:10.1039/c5pp00132c · Cited by 503 · see citing works
Photodynamic therapy in cancer treatment - an update review
Santos, A. F. D., de Almeida, D. R. Q., Terra, L. F., Maur�cio, B., & Labriola, L. (2019) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2018.83 · Cited by 450 · see citing works
Cell death in photodynamic therapy: From oxidative stress to anti-tumor immunity
Donohoe, C. L., Senge, M. O., Arnaut, L. G., & Gomes-da-Silva, L. C. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.07.003 · Cited by 444 · see citing works
Cell death and immunity in cancer: From danger signals to mimicry of pathogen defense responses
Garg, A. D., & Agostinis, P. (2017) · Immunological Reviews · doi:10.1111/imr.12574 · Cited by 448 · see citing works
Self-citationYu, Z., Guo, J., Hu, M., Gao, Y., & Huang, L. (2020) · ACS Nano · doi:10.1021/acsnano.0c00708 · Cited by 433 · see citing works
Mito‐Bomb: Targeting Mitochondria for Cancer Therapy
Guo, X., Yang, N., Ji, W., Zhang, H., Dong, X., Zhou, Z., Li, L., Shen, H., Yao, S. Q., & Huang, W. (2021) · Advanced Materials · doi:10.1002/adma.202007778 · Cited by 424 · see citing works
Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death
Garg, A. D., Galluzzi, L., Apétoh, L., Baert, T., Birge, R. B., Pedro, J. M. B., Breckpot, K., Brough, D., Chaurio, R. A., Cirone, M., et al. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00588 · Cited by 409 · see citing works
Self-citationDudek, A. M., Martin, S., Garg, A. D., & Agostinis, P. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00438 · Cited by 394 · see citing works
Self-citationHuang, Q., Zhan, L., Cao, H., Li, J., Lyu, Y., Guo, X., Zhang, J., Ji, L., Ren, T., An, J., et al. (2016) · Autophagy · doi:10.1080/15548627.2016.1166318 · Cited by 392 · see citing works
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Bezu, L., Gomes-da-Silva, L. C., Dewitte, H., Breckpot, K., Fucikova, J. P., Špíšek, R., Galluzzi, L., Kepp, O., & Kroemer, G. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00187 · Cited by 389 · see citing works
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Englinger, B., Pirker, C., Heffeter, P., Terenzi, A., Kowol, C. R., Keppler, B. K., & Berger, W. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00396 · Cited by 355 · see citing works
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Hou, Y., Yang, X., Liu, R., Zhao, D., Guo, C., Zhu, A., Wen, M., Liu, Z., Qu, G., & Meng, H. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s269321 · Cited by 351 · see citing works
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Showalter, A., Limaye, A., Oyer, J. L., Igarashi, R. Y., Kittipatarin, C., Copik, A. J., & Khaled, A. R. (2017) · Cytokine · doi:10.1016/j.cyto.2017.05.024 · Cited by 322 · see citing works
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Galluzzi, L., Bravo-San Pedro, J. M., Demaria, S., Formenti, S. C., & Kroemer, G. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.183 · Cited by 314 · see citing works
Trial Watch: Immunogenic cell death inducers for anticancer chemotherapy
Pol, J. G., Vacchelli, E., Aranda, F., Castoldi, F., Eggermont, A. M. M., Cremer, I., Sautès‐Fridman, C., Fucikova, J. P., Galon, J., Špíšek, R., et al. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1008866 · Cited by 306 · see citing works
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Rybstein, M. D., Pedro, J. M. B., Kroemer, G., & Galluzzi, L. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0042-2 · Cited by 287 · see citing works
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Turubanova, V. D., Владимировна, Б. И., Mishchenko, T. A., Catanzaro, E., Alzeibak, R., Peskova, N. N., Efimova, I., Bachert, C., Mitroshina, Е. V., Krysko, O., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0826-3 · Cited by 283 · see citing works
Self-citationRepurposing drugs in oncology (ReDO)—Cimetidine as an anti-cancer agent
Pantziarka, P. (2014) · ecancermedicalscience · doi:10.3332/ecancer.2014.485 · Cited by 280 · see citing works
Trial watch: Immunogenic cell death induction by anticancer chemotherapeutics
Garg, A. D., More, S., Rufo, N., Meçe, O., Sassano, M. L., Agostinis, P., Zitvogel, L., Kroemer, G., & Galluzzi, L. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1386829 · Cited by 277 · see citing works
Self-citationGarg, A. D., & Agostinis, P. (2014) · Photochemical & Photobiological Sciences · doi:10.1039/c3pp50333j · Cited by 276 · see citing works
Self-citationGarg, A. D., Vandenberk, L., Koks, C., Verschuere, T., Boon, L., Van Gool, S. W., & Agostinis, P. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aae0105 · Cited by 270 · see citing works
Self-citationAutophagy: shaping the tumor microenvironment and therapeutic response
Maes, H., Rubio, N., Garg, A. D., & Agostinis, P. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.04.005 · Cited by 266 · see citing works
Self-citationVacchelli, E., Senovilla, L., Eggermont, A. M. M., Fridman, W. H., Galon, J., Zitvogel, L., Kroemer, G., & Galluzzi, L. (2013) · OncoImmunology · doi:10.4161/onci.23510 · Cited by 265 · see citing works
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Mfouo-Tynga, I. S., Dias, L. D., Inada, N. M., & Kurachi, C. (2021) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2020.102091 · Cited by 266 · see citing works
Garg, A. D., Dudek-Perić, A. M., Romano, E., & Agostinis, P. (2015) · The International Journal of Developmental Biology · doi:10.1387/ijdb.150061pa · Cited by 244 · see citing works
Self-citationGarg, A. D., Ruysscher, D. D., & Agostinis, P. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1069938 · Cited by 229 · see citing works
Self-citationTrial watch: chemotherapy-induced immunogenic cell death in immuno-oncology
Vanmeerbeek, I., Sprooten, J., Ruysscher, D. D., Tejpar, S., Vandenberghe, P., Fucikova, J. P., Špíšek, R., Zitvogel, L., Kroemer, G., Galluzzi, L., et al. (2020) · OncoImmunology · doi:10.1080/2162402x.2019.1703449 · Cited by 226 · see citing works
Self-citationDanger signalling during cancer cell death: origins, plasticity and regulation
Garg, A. D., Martin, S., Gołąb, J., & Agostinis, P. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.48 · Cited by 225 · see citing works
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Ohta, S. (2015) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2014.11.038 · Cited by 224 · see citing works
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Sarhan, M., Land, W. G., Tonnus, W., Hugo, C., & Linkermann, A. (2018) · Physiological Reviews · doi:10.1152/physrev.00041.2016 · Cited by 210 · see citing works
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Niu, X., You, Q., Hou, K., Tian, Y., Wei, P., Zhu, Y., Gao, B., Ashrafizadeh, M., Aref, A. R., Kalbasi, A., et al. (2024) · Drug Resistance Updates · doi:10.1016/j.drup.2024.101170 · Cited by 217 · see citing works
Koks, C., Garg, A. D., Ehrhardt, M., Riva, M., Vandenberk, L., Boon, L., Vleeschouwer, S. D., Agostinis, P., Graf, N. M., & Gool, S. V. (2014) · International Journal of Cancer · doi:10.1002/ijc.29202 · Cited by 206 · see citing works
Self-citationThe multifaceted role of autophagy in cancer and the microenvironment
Folkerts, H., Hilgendorf, S., Vellenga, E., Bremer, E., & Wiersma, V. R. (2018) · Medicinal Research Reviews · doi:10.1002/med.21531 · Cited by 201 · see citing works
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Adkins, I., Fucikova, J., Garg, A. D., Agostinis, P., & Špíšek, R. (2014) · OncoImmunology · doi:10.4161/21624011.2014.968434 · Cited by 200 · see citing works
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del Valle, A. S., Anel, A., Naval, J., & Marzo, I. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00050 · Cited by 196 · see citing works
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Cancel, J.-C., Crozat, K., Dalod, M., & Mattiuz, R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00009 · Cited by 190 · see citing works
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Kang, R., & Tang, D. (2017) · Current Pathobiology Reports · doi:10.1007/s40139-017-0139-5 · Cited by 185 · see citing works
Non-coding RNAs and ferroptosis: potential implications for cancer therapy
Balihodzic, A., Prinz, F., Dengler, M. A., Călin, G. A., Jost, P. J., & Pichler, M. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-00998-x · Cited by 170 · see citing works
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Land, W. G., Agostinis, P., Gasser, S., Garg, A. D., & Linkermann, A. (2016) · American Journal of Transplantation · doi:10.1111/ajt.13963 · Cited by 166 · see citing works
Self-citationZhang, L., Wang, H., Xu, J., Zhu, J., & Ding, K. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.05.015 · Cited by 160 · see citing works
Arginine metabolism and deprivation in cancer therapy
Zou, S., Wang, X., Liu, P., Ke, C., & Xu, S. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109210 · Cited by 159 · see citing works
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Rondas, D., Crèvecoeur, I., D’Hertog, W., Ferreira, G. B., Staes, A., Garg, A. D., Eizirik, D. L., Agostinis, P., Gevaert, K., Overbergh, L., et al. (2014) · Diabetes · doi:10.2337/db14-0621 · Cited by 156 · see citing works
Self-citationHeterojunction engineered bioactive chlorella for cascade promoted cancer therapy
Ou, M., Lin, C., Wang, Y., Lü, Y., Wang, W., Li, Z., Zeng, W., Zeng, X., Ji, X., & Mei, L. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.03.059 · Cited by 153 · see citing works
Vacchelli, E., Aranda, F., Eggermont, A. M. M., Galon, J., Sautès‐Fridman, C., Cremer, I., Zitvogel, L., Kroemer, G., & Galluzzi, L. (2014) · OncoImmunology · doi:10.4161/onci.27878 · Cited by 150 · see citing works
Nath, S., Obaid, G., & Hasan, T. G. (2019) · Photochemistry and Photobiology · doi:10.1111/php.13173 · Cited by 144 · see citing works
Zhou, Z., Ni, K., Deng, H., & Chen, X. S. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.006 · Cited by 139 · see citing works
Weijer, R., Broekgaarden, M., Kos, M., van Vught, R., Rauws, E. A., Breukink, E. J., van Gulik, T. M., Storm, G., & Heger, M. (2015) · Journal of Photochemistry and Photobiology C Photochemistry Reviews · doi:10.1016/j.jphotochemrev.2015.05.002 · Cited by 139 · see citing works
Ashraf, R., & Kumar, S. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04595-6 · Cited by 138 · see citing works
Photodynamic therapy combined with immunotherapy: Recent advances and future research directions
Warszyńska, M., Repetowski, P., & Dąbrowski, J. M. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215350 · Cited by 138 · see citing works
Yu, W., Wang, Y., Zhu, J., Jin, L., Liu, B., Xia, K., Wang, J., Gao, J., Liang, C., & Tao, H. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.11.019 · Cited by 139 · see citing works
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Gao, L., Loveless, J., Shay, C., & Teng, Y. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-42667-5_1 · Cited by 133 · see citing works
Garg, A. D., Romano, E., Rufo, N., & Agostinis, P. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.5 · Cited by 131 · see citing works
Self-citationLiu, X., Jiang, J., Liao, Y., Tang, I., Zheng, E., Qiu, W., Lin, M. J., Wang, X., Ji, Y. C., Mei, K., et al. (2021) · Advanced Science · doi:10.1002/advs.202002147 · Cited by 131 · see citing works
Chen, Q., Liu, L., Lü, Y., Chen, X., Zhang, Y., Zhou, W., Guo, Q., Li, C., Zhang, Y., Zhang, Y. X., et al. (2019) · Advanced Science · doi:10.1002/advs.201802134 · Cited by 125 · see citing works
Crosstalk Between Autophagy and Ferroptosis and Its Putative Role in Ischemic Stroke
Liu, J., Guo, Z., Yan, X., Huang, S., Ren, J., Luo, Y., & Yang, Y. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.577403 · Cited by 119 · see citing works
Wei, X.-B., Jiang, W.-Q., Zeng, J.-H., Huang, L.-Q., Ding, H.-G., Jing, Y.-W., Han, Y.-L., Li, Y.-C., & Chen, S.-L. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02738-1 · Cited by 123 · see citing works
Loenhout, J. V., Flieswasser, T., Boullosa, L. F., Waele, J. D., Audenaerde, J. R. M. V., Marcq, E., Jacobs, J., Lin, A. G., Lion, E., Dewitte, H., et al. (2019) · Cancers · doi:10.3390/cancers11101597 · Cited by 118 · see citing works
Glutathione‐Depleting Organic Metal Adjuvants for Effective NIR‐II Photothermal Immunotherapy
Chen, Y., He, P., Jana, D., Wang, D., Wang, M., Yu, P., Zhu, W., & Zhao, Y. (2022) · Advanced Materials · doi:10.1002/adma.202201706 · Cited by 115 · see citing works
Kleemann, B., Loos, B., Scriba, T. J., Lang, D. M., & Davids, L. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103762 · Cited by 109 · see citing works
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Garg, A. D., Dudek, A. M., & Agostinis, P. (2013) · BioFactors · doi:10.1002/biof.1125 · Cited by 108 · see citing works
Self-citationAmplifying “eat me signal” by immunogenic cell death for potentiating cancer immunotherapy
Xi, Y., Chen, L., Wang, L., Yu, B., Shen, W., & Niu, X. (2023) · Immunological Reviews · doi:10.1111/imr.13251 · Cited by 108 · see citing works
Han, X. B., Li, H. X., Jiang, Y., Wang, H., Li, X. S., Kou, J., Zheng, Y., Liu, Z. N., Li, H., Li, J., et al. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.242 · Cited by 106 · see citing works
Loenhout, J. V., Peeters, M., Bogaerts, A., Smits, E., & Deben, C. (2020) · Antioxidants · doi:10.3390/antiox9121188 · Cited by 105 · see citing works
Immunogenic Apoptotic Cell Death and Anticancer Immunity
Vandenabeele, P., Vandecasteele, K., Bachert, C., Krysko, O., & Krysko, D. V. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-39406-0_6 · Cited by 100 · see citing works
Self-citationDudek-Perić, A. M., Ferreira, G. B., Muchowicz, A., Wouters, J., Prada, N., Martin, S., Kiviluoto, S., Winiarska, M., Boon, L., Mathieu, C., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2089 · Cited by 99 · see citing works
Self-citationAutophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?
Peña‐Oyarzún, D., Bravo, R., Díaz‐Vegas, A., Aleman, L., Chiong, M., Garcı́a, L., Claudia Bambs, S., Troncoso, R., Cifuentes, M., Morselli, E., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.05.084 · Cited by 101 · see citing works
Wang, T., Wu, X., Rudaisat, M. A., Song, Y., & Cheng, H. (2020) · Journal of Cancer · doi:10.7150/jca.45176 · Cited by 97 · see citing works
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Zaarour, R. F., Azakir, B., Hajam, E. Y., Nawafleh, H. H., Zeinelabdin, N. A., Engelsen, A. S. T., Thiery, J., Jamora, C., & Chouaı̈b, S. (2021) · Cancers · doi:10.3390/cancers13030533 · Cited by 98 · see citing works
Anzengruber, F., Avci, P., de Freitas, L. F., & Hamblin, M. R. (2015) · Photochemical & Photobiological Sciences · doi:10.1039/c4pp00455h · Cited by 95 · see citing works
Autophagy: An adaptive metabolic response to stress shaping the antitumor immunity
Viry, E., Paggetti, J., Bagińska, J., Mgrditchian, T., Berchem, G., Moussay, E., & Janji, B. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.07.006 · Cited by 95 · see citing works
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Huang, C. L., Li, J., Wu, R., Li, Y., & Zhang, C. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02344-4 · Cited by 103 · see citing works
Exploiting the Immunogenic Potential of Cancer Cells for Improved Dendritic Cell Vaccines
Vandenberk, L., Belmans, J., Woensel, M. V., Riva, M., & Gool, S. V. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00663 · Cited by 90 · see citing works
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Birmpilis, A. I., Paschalis, A., Mourkakis, A., Christodoulou, P., Kostopoulos, I. V., Antimissari, E., Terzoudi, G. I., Georgakilas, A. G., Armpilia, C., Papageorgis, P., et al. (2022) · Cells · doi:10.3390/cells11091415 · Cited by 91 · see citing works
Nano Delivery of Chemotherapeutic ICD Inducers for Tumor Immunotherapy
Guo, J., Zou, Y., & Huang, L. (2023) · Small Methods · doi:10.1002/smtd.202201307 · Cited by 91 · see citing works
Ferroptosis: Cancer Stem Cells Rely on Iron until “to Die for” It
Cosialls, E., Elhage, R., Santos, L. D., Gong, C., Mehrpour, M., & Hamaï, A. (2021) · Cells · doi:10.3390/cells10112981 · Cited by 90 · see citing works
Vig, S., Buitinga, M., Rondas, D., Crèvecoeur, I., van Zandvoort, M. A. M. J., Waelkens, E., Eizirik, D. L., Gysemans, C. A., Baatsen, P., Mathieu, C., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1518-0 · Cited by 88 · see citing works
Self-citationTuli, H. S., Kaur, J., Vashishth, K., Sak, K., Sharma, U., Choudhary, R., Behl, T., Singh, T., Sharma, S., Saini, A. K., et al. (2022) · Archives of Toxicology · doi:10.1007/s00204-022-03421-z · Cited by 88 · see citing works
Garg, A. D., Elsen, S., Krysko, D. V., Vandenabeele, P., de Witte, P., & Agostinis, P. (2015) · Oncotarget · doi:10.18632/oncotarget.4754 · Cited by 87 · see citing works
Self-citationLi, Y., Gong, T., Gao, H., Chen, Y., Li, H., Zhao, P., Jiang, Y., Wang, K., Wu, Y., Zheng, X., et al. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202103015 · Cited by 88 · see citing works
Xu, C., Yu, Y., Sun, Y., Kong, L., Yang, C., Hu, M. Y., Yang, T., Zhang, J., Hu, Q., & Zhang, Z. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201905213 · Cited by 84 · see citing works
Role of autophagy on cancer immune escape
Duan, Y., Tian, X., Liu, Q., Jin, J., Shi, J., & Hou, Y. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00769-0 · Cited by 83 · see citing works
Autophagy Regulation and Photodynamic Therapy: Insights to Improve Outcomes of Cancer Treatment
Martins, W. K., Belotto, R. A., Silva, M. N., Grasso, D., Franco, M. D. S., de Lavor, T. S., Itri, R., Baptista, M. S., & Tsubone, T. M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.610472 · Cited by 82 · see citing works
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Land, W. G., Agostinis, P., Gasser, S., Garg, A. D., & Linkermann, A. (2016) · American Journal of Transplantation · doi:10.1111/ajt.14012 · Cited by 78 · see citing works
Self-citationYang, Y., Hu, Y., & Wang, H. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/5274084 · Cited by 76 · see citing works
Bauzon, M., Drake, P. M., Barfield, R. M., Cornali, B. M., Rupniewski, I., & Rabuka, D. (2019) · OncoImmunology · doi:10.1080/2162402x.2019.1565859 · Cited by 76 · see citing works
- Authors
- Garg, A. D., Dudek, A. M., Ferreira, G. B., Verfaillie, T., Vandenabeele, P., Krysko, D. V., Mathieu, C., & Agostinis, P.
- Affiliations
- KU Leuven (BE)
- Ghent University (BE)
- Corresponding author
- Agostinis, Patrizia
- ORCID
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2013-09-29
- Volume
- 9
- Issue
- 9
- Pages
- 1292-1307
- ISSN
- 1554-8627 (ISSN-L)
- 1554-8635
- OpenAlex
- W2091209638
- Cited by
- 305
- References
- 62
- Citations by year
- 2026: 12 · 2025: 14 · 2024: 21 · 2023: 35 · 2022: 32 · 2021: 25 · 2020: 27 · 2019: 28 · 2018: 19 · 2017: 10 · 2016: 32 · 2015: 20 · 2014: 22 · 2013: 8
- FWCI
- 19.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Autophagy (publishedVersion)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (submittedVersion, other-oa)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- Fonds Wetenschappelijk Onderzoek (G.0661.09, G.0728.10)
- KU Leuven (GOA/11/009)
- Universiteit Gent
- Servier
- Vlaamse regering
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- immunogenic cell death, reactive oxygen species, endoplasmic reticulum stress, hypericin, photodynamic therapy, calreticulin exposure, ATP release, dendritic cell maturation, T cell proliferation, ATG5, tumor immunosuppression
- MeSH terms
- Autophagy-Related Protein 5, Adenosine Triphosphate, Anthracenes, Autophagy, Dendritic Cells, Glutathione Peroxidase, Histidine, Humans, Interferon-gamma, Microtubule-Associated Proteins, Models, Biological, Neoplasms, Oxidation-Reduction, Perylene, Phenotype, Photochemotherapy, CD4-Positive T-Lymphocytes, Interleukin-6, Reactive Oxygen Species, CD8-Positive T-Lymphocytes, Calreticulin, Cell Line, Tumor, Cell Proliferation, Gene Knockdown Techniques
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