The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate
Open accessAbstract
Stem cells sense and respond to the mechanical properties of the extracellular matrix. However, both the extent to which extracellular matrix mechanics affect stem cell fate in 3D micro-environments and the underlying biophysical mechanisms are unclear. We demonstrate that the commitment of mesenchymal stem cell (MSC) populations changes in response to the rigidity of 3D micro-environments, with osteogenesis occurring predominantly at 11–30 kPa. In contrast to previous 2D work, however, cell fate was not correlated with morphology. Instead, matrix stiffness regulated integrin binding as well as reorganization of adhesion ligands on the nanoscale, both of which were traction-dependent and correlated with osteogenic commitment of MSC populations. These findings suggest that cells interpret changes in the physical properties of adhesion substrates as changes in adhesion ligand presentation, and that cells themselves can be harnessed as tools to mechanically process materials into structures that feedback to manipulate their fate.
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Citations
Cites
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
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Tissue Cells Feel and Respond to the Stiffness of Their Substrate
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Taking Cell-Matrix Adhesions to the Third Dimension
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Cellular mechanotransduction: putting all the pieces together again
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Repair of bone defects using synthetic mimetics of collagenous extracellular matrices
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Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation
Keselowsky, B. G., Collard, D. M., & García, A. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407356102 · Cited by 687
Cited by
Advances in engineering hydrogels
Zhang, Y. S., & Khademhosseini, A. (2017) · Science · doi:10.1126/science.aaf3627 · Cited by 2,908
Hydrogels with tunable stress relaxation regulate stem cell fate and activity
Chaudhuri, O., Gu, L., Klumpers, D., Darnell, M., Bencherif, S. A., Weaver, J. C., Huebsch, N., Lee, H.-P., Lippens, E., Duda, G. N., et al. (2016) · Nature Materials · doi:10.1038/nmat4489 · Cited by 2,443
Self-citationEffects of extracellular matrix viscoelasticity on cellular behaviour
Chaudhuri, O., Cooper-White, J., Janmey, P. A., Mooney, D. J., & Shenoy, V. B. (2020) · Nature · doi:10.1038/s41586-020-2612-2 · Cited by 2,224
Self-citationA practical guide to hydrogels for cell culture
Caliari, S. R., & Burdick, J. A. (2016) · Nature Methods · doi:10.1038/nmeth.3839 · Cited by 2,075
Mesenchymal stem cell perspective: cell biology to clinical progress
Pittenger, M. F., Discher, D. E., Péault, B. M., Phinney, D. G., Hare, J. M., & Caplan, A. I. (2019) · npj Regenerative Medicine · doi:10.1038/s41536-019-0083-6 · Cited by 2,008
Metadata
- Authors
- Huebsch, N., Arany, P. R., Mao, A. S., Shvartsman, D., Ali, O. A., Bencherif, S. A., Rivera-Feliciano, J., & Mooney, D. J.
- Venue
- Nature Materials
- Published
- 2010-04-25
- Volume
- 9
- Issue
- 6
- Pages
- 518-526
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W2113547540
- Cited by
- 1,569
- References
- 8
- FWCI
- 34.56
- Type
- journal article
- Language
- en
- Open access
- green
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- Huebsch, N., Arany, P. R., Mao, A. S., Shvartsman, D., Ali, O. A., Bencherif, S. A., Rivera-Feliciano, J., & Mooney, D. J. (2010). Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate. Nature Materials. https://doi.org/10.1038/nmat2732
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
