The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy
Open accessAbstract
The tumour microenvironment thwarts conventional immunotherapy through multiple immunologic mechanisms, such as the secretion of the transforming growth factor-β (TGF-β), which stunts local tumour immune responses. Therefore, high doses of interleukin-2 (IL-2), a conventional cytokine for metastatic melanoma, induces only limited responses. To overcome the immunoinhibitory nature of the tumour microenvironment, we developed nanoscale liposomal polymeric gels (nanolipogels; nLGs) of drug-complexed cyclodextrins and cytokine-encapsulating biodegradable polymers that can deliver small hydrophobic molecular inhibitors and water-soluble protein cytokines in a sustained fashion to the tumour microenvironment. nLGs releasing TGF-β inhibitor and IL-2 significantly delayed tumour growth, increased survival of tumour-bearing mice, and increased the activity of natural killer cells and of intratumoral-activated CD8+ T-cell infiltration. We demonstrate that the efficacy of nLGs in tumour immunotherapy results from a crucial mechanism involving activation of both innate and adaptive immune responses.
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Metadata
- Authors
- Park, J., Wrzesinski, S. H., Stern, E., Look, M., Criscione, J., Ragheb, R., Jay, S. M., Demento, S. L., Agawu, A., Licona Limon, P., Ferrandino, A. F., Gonzalez, D., Habermann, A., Flavell, R. A., & Fahmy, T. M.
- Venue
- Nature Materials
- Published
- 2012-07-15
- Volume
- 11
- Issue
- 10
- Pages
- 895-905
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W2003690177
- Cited by
- 494
- References
- 46
- FWCI
- 9.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Park, J., Wrzesinski, S. H., Stern, E., Look, M., Criscione, J., Ragheb, R., Jay, S. M., Demento, S. L., Agawu, A., Licona Limon, P., Ferrandino, A. F., Gonzalez, D., Habermann, A., Flavell, R. A., & Fahmy, T. M. (2012). Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy. Nature Materials. https://doi.org/10.1038/nmat3355
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