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Propulsion and navigation within the advancing monolayer sheet
Open accessAbstract
As a wound heals, or a body plan forms, or a tumor invades, observed cellular motions within the advancing cell swarm are thought to stem from yet to be observed physical stresses that act in some direct and causal mechanical fashion. Here we show that such a relationship between motion and stress is far from direct. Using monolayer stress microscopy, we probed migration velocities, cellular tractions and intercellular stresses in an epithelial cell sheet advancing towards an island on which cells cannot adhere. We found that cells located near the island exert tractions that pull systematically towards this island regardless of whether the cells approach the island, migrate tangentially along its edge or, paradoxically, recede from it. This unanticipated cell-patterning motif, which we call kenotaxis, represents the robust and systematic mechanical drive of the cellular collective to fill unfilled space.
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Cited by
An introduction to the wound healing assay using live-cell microscopy
Jonkman, J. E. N., Cathcart, J. A., Xu, F., Bartolini, M. E., Amon, J. E., Stevens, K. M., & Colarusso, P. (2014) · Cell Adhesion & Migration · doi:10.4161/cam.36224 · Cited by 729
Unjamming and cell shape in the asthmatic airway epithelium
Park, J.-A., Kim, J. H., Bi, D., Mitchel, J. A., Qazvini, N. T., Tantisira, K., Park, C. Y., McGill, M., Kim, S.-H., Gweon, B., et al. (2015) · Nature Materials · doi:10.1038/nmat4357 · Cited by 677
Self-citationMotility-Driven Glass and Jamming Transitions in Biological Tissues
Bi, D., Yang, X., Marchetti, M. C., & Manning, M. L. (2016) · Physical Review X · doi:10.1103/physrevx.6.021011 · Cited by 677
Forces driving epithelial wound healing
Brugués, A., Anon, E., Conte, V., Veldhuis, J. H., Gupta, M., Colombelli, J., Muñoz, J. J., Brodland, G. W., Ladoux, B., & Trepat, X. (2014) · Nature Physics · doi:10.1038/nphys3040 · Cited by 450
Self-citationPhysical Models of Collective Cell Migration
Alert, R., & Trepat, X. (2020) · Annual Review of Condensed Matter Physics · doi:10.1146/annurev-conmatphys-031218-013516 · Cited by 375
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Metadata
- Authors
- Kim, J. H., Serra-Picamal, X., Tambe, D. T., Zhou, E. H., Park, C. Y., Sadati, M., Park, J.-A., Krishnan, R., Gweon, B., Millet, E., Butler, J. P., Trepat, X., & Fredberg, J. J.
- Venue
- Nature Materials
- Published
- 2013-06-23
- Volume
- 12
- Issue
- 9
- Pages
- 856-863
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W2048942861
- Cited by
- 181
- References
- 0
- FWCI
- 10.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Kim, J. H., Serra-Picamal, X., Tambe, D. T., Zhou, E. H., Park, C. Y., Sadati, M., Park, J.-A., Krishnan, R., Gweon, B., Millet, E., Butler, J. P., Trepat, X., & Fredberg, J. J. (2013). Propulsion and navigation within the advancing monolayer sheet. Nature Materials. https://doi.org/10.1038/nmat3689
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