The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Forces driving epithelial wound healing
Open accessAbstract
A fundamental feature of multicellular organisms is their ability to self-repair wounds through the movement of epithelial cells into the damaged area. This collective cellular movement is commonly attributed to a combination of cell crawling and ‘purse-string’ contraction of a supracellular actomyosin ring. Here we show by direct experimental measurement that these two mechanisms are insufficient to explain force patterns observed during wound closure. At early stages of the process, leading actin protrusions generate traction forces that point away from the wound, showing that wound closure is initially driven by cell crawling. At later stages, we observed unanticipated patterns of traction forces pointing towards the wound. Such patterns have strong force components that are both radial and tangential to the wound. We show that these force components arise from tensions transmitted by a heterogeneous actomyosin ring to the underlying substrate through focal adhesions. The structural and mechanical organization reported here provides cells with a mechanism to close the wound by cooperatively compressing the underlying substrate. Wound repair is thought to involve cell migration and the contraction of a tissue-level biopolymer ring—invoking analogy with the pulling of purse strings. Traction-force measurements now show that this ring engages the tissue's surroundings to steer migration, prompting revision of the purse-string mechanism.
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Cites
Cell Movement Is Guided by the Rigidity of the Substrate
Lo, C.-M., Wang, H.-B., Dembo, M., & Wang, Y.-L. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76279-5 · Cited by 3,289
Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
Yeung, T., Georges, P. C., Flanagan, L. A., Marg, B., Ortiz, M., Funaki, M., Zahir, N., Ming, W., Weaver, V., & Janmey, P. A. (2005) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20041 · Cited by 2,325
Cells lying on a bed of microneedles: An approach to isolate mechanical force
Tan, J. L., Tien, J., Pirone, D. M., Gray, D. S., Bhadriraju, K., & Chen, C. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0235407100 · Cited by 1,962
Stresses at the Cell-to-Substrate Interface during Locomotion of Fibroblasts
Dembo, M., & Wang, Y.-L. (1999) · Biophysical Journal · doi:10.1016/s0006-3495(99)77386-8 · Cited by 1,287
Physical forces during collective cell migration
Trepat, X., Wasserman, M. R., Angelini, T. E., Millet, E., Weitz, D. A., Butler, J. P., & Fredberg, J. J. (2009) · Nature Physics · doi:10.1038/nphys1269 · Cited by 1,195
Self-citationCollective migration of an epithelial monolayer in response to a model wound
Poujade, M., Grasland-Mongrain, E., Hertzog, A., Jouanneau, J., Chavrier, P., Ladoux, B., Buguin, A., & Silberzan, P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705062104 · Cited by 912
Self-citationPlotnikov, S. V., Pasapera, A. M., Sabass, B., & Waterman, C. M. (2012) · Cell · doi:10.1016/j.cell.2012.11.034 · Cited by 866
Force mapping in epithelial cell migration
du Roure, O., Saez, A., Buguin, A., Austin, R. H., Chavrier, P., Siberzan, P., & Ladoux, B. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408482102 · Cited by 779
Self-citationShaw, T. J., & Martin, P. (2009) · Journal of Cell Science · doi:10.1242/jcs.031187 · Cited by 765
Epithelial repair mechanisms in the lung
Crosby, L. M., & Waters, C. M. (2010) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00361.2009 · Cited by 705
Cited by
Topological defects in epithelia govern cell death and extrusion
Saw, T. B., Doostmohammadi, A., Nier, V., Kocgozlu, L., Thampi, S., Toyama, Y., Marcq, P., Lim, C. T., Yeomans, J. M., & Ladoux, B. (2017) · Nature · doi:10.1038/nature21718 · Cited by 831
Self-citationMechanobiology of collective cell behaviours
Ladoux, B., & Mège, R.-M. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.98 · Cited by 749
Self-citationKomi, D. E. A., Khomtchouk, K., & Santa Maria, P. L. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-019-08729-w · Cited by 384
Physical Models of Collective Cell Migration
Alert, R., & Trepat, X. (2020) · Annual Review of Condensed Matter Physics · doi:10.1146/annurev-conmatphys-031218-013516 · Cited by 375
Self-citationTuning Collective Cell Migration by Cell–Cell Junction Regulation
Friedl, P., & Mayor, R. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a029199 · Cited by 357
Metadata
- Authors
- Brugués, A., Anon, E., Conte, V., Veldhuis, J. H., Gupta, M., Colombelli, J., Muñoz, J. J., Brodland, G. W., Ladoux, B., & Trepat, X.
- Venue
- Nature Physics
- Published
- 2014-08-03
- Volume
- 10
- Issue
- 9
- Pages
- 683-690
- ISSN
- 1745-2473 (ISSN-L)
- 1745-2481
- OpenAlex
- W2076394578
- Cited by
- 450
- References
- 47
- FWCI
- 14.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Brugués, A., Anon, E., Conte, V., Veldhuis, J. H., Gupta, M., Colombelli, J., Muñoz, J. J., Brodland, G. W., Ladoux, B., & Trepat, X. (2014). Forces driving epithelial wound healing. Nature Physics. https://doi.org/10.1038/nphys3040
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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