The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals
Open accessAbstract
Stimuli-responsive nanomaterials are increasingly important in a variety of applications such as biosensing, molecular imaging, drug delivery and tissue engineering. For cancer detection, a paramount challenge still exists in search of methods that can illuminate tumors universally regardless of their genotypes and phenotypes. Here we capitalized on the acidic, angiogenic tumor microenvironment to achieve broad detection of tumor tissues in a wide variety of mouse cancer models. This was accomplished using ultra-pH sensitive fluorescent nanoprobes that have tunable, exponential fluorescence activation upon encountering subtle, physiologically relevant pH transitions. These nanoprobes were silent in the circulation, then dramatically activated (>300 fold) in response to neovasculature or to the low extracellular pH in tumors. Thus, we have established non-toxic, fluorescent nanoreporters that can non-linearly amplify tumor microenvironmental signals, permitting identification of tumor tissue independently of histological type or driver mutation, and detection of acute treatment responses much more rapidly than conventional imaging approaches.
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Cites
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Cancer nanomedicine: progress, challenges and opportunities
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Diverse Applications of Nanomedicine
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Self-citationThe Smart Drug Delivery System and Its Clinical Potential
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Polymer–drug conjugate therapeutics: advances, insights and prospects
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Recent progress in drug delivery
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Metadata
- Authors
- Wang, Y., Zhou, K., Huang, G., Hensley, C., Huang, X., Ma, X., Zhao, T., Sumer, B. D., DeBerardinis, R. J., & Gao, J.
- Venue
- Nature Materials
- Published
- 2013-12-08
- Volume
- 13
- Issue
- 2
- Pages
- 204-212
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W2149597677
- Cited by
- 773
- References
- 38
- FWCI
- 29.41
- Type
- journal article
- Language
- en
- Open access
- green
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- Wang, Y., Zhou, K., Huang, G., Hensley, C., Huang, X., Ma, X., Zhao, T., Sumer, B. D., DeBerardinis, R. J., & Gao, J. (2014). A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals. Nature Materials. https://doi.org/10.1038/nmat3819
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