The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Biodegradable silicon nanoneedles delivering nucleic acids intracellularly induce localized in vivo neovascularization
Open accessAbstract
The controlled delivery of nucleic acids to selected tissues remains an inefficient process mired by low transfection efficacy, poor scalability because of varying efficiency with cell type and location, and questionable safety as a result of toxicity issues arising from the typical materials and procedures employed. High efficiency and minimal toxicity in vitro has been shown for intracellular delivery of nuclei acids by using nanoneedles, yet extending these characteristics to in vivo delivery has been difficult, as current interfacing strategies rely on complex equipment or active cell internalization through prolonged interfacing. Here, we show that a tunable array of biodegradable nanoneedles fabricated by metal-assisted chemical etching of silicon can access the cytosol to co-deliver DNA and siRNA with an efficiency greater than 90%, and that in vivo the nanoneedles transfect the VEGF-165 gene, inducing sustained neovascularization and a localized sixfold increase in blood perfusion in a target region of the muscle.
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Cites
Vascular-specific growth factors and blood vessel formation
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Knocking down barriers: advances in siRNA delivery
Whitehead, K. A., Langer, R., & Anderson, D. G. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2742 · Cited by 3,115
Protein Therapeutics: A Summary and Pharmacological Classification
Leader, B., Baca, Q. J., & Golan, D. E. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2399 · Cited by 2,161
Therapeutic in vivo gene transfer for genetic disease using AAV: Progress and challenges
Mingozzi, F., & High, K. A. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2988 · Cited by 893
Cited by
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Self-citationBiomimetic proteolipid vesicles for targeting inflamed tissues
Molinaro, R., Corbo, C., Martinez, J. O., Taraballi, F., Evangelopoulos, M., Minardi, S., Yazdi, I. K., Zhao, P., De Rosa, E., Sherman, M. B., et al. (2016) · Nature Materials · doi:10.1038/nmat4644 · Cited by 451
Self-citationCardiac cell–integrated microneedle patch for treating myocardial infarction
Tang, J., Wang, J., Huang, K., Ye, Y., Su, T., Qiao, L., Hensley, M. T., Caranasos, T. G., Zhang, J., Gu, Z., et al. (2018) · Science Advances · doi:10.1126/sciadv.aat9365 · Cited by 316
Rekindling RNAi Therapy: Materials Design Requirements for In Vivo siRNA Delivery
Kim, B., Park, J., & Sailor, M. J. (2019) · Advanced Materials · doi:10.1002/adma.201903637 · Cited by 298
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Metadata
- Authors
- Chiappini, C., De Rosa, E., Martinez, J. O., Liu, X., Steele, J., Stevens, M. M., & Tasciotti, E.
- Venue
- Nature Materials
- Published
- 2015-03-30
- Volume
- 14
- Issue
- 5
- Pages
- 532-539
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W2020197664
- Cited by
- 446
- References
- 4
- FWCI
- 20.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Chiappini, C., De Rosa, E., Martinez, J. O., Liu, X., Steele, J., Stevens, M. M., & Tasciotti, E. (2015). Biodegradable silicon nanoneedles delivering nucleic acids intracellularly induce localized in vivo neovascularization. Nature Materials. https://doi.org/10.1038/nmat4249
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