The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices
Open accessAbstract
Devices resident in the stomach -- which are used for a variety of clinical applications including nutritional modulation for bariatrics, ingestible electronics for diagnosis and monitoring, and gastric retentive dosage forms for prolonged drug delivery -- typically incorporate elastic polymers to compress the devices during delivery through the esophagus and other narrow orifices in the digestive system. However, in the event of accidental device fracture or migration, the non-degradable nature of these materials risks intestinal obstruction. Here, we show that an elastic, pH-responsive supramolecular gel remains stable and elastic in the acidic environment of the stomach but can be dissolved in the neutral-pH environment of the small and large intestines. In a large animal model, prototype devices with these materials as the key component demonstrated prolonged gastric retention and safe passage. These enteric elastomers should increase the safety profile for a wide range of gastric retentive devices.
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Cites
The return of a forgotten polymer—Polycaprolactone in the 21st century
Woodruff, M. A., & Hutmacher, D. W. (2010) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2010.04.002 · Cited by 4,033
Bioenterics intragastric balloon: the Italian experience with 2,515 patients
Genco, A., Bruni, T., Doldi, S. B., Forestieri, P., Marino, M., Busetto, L., Giardiello, C., Angrisani, L., Pecchioli, L., Stornelli, P., et al. (2005) · Obesity Surgery · doi:10.1381/0960892055002202 · Cited by 361
Feasibility of an Ingestible Sensor-Based System for Monitoring Adherence to Tuberculosis Therapy
Belknap, R., Weis, S., Brookens, A., Au-Yeung, K. Y., Moon, G., DiCarlo, L., & Reves, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053373 · Cited by 160
Cited by
Designing hydrogels for controlled drug delivery
Li, J., & Mooney, D. J. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.71 · Cited by 4,832
Advances in Biomaterials for Drug Delivery
Fenton, O. S., Olafson, K. N., Pillai, P. S., Mitchell, M. J., & Langer, R. (2018) · Advanced Materials · doi:10.1002/adma.201705328 · Cited by 855
Self-citationChallenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals
Homayun, B., Lin, X., & Choi, H.-J. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11030129 · Cited by 837
Layer‐by‐Layer Encapsulation of Probiotics for Delivery to the Microbiome
Anselmo, A. C., McHugh, K. J., Webster, J., Langer, R., & Jaklenec, A. (2016) · Advanced Materials · doi:10.1002/adma.201603270 · Cited by 422
Self-citationpH-Responsive carriers for oral drug delivery: Challenges and opportunities of current platforms
Liu, L., Yao, W., Rao, Y., Lu, X., & Gao, J. (2017) · Drug Delivery · doi:10.1080/10717544.2017.1279238 · Cited by 420
Metadata
- Authors
- Zhang, S., Bellinger, A. M., Glettig, D. L., Barman, R., Lee, Y.-A. L., Zhu, J., Cleveland, C., Montgomery, V. A., Gu, L., Nash, L. D., Maitland, D. J., Langer, R., & Traverso, G.
- Venue
- Nature Materials
- Published
- 2015-07-27
- Volume
- 14
- Issue
- 10
- Pages
- 1065-1071
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W1929445570
- Cited by
- 326
- References
- 3
- FWCI
- 11.14
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhang, S., Bellinger, A. M., Glettig, D. L., Barman, R., Lee, Y.-A. L., Zhu, J., Cleveland, C., Montgomery, V. A., Gu, L., Nash, L. D., Maitland, D. J., Langer, R., & Traverso, G. (2015). A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices. Nature Materials. https://doi.org/10.1038/nmat4355
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
