pH-Responsive carriers for oral drug delivery: Challenges and opportunities of current platforms

Stimuli-responsive nanocarriers for drug delivery

Mura, S., Nicolas, J., & Couvreur, P. (2013) · Nature Materials · doi:10.1038/nmat3776 · Cited by 6,289 · see citing works

Hydrogels in pharmaceutical formulations

Peppas, N. (2000) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(00)00090-4 · Cited by 4,011 · see citing works

Environment-sensitive hydrogels for drug delivery

Qiu, Y., & Park, K. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00203-4 · Cited by 3,917 · see citing works

Long-Circulating and Target-Specific Nanoparticles: Theory to Practice

Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01494-7 · Cited by 3,521 · see citing works

Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan—a review

George, M., & Abraham, T. E. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.04.017 · Cited by 2,012 · see citing works

Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities

Cheng, Z., Zaki, A. A., Hui, J. Z., Muzykantov, V. R., & Tsourkas, A. (2012) · Science · doi:10.1126/science.1226338 · Cited by 1,322 · see citing works

Measurement of gastrointestinal pH profiles in normal ambulant human subjects

Evans, D. F., Pye, G., Bramley, R., Clark, A. G., Dyson, T. J., & Hardcastle, J. D. (1988) · Gut · doi:10.1136/gut.29.8.1035 · Cited by 1,240 · see citing works

Chitosan-modifications and applications: Opportunities galore

Mourya, V. K., & Inamdar, N. N. (2008) · Reactive and Functional Polymers · doi:10.1016/j.reactfunctpolym.2008.03.002 · Cited by 1,150 · see citing works

A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery

Chen, S.-C., Wu, Y.-C., Mi, F., Lin, Y.-H., Yu, L.-C., & Sung, H. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.02.002 · Cited by 935 · see citing works

Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo

Pan, Y., Li, Y.-J., Zhao, H.-Y., Zheng, J.-M., Xu, H., Wei, G., Hao, J.-S., & Fu-de, C. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00486-6 · Cited by 686 · see citing works

Polymeric Micelles, a Promising Drug Delivery System to Enhance Bioavailability of Poorly Water-Soluble Drugs

Xu, W., Ling, P., & Zhang, T. (2013) · Journal of Drug Delivery · doi:10.1155/2013/340315 · Cited by 595 · see citing works

Surface-Engineered Magnetic Nanoparticle Platforms for Cancer Imaging and Therapy

Xie, J., Liu, G., Eden, H. S., Ai, H., & Chen, X. S. (2011) · Accounts of Chemical Research · doi:10.1021/ar200044b · Cited by 582 · see citing works

Challenges for the oral delivery of macromolecules

Goldberg, M. F., & Gómez-Orellana, I. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1067 · Cited by 545 · see citing works

Biological activity of chitosan: ultrastructural study

Müzzarelli, R. A. A., Baldassarre, V., Conti, F., Ferrara, P., Biagini, G., Gazzanelli, G., & Vasi, V. (1988) · Biomaterials · doi:10.1016/0142-9612(88)90092-0 · Cited by 533 · see citing works

pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates

Felber, A. E., Dufresne, M.-H., & Leroux, J. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.09.006 · Cited by 480 · see citing works

Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules

Chen, M., Mi, F., Liao, Z., Hsiao, C., Sonaje, K., Chung, M., Hsu, L., & Sung, H. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.10.010 · Cited by 453 · see citing works

Swelling/deswelling of anionic copolymer gels

Khare, A. R., & Peppas, N. A. (1995) · Biomaterials · doi:10.1016/0142-9612(95)91130-q · Cited by 431 · see citing works

Oral delivery of insulin using pH‐responsive complexation gels

Lowman, A. M., Morishita, M., Kajita, M., NAGAI, T., & Peppas, N. A. (1999) · Journal of Pharmaceutical Sciences · doi:10.1021/js980337n · Cited by 407 · see citing works

Preparation and Characterization of Freeze-dried Chitosan-Poly(Ethylene Oxide) Hydrogels for Site-Specific Antibiotic Delivery in the Stomach

Patel, V. R., & Amiji, M. M. (1996) · Pharmaceutical Research · doi:10.1023/a:1016054306763 · Cited by 398 · see citing works

Positively charged nanoparticles for improving the oral bioavailability of cyclosporin-A

El-Shabouri, M. H. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00461-1 · Cited by 392 · see citing works

pH- and ion-sensitive polymers for drug delivery

Yoshida, T., Lai, T. C., Kwon, G. S., & Sako, K. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.821978 · Cited by 367 · see citing works

Therapeutic applications of hydrogels in oral drug delivery

Sharpe, L. A., Daily, A. M., Horava, S. D., & Peppas, N. A. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.902047 · Cited by 354 · see citing works

Lipoprotein-Inspired Nanoparticles for Cancer Theranostics

Ng, K. K., Lovell, J. F., & Zheng, G. (2011) · Accounts of Chemical Research · doi:10.1021/ar200017e · Cited by 331 · see citing works

PEGylated PLGA-based nanoparticles targeting M cells for oral vaccination

Garinot, M., Fiévez, V., Pourcelle, V., Stoffelbach, F., des Rieux, A., Plapied, L., Theate, I., Freichels, H., Jérôme, C., Marchand-Brynaert, J., et al. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.04.021 · Cited by 331 · see citing works

A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices

Zhang, S., Bellinger, A. M., Glettig, D. L., Barman, R. A., Lee, Y. L., Zhu, J., Cleveland, C., Montgomery, V. A., Gu, L., Nash, L. D., et al. (2015) · Nature Materials · doi:10.1038/nmat4355 · Cited by 328 · see citing works

Synthesis and pH sensitivity of carboxymethyl chitosan-based polyampholyte hydrogels for protein carrier matrices

Chen, L., Tian, Z., & Du, Y. (2003) · Biomaterials · doi:10.1016/j.biomaterials.2003.09.100 · Cited by 322 · see citing works

Molecular aspects of muco- and bioadhesion:

Huang, Y., Leobandung, W., Foss, A. C., et al. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00233-3 · Cited by 316 · see citing works

A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules

Choonara, B. F., Choonara, Y. E., Kumar, P., Bijukumar, D. R., du Toit, L. C., & Pillay, V. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2014.07.006 · Cited by 314 · see citing works

Chitosan–PEG nanocapsules as new carriers for oral peptide delivery

Prego, C., Torres, D., Fernández-Megía, E., Novoa-Carballal, R., Quiñoá, E., & Alonso, M. J. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.12.015 · Cited by 308 · see citing works

pH-sensitive chitosan/alginate core-shell nanoparticles for efficient and safe oral insulin delivery

Mukhopadhyay, P., Chakraborty, S., Bhattacharya, S., et al. (2014) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2014.08.040 · Cited by 308 · see citing works

In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery

Sonaje, K., Lin, Y.-H., Juang, J.-H., Wey, S., Chen, C.-T., & Sung, H. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.066 · Cited by 295 · see citing works

Enteric-coated capsules filled with freeze-dried chitosan/poly(γ-glutamic acid) nanoparticles for oral insulin delivery

Sonaje, K., Chen, Y., Chen, H., Wey, S., Juang, J., Nguyen, H.-N., Hsu, C., Lin, K., & Sung, H. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.01.042 · Cited by 282 · see citing works

Nanoscale technology of mucoadhesive interactions

Peppas, N. A., & Huang, Y. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.03.001 · Cited by 265 · see citing works

Peroral Route: An Opportunity for Protein and Peptide Drug Delivery

Sood, A., & Panchagnula, R. (2001) · Chemical Reviews · doi:10.1021/cr000700m · Cited by 222 · see citing works

Preparation and modification of N-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride nanoparticle as a protein carrier

Xu, Y., Du, Y., Huang, R., & Gao, L. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00408-3 · Cited by 217 · see citing works

Synthesis and evaluation of lauryl succinyl chitosan particles towards oral insulin delivery and absorption

Rekha, M. R., & Sharma, C. P. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.01.011 · Cited by 216 · see citing works

A Virus‐Mimetic Nanogel Vehicle

Lee, E. S., Kim, D., Youn, Y. S., et al. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200704121 · Cited by 215 · see citing works

Chitosan Based Water-Resistant Adhesive. Analogy to Mussel Glue

Yamada, K., Chen, T., Kumar, G., et al. (2000) · Biomacromolecules · doi:10.1021/bm0003009 · Cited by 214 · see citing works

Poly(vinyl alcohol) and poly(acrylic acid) sequential interpenetrating network pH-sensitive microspheres for the delivery of diclofenac sodium to the intestine

Kurkuri, M. D., & Aminabhavi, T. M. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2003.12.025 · Cited by 210 · see citing works

Synthesis and Characterization of Positive‐Charge Functionalized Mesoporous Silica Nanoparticles for Oral Drug Delivery of an Anti‐Inflammatory Drug

Lee, C., Lo, L., Mou, C., & Yang, C. (2008) · Advanced Functional Materials · doi:10.1002/adfm.200800521 · Cited by 205 · see citing works

Nanoparticles and microparticles for drug and vaccine delivery.

Kreuter, J. (1996) · Europe PMC (PubMed Central) · Cited by 205 · see citing works

Multi-ion-crosslinked nanoparticles with pH-responsive characteristics for oral delivery of protein drugs

Lin, Y.-H., Sonaje, K., Lin, K. M.-C., Juang, J.-H., Mi, F., Yang, H.-W., & Sung, H. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.08.020 · Cited by 194 · see citing works

pH-Sensitive nanospheres for colon-specific drug delivery in experimentally induced colitis rat model

Makhlof, A., Tozuka, Y., & Takeuchi, H. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.12.013 · Cited by 192 · see citing works

pH-sensitive polymeric nanoparticles to improve oral bioavailability of peptide/protein drugs and poorly water-soluble drugs

Wang, X., & Zhang, Q. (2012) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2012.07.014 · Cited by 189 · see citing works

Acetal-linked paclitaxel prodrug micellar nanoparticles as a versatile and potent platform for cancer therapy

Gu, Y., Zhong, Y., Meng, F., Cheng, R., Deng, C., & Zhong, Z. (2013) · Biomacromolecules · doi:10.1021/bm400615n · Cited by 187 · see citing works

Biodistribution, pharmacodynamics and pharmacokinetics of insulin analogues in a rat model: Oral delivery using pH-Responsive nanoparticles vs. subcutaneous injection

Sonaje, K., Lin, K., Wey, S., Lin, C.-K., Yeh, T.-H., Nguyen, H.-N., Hsu, C., Yen, T., Juang, J., & Sung, H. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.05.042 · Cited by 187 · see citing works

An oral preparation to release drugs in the human colon.

Dew, M. J., Hughes, P., Lee, M., Evans, B., & Rhodes, J. (1982) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1982.tb01999.x · Cited by 186 · see citing works

Devices based on intelligent biopolymers for oral protein delivery

Peppas, N. A. (2004) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2003.03.001 · Cited by 174 · see citing works

Water state characterization, swelling behavior, thermal and mechanical properties of chitosan based networks

Khalid, M. N., Agnely, F., Yagoubi, N., et al. (2002) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(02)00029-5 · Cited by 174 · see citing works

Development of pH-responsive chitosan/heparin nanoparticles for stomach-specific anti-Helicobacter pylori therapy

Lin, Y.-H., Chang, C., Wu, Y.-S., Hsu, Y., Chiou, S.-F., & Chen, Y. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.02.036 · Cited by 173 · see citing works

In-vitro release kinetics of cefadroxil-loaded sodium alginate interpenetrating network beads

Kulkarni, A. R., Soppimath, K. S., Aminabhavi, T. M., et al. (2001) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(00)00150-8 · Cited by 166 · see citing works

pH-sensitive nanoparticles for improving the oral bioavailability of cyclosporine A

Dai, J.-D., Nagai, T., Wang, X., Zhang, T., Meng, M., & Zhang, Q. (2004) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2004.05.006 · Cited by 159 · see citing works

Oral colon-specific therapeutic approaches toward treatment of inflammatory bowel disease

Xiao, B., & Merlin, D. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.730517 · Cited by 156 · see citing works

Vitamin B12 functionalized layer by layer calcium phosphate nanoparticles: A mucoadhesive and pH responsive carrier for improved oral delivery of insulin

Verma, A., Sharma, S., Gupta, P. K., Singh, A. K., Teja, B. V., Dwivedi, P., Gupta, G. K., Trivedi, R., & Mishra, P. R. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.12.017 · Cited by 153 · see citing works

Nanoparticles Incorporated in pH-Sensitive Hydrogels as Amoxicillin Delivery for Eradication of Helicobacter pylori

Chang, C., Lin, Y.-H., Yeh, C., et al. (2009) · Biomacromolecules · doi:10.1021/bm900985h · Cited by 150 · see citing works

Biodegradable, p H ‐ R esponsive Carboxymethyl Cellulose/ P oly( A crylic Acid) Hydrogels for Oral Insulin Delivery

Gao, X., Cao, Y. Z., Song, X., et al. (2013) · Macromolecular Bioscience · doi:10.1002/mabi.201300384 · Cited by 149 · see citing works

Preparation of chitosan nanoparticles using methacrylic acid

de Moura, M. R., Aouada, F. A., & Mattoso, L. H. C. (2008) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2008.02.006 · Cited by 149 · see citing works

Electrospun Nanofibers in Oral Drug Delivery

Ignatious, F., Sun, L., Lee, C.-P., & Baldoni, J. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0061-6 · Cited by 145 · see citing works

Colonic drug delivery of 5-fluorouracil: an in vitro evaluation

Sinha, V. R., Mittal, B. R., Bhutani, K. K., et al. (2003) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2003.09.036 · Cited by 144 · see citing works

Buccal penetration enhancement properties of N-trimethyl chitosan: Influence of quaternization degree on absorption of a high molecular weight molecule

Sandri, G., Rossi, S., Bonferoni, M. C., et al. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.03.017 · Cited by 140 · see citing works

Self-associating networks of poly(methacrylic acid-g-ethylene glycol)

Klier, J., Scranton, A. B., & Peppas, N. A. (1990) · Macromolecules · doi:10.1021/ma00225a011 · Cited by 139 · see citing works

Physicochemical behavior and cytotoxic effects of p(methacrylic acid–g-ethylene glycol) nanospheres for oral delivery of proteins

Torres‐Lugo, M., García-Fuentes, M., Record, R. D., & Peppas, N. A. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00027-5 · Cited by 138 · see citing works

Bioreducible Block Copolymers Based on Poly(Ethylene Glycol) and Poly(γ-Benzyl <scp>l</scp>-Glutamate) for Intracellular Delivery of Camptothecin

Thambi, T., Yoon, H. Y., Kim, K., Kwon, I. C., Yoo, C. K., & Park, J. H. (2011) · Bioconjugate Chemistry · doi:10.1021/bc2000963 · Cited by 138 · see citing works

Preparation of insulin loaded PLGA-Hp55 nanoparticles for oral delivery

Cui, F., Tao, A., Cun, D., et al. (2006) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20750 · Cited by 136 · see citing works

Controlled release by using poly(methacrylic acid-g-ethylene glycol) hydrogels

Peppas, N. A., & Klier, J. (1991) · Journal of Controlled Release · doi:10.1016/0168-3659(91)90044-e · Cited by 136 · see citing works

Enzyme- and pH-Responsive Microencapsulated Nanogels for Oral Delivery of siRNA to Induce TNF-α Knockdown in the Intestine

Knipe, J. M., Strong, L. E., & Peppas, N. A. (2016) · Biomacromolecules · doi:10.1021/acs.biomac.5b01518 · Cited by 135 · see citing works

Preparation and characterization of hybrid pH-sensitive hydrogels of chitosan-co-acrylic acid for controlled release of verapamil

Ranjha, N. M., Ayub, G., Naseem, S., & Ansari, M. T. (2010) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-010-4134-1 · Cited by 132 · see citing works

Preparation, Characterization, and Oral Delivery of Insulin Loaded Carboxylated Chitosan Grafted Poly(methyl methacrylate) Nanoparticles

Cui, F., Qian, F., Zhao, Z., et al. (2009) · Biomacromolecules · doi:10.1021/bm900035u · Cited by 130 · see citing works

Effective oral chemotherapy for breast cancer: pillars of strength

Findlay, M. P. N., von Minckwitz, G., & Wardley, A. M. (2007) · Annals of Oncology · doi:10.1093/annonc/mdm285 · Cited by 124 · see citing works

Nanoparticles based on the complex of chitosan and polyaspartic acid sodium salt: Preparation, characterization and the use for 5-fluorouracil delivery

Zheng, Y., Yang, W., Wang, C., et al. (2007) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2007.04.007 · Cited by 123 · see citing works

pH-responsive and enzymatically-responsive hydrogel microparticles for the oral delivery of therapeutic proteins: Effects of protein size, crosslinking density, and hydrogel degradation on protein delivery

Koetting, M. C., Guido, J. F., Gupta, M., Zhang, A., & Peppas, N. A. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.11.023 · Cited by 123 · see citing works

Enhanced Oral Absorption of Hydrophobic and Hydrophilic Drugs Using Quaternary Ammonium Palmitoyl Glycol Chitosan Nanoparticles

Siew, A., Le, H., Thiovolet, M., et al. (2011) · Molecular Pharmaceutics · doi:10.1021/mp200469a · Cited by 121 · see citing works

Mussel-inspired protein-mediated surface functionalization of electrospun nanofibers for pH-responsive drug delivery

Jiang, J., Xie, J., Ma, B., et al. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.11.012 · Cited by 120 · see citing works

Self‐Assembled pH‐Sensitive Nanoparticles: A Platform for Oral Delivery of Protein Drugs

Sonaje, K., Lin, K., Wang, J., et al. (2010) · Advanced Functional Materials · doi:10.1002/adfm.201001014 · Cited by 119 · see citing works

Biocompatible and Mucoadhesive Bacterial Cellulose-g-Poly(acrylic acid) Hydrogels for Oral Protein Delivery

Ahmad, N., Amin, M. C. I. M., Mahali, S. M., Ismail, I., & Chuang, V. T. G. (2014) · Molecular Pharmaceutics · doi:10.1021/mp5003015 · Cited by 118 · see citing works

Micro/nanofabricated platforms for oral drug delivery

Fox, C. B., Kim, J., Le, L. V., Nemeth, C. L., Chirra, H. D., & Desai, T. A. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.07.033 · Cited by 112 · see citing works

Bioavailability and pharmacokinetics of sorafenib suspension, nanoparticles and nanomatrix for oral administration to rat

Wang, X., Fan, J.-M., Liu, Y., et al. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.08.003 · Cited by 112 · see citing works

Mini-tablets: a contemporary system for oral drug delivery in targeted patient groups

Aleksovski, A., Dreu, R., Gašperlin, M., et al. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.951633 · Cited by 111 · see citing works

Insulin-Loaded pH-Sensitive Hyaluronic Acid Nanoparticles Enhance Transcellular Delivery

Han, L., Zhao, Y., Yin, L., et al. (2012) · AAPS PharmSciTech · doi:10.1208/s12249-012-9807-2 · Cited by 110 · see citing works

Development, characterization, and in vivo assessment of mucoadhesive nanoparticles containing fluconazole for the local treatment of oral candidiasis

Rençber, S., Karavana, S. Y., Yılmaz, F. F., Eraç, B., Nenni, M., Özbal, S., Pekçetin, Ç., Gürer-Orhan, H., Limoncu, M. H., Güneri, P., et al. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s103762 · Cited by 110 · see citing works

Novel Platforms for Oral Drug Delivery

Colombo, P., Sonvico, F., Colombo, G., & Bettini, R. (2009) · Pharmaceutical Research · doi:10.1007/s11095-008-9803-0 · Cited by 108 · see citing works

Chitosan-modified porous silicon microparticles for enhanced permeability of insulin across intestinal cell monolayers

Shrestha, N., Shahbazi, M., Araújo, F., et al. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.04.104 · Cited by 108 · see citing works

The Physiological Rationale for Oral Insulin Administration

Arbit, E. (2004) · Diabetes Technology & Therapeutics · doi:10.1089/1520915041705929 · Cited by 108 · see citing works

Orally disintegrating dosage forms and taste-masking technologies; 2010

Douroumis, D. (2011) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2011.566553 · Cited by 107 · see citing works

A nanogel of on-site tunable pH-response for efficient anticancer drug delivery

Zhou, T., Xiao, C., Fan, J. R., Chen, S., Shen, J., Wu, W., & Zhou, S. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.08.017 · Cited by 103 · see citing works

Novel pH switchable gelatin based hydrogel for the controlled delivery of the anti cancer drug 5-fluorouracil

Anirudhan, T. S., & Mohan, A. (2014) · RSC Advances · doi:10.1039/c3ra47991a · Cited by 102 · see citing works

Enzymatic Biodegradation of Hydrogels for Protein Delivery Targeted to the Small Intestine

Knipe, J. M., Chen, F., & Peppas, N. A. (2015) · Biomacromolecules · doi:10.1021/bm501871a · Cited by 101 · see citing works

Characterization of pH‐responsive hydrogels of poly(itaconic acid‐g‐ethylene glycol) prepared by UV‐initiated free radical polymerization as biomaterials for oral delivery of bioactive agents

Betancourt, T., Pardo, J., Soo, K., et al. (2009) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32510 · Cited by 97 · see citing works

Antigen targeting to M cells for enhancing the efficacy of mucosal vaccines

Kim, S., & Jang, Y. (2014) · Experimental & Molecular Medicine · doi:10.1038/emm.2013.165 · Cited by 96 · see citing works

Mucosal immune responses following oral immunization with rotavirus antigens encapsulated in alginate microspheres

Kim, B. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00280-8 · Cited by 93 · see citing works

Systemic peptide delivery via the stomach: in vivo evaluation of an oral dosage form for salmon calcitonin

Guggi, D., Krauland, A. H., & Bernkop‐Schnürch, A. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00299-2 · Cited by 92 · see citing works

Oral bioavailability of a poorly water soluble HIV-1 protease inhibitor incorporated into pH-sensitive particles: effect of the particle size and nutritional state

Jaeghere, F. D., Allémann, É., Kubel, F., et al. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00272-8 · Cited by 92 · see citing works

Novel complexation hydrogels for oral peptide delivery: In vitro evaluation of their cytocompatibility and insulin‐transport enhancing effects using Caco‐2 cell monolayers

Ichikawa, H., & Peppas, N. A. (2003) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.10128 · Cited by 91 · see citing works

pH-Sensitive Nanoparticles of Curcumin–Celecoxib Combination: Evaluating Drug Synergy in Ulcerative Colitis Model

Gugulothu, D. B., Kulkarni, A., Patravale, V. B., & Dandekar, P. P. (2013) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.23828 · Cited by 91 · see citing works

Development of pH-sensitive Insulin Nanoparticles using Eudragit L100-55 and Chitosan with Different Molecular Weights

Jelvehgari, M., Zakeri‐Milani, P., Siahi-Shadbad, M. R., et al. (2010) · AAPS PharmSciTech · doi:10.1208/s12249-010-9488-7 · Cited by 90 · see citing works

Transmucosal, Oral Controlled-Release, and Transdermal Drug Administration in Human Subjects: A Crossover Study with Melatonin

Bénès, L., Claustrat, B., Horrière, F., et al. (1997) · Journal of Pharmaceutical Sciences · doi:10.1021/js970011z · Cited by 88 · see citing works

pH-Responsive guar gum hydrogels for controlled delivery of dexamethasone to the intestine

Das, S., & Subuddhi, U. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.06.008 · Cited by 86 · see citing works

pH-responsive thiolated chitosan nanoparticles for oral low-molecular weight heparin delivery: in vitro and in vivo evaluation

Fan, B., Xing, Y., Zheng, Y., et al. (2014) · Drug Delivery · doi:10.3109/10717544.2014.909908 · Cited by 86 · see citing works

Multistage pH-responsive mucoadhesive nanocarriers prepared by aerosol flow reactor technology: A controlled dual protein-drug delivery system

Shrestha, N., Shahbazi, M., Araújo, F., Mäkilä, E. M., Raula, J., Kauppinen, E. I., Salonen, J., Sarmento, B. F. C. C., Hirvonen, J. J., & Santos, H. A. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.07.045 · Cited by 85 · see citing works

Perivascular graft heparin delivery using biodegradable polymer wraps

Edelman, E. R., Nathan, A. T., Katada, M., Gates, J. D., & Karnovsky, M. J. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00154-x · Cited by 84 · see citing works

Exploiting the Vitamin B12 Pathway To Enhance Oral Drug Delivery via Polymeric Micelles

Francis, M. F., Cristea, M., & Winnik, F. M. (2005) · Biomacromolecules · doi:10.1021/bm0503165 · Cited by 84 · see citing works

Surface-Modified P(HEMA- co -MAA) Nanogel Carriers for Oral Vaccine Delivery: Design, Characterization, and In Vitro Targeting Evaluation

Durán‐Lobato, M., Carrillo‐Conde, B., Khairandish, Y., & Peppas, N. A. (2014) · Biomacromolecules · doi:10.1021/bm500588x · Cited by 83 · see citing works

Patient preference for oral or intravenous chemotherapy: A randomised cross-over trial comparing capecitabine and Nordic fluorouracil/leucovorin in patients with colorectal cancer

Pfeiffer, P., Mortensen, J. P., Bjerregaard, B., et al. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.06.027 · Cited by 83 · see citing works

Identification of Cell Adhesion Molecules in the Human Follicle-Associated Epithelium That Improve Nanoparticle Uptake into the Peyer’s Patches

Gullberg, E., Keita, Å. V., Salim, S. Y., Andersson, M., Caldwell, K. D., Söderholm, J. D., & Artursson, P. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.107847 · Cited by 83 · see citing works

Multilayered mucoadhesive hydrogel films based on thiolated hyaluronic acid and polyvinylalcohol for insulin delivery

Ding, J., He, R., Zhou, G., et al. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.06.027 · Cited by 81 · see citing works

Complexation hydrogels for intestinal delivery of interferon β and calcitonin

Kamei, N., Morishita, M., Chiba, H., Kavimandan, N. J., Peppas, N. A., & Takayama, K. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.11.014 · Cited by 80 · see citing works

Eudragit S100-Coated Chitosan Nanoparticles Co-loading Tat for Enhanced Oral Colon Absorption of Insulin

Chen, S., Guo, F., Deng, T., et al. (2016) · AAPS PharmSciTech · doi:10.1208/s12249-016-0594-z · Cited by 79 · see citing works

Co-delivery of small interfering RNA and plasmid DNA using a polymeric vector incorporating endosomolytic oligomeric sulfonamide

Kang, H. C., & Bae, Y. H. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.03.042 · Cited by 78 · see citing works

Development and performance evaluation of novel nanoparticles of a grafted copolymer loaded with curcumin

Mutalik, S., Suthar, N. A., Managuli, R. S., Shetty, P., Avadhani, K. S., Kalthur, G., Kulkarni, R. V., & Thomas, R. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.11.092 · Cited by 78 · see citing works

Colonic luminal surface retention of meloxicam microsponges delivered by erosion based colon-targeted matrix tablet

Srivastava, R., Kumar, D. M., & Pathak, K. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.01.036 · Cited by 76 · see citing works

pH-Responsive poly(itaconic acid-co-N-vinylpyrrolidone) hydrogels with reduced ionic strength loading solutions offer improved oral delivery potential for high isoelectric point-exhibiting therapeutic proteins

Koetting, M. C., & Peppas, N. A. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.05.023 · Cited by 75 · see citing works

Pharmacokinetics of a Novel HIV-1 Protease Inhibitor Incorporated into Biodegradable or Enteric Nanoparticles following Intravenous and Oral Administration to Mice

Leroux, J., Cozens, R. M., Roesel, J. L., Galli, B., Kubel, F., Doelker, É., & Gurny, R. (1995) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600841202 · Cited by 75 · see citing works

Mussel inspired protein‐mediated surface modification to electrospun fibers and their potential biomedical applications

Xie, J., Michael, P. L., Zhong, S., et al. (2012) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34030 · Cited by 74 · see citing works

Insulin Therapy during Peritoneal Dialysis

Quellhorst, E. A. (2002) · Journal of the American Society of Nephrology · doi:10.1681/asn.v13suppl_1s92 · Cited by 68 · see citing works

A novel nanomatrix system consisted of colloidal silica and pH-sensitive polymethylacrylate improves the oral bioavailability of fenofibrate

Jia, Z., Lin, P., Xiang, Y., et al. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2011.05.009 · Cited by 65 · see citing works

A pH‐sensitive chitosan‐tripolyphosphate hydrogel beads for controlled glipizide delivery

Sun, P. C., Li, P., Li, Y., et al. (2011) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.31801 · Cited by 64 · see citing works

Nanocarrier‐Integrated Microspheres: Nanogel Tectonic Engineering for Advanced Drug‐Delivery Systems

Tahara, Y., Mukai, S., Sawada, S., et al. (2015) · Advanced Materials · doi:10.1002/adma.201501557 · Cited by 64 · see citing works

pH‐responsive hydrogels with dispersed hydrophobic nanoparticles for the oral delivery of chemotherapeutics

Schoener, C. A., Hutson, H. N., & Peppas, N. A. (2012) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34532 · Cited by 64 · see citing works

Controlled and targeted release of antigens by intelligent shell for improving applicability of oral vaccines

Zhang, L., Zeng, Z., Hu, C., Bellis, S. L., Yang, W., Su, Y., Zhang, X., & Wu, Y. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.11.009 · Cited by 62 · see citing works

Bioavailability and pharmacokinetics of cyclosporine A-loaded pH-sensitive nanoparticles for oral administration

Wang, X., Dai, J.-D., Chen, Z., et al. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.03.003 · Cited by 61 · see citing works

Noninvasive imaging oral absorption of insulin delivered by nanoparticles and its stimulated glucose utilization in controlling postprandial hyperglycemia during OGTT in diabetic rats

Chuang, E., Lin, K., Su, F.-Y., Mi, F., Maiti, B., Chen, C.-T., Wey, S., Yen, T., Juang, J.-H., & Sung, H. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.05.006 · Cited by 55 · see citing works

Coating alginate microspheres with a serum albumin-alginate membrane: application to the encapsulation of a peptide

Hurteaux, R., Edwards‐Lévy, F., Laurent‐Maquin, D., et al. (2004) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2004.10.010 · Cited by 55 · see citing works

Enteric trimethyl chitosan nanoparticles containing hepatitis B surface antigen for oral delivery

Farhadian, A., Dounighi, N. M., & Avadi, M. (2015) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2015.1053663 · Cited by 55 · see citing works

Comparative drug release studies of two cationic drugs from pH-responsive nanogels

Tan, J. P. K., Goh, C. H., & Tam, K. C. (2007) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2007.08.010 · Cited by 54 · see citing works

pH responsive cylindrical MSN for oral delivery of insulin-design, fabrication and evaluation

Guha, A., Biswas, N., Bhattacharjee, K., et al. (2016) · Drug Delivery · doi:10.1080/10717544.2016.1209796 · Cited by 54 · see citing works

In Vivo Phage Display to Identify M Cell-Targeting Ligands

Higgins, L. M., Lambkin, I., Donnelly, G., Byrne, D., Wilson, C., Dee, J., Smith, M. W., & O’Mahony, D. J. (2004) · Pharmaceutical Research · doi:10.1023/b:pham.0000022418.80506.9a · Cited by 53 · see citing works

Attuning hydroxypropyl methylcellulose phthalate to oral delivery vehicle for effective and selective delivery of protein vaccine in ileum

Singh, B., Maharjan, S., Jiang, T., Kang, S., Choi, Y.-J., & Cho, C. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.04.017 · Cited by 49 · see citing works

A strategy for oral chemotherapy via dual pH-sensitive polyelectrolyte complex nanoparticles to achieve gastric survivability, intestinal permeability, hemodynamic stability and intracellular activity

Deng, L., Dong, H., Dong, A., et al. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.10.010 · Cited by 49 · see citing works

A new hyaluronic acid pH sensitive derivative obtained by ATRP for potential oral administration of proteins

Fiorica, C., Pitarresi, G. L., Palumbo, F. S., et al. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.09.005 · Cited by 47 · see citing works

pH-Dependent dissolving nano- and microparticles for improved peroral delivery of a highly lipophilic compound in dogs

Jaeghere, F. D., Allémann, É., Doelker, É., Gurny, R., Cerny, R., Galli, B., Steulet, A.-F., Müller, I., & Schütz, H. (2001) · AAPS PharmSci · doi:10.1208/ps030108 · Cited by 44 · see citing works

Formulation and evaluation of ileo-colonic targeted matrix-mini-tablets of Naproxen for chronotherapeutic treatment of rheumatoid arthritis

Hadi, M. A., Rao, N. G. R., & Rao, A. S. (2015) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2015.03.001 · Cited by 44 · see citing works

Multi-laminated metal hydroxide nanocontainers for oral-specific delivery for bioavailability improvement and treatment of inflammatory paw edema in mice

Kankala, R. K., Kuthati, Y., Sie, H.-W., et al. (2015) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2015.07.044 · Cited by 43 · see citing works

pH-and thermo-sensitive pluronic/poly(acrylic acid)in situhydrogels for sustained release of an anticancer drug

Lo, Y., Hsu, C.-Y., & Lin, H.-R. (2012) · Journal of drug targeting · doi:10.3109/1061186x.2012.725406 · Cited by 43 · see citing works

Application of drug selective electrode in the drug release study of pH-responsive microgels

Tan, J. P. K., & Tam, K. C. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.11.017 · Cited by 41 · see citing works

Enhancement of oral insulin bioavailability:in vitroandin vivoassessment of nanoporous stimuli-responsive hydrogel microparticles

Ahmad, N., Amin, M. C. I. M., Ismail, I., & Buang, F. (2016) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2016.1160889 · Cited by 41 · see citing works

Sodium dodecyl sulfate/β-cyclodextrin vesicles embedded in chitosan gel for insulin delivery with pH-selective release

Li, Z., Li, H., Wang, C., et al. (2016) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2016.03.003 · Cited by 41 · see citing works

Distribution, transition, adhesion and release of insulin loaded nanoparticles in the gut of rats

Li, M., Lü, W.-L., Wang, J., et al. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.08.040 · Cited by 40 · see citing works

Numerical modelling of insulin and amyloglucosidase release from swelling Ca–alginate beads

Rasmussen, M. R., Snabe, T., & Pedersen, L. H. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00262-1 · Cited by 39 · see citing works

Complexation Hydrogels for the Oral Delivery of Growth Hormone and Salmon Calcitonin

Carr, D. A., Gómez-Burgaz, M., Boudes, M. C., & Peppas, N. A. (2010) · Industrial & Engineering Chemistry Research · doi:10.1021/ie1008025 · Cited by 38 · see citing works

Development of a Mini-Tablet of Co-Grinded Prednisone–Neusilin Complex for Pediatric Use

Lou, H., Liu, M., Wang, L., et al. (2013) · AAPS PharmSciTech · doi:10.1208/s12249-013-9981-x · Cited by 37 · see citing works

Poly(ester amide) blend microspheres for oral insulin delivery

He, P., Liu, H., Tang, Z., Deng, M., Yang, Y., Pang, X., & Chen, X. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.07.022 · Cited by 37 · see citing works

Bioavailability and pharmacokinetics of cyclosporine A-loaded pH-sensitive nanoparticles for oral administration

Wang, X., DAI, J., CHEN, Z., et al. (2004) · Journal of Controlled Release · doi:10.1016/s0168-3659(04)00121-x · Cited by 37 · see citing works

Inorganic matrices: an answer to low drug solubility problem

Perioli, L., & Pagano, C. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.733693 · Cited by 33 · see citing works

Drug release from α,β-poly(N-2-hydroxyethyl)-dl-aspartamide-based microparticles

Pitarresi, G. L., Pierro, P., Giammona, G., et al. (2003) · Biomaterials · doi:10.1016/j.biomaterials.2003.11.015 · Cited by 33 · see citing works

Swelling/syneresis phenomena in gel-forming interpolymer complexes

Bell, C. L., & Peppas, N. A. (1996) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856296x00444 · Cited by 32 · see citing works

Preparation and Characterization of Insulin Nanoparticles Employing Chitosan and Poly(methylmethacrylate/methylmethacrylic acid) Copolymer

Li, M., Lü, W.-L., Wang, J., et al. (2006) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2006.411 · Cited by 32 · see citing works

Preparation and characterization of pH-sensitive hydrogel of chitosan/poly(acrylic acid) co-polymer

Shi, L., Yang, L., Chen, J., et al. (2004) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856204323005316 · Cited by 30 · see citing works

Poly (vinyl alcohol) hydrogels for pH dependent colon targeted drug delivery

Basak, P., & Adhikari, B. (2008) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-008-3496-0 · Cited by 29 · see citing works

Targeted delivery of antigens to the gut-associated lymphoid tissues: 2.Ex vivoevaluation of lectin-labelled albumin microspheres for targeted delivery of antigens to the M-cells of the Peyer's patches

Akande, J., Yeboah, K. G., Addo, R. T., Siddig, A., Oettinger, C. W., & D’Souza, M. J. (2010) · Journal of Microencapsulation · doi:10.3109/02652040903191834 · Cited by 29 · see citing works

Nanoencapsulation of psoralidin via chitosan and Eudragit S100 for enhancement of oral bioavailability

Yin, J., Xiang, C., & Song, X. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.05.007 · Cited by 28 · see citing works

Controlled Dissolution of Griseofulvin Solid Dispersions from Electrosprayed Enteric Polymer Micromatrix Particles: Physicochemical Characterization and in Vitro Evaluation

Roine, J., Kaasalainen, M. H., Peurla, M., et al. (2015) · Molecular Pharmaceutics · doi:10.1021/mp500787b · Cited by 28 · see citing works

Sylysia 350/Eudragit S100 solid nanomatrix as a promising system for oral delivery of cyclosporine A

Dai, W., Yulan, G., Zhang, H., et al. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.11.030 · Cited by 27 · see citing works

Exploring the Implications of Vitamin B 12 Conjugation to Insulin on Insulin Receptor Binding

Petrus, A. K., Allis, D. G., Smith, R. P., et al. (2008) · ChemMedChem · doi:10.1002/cmdc.200800346 · Cited by 26 · see citing works

Self-Assembly of pH-Responsive Microspheres for Intestinal Delivery of Diverse Lipophilic Therapeutics

Zhou, X. W., Yang, Z., Chen, S., et al. (2016) · Biomacromolecules · doi:10.1021/acs.biomac.6b00512 · Cited by 26 · see citing works

Versatile particles from water-soluble chitosan and sodium alginate for loading toxic or bioactive substance

You, R., Xiao, C., Zhang, L., et al. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.05.025 · Cited by 25 · see citing works

Characterization of Norfloxacine Release from Tablet Coated with a New pH-Sensitive Polymer, P-4135F

Hu, Z., Shimokawa, T., Ohno, T., et al. (1999) · Journal of drug targeting · doi:10.3109/10611869909085505 · Cited by 25 · see citing works

Absorption Mechanism of Cyclosporine A Loaded pH-Sensitive Nanoparticles in Rats

Wang, X., Dai, J., Zhang, H., et al. (2008) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2008.18277 · Cited by 25 · see citing works

A silica-based pH-sensitive nanomatrix system improves the oral absorption and efficacy of incretin hormone glucagon-like peptide-1

Zhang, Q., Qu, Li, Hovgaard, L., Li, Wang, J., Zhang, X., & Zhang, Q. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s30013 · Cited by 23 · see citing works

Simultaneous Effect of Thiolation and Carboxylation of Chitosan Particles Towards Mucoadhesive Oral Insulin Delivery Applications: An In Vitro and In Vivo Evaluation

Rekha, M. R., & Sharma, C. P. (2014) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2015.1904 · Cited by 23 · see citing works

In vitro and in vivo evaluation of a novel capsule for colon-specific drug delivery

Han, M. Y., Fang, Q.-L., Zhan, H., et al. (2008) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21627 · Cited by 22 · see citing works

Polymeric Nanocarriers for siRNA Delivery to Murine Macrophages

Forbes, D. C., & Peppas, N. A. (2014) · Macromolecular Bioscience · doi:10.1002/mabi.201400027 · Cited by 21 · see citing works

Formulation and Evaluation of pH-Responsive Mini-Tablets for Ileo-Colonic Targeted Drug Delivery

Hadi, M., Rao, N., & Rao, A. (2014) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v13i7.3 · Cited by 19 · see citing works

Cost Analysis of Capecitabine vs 5-Fluorouracil-Based Treatment for Metastatic Colorectal Cancer Patients

de Portu, S., Mantovani, L. G., Ravaioli, A., et al. (2010) · Journal of Chemotherapy · doi:10.1179/joc.2010.22.2.125 · Cited by 17 · see citing works

Inulin-Based Tablet in Capsule Device for Variable Multipulse Delivery of Aceclofenac: Optimization and In Vivo Roentgenography

Sharma, P., & Pathak, K. (2013) · AAPS PharmSciTech · doi:10.1208/s12249-013-9959-8 · Cited by 12 · see citing works

Evaluation of In Vivo Transfection Efficiency of Eudragit Coated Nanoparticles of Chitosan-DNA: A pH-sensitive System Prepared for Oral DNA Delivery

Momenzadeh, S., Sadeghi, A., Vatandoost, N., et al. (2015) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.17(4)2015.16761 · Cited by 11 · see citing works

Pharmacokinetic Parameters Determination and In Vitro–In Vivo Correlation of Ileocolonic-Targeted pH-Responsive Coated Mini-Tablets of Naproxen

Hadi, M. A. (2015) · Scientia Pharmaceutica · doi:10.3797/scipharm.1503-16 · Cited by 8 · see citing works

Preparation of an alternative freeze-dried pH-sensitive cyclosporine A loaded nanoparticles formulation and its pharmacokinetic profile in rats.

Yang, Z., Xu, J., Pan, P., et al. (2009) · PubMed · Cited by 5 · see citing works

<scp>pH</scp> ‐responsive polymers for drug delivery: Trends and opportunities

Singh, J., & Nayak, P. (2023) · Journal of Polymer Science · doi:10.1002/pol.20230403 · Cited by 327 · see citing works

Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application

CHATTERJEE, S., & Chi-leung HUI, P. (2019) · Molecules · doi:10.3390/molecules24142547 · Cited by 201 · see citing works

Ph-responsive drug delivery systems as intelligent carriers for targeted drug therapy: brief history, properties, synthesis, mechanism and application

Bami, M. S., Raeisi Estabragh, M. A., Khazaeli, P., Ohadi, M., & Dehghannoudeh, G. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102987 · Cited by 101 · see citing works

Pharmacokinetics of a Micronized, Poorly Water-Soluble Drug, HO-221, in Experimental Animals.

Kondo, N., Toru, I. W. A. O., Kikuchi, M., et al. (1993) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.16.796 · Cited by 18 · see citing works

Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine

Olsson, B., Johansson, M., Gabrielsson, J., & Bolme, P. (1988) · European Journal of Clinical Pharmacology · doi:10.1007/bf01061422 · Cited by 352 · see citing works

Enhanced Oral Bioavailability of DDI After Administration of 6-Cl-ddP, an Adenosine Deaminase-Activated Prodrug, to Chronically Catheterized Rats

Anderson, B. D., Morgan, M. E., & Singhal, D. (1995) · Pharmaceutical Research · doi:10.1023/a:1016299507382 · Cited by 20 · see citing works

Repeated oral administration modulates the pharmacokinetic behavior of the chemopreventive agent phenethyl isothiocyanate in rats

Konsue, N., Kirkpatrick, J., Kuhnert, N., et al. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900090 · Cited by 37 · see citing works

Bioavailability and first‐pass metabolism of oral pentazocine in man

Ehrnebo, M., Boréus, L. O., & Lönroth, U. (1977) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1977226888 · Cited by 65 · see citing works