The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells
Open accessAbstract
During mesenchymal development, the microenvironment gradually transitions from one that is rich in cell-cell interactions to one that is dominated by cell-extracellular-matrix (ECM) interactions. Because these cues cannot readily be decoupled in vitro or in vivo, how they converge to regulate mesenchymal stem cell (MSC) mechanosensing is not fully understood. Here, we show that a hyaluronic acid hydrogel system enables, across a physiological range of ECM stiffness, the independent co-presentation of the HAVDI adhesive motif from the EC1 domain of N-Cadherin and the RGD adhesive motif from fibronectin. Decoupled presentation of these cues revealed that HAVDI ligation (at constant RGD ligation) reduced the contractile state and thereby nuclear YAP/TAZ localization in MSCs, resulting in altered interpretation of ECM stiffness and subsequent changes in downstream cell proliferation and differentiation. Our findings reveal that, in an evolving developmental context, HAVDI/N-Cadherin interactions can alter stem cell perception of the stiffening extracellular microenvironment.
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Cites
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Self-citation
Cited by
Mechanical forces direct stem cell behaviour in development and regeneration
Vining, K. H., & Mooney, D. J. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.108 · Cited by 1,656
Mechanobiology of YAP and TAZ in physiology and disease
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Extracellular matrix as a driver of progressive fibrosis
Herrera, J., Henke, C. A., & Bitterman, P. B. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93557 · Cited by 615
Loebel, C., Mauck, R. L., & Burdick, J. A. (2019) · Nature Materials · doi:10.1038/s41563-019-0307-6 · Cited by 402
Self-citationBioengineering strategies to accelerate stem cell therapeutics
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Metadata
- Authors
- Cosgrove, B. D., Mui, K. L., Driscoll, T. P., Caliari, S. R., Mehta, K. D., Assoian, R. K., Burdick, J. A., & Mauck, R. L.
- Venue
- Nature Materials
- Published
- 2016-08-15
- Volume
- 15
- Issue
- 12
- Pages
- 1297-1306
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W2508796198
- Cited by
- 344
- References
- 55
- FWCI
- 21.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Cosgrove, B. D., Mui, K. L., Driscoll, T. P., Caliari, S. R., Mehta, K. D., Assoian, R. K., Burdick, J. A., & Mauck, R. L. (2016). N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells. Nature Materials. https://doi.org/10.1038/nmat4725
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