The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Designer vaccine nanodiscs for personalized cancer immunotherapy
Open accessAbstract
Despite the tremendous potential of peptide-based cancer vaccines, their efficacy has been limited in humans. Recent innovations in tumor exome sequencing have signaled the new era of personalized immunotherapy with patient-specific neo-antigens, but a general methodology for stimulating strong CD8α+ cytotoxic T-lymphocyte (CTL) responses remains lacking. Here we demonstrate that high density lipoprotein-mimicking nanodiscs coupled with antigen (Ag) peptides and adjuvants can markedly improve Ag/adjuvant co-delivery to lymphoid organs and sustain Ag presentation on dendritic cells. Strikingly, nanodiscs elicited up to 47-fold greater frequencies of neoantigen-specific CTLs than soluble vaccines and even 31-fold greater than perhaps the strongest adjuvant in clinical trials (i.e. CpG in Montanide). Moreover, multi-epitope vaccination generated broad-spectrum T-cell responses that potently inhibited tumor growth. Nanodiscs eliminated established MC-38 and B16F10 tumors when combined with anti-PD-1 and anti-CTLA-4 therapy. These findings represent a new powerful approach for cancer immunotherapy and suggest a general strategy for personalized nanomedicine.
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Cites
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Cited by
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Block copolymer micelles in nanomedicine applications
Cabral, H., Miyata, K., Osada, K., & Kataoka, K. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00199 · Cited by 1,309
Targeted drug delivery strategies for precision medicines
Manzari, M. T., Shamay, Y., Kiguchi, H., Rosen, N., Scaltriti, M., & Heller, D. A. (2021) · Nature Reviews Materials · doi:10.1038/s41578-020-00269-6 · Cited by 1,183
Lung cancer immunotherapy: progress, pitfalls, and promises
Lahiri, A., Maji, A., Potdar, P. D., Singh, N., Parikh, P., Bisht, B., Mukherjee, A., & Paul, M. K. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01740-y · Cited by 1,102
Towards personalized, tumour-specific, therapeutic vaccines for cancer
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Metadata
- Authors
- Kuai, R., Ochyl, L. J., Bahjat, K. S., Schwendeman, A., & Moon, J. J.
- Venue
- Nature Materials
- Published
- 2016-12-26
- Volume
- 16
- Issue
- 4
- Pages
- 489-496
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W2564809671
- Cited by
- 1,056
- References
- 7
- FWCI
- 40.04
- Type
- journal article
- Language
- en
- Open access
- green
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- Kuai, R., Ochyl, L. J., Bahjat, K. S., Schwendeman, A., & Moon, J. J. (2017). Designer vaccine nanodiscs for personalized cancer immunotherapy. Nature Materials. https://doi.org/10.1038/nmat4822
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