The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche
Open accessAbstract
Amniogenesis-the development of amnion-is a critical developmental milestone for early human embryogenesis and successful pregnancy. However, human amniogenesis is poorly understood due to limited accessibility to peri-implantation embryos and a lack of in vitro models. Here we report an efficient biomaterial system to generate human amnion-like tissue in vitro through self-organized development of human pluripotent stem cells (hPSCs) in a bioengineered niche mimicking the in vivo implantation environment. We show that biophysical niche factors act as a switch to toggle hPSC self-renewal versus amniogenesis under self-renewal-permissive biochemical conditions. We identify a unique molecular signature of hPSC-derived amnion-like cells and show that endogenously activated BMP-SMAD signalling is required for the amnion-like tissue development by hPSCs. This study unveils the self-organizing and mechanosensitive nature of human amniogenesis and establishes the first hPSC-based model for investigating peri-implantation human amnion development, thereby helping advance human embryology and reproductive medicine.
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Capturing Cardiogenesis in Gastruloids
Rossi, G., Broguiere, N., Miyamoto, M., Boni, A., Guiet, R., Girgin, M., Kelly, R. G., Kwon, C., & Lutolf, M. P. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2020.10.013 · Cited by 306
Metadata
- Authors
- Shao, Y., Taniguchi, K., Gurdziel, K., Townshend, R. F., Xue, X., Yong, K. M. A., Sang, J., Spence, J. R., Gumucio, D. L., & Fu, J.
- Venue
- Nature Materials
- Published
- 2016-12-12
- Volume
- 16
- Issue
- 4
- Pages
- 419-425
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W2564061777
- Cited by
- 236
- References
- 7
- FWCI
- 9.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Shao, Y., Taniguchi, K., Gurdziel, K., Townshend, R. F., Xue, X., Yong, K. M. A., Sang, J., Spence, J. R., Gumucio, D. L., & Fu, J. (2017). Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche. Nature Materials. https://doi.org/10.1038/nmat4829
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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