The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Tissue tectonics: morphogenetic strain rates, cell shape change and intercalation
Open accessAbstract
The dynamic reshaping of tissues during morphogenesis results from a combination of individual cell behaviors and collective cell rearrangements. However, a comprehensive framework to unambiguously measure and link cell behavior to tissue morphogenesis is lacking. Here we introduce such a kinematic framework, bridging cell and tissue behaviors at an intermediate, mesoscopic, level of cell clusters or domains. By measuring domain deformation in terms of the relative motion of cell positions and the evolution of their shapes, we characterized the basic invariant quantities that measure fundamental classes of cell behavior, namely tensorial rates of cell shape change and cell intercalation. In doing so we introduce an explicit definition of cell intercalation as a continuous process. We mapped strain rates spatiotemporally in three models of tissue morphogenesis, gaining insight into morphogenetic mechanisms. Our quantitative approach has broad relevance for the precise characterization and comparison of morphogenetic phenotypes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Draper, N. R., & Smith, H. (1998) · Wiley Series in Probability and Statistics · doi:10.1002/9781118625590 · Cited by 5,024
The embryonic development of Drosophila melanogaster
(1938) · Protoplasma · doi:10.1007/bf01613769 · Cited by 2,142
Reconstruction of Zebrafish Early Embryonic Development by Scanned Light Sheet Microscopy
Keller, P. J., Schmidt, A. D., Wittbrodt, J., & Stelzer, E. H. K. (2008) · Science · doi:10.1126/science.1162493 · Cited by 1,560
The Influence of Cell Mechanics, Cell-Cell Interactions, and Proliferation on Epithelial Packing
Farhadifar, R., Röper, J.-C., Aigouy, B., Eaton, S., & Jülicher, F. (2007) · Current Biology · doi:10.1016/j.cub.2007.11.049 · Cited by 1,253
Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation
Bertet, C., Sulak, L., & Lecuit, T. (2004) · Nature · doi:10.1038/nature02590 · Cited by 1,020
de Gennes, P. G. (1999) · Cited by 956
Multicellular Rosette Formation Links Planar Cell Polarity to Tissue Morphogenesis
Blankenship, J. T., Backovic, S. T., Sanny, J. S. P., Weitz, O., & Zallen, J. A. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.09.007 · Cited by 707
The Embryonic Development of Drosophila melanogaster
Campos-Ortega, J. A., & Hartenstein, V. (1997) · Springer eBooks · doi:10.1007/978-3-662-22489-2 · Cited by 692
Multiple Forces Contribute to Cell Sheet Morphogenesis for Dorsal Closure in Drosophila
Kiehart, D. P., Galbraith, C. G., Edwards, K. A., Rickoll, W. L., & Montague, R. A. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.2.471 · Cited by 642
Forces for Morphogenesis Investigated with Laser Microsurgery and Quantitative Modeling
Hutson, M. S., Tokutake, Y., Chang, M.-S., Bloor, J. W., Venakides, S., Kiehart, D. P., & Edwards, G. S. (2003) · Science · doi:10.1126/science.1079552 · Cited by 528
Cited by
Mechanical waves during tissue expansion
Serra-Picamal, X., Conte, V., Vincent, R., Anon, E., Tambe, D. T., Bazellieres, E., Butler, J. P., Fredberg, J. J., & Trepat, X. (2012) · Nature Physics · doi:10.1038/nphys2355 · Cited by 526
Le, H. Q., Ghatak, S., Yeung, C.-Y. C., Tellkamp, F., Günschmann, C., Dieterich, C., Yeroslaviz, A., Habermann, B., Pombo, A., Niessen, C. M., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3387 · Cited by 477
Apical constriction: A cell shape change that can drive morphogenesis
Sawyer, J. M., Harrell, J. R., Shemer, G., Sullivan-Brown, J., Roh-Johnson, M., & Goldstein, B. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2009.09.009 · Cited by 448
Vertex models: from cell mechanics to tissue morphogenesis
Alt, S., Ganguly, P., & Salbreux, G. (2017) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0520 · Cited by 445
Interplay of cell dynamics and epithelial tension during morphogenesis of the Drosophila pupal wing
Etournay, R., Popović, M., Merkel, M., Nandi, A., Blasse, C., Aigouy, B., Brandl, H., Myers, G., Salbreux, G., Jülicher, F., et al. (2015) · eLife · doi:10.7554/elife.07090 · Cited by 373
Metadata
- Authors
- Blanchard, G. B., Kabla, A. J., Schultz, N. L., Butler, L. C., Sanson, B., Gorfinkiel, N., Mahadevan, L., & Adams, R. J.
- Venue
- Nature Methods
- Published
- 2009-05-03
- Volume
- 6
- Issue
- 6
- Pages
- 458-464
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W1992172233
- Cited by
- 302
- References
- 29
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Tissue tectonics: morphogenetic strain rates, cell shape change and intercalation. https://app.cochat.ai/papers/10.1038/nmeth.1327
- The paper
- Blanchard, G. B., Kabla, A. J., Schultz, N. L., Butler, L. C., Sanson, B., Gorfinkiel, N., Mahadevan, L., & Adams, R. J. (2009). Tissue tectonics: morphogenetic strain rates, cell shape change and intercalation. Nature Methods. https://doi.org/10.1038/nmeth.1327
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
